Critical Essential Core Tested Community Questions (4) (M2.PY.4684) A 21-year-old man presents to the clinic complaining of feeling tired during the day. [medbullets.com]

The curtailed sleep pattern is present most days for at least three months. [snane.ch]

It can take a number of years for this symptom to progress to a point of concern and for other related symptoms to present. [sleepassociation.org]

Sudhansu Chokroverty—a world-recognized expert in sleep medicine—presents the third edition of Sleep Disorders Medicine for the latest developments in this rapidly expanding specialty, with coverage of neuroscience and clinical application. [books.google.ro]

Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. [medicinenet.com]

• Fatigue

  Less restful sleep can result in fatigue during the day. Even moderate alcohol consumption can be discouraged if you have narcolepsy. [24] Caffeine is often used by narcoleptics to manage feelings of fatigue throughout the day. [wikihow.com]

  Startling stimuli, stress, physical fatigue, or sleepiness may also be important triggers or factors that exacerbate cataplexy. The person is usually alert and oriented during the event despite the inability to respond during the event. [holistic-online.com]

  If you have been experiencing symptoms such fatigue, daytime sleepiness, hallucinations, or sleep attacks, then it is very likely you might have Narcolepsy or another sleep disorder. [valleysleepcenter.com]

  A person with signs of narcolepsy will experience extreme fatigue and may fall asleep at odd and inappropriate times, such as during work or school. A brief nap is generally refreshing, but the sleepiness re-occur rapidly a few hours later. [stanfordhealthcare.org]

  Thank you, Jack I'm really sorry to hear this, Jack I can sympathise in a way, because I was diagnosed with Chronic Fatigue Syndrome while in school and it got particularly severe, even leaving me housebound for a few months, in my final year of school [thestudentroom.co.uk]

• Weight Gain

  The weight gain may be related to a low metabolism. Jan. 12, 2019 [mayoclinic.org]

  Yet we often only hear of diet and exercise hailed as the keys to longevity, protecting us from the evils that make us feel bad (heart disease, diabetes, depression) and look bad (excessive weight gain, poor complexion). [huffpost.com]

  Aripiprazole might be somewhat less sedating and have less weight gain than other antipsychotics ( 30 ). [frontiersin.org]

  Such meds can cause some side effects, such as weight gain, sexual dysfunction, and digestive problems. [14] Examples of TCA's include imipramine and clomipramine. [15] If SSRI's and SNRI's do not work, older types of antidepressants may be prescribed [wikihow.com]

• Fever

  Picchioni et al., in a case-controlled study, associated inexplicable fevers and flu with increased risk of 3.9 and 1.8 times, respectively, for narcolepsy [3]. [sleepscience.org.br]

  Colonic Disease, Behcets Disease, Collagenous Colitis, Mastitis, Colitis, Intestinal Obstruction, Colorectal Cancer, Pyoderma Gangrenosum, Pyoderma, Psoriatic Juvenile Idiopathic Arthritis, Ocular Toxoplasmosis, Toxoplasmosis, Familial Mediterranean Fever [genecards.weizmann.ac.il]

• Unconsciousness

  As she fights through the cataplexy, Wheaton experiences micronaps, short bursts of unconsciousness. “To see this in video form, it really helps to capture the extremes of what cataplexy can do to you. [today.com]

• Flushing

  […] including: hallucinations – seeing or hearing things that aren't real, particularly when going to sleep or waking up; a presence in the bedroom is the most commonly reported hallucination memory problems headaches restless sleep – for example, having hot flushes [nhs.uk]

• Aggressive Behavior

  Children and adolescents with narcolepsy may struggle with emotional regulation and display aggressive behaviors that lead to social exclusion and feelings of self-loathing and shame. [wakeupnarcolepsy.org]

• Abnormal Gait

  NEDLBA OMIM:617710 Neurodevelopmental Disorder, Mitochondrial, with Abnormal Movements and Lactic Acidosis, with or without Seizures; NEMMLAS OMIM:617807 Neurodevelopmental Disorder with Ataxic Gait, Absent Speech, and Decreased Cortical White Matter [informatics.jax.org]

  Overall, nine children (23%) had a combination of hypotonia and abnormal gait, whereas seven (18%) and one (3%) presented only mild hypotonia or abnormal gait, respectively. 16 [Level 4] A systematic review of physical examination findings was not present [jcsm.aasm.org]

Awareness was aroused and referrals to specialist and diagnostic workup expedited only after the media attention from Sweden broke out in August 2010. [journals.plos.org]

The history of its treatment originated with traditional stimulants, such as methylphenidate and the amphetamine—which are still used—but, he said, “they have significant adverse effects. [neurologylive.com]

Monitoring during treatment - baseline electrocardiogram pre-treatment; monitor blood pressure and heart rate/rhythm; stop treatment if these are abnormal. [patient.info]

In all cases in that controlled trial, the confusion resolved soon after termination of treatment. [xyremhcp.com]

Non-drug treatments Non-drug treatments include education of the patient and family members and modification of behavior patterns. [medicinenet.com]

What is the Prognosis of Narcolepsy? (Outcomes/Resolutions) The prognosis of Narcolepsy is determined by the severity of its signs and symptoms. [dovemed.com]

Patients who have narcolepsy with cataplexy have been found to be more impulsive and more prone to binge eating than patients without cataplexy and controls. [ 28 ] There is a high risk of obesity and metabolic syndrome. [ 10 ] Prognosis [ 4, 29 ] Symptoms [patient.info]

[…] heterogeneous disease conditions, but the hypocretin systems are often impaired. 2, 3 Gaining the basic knowledge of symptomatic narcolepsy in immune-mediated conditions will be not only useful for selecting the most appropriate treatment and predicting the prognosis [jamanetwork.com]

Since narcolepsy is also tightly associated with HLA antigen positivity (HLA DR2/DQB1*0602), an involvement of autoimmune mechanisms in its etiology is suggested, but this has not been proven yet. 1 Narcolepsy also occurs during the course of various [jamanetwork.com]

Narcolepsy pathophysiology is linked to loss of signaling by hypocretin-producing neurons; an autoimmune etiology possibly triggered by some environmental agent may precipitate hypocretin neuronal loss. [dovepress.com]

So you can see why scientists get petulant when the press reports that Dr Mephistopheles has found The gene for homosexuality, schizophrenia, gout or any other traits with complex causation (or etiology αἰτιολογία as we like to call it to bamboozle outsiders [geneticdisorders.info]

The etiology of primary enuresis is likely to be multifactorial. A strong family history of enuresis is often present. [aafp.org]

(Etiology) Narcolepsy is caused by the deficiency of hypocretins (also known as orexins). Hypocretins (hypocretin 1 and hypocretin 2) are neurotransmitters in the brain. [dovemed.com]

Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also [books.google.com]

An epidemiological study on prevalence of narcolepsy in Japanese. J Sleep Res. 1992;1(suppl):228. Google Scholar 30. Ohayon M. Epidemiology of narcolepsy. In: Bassetti C, Billiard M, Mignot E, editors. Narcolepsy and hypersomnia. [link.springer.com]

The findings, from one of the largest known studies of narcolepsy epidemiologic patterns, are the latest piece of the puzzle for European health officials who have been investigating a link between narcolepsy and vaccination with Pandemrix, a monovalent [cidrap.umn.edu]

The epidemiologic observation that influenza A (H1N1) infection and vaccination are potential triggering factors of narcolepsy type 1 (discovered during the 2009 H1N1 pandemic) has increased interest in this rare disease, and progress is being made to [journals.lww.com]

Narcolepsy in association with pandemic influenza vaccination (a multi-country European epidemiological investigation) Cdc-pdf External. Stockholm: ECDC ; September 2012. Eurosurveillance editorial team. [cdc.gov]

Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy. [ncbi.nlm.nih.gov]

Sleep Neurology p. 989-1004 August 2017, Vol.23, No.4 doi: 10.1212/CON.0000000000000492 REVIEW ARTICLES Article Related Links Abstract Purpose of Review: This article focuses on the clinical presentation, pathophysiology, diagnosis, differential diagnosis [journals.lww.com]

Narcolepsy pathophysiology is linked to loss of signaling by hypocretin-producing neurons; an autoimmune etiology possibly triggered by some environmental agent may precipitate hypocretin neuronal loss. [dovepress.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Narcolepsy affects 0.02% to 0.05% of the population and the onset of symptoms often occurs in adolescence. [mayocliniclabs.com]

Narcolepsy: genetics, immunology, and pathophysiology. In: Kryger M, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 6th ed. Philadelphia, PA: Elsevier; 2017:chap 89. Updated by: Amit M. [medlineplus.gov]

Use the filters to find everything you need. node teaser Accident prevention/safety Be aware of situations where you are likely to be at risk of falling asleep or suffer from a cataplexy attack and inform others around you It may clearly be hazardous [narcolepsy.org.uk]

Immunotherapy to prevent hypocretin neuronal death is reviewed. [dovepress.com]

[…] neurons and prevent chronic sleep-related symptoms. [jamanetwork.com]

The study, published in the February 6 issue of Vaccine, was conducted by members of the Vaccine Adverse Events Surveillance and Communication (VAESCO) consortium based on a request from their partners at the European Centre for Disease Prevention and [cidrap.umn.edu]

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