Recent epidemiological studies have demonstrated that postprandial hyperglycemia can result in arteriosclerosis, and that advanced arteriosclerosis is present in the initial stage of impaired glucose tolerance. [ncbi.nlm.nih.gov]

E-mail: james.mangold{at}pharma.novartis.com This work was presented in part at the 9th North American International Society for the Study of Xenobiotics (ISSX) Meeting in Nashville, TN, Oct. 24–28, 1999. [dmd.aspetjournals.org]

• Thrombosis

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Final FBG and PBG were comparable for the two treatments. There were 2.8% subjects treated with nateglinide who had hypoglycaemic episodes, but none in the mitiglinide treatment group. [ncbi.nlm.nih.gov]

Figure 1— A : Mean HbA 1c values during treatment. SE values are indicated by bars. B : Mean FPG values during treatment. SE values are indicated by bars. Figure 2— Mean 8-point blood glucose profiles at end of study. [doi.org]

Epidemiological studies have shown that post-prandial hyperglycaemia, rather than fasting hyperglycaemia, is more closely related to cardiovascular complications. [oadoi.org]

Recent epidemiological studies have demonstrated that postprandial hyperglycemia can result in arteriosclerosis, and that advanced arteriosclerosis is present in the initial stage of impaired glucose tolerance. [ncbi.nlm.nih.gov]

Diabet Med. 2004; 21: 208-213 DECODE Study Group, the European Diabetes Epidemiology Group Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria.Arch Intern Med. 2001; 161: 397-405 Meigs J.B. [diabetesresearchclinicalpractice.com]

Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence. Diabetologia. 2001 ; 44 : 2107–2114. Crossref Medline Google Scholar 4 Standards of medical care in diabetes–2007. [ahajournals.org]

CONCLUSIONS: Nateglinide and acarbose were comparably effective in reducing postprandial glycemic excursions in antihyperglycemic agent-naive Chinese patients with type 2 diabetes, possibly through different pathophysiological mechanisms. [ncbi.nlm.nih.gov]

This book gives a practical, no-nonsense approach to understanding the basic pathophysiology of diabetes and the metabolic syndrome, an approach to treatment with oral agents and insulin, and an approach to risk factor management. [books.google.com]

The purpose of the current study was also to ascertain whether anti-diabetic agents with different primary mechanisms of action targeting the two main pathophysiological defects of type 2 diabetes would have different effects on these parameters and if [dmsjournal.biomedcentral.com]

However, it remains to be elucidated whether correction of the postprandial glycemic status prevents atherosclerotic changes. [ncbi.nlm.nih.gov]

Keywords: nateglinide, type 2 diabetes mellitus, postprandial glycemia, impaired glucose tolerance, prevention of type 2 diabetes Download Article [PDF] [dovepress.com]