Presentation
The main presenting feature of NAM is subacute severe symmetrical proximal myopathy, with a markedly elevated creatine kinase (CK) level. [orpha.net]
Entire Body System
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Weakness
Creatine kinase (CK) levels are often more than 10 times above the upper limit of normal at the time of onset of muscle weakness. Magnetic resonance imaging (MRI) may show diffuse or patchy edema within muscles. [orpha.net]
Gastrointestinal
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Dysphagia
Other manifestations include fatigue, weight loss dysphagia and dyspnea. Interstitial lung disease (see this term) and cardiac involvement have also been reported. [orpha.net]
Musculoskeletal
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Muscle Weakness
Creatine kinase (CK) levels are often more than 10 times above the upper limit of normal at the time of onset of muscle weakness. Magnetic resonance imaging (MRI) may show diffuse or patchy edema within muscles. [orpha.net]
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Myopathy
The main presenting feature of NAM is subacute severe symmetrical proximal myopathy, with a markedly elevated creatine kinase (CK) level. [orpha.net]
Treatment
Management and treatment Treatment of the underlying cause, if identified, is essential (statin discontinuation, or malignancy). [orpha.net]
Etiology
Etiology The disease is thought to be related to an immune response possibly triggered by drug therapy (statins), connective tissue diseases, or cancer. [orpha.net]
Epidemiology
Summary Epidemiology The prevalence and annual incidence of NAM are not known but the disorder is very rare. About 300 cases have been reported to date. Clinical description Age of onset ranges from 30 to 70 years of age in reported cases. [orpha.net]