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Necrotizing Myopathy


Presentation

  • The main presenting feature of NAM is subacute severe symmetrical proximal myopathy, with a markedly elevated creatine kinase (CK) level.[orpha.net]
Weight Loss
  • Other manifestations include fatigue, weight loss dysphagia and dyspnea. Interstitial lung disease (see this term) and cardiac involvement have also been reported.[orpha.net]
Fatigue
  • Other manifestations include fatigue, weight loss dysphagia and dyspnea. Interstitial lung disease (see this term) and cardiac involvement have also been reported.[orpha.net]
Pharyngitis
  • Its presentation is similar to that of polymyositis (see this term) with upper and lower limb weakness causing difficulty in moving from a sitting position, climbing stairs, or lifting objects The neck flexor, pharyngeal, and respiratorymuscles may also[orpha.net]
Dyspnea
  • Other manifestations include fatigue, weight loss dysphagia and dyspnea. Interstitial lung disease (see this term) and cardiac involvement have also been reported.[orpha.net]
Limb Weakness
  • Its presentation is similar to that of polymyositis (see this term) with upper and lower limb weakness causing difficulty in moving from a sitting position, climbing stairs, or lifting objects The neck flexor, pharyngeal, and respiratorymuscles may also[orpha.net]

Treatment

  • Management and treatment Treatment of the underlying cause, if identified, is essential (statin discontinuation, or malignancy).[orpha.net]

Etiology

  • Etiology The disease is thought to be related to an immune response possibly triggered by drug therapy (statins), connective tissue diseases, or cancer.[orpha.net]

Epidemiology

  • Summary Epidemiology The prevalence and annual incidence of NAM are not known but the disorder is very rare. About 300 cases have been reported to date. Clinical description Age of onset ranges from 30 to 70 years of age in reported cases.[orpha.net]
Sex distribution
Age distribution

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