The case report presents a unique situation: an uncommon etiology of neonatal meningitis and favorable evolution, despite neurological sequels reported in the literature. [ncbi.nlm.nih.gov]

Comparative analysis showed that four genes are uniquely present in H44/76 and nine genes are only present in MC58. Of all ORFs in H44/76, 2,317 (93%) show more than 99% sequence identity. [doi.org]

• Pain

  However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. [ncbi.nlm.nih.gov]

  The most commonly reported side effects by those who received Trumenba were pain and swelling at the injection site, headache, diarrhea, muscle pain, joint pain, fatigue and chills. [fda.gov]

  Furthermore, cases were reviewed if patients presented with no evidence of meningeal symptoms such as neck rigidity, neck or back pain, or delirium. [healio.com]

• Swelling

  A 78-year-old female patient presented to our emergency department with a 5-day history of throat pain, hoarseness and a progressive and dolorous submandibular swelling. [ncbi.nlm.nih.gov]

  Side Effects Pain/redness/swelling at the injection site, headache, fever, chills, drowsiness, tiredness, joint / muscle pain, nausea, loss of appetite, or diarrhea may occur. [webmd.com]

  The most common side effects with Bexsero in adolescents from 11 years of age and adults (seen in more than 1 patient in 10) are headache, nausea (feeling sick) and malaise (feeling unwell), myalgia (muscle pain) and arthralgia as well as pain, swelling [ema.europa.eu]

  The most commonly reported side effects by those who received Trumenba were pain and swelling at the injection site, headache, diarrhea, muscle pain, joint pain, fatigue and chills. [fda.gov]

• Veterinarian

  Who is required to report Health care practitioners (health care facilities, medical laboratories, and in certain circumstances veterinarians and veterinary medical laboratories) are required to report disease to the Minnesota Department of Health (MDH [health.state.mn.us]

• Unconsciousness

  On December 11, 2009, the California Department of Public Health (CDPH) initiated an investigation of two secondary cases of meningococcal disease in a police officer and a respiratory therapist following occupational contact with an unconscious adult [ncbi.nlm.nih.gov]

  Upon arrival, the patient was unconscious with systemic shock and died a few minutes later in the emergency room. One episode of seizure was described before the fatal outcome. [scielo.br]

• Whipple Disease

  This approach has had major applications in the detection of infections due to microorganisms that are difficult to culture (e.g. the human immunodeficiency virus) or that have not as yet been successfully cultured (e.g. the Whipple's disease bacillus [ncbi.nlm.nih.gov]

• Pneumonia

  Streptococcus pneumoniae (Gram-positive bacteria) was recognized as a major cause of pneumonia in the late 19th century and is the most common cause of bacterial meningitis in adults and children. [mikrogen.de]

  Furthermore, individuals giving correct answers to all knowledge items were more in favour of both HPV and S. pneumoniae vaccination. [ncbi.nlm.nih.gov]

  3 Months – 18 Years Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae 18 – 50 Years Neisseria meningitidis Streptococcus pneumoniae > 50 Years Listeria monocytogenes Streptococcus pneumoniae 12. [de.slideshare.net]

• Respiratory Insufficiency

  An analysis of arterial blood gases revealed both respiratory and metabolic acidosis. Blood and urine culture samples were obtained. The patient was diagnosed with sepsis and respiratory insufficiency based on the clinical and laboratory findings. [jcm.asm.org]

  Patients with fulminant meningococcemia may develop respiratory insufficiency and require mechanical ventilation. Those with severe DIC may bleed into their lungs, urinary tract, and gastrointestinal tract. [emedicine.medscape.com]

• Skin Rash

  rash is a very important sign to watch for. [webmd.com]

  The petechial rash of meningococcemia may also occur. [bu.edu]

  Meningococcemia : Patients present with rapid onset of fever, vomiting, photophobia, convulsions, skin rash, lethargy, irritability, drowsiness, diarrhea, muscular pain, arthralgia, and rarely, acute abdominal pain Footnote 3. [phac-aspc.gc.ca]

• Eruptions

  The patient did not exhibit organomegaly or eruptions. The capillary filling time was 2 s. [jcm.asm.org]

  The rash disseminated with appearance of extensive purpuric eruptions over all four extremities and the face. [scielo.br]

  The skin rash may progress from a few ill-defined lesions to a widespread eruption within a few hours. Acute bacterial meningitis has characteristic signs and symptoms. [ncbi.nlm.nih.gov]

  In fulminant meningococcemia, a hemorrhagic eruption, hypotension, and cardiac depression, as well as rapid enlargement of petechiae and purpuric lesions (see the image below) Child with severe meningococcal disease and purpura fulminans. [emedicine.medscape.com]

• Photophobia

  Other symptoms may include rash, nausea, vomiting, photophobia, confusion, and sleepiness. As the disease progresses, patients may also experience seizures. Without antibiotic treatment, patients with invasive meningococcal disease can die. [phpa.health.maryland.gov]

  Other symptoms include nausea, vomiting, photophobia and altered mental state. Meningococcal meningitis can be fatal in as little as a few hours. Complications include bacteremia or septicemia. [dentalcare.com]

  Meningococcemia : Patients present with rapid onset of fever, vomiting, photophobia, convulsions, skin rash, lethargy, irritability, drowsiness, diarrhea, muscular pain, arthralgia, and rarely, acute abdominal pain. [bu.edu]

  Upon examination, the male demonstrates nuchal rigidity and photophobia. His past medical history is notable for a lack of vaccinations beginning from infancy due to his parents' belief that vaccinations may cause autism. [medbullets.com]

• Arthralgia

  A patient with well-controlled HIV-1 infection presented with fever and rigors, a widespread maculopapular rash, and severe generalised arthralgia. [ncbi.nlm.nih.gov]

  The most common side effects with Bexsero in adolescents from 11 years of age and adults (seen in more than 1 patient in 10) are headache, nausea (feeling sick) and malaise (feeling unwell), myalgia (muscle pain) and arthralgia as well as pain, swelling [ema.europa.eu]

  Meningococcemia : Patients present with rapid onset of fever, vomiting, photophobia, convulsions, skin rash, lethargy, irritability, drowsiness, diarrhea, muscular pain, arthralgia, and rarely, acute abdominal pain. [bu.edu]

  Meningococcemia • Intravascular multiplication of Neisseria meningitidis • Abrupt onset of spiking fever, chills, arthralgia and muscle pains • Abrupt onset of hypotension and tachycardia • Rapidly enlarging petechial lesions • Wide spread purpura coalesce [de.slideshare.net]

  Meningococcemia : Patients present with rapid onset of fever, vomiting, photophobia, convulsions, skin rash, lethargy, irritability, drowsiness, diarrhea, muscular pain, arthralgia, and rarely, acute abdominal pain Footnote 3. [phac-aspc.gc.ca]

• Myalgia

  Common solicited adverse reactions among adolescents and adults were pain at the injection site, headache, myalgia, malaise, and nausea. [menveo.com]

  The most common side effects with Bexsero in adolescents from 11 years of age and adults (seen in more than 1 patient in 10) are headache, nausea (feeling sick) and malaise (feeling unwell), myalgia (muscle pain) and arthralgia as well as pain, swelling [ema.europa.eu]

  On the next day, he had the onset of myalgia, vomiting, and a petechial rash. Patient became confused, and his level of consciousness deteriorated progressively. [scielo.br]

(See Pathophysiology, Etiology, and Workup.) Gram-negative intracellular diplococci. Courtesy Professor Chien Liu. [emedicine.medscape.com]

Diagnosis is a clinical challenge, requiring diagnostic sampling and treatment from both pediatricians and ophthalmologists. Delayed or incorrect treatment risks blindness, disability, or death. [ncbi.nlm.nih.gov]

[…] poor prognosis include shock, young and old age, coma, purpura fulminans, and disseminated intravascular coagulation Presentation Symptoms headache fever neck stiffness nausea and vomiting myalgias Physical petechial rash nuchal rigidity Brudzinki sign [medbullets.com]

Prognosis is much worse if infection has a septicemic component. [ncbi.nlm.nih.gov]

Isolated meningococcal meningitis (5% mortality rate) has a better prognosis than meningococcal septicemia (10%-40% mortality rate). [emedicine.medscape.com]

Information about the disease must be given out in an attempt to improve the prognosis, including early treatment with parenteral antibiotics and training of the communities' health agents to recognize a suggestive rash. [scielo.br]

Neisseria meningitidis is a rare etiology of keratoconjunctivitis and its ocular presentations are quite similar with other bacterial or viral infection. [ncbi.nlm.nih.gov]

Meningitis, Meningococcal/microbiology* Molecular Typing Neisseria meningitidis/genetics* Neisseria meningitidis/isolation & purification Neisseria meningitidis, Serogroup C/genetics* Neisseria meningitidis, Serogroup C/isolation & purification Niger/epidemiology [ncbi.nlm.nih.gov]

This led the Regional Health Authority of Tuscany to implement a reactive immunisation campaign and to launch an epidemiological field investigation aiming to address targeted immunisation interventions. [eurosurveillance.org]

Modification of subarachnoid space inflammation by anti-inflammatory agents may lessen many of the pathophysiologic consequences of bacterial meningitis. [ncbi.nlm.nih.gov]

As such, it represents a unique human infectious disease, because the pathophysiologic effects of disease progression and suboptimal outcomes occur despite bacteriologic cure of the infection. 1 Specifically, the mortality rate for adults who have Streptococcus [nejm.org]

Pathogenesis and pathophysiology of bacterial meningitis. Clin Microbiol Rev 1993 ; 6 : 118 –36. ↵ Quagliarello V, Scheld WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med 1992 ; 327 : 864 –72. ↵ Welch SB, Nadel S. [adc.bmj.com]

Although capillary leak is the most important clinical event, the underlying pathophysiology is unclear. [emedicine.medscape.com]

Pathophysiology, treatment and outcome of meningococcemia:a review and recent experience. Pediatr Infect Dis J 1996;15:967-79. 8. Caugant DA. Population genetics and molecular epidemiology of Neisseria meningitidis. APMIS 1998;106:505-25. 9. [doi.org]

Author information 1 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. 2 Zhejiang [ncbi.nlm.nih.gov]

Prevention General Meningococcal disease prevention advice includes maintaining good overall health, avoiding first and second-hand tobacco smoke, using cough etiquette, and minimizing shared saliva. [dph.georgia.gov]