Congenital cutaneous candidiasis (CCC) presents within the first 6 days of life as a skin eruption caused by Candida spp. [latunisiemedicale.com]

• Candidiasis

  Early neonatal cutaneous candidiasis. Helv Paediatr Acta 1984;39:265–8 Arbegast KD, Lamberty LF, Koh JK. Congenital candidiasis limited to the nail plates. Pediatr Dermatol. 1990;7:310–12 Baley JE, Silverman RA. [latunisiemedicale.com]

• Inflammation

  Placental inflammation and infection. A prospective bacteriologic and histologic study. Am J Obstet Gynecol 1966;95:648–59 Delaplane D, Wiringa KS, Shulman ST, Yogev R. Congenital mucocutaneous candidiasis following diagnostic amniocentesis. [latunisiemedicale.com]

• Respiratory Distress

  This patient developed at 50 hours of life a secondary respiratory distress with tachypnea of 80 breaths per minute, sub-costal retractions and fever of 39°C. Chest X ray showed bilateral lungs infiltrates. [latunisiemedicale.com]

• Skin Lesion

  Ear, anus and gastric swabs and skin lesion sample were performed. The new born was treated with topical antifungal therapy (Econazole). [latunisiemedicale.com]

• Erythema

  The differential diagnosis includes other neonatal vesiculopustular disorders, such as listeriosis, syphilis, staphylococcal and herpes simplex infections, as well as erythema toxicum neonatorum, transient neonatal pustular melanosis, miliaria rubra, [latunisiemedicale.com]

• Candida

  DISCUSSION: CCC occurs in the setting of candidal vulvovaginitis, which is present in 20% to 25% of all pregnant women [3,4].Despite its frequent presence in the vagina, Candida can be shown on the fetal surface of < 1% of placentas[5].Extension of Candida [latunisiemedicale.com]

Amphotericin B is the first-line agent for treatment for 21 days and the use of fluconazole may be considered when toxicity to amphotericin B is prohibitive and the organism is susceptible, although data to support its use for treatment of systemic candidal [latunisiemedicale.com]

In our patient, early topic therapy did not prevent systemic spread. The current recommendation is to start antifungal therapy when the disease has systemic involvement or extensive burn-like dermatitis. [latunisiemedicale.com]