Other features of Alagille's syndrome were not present; other conditions frequently associated with interlobular bile duct paucity were also excluded. Subsequently, the infant was found to have cystic fibrosis. [ncbi.nlm.nih.gov]

In contrast with physiologic neonatal jaundice, infants with neonatal hepatitis present with dark urine. Infants may also present with delayed growth.[1] Causes[edit] The cases of neonatal hepatitis are many. [en.wikipedia.org]

• Failure to Thrive

  Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. Rarely, severe illness may cause acute liver failure requiring liver transplantation. [msdmanuals.com]

  By the age of 2 to 3 months, it becomes clear that an infant with neonatal hepatitis is not gaining weight and is growing at a slower than normal rate (failure to thrive). The infant may be irritable because of excessively itchy skin (pruritus). [rarediseases.org]

• Clay-Colored Stool

  The younger brother developed jaundice and clay-colored stools at the age of 1 month. The diagnosis of extrahepatic biliary atresia was made at laparotomy at the age of 4 1/2 months. [ncbi.nlm.nih.gov]

  Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. Rarely, severe illness may cause acute liver failure requiring liver transplantation. [msdmanuals.com]

• Jaundice

  The observations on the critical evaluation of the neonatal jaundice cases led us to propose AIIMS clinical score (ACS) and this retrospective study was designed to evaluate the reliability of the ACS in all the 120 babies with jaundice referred to the [ncbi.nlm.nih.gov]

  Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice. [en.wikipedia.org]

  Main Article Content Abstract It is known in this country that surgical obstructive jaundice cases used to be sent to the surgeon in the terminal state. [paediatricaindonesiana.org]

• Hepatomegaly

  We present a case of severe HIDS in a young girl, whose symptoms started in the neonatal period with hepatomegaly, hepatitis, thrombocytopenia, and conjugated hyperbilirubinemia. [hindawi.com]

  The hepatitis group had the highest frequencies of high-grade hepatomegaly and splenomegaly. Fifty six cases completely recovered. Two died of hepatic failure in early infancy and four had chronic liver diseases at the age of 12 months. [ncbi.nlm.nih.gov]

  There was jaundice and hepatomegaly. Others systems were normal. [pediatriconcall.com]

  […] idiopathic • By mid-2000s, idiopathic neonatal hepatitis (INH) comprised only 15-30% of neonatal cholestasis due to increased ability to detect and diagnose metabolic and genetic disorders previously considered idiopathic Clinical Issues • Jaundice • Hepatomegaly [basicmedicalkey.com]

• Neonatal Jaundice

  Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice. In contrast with physiologic neonatal jaundice, infants with neonatal hepatitis present with dark urine. [en.wikipedia.org]

  The observations on the critical evaluation of the neonatal jaundice cases led us to propose AIIMS clinical score (ACS) and this retrospective study was designed to evaluate the reliability of the ACS in all the 120 babies with jaundice referred to the [ncbi.nlm.nih.gov]

  The detection of Au-Ag in prolonged neonatal jaundice with direct bilirubinemia favors a diagnosis of hepatitis type B, which in our experience carries a graver prognosis reflected in deaths and cirrhosis when compared to neonatal hepatitis not associated [pediatrics.aappublications.org]

• Scleral Icterus

  At 30 hours of life, the infant was noted to have scleral icterus. Total and direct bilirubin was 26.6 and 15.1 mg/dl, respectively, and on repeat were 25.5 and 14.5 mg/dl. [nature.com]

  CLINICAL PRESENTATIONCLINICAL PRESENTATION Jaundice Scleral icterus Hepatomegaly Acholic stools Dark urine Other signs and symptoms depend on specific disease process 18. [slideshare.net]

  icterus, acholic stools, dark yellow urine, and hepatomegaly. [ncbi.nlm.nih.gov]

• Cutis Laxa

  Paediatricians need to look for additional clinical signs, such as ichthyosis, hypertrichosis, cutis laxa, skeletal changes, or congenital deafness, which could point to new conditions emerging in the spectrum of prolonged neonatal cholestasis. [journals.lww.com]

• Hypertrichosis

  Paediatricians need to look for additional clinical signs, such as ichthyosis, hypertrichosis, cutis laxa, skeletal changes, or congenital deafness, which could point to new conditions emerging in the spectrum of prolonged neonatal cholestasis. [journals.lww.com]

We established a 3-day workup protocol for the differential diagnosis of biliary atresia and neonatal hepatitis and compared the diagnostic accuracy, sensitivity, specificity, and predictive values of various methods. [ncbi.nlm.nih.gov]

Some children may require a liver biopsy as part of their diagnostic workup. If no specific cause of liver dysfunction is identified, neonatal hepatitis is the term used to describe the inflammatory process happening in the infant’s liver. [liver.ca]

• C-Reactive Protein Increased

  Serum C-reactive protein increased to 33.9 mg/L. [ncbi.nlm.nih.gov]

• Trophoblastic Cells

  Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J Cell Physiol. 2005; 204 901-912 10 Nicolas G, Bennoun M, Devaux I et al.. [doi.org]

In 9 of 12 infants, liver disease resolved within 6 wk following treatment with thyroxine, hydrocortisone and, where appropriate, growth hormone, including Cases 9 and 1 in whom diagnosis and treatment were delayed until 3 mo and 3 y of age, respectively [ncbi.nlm.nih.gov]

Other tests used to make a hepatitis diagnosis include: A type of nuclear medicine test called a hepatobiliary iminodiacetic acid (HIDA) scan Liver biopsy Ultrasound Treatments Treatments Treatment of neonatal hepatitis depends on the underlying cause [rileychildrens.org]

Although the prognosis varies for the familial and sporadic forms of neonatal hepatitis, a poor outcome is generally distinguished by chronic and progressive liver failure. [ncbi.nlm.nih.gov]

Prognosis of babies with neonatal hepatitis. Abstract 105 babies with neonatal hepatitis were studied carefully and followed for up to 11 1/2 years. [adc.bmj.com]

Neonatal hepatitis with acute liver failure due to varied etiology including various infections is reported in the past. Scrub typhus as a cause of neonatal hepatitis has rarely been reported in literature. [ncbi.nlm.nih.gov]

Terminology Also known as neonatal giant cell hepatitis because of frequent syncytial giant cell formation Etiology Intrahepatic neonatal cholestasis accounts for 60 - 70% of all neonatal cholestasis Usual causes include (Front Pediatr 2015;3:43): 9 [pathologyoutlines.com]

Liver biopsy distinguishes NGCH from other etiologies. [nature.com]

[…] vaccination program View more NSW Public Health Bulletin archive Sharmila Jayaram Citation Download this citation in one of the formats below: PDF Author details About the author/s Sharmila Jayaram Abstract Australia has a unique pattern of hepatitis B (HB) epidemiology [phrp.com.au]

Published by Oxford University Press on behalf of the International Epidemiological Association 2016. This work is written by US Government employees and is in the public domain in the United States. [academic.oup.com]

Dick MC, Mowat AP (1985) Hepatitis syndrome in infancy — an epidemiologic survey with 10 year follow up. Arch Dis Child 60: 512–516 PubMed CrossRef Google Scholar 15. [link.springer.com]

Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv. 2002;57:245–256. [PubMed] [Google Scholar] 8. Fowler KB, Stagno S, Pass RF. [ncbi.nlm.nih.gov]

This study demonstrates the possibility of metabolomics as non-invasive biomarkers for the early detection of BA and also provides new insight into pathophysiologic mechanisms for BA. [ncbi.nlm.nih.gov]

Etiology/Pathophysiology: These two entities are thought to be in the spectrum of the same inflammatory process with more advanced sclerosing cholangitis of the extrahepatic ducts in biliary atresia. [virtualpediatrichospital.org]

This video covers the known pathophysiology, important clinical signs and symptoms, laboratory results, and treatments for hepatitis in newborns. [commons.wikimedia.org]

However, in our study, the BA patients did not show such clinical onset, so the further mechanisms that lead to the pathophysiological changes are to be studied. [journals.plos.org]

CONCLUSIONS: This pilot project provides grounds for further exploring how midwives prioritise and conceptualise their health promoting role with regard to infectious disease prevention. [ncbi.nlm.nih.gov]

This hypothesis led to a trial of gestational treatment to prevent the recurrence of severe NH, which has been highly successful adding strength to the alloimmune hypothesis. [citeseerx.ist.psu.edu]

GPs need to be aware of the Neonatal Hepatitis B Prevention and Vaccination Program NSW Health Policy Directive when treating pregnant women. [cesphn.org.au]