Other features of Alagille's syndrome were not present; other conditions frequently associated with interlobular bile duct paucity were also excluded. Subsequently, the infant was found to have cystic fibrosis. [ncbi.nlm.nih.gov]

In contrast with physiologic neonatal jaundice, infants with neonatal hepatitis present with dark urine. Infants may also present with delayed growth.[1] Causes[edit] The cases of neonatal hepatitis are many. [en.wikipedia.org]

• Failure to Thrive

  Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. Rarely, severe illness may cause acute liver failure requiring liver transplantation. [msdmanuals.com]

  By the age of 2 to 3 months, it becomes clear that an infant with neonatal hepatitis is not gaining weight and is growing at a slower than normal rate (failure to thrive). The infant may be irritable because of excessively itchy skin (pruritus). [rarediseases.org]

• Clay-Colored Stool

  After laparotomy, jaundice rapidly disappeared, and stools became yellow. His liver function has been normal since age 6 months to the present (6 years old). The younger brother developed jaundice and clay-colored stools at the age of 1 month. [ncbi.nlm.nih.gov]

  Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. Rarely, severe illness may cause acute liver failure requiring liver transplantation. [msdmanuals.com]

• Jaundice

  The observations on the critical evaluation of the neonatal jaundice cases led us to propose AIIMS clinical score (ACS) and this retrospective study was designed to evaluate the reliability of the ACS in all the 120 babies with jaundice referred to the [ncbi.nlm.nih.gov]

  Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice. [en.wikipedia.org]

  There was jaundice and hepatomegaly. Others systems were normal. [pediatriconcall.com]

• Hepatomegaly

  We present a case of severe HIDS in a young girl, whose symptoms started in the neonatal period with hepatomegaly, hepatitis, thrombocytopenia, and conjugated hyperbilirubinemia. [hindawi.com]

  The hepatitis group had the highest frequencies of high-grade hepatomegaly and splenomegaly. Fifty six cases completely recovered. Two died of hepatic failure in early infancy and four had chronic liver diseases at the age of 12 months. [ncbi.nlm.nih.gov]

  There was jaundice and hepatomegaly. Others systems were normal. [pediatriconcall.com]

  […] idiopathic • By mid-2000s, idiopathic neonatal hepatitis (INH) comprised only 15-30% of neonatal cholestasis due to increased ability to detect and diagnose metabolic and genetic disorders previously considered idiopathic Clinical Issues • Jaundice • Hepatomegaly [basicmedicalkey.com]

• Neonatal Jaundice

  Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice. [en.wikipedia.org]

  Abstract It is important to distinguish neonatal hepatitis (NH) from extra hepatic biliary atresia (EHBA) in a neonate presented with jaundice as the former is purely medical management and the latter requires surgical procedure at the earliest. [ncbi.nlm.nih.gov]

  P59.0 Neonatal jaundice associated with preterm delivery P59.1 Inspissated bile syndrome P59.2 Neonatal jaundice from other and unspecified hepatocellular damage P59.20 Neonatal jaundice from unspecified hepatocellular damage P59.29 Neonatal jaundice [icd10data.com]

  The thirty-three patients with neonatal jaundice were confirmed as neonatal hepatitis (NH) in 28 patients (57%) and biliary atresia (BA) with underlying neonatal hepatitis in 5 patients (10%). [kumel.medlib.dsmc.or.kr]

• Scleral Icterus

  At 30 hours of life, the infant was noted to have scleral icterus. Total and direct bilirubin was 26.6 and 15.1 mg/dl, respectively, and on repeat were 25.5 and 14.5 mg/dl. [nature.com]

  CLINICAL PRESENTATIONCLINICAL PRESENTATION Jaundice Scleral icterus Hepatomegaly Acholic stools Dark urine Other signs and symptoms depend on specific disease process 18. [slideshare.net]

  icterus, acholic stools, dark yellow urine, and hepatomegaly. [ncbi.nlm.nih.gov]

• Cutis Laxa

  Paediatricians need to look for additional clinical signs, such as ichthyosis, hypertrichosis, cutis laxa, skeletal changes, or congenital deafness, which could point to new conditions emerging in the spectrum of prolonged neonatal cholestasis. [journals.lww.com]

We established a 3-day workup protocol for the differential diagnosis of biliary atresia and neonatal hepatitis and compared the diagnostic accuracy, sensitivity, specificity, and predictive values of various methods. [ncbi.nlm.nih.gov]

Some children may require a liver biopsy as part of their diagnostic workup. If no specific cause of liver dysfunction is identified, neonatal hepatitis is the term used to describe the inflammatory process happening in the infant’s liver. [liver.ca]

• Erythroblast

  Some groupings of erythroblasts Groupings of erythroblasts and megakaryocytes Siderosis Deposits of ferric pigment in only a few Kupffer cells Deposits of ferric pigment in Kupffer cells and a few hepatocytes Deposits of ferric pigment in the majority [ncbi.nlm.nih.gov]

In 9 of 12 infants, liver disease resolved within 6 wk following treatment with thyroxine, hydrocortisone and, where appropriate, growth hormone, including Cases 9 and 1 in whom diagnosis and treatment were delayed until 3 mo and 3 y of age, respectively [ncbi.nlm.nih.gov]

Other tests used to make a hepatitis diagnosis include: A type of nuclear medicine test called a hepatobiliary iminodiacetic acid (HIDA) scan Liver biopsy Ultrasound Treatments Treatments Treatment of neonatal hepatitis depends on the underlying cause [rileychildrens.org]

Complications may develop with an increased frequency, if the infant is born preterm, or is severely malnourished, does not get the correct treatment, or if the treatment is delayed. [dovemed.com]

Prognosis of babies with neonatal hepatitis. Abstract 105 babies with neonatal hepatitis were studied carefully and followed for up to 11 1/2 years. [adc.bmj.com]

Although the prognosis varies for the familial and sporadic forms of neonatal hepatitis, a poor outcome is generally distinguished by chronic and progressive liver failure. [ncbi.nlm.nih.gov]

Terminology Also known as neonatal giant cell hepatitis because of frequent syncytial giant cell formation Etiology Intrahepatic neonatal cholestasis accounts for 60 - 70% of all neonatal cholestasis Usual causes include (Front Pediatr 2015;3:43): 9 [pathologyoutlines.com]

Liver biopsy distinguishes NGCH from other etiologies. [nature.com]

A significant difference was observed in IHNC of infectious etiology, which presented with more severe erythropoiesis than the genetic-endocrine-metabolic and idiopathic etiologies. [ncbi.nlm.nih.gov]

[…] vaccination program View more NSW Public Health Bulletin archive Sharmila Jayaram Citation Download this citation in one of the formats below: PDF Author details About the author/s Sharmila Jayaram Abstract Australia has a unique pattern of hepatitis B (HB) epidemiology [phrp.com.au]

Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv. 2002;57:245–256. [PubMed] [Google Scholar] 8. Fowler KB, Stagno S, Pass RF. [ncbi.nlm.nih.gov]

This study demonstrates the possibility of metabolomics as non-invasive biomarkers for the early detection of BA and also provides new insight into pathophysiologic mechanisms for BA. [ncbi.nlm.nih.gov]

Etiology/Pathophysiology: These two entities are thought to be in the spectrum of the same inflammatory process with more advanced sclerosing cholangitis of the extrahepatic ducts in biliary atresia. [virtualpediatrichospital.org]

This video covers the known pathophysiology, important clinical signs and symptoms, laboratory results, and treatments for hepatitis in newborns. [commons.wikimedia.org]

Pathophysiology In hemochromatosis, hepatocytes are the first site of iron deposition. Liver tissue of affected infants displays severe injury with marked loss of hepatocytes. [emedicine.medscape.com]

CONCLUSIONS: This pilot project provides grounds for further exploring how midwives prioritise and conceptualise their health promoting role with regard to infectious disease prevention. [ncbi.nlm.nih.gov]

GPs need to be aware of the Neonatal Hepatitis B Prevention and Vaccination Program NSW Health Policy Directive when treating pregnant women. [cesphn.org.au]

Cirrhosis- Treated with liver transplant Prevention- Prevent viral infection transmission from mother to infant. 6 Symptomatic Treatment- For Fever- Tylenol For Seizures- Anti-seizure medication like phenobarbital. [epainassist.com]