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Neonatal Isoimmune Neutropenia

Alloimmune Neonatal Neutropenia


Presentation

  • AB - The third child of a 34-year-old Caucasian woman presented at two weeks of age with pyoderma of five days' duration and severe neutropenia. The neutropenia persisted for at least 28 days.[experts.umich.edu]
  • This first- reported case of ophthalmia neonatorum associated with isoimmune neonatal neutropenia is presented to show the need for medical workup for underlying predisposing disease.[healio.com]
  • Weiner, Bernard Gonik, Caroline Crowther, and Stephen Robson present an evidence-based approach to the available management options, equipping you with the most appropriate strategy for each patient.[books.google.com]
  • The infant has remained healthy up to the present time (16 months of age).[kundoc.com]
  • By messenger RNA and DNA analysis (with an FcRIII-cDNA probe and restriction endonucleases) the neutrophil-FcRIII deficiency appeared to be due to deletion of the FcRIII-1 gene in both individuals, while the FcRIII-2 gene was normally present.[bloodjournal.org]
Pathologist
  • SNOMED CT (R) was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO."[doctor.am]
  • There is much for pathologists to ponder as they sort through etiologies, assessments, and diagnoses.[captodayonline.com]
  • Chicago, American Society of Clinical Pathologists Press. M ORITZ E, C HIBA AK, P INOTTI F, Y AMAMOTO M AND B ORDIN JO. 2007. Características fenotípicas do an- tígeno de neutróï lo humano HNA-2a (NB1, CD177) em indivíduos brasileiros.[redalyc.org]
Strabismus
  • Journal of Pediatric Ophthalmology and Strabismus 39(3): 181-181, 2002 Isoimmune neonatal neutropenia: apropos of a case .[m.eurekamag.com]
  • Journal of Pediatric Ophthalmology and Strabismus 39(3): 181-181, 2002 Isoimmune neonatal neutropenia: apropos of a case.[eurekamag.com]
Chemosis
  • Ophthalmologic exam was significant for eyelid edema, conjunctiva] chemosis and injection, and yellow discharge of the right eye. Treatment consisted of intravenous ceftriaxone and oral erythromycin.[healio.com]
Neglect
  • Agranulocytosis Antibody Formation Antigens, Surface Female Fetus Humans Immune System Diseases Infant, Newborn Isoantigens Neutropenia Pregnancy Pub Type(s) Journal Article Language eng PubMed ID 3600474 TY - JOUR T1 - Alloimmune neonatal neutropenia--a neglected[unboundmedicine.com]

Workup

  • This first- reported case of ophthalmia neonatorum associated with isoimmune neonatal neutropenia is presented to show the need for medical workup for underlying predisposing disease.[healio.com]
  • INITIAL CLINICAL APPROACH Because the severity and the cause of neutropenia may often be fatal in this patient population and because of the limitations of blood volume available for laboratory testing, a prompt but logical approach to the workup is essential[mhmedical.com]
  • Obtaining a history of infections may aid in the current diagnostic workup. Obtaining a careful drug history may reveal the offending agent and spare the patient from an extensive diagnostic workup.[odlarmed.com]
  • But the peripheral blood smear remains the mainsail of these patient workups.[captodayonline.com]
Chlamydia
  • These findings are consistent with the proposal that because of the presence of Fc gamma RIII receptors, HeLa cells facilitate infectivity and thus block neutralization through the uptake of an IgG2b-chlamydia complex. Paper-7567822 .[ihop-net.org]
HLA-B8
  • Flow cytometry detected a serologic incompatibility between the mother’s serum and the father’s neutrophils; this reactivity was also noted after absorption of HLA antibodies, which had HLA-B8 specificity.[doctiktak.com]
  • HLA-B8 antigen and anti-PLA1 alloimmunization. Tissue Antigens 1982; 19: 154-158. 30. Tazzari PL, Ricci F, Tassi C, Bontadini A, Fruet F, Conte R.[indianpediatrics.net]

Treatment

  • TY - JOUR T1 - Intravenous gammaglobulin in treatment of isoimmune neonatal neutropenia.[unboundmedicine.com]
  • Ophthalmia neonatorum requires clinical and laboratory evaluation to provide appropriate treatment.[healio.com]
  • Massey GV, McWilliams NB, Mueller DG, Napolitano A, Maurer HM (1987) Intravenous immunoglobulin in treatment of neonatal isoimmune thrombocytopenia. J Pediatr 111:133–135 Google Scholar 8.[link.springer.com]
  • Pagina 336 - EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 90: 354-371. ‎[books.google.it]

Prognosis

  • NEUTROPENIA PROGNOSIS There is an excellent prognosis for Neutropenia. Patients' recovery will depend on how severe the complications are.[medicalook.com]
  • […] anemia –May involve neutropenia, anemia, thrombocytopenia, or pancytopenia –Associated with absent radius, thumb abnormalities, short stature * Cartilage-hair hypoplasia * Dyskeratosis congenita * Chédiak-Higashi * Reticular dysgenesis * Myelokathexis Prognosis[checkorphan.org]
  • Prognosis [ edit ] This form usually lessens in severity within two years of diagnosis. [ citation needed ] The use of prophylactic antibiotics has been proposed. [2] See article at BioMed Central site: [1] [ verification needed ] References [ edit ][en.wikipedia.org]
  • […] are asymptomatic § Skin and visceral abscesses § Associated with McLeod phenotype § Nitro blue tetrazolium test positive § Antibiotics and IFN-gamma § MPO deficiency § AR § Often asymptomatic § Manifests in diabetics, candida albicans common § Good prognosis[ihaematology.com]
  • Portal vein thrombosis and portal hypertension may occur in children undergoing exchange transfusion. [ 12 ] One meta-analysis showed a significant link between feto-maternal rhesus incompatibility and schizophrenia. [ 13 ] Prognosis Overall survival[patient.info]

Etiology

  • Laboratory testing is important in determining the etiologic agent and appropriate treatment. The absolute neutrophil count (ANC) is usually greater than 1.5 ? 109/L There is a risk of serious infection when the ANC drops below 0.5 ? 109/L.'[healio.com]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • Chronic Benign Neutropenia of Childhood Inheritance: Etiology: Unknown. Symptoms: Infections rare (if common, it's not benign). Schwachman Syndrome Inheritance: AR Etiology: Unknown.[netscut.templaro.com]
  • The patient may have different clinical presentations depending on the etiology. Because of the low neutrophil reserve (capacity to produce neutrophils) in the bone marrow, the neonate is especially prone to development of neutropenia.[mhmedical.com]

Epidemiology

  • Tamra Carlson - 2019-03-11 15:17 Disease Topic Inherited T-Cell Deficiency Disorders granulomatous disease (CGD) Neutrophil disorders Epidemiology Incidence – rare Age – most commonly discovered ...[arupconsult.com]
  • Syndrome 1160 137 Neuroprotective Strategies 1173 138 Cerebral Hemorrhage 1180 139 Neonatal Arterial Stroke 1192 140 Neonatal Seizures 1199 141 The Timing of Neonatal Brain Damage 1208 142 Thrombosis in the Development of Newborn Brain Damage 1216 143 Epidemiology[books.google.ro]
  • Epidemiology The incidence of haemolytic disease of the newborn (HDN) depends on the proportion of the population who are RhD negative.[patient.info]
  • "Epidemiology of cerebral palsy". Seminars in Fetal and Neonatal Medicine . 11 (2): 117–25. doi : 10.1016/j.siny.2005.10.010 . PMID 16338186 . Lande, Lottie (1948).[en.wikipedia.org]
  • Weingarten MA, Pottick-Schwartz EA, Brauner A: The epidemiology of benign leukopenia in Yemenite Jews. Isr J Med Sci 29:297, 1993. 3.[medtextfree.wordpress.com]
Sex distribution
Age distribution

Pathophysiology

  • 699 92 Meconium Plug Syndrome 704 93 Hirschsprungs Disease 708 94 Gastroenteritis and Intractable Diarrhea 713 95 Rehydration after Diarrhea 719 96 Necrotizing Enterocolitis 724 97 Surgical Treatment of Necrotizing Enterocolitis 731 Overview 735 99 Pathophysiology[books.google.ro]
  • Pathophysiology and treatment of severe chronic neutropenia. Ann Hematol . 1996 Apr. 72(4):158-65. [Medline] . Young NS. Agranulocytosis. JAMA . 1994 Mar 23-30. 271(12):935-8. [Medline] . Berliner N, Horwitz M, Loughran TP Jr.[medscape.com]
  • [This review describes the pathophysiology of various forms of severe congenital neutropenia and neutrophil dysfunction based on an understanding of the genetic defects affecting neutrophil number and function.][qa1.hematologyadvisor.com]
  • "A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry".[en.wikipedia.org]

Prevention

  • Prevention of febrile neutropenia: use of prophylactic antibiotics. Br J Cancer . 2009 Sep. 101 Suppl 1:S11-4. [Medline] . [Full Text] . Krell D, Jones AL. Impact of effective prevention and management of febrile neutropenia.[medscape.com]
  • Succinct, targeted coverage of normal childhood growth and development, as well as the diagnosis, management, and prevention of common pediatric diseases and disorders, make this an ideal medical reference book for students, pediatric residents, nurse[books.google.it]
  • They should also avoid exposing themselves to other people who are sick to prevent any contamination.[medicalook.com]

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