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Neonatal Osteosclerotic Dysplasia


  • Features of the Color Atlas of Pediatric Pathology include: Comprehensive coverage of pediatric surgical and autopsy pathology Each chapter is presented by a recognized expert Practical presentation: concise text highlights diagnostic features making[books.google.com]
  • Primary lymphoma of bone also presents with permeative pattern of destruction and often a large soft tissue mass. The mean age of presentation in these patients is usualy higher than in Ewing sarcoma.[radiologyassistant.nl]
  • Images are presented with each case illustrating different imaging modalities and with gross and/or histopathology findings. Brief clinical findings are also given where available.[bokus.com]
  • . - Small stromal hemorrhages and hemosiderin may be present.[pedorthpath.com]
  • The Color Atlas of Pediatric Pathology is a practical working resource for every pathologist who sees pediatric cases as well as the pathology trainee.[books.google.com]
  • Pediatricians, orthopedic surgeons, dental specialists, speech pathologists, specialists who assess and treat hearing problems (audiologists), physical therapists, and other health care professionals may need to systematically and comprehensively plan[rarediseases.org]
  • The treatment of osteosarcoma requires a multidisciplinary approach involving the family physician, orthopedic oncologist, medical oncologist, radiologist and pathologist. Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma.[aafp.org]
  • Disclaimer: this information is intended for pathologists, orthopedic surgeons and laboratory personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable[pedorthpath.com]
  • Disorganized Development of Skeletal Component Group Disorganized development of skeletal component group (group 29) constitutes several tumefactive lesions of bone, some of which are familiar to pathologists including polyostotic FD, multiple osteochondromas[basicmedicalkey.com]
Hydrops Fetalis
  • Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care[books.google.com]
  • A: Severe micromelia and hydrops fetalis are noted in this anterior view. B: A profile view shows not only the severe micromelia but the presence of a cystic hygroma. (Contributed by Bahig M. Shehata, MD, Atlanta, GA.)[basicmedicalkey.com]
Leg Length Inequality
  • length inequality is common and there may be a need for contralateral epiphyseodesis or rarely ipsilateral lengthening Prognosis 50% of fractures will heal with firm internal fixation (IM nail prefered) and autogenous bone graft, the use of electrical[flinders.edu.au]
  • A scholarly effort to bring order into this confusing field must be welcomed. Professors Beighton and Cremin have skillfully defined the problem and concisely yet thoroughly have identified the various sclerosing dysplasias.[books.google.com]
  • Gorlin (1978) reports that there is much confusion about the differentiation of the genetic disorders characterized by remodeling errors of the tubular and cranial bones.[blackstar.forp.usp.br]
  • . - Chondromas of Ollier disease are histologically similar to those of sporadic solitary tumors; however, they frequently demonstrate a greater degree of cellularity, cytologic atypia, and may contain myxoid stroma, which may be confused with diagnosis[pedorthpath.com]
  • May be confused with giant cell tumor when located in the epi-metaphysis. On the left a patient who had a nefrectomy for renal cell carcinoma and who was on dialysis. Multiple well-defined osteolytic lesions were found on a follow up CT scan.[radiologyassistant.nl]


  • The workup of a potentially battered child is extremely serious, and involves significant legal and social investigations of the parents.[rad.washington.edu]
  • Multiple Myeloma Radiographic bone survey remains mainstay of diagnostic workup.[radcharts.org]


  • Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout.[books.google.com]
  • Few recent reports [54], [55] show promising results with medical treatment.[ijps.org]
  • Various treatment options have been suggested for osteopetrosis, but hematopoietic stem cell transplantation still remains the only curative treatment option presently.[academic.oup.com]


  • Prognosis: - Good. - Therapy ranges from observation to surgical removal.[pedorthpath.com]
  • Gloomy prognosis [ Back to the Top ] Metaphyseal Dysplasias (hyperdysplasias) 1.[flinders.edu.au]
  • The classic autosomal recessive form (also known as malignant infantile osteopetrosis – MIOP) has poor prognosis.[academic.oup.com]
  • Each condition has a brief summary including synonyms, incidence, genetics, age at presentation, clinical, prenatal ultrasound and postnatal radiological features, bone histology, prognosis and differential diagnosis.[bokus.com]


  • The underlying etiology is often consumption of lead-containing substances including old paint chips.[med-ed.virginia.edu]
  • Genetic testing may be indicated for the evaluation of polyostotic bone lesions secondary to syndromic etiologies. References Levine SM, Lambaise RE, Petchprapa CN.[jaocr.org]
  • (Etiology) Craniometaphyseal Dysplasia is a congenital condition that may be inherited in an autosomal dominant or autosomal recessive manner.[dovemed.com]
  • Etiology The fundamental abnormality in HIE is a deficit of oxygen supply. This is due to hypoxemia (diminished amount of oxygen in th blood supply) and ischemia (a diminished amount of blood perfusing the brain).[atlases.muni.cz]


  • Epidemiology: - 85% of patients in the first decades of life. - Male:Female ratio 3:1.[pedorthpath.com]
  • Relevant External Links for FAM20C Genetic Association Database (GAD) FAM20C Human Genome Epidemiology (HuGE) Navigator FAM20C Atlas of Genetics and Cytogenetics in Oncology and Haematology: FAM20C No data available for Genatlas for FAM20C Gene Mutations[genecards.org]
  • […] be taken off of a ventilator. [10] Evidence suggests that vitamin A in LBW babies is associated with a reduction in mortality and bronchopulmonary dysplasia. [11] Oxygen therapy at home is recommended in those with significant low oxygen levels. [12] Epidemiology[en.wikipedia.org]
  • Benli IT et al (1992) Epidemiological, clinical and radiological aspects of osteopoikilosis. J Bone Joint Surg Br 74:504–506 PubMed Google Scholar 5.[link.springer.com]
Sex distribution
Age distribution


  • Pathophysiology and treatment. Clin Othop Relat Res 1993 ; 294 : 64 – 68. 13. Infantile osteopetrosis complicated by rickets. AJR Am J Roentgenol 1994 ; 164 : 968 – 70. 14. Malignant infantile osteopetrosis presenting with neonatal hypocalcaemia.[academic.oup.com]
  • Pathophysiology and treatment. Clin Orthop Relat Res 294:64–78 PubMed Google Scholar 41. Karakida K et al (2010) Multiple giant cell tumors in maxilla and skull complicating Paget’s disease of bone.[link.springer.com]
  • Fibrous dysplasia: Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am 2005;87: 1848-64. 8. Osada H, Sakamoto R, Seki K, Sekiya S. Accelerated bone turnover in pregnant women with McCune-Albright syndrome.[ijps.org]


  • "Vitamin A in prevention of bronchopulmonary dysplasia". Current Pharmaceutical Design . 18 (21): 3101–3113. ISSN 1873-4286 . PMID 22564302 .[en.wikipedia.org]
  • Centers for Disease Control and Prevention Intersex (Medical Encyclopedia) [ Read More ][icdlist.com]
  • It has been observed heterozygous mutations located in the secretion signal of the SOST gene in two CDD patients and demonstrated that these SOST mutations prevent sclerostin secretion resulting in increased bone formation.[iofbonehealth.org]
  • As a means to prevent large lesions from causing a fracture in long bones.[ijps.org]

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