Benign idiopathic neonatal seizures typically present at day 5 of life (ie, fifth day fits), with the vast majority presenting between days 4 and 6 of life. Seizures are often multifocal. Cerebrospinal fluid (CSF) analysis is usually unremarkable. [emedicine.medscape.com]

We review neonatal seizures and hypocalcemia and present the case of a 6-day-old male infant who presented to a tertiary pediatric emergency department with seizure-like episodes. [ncbi.nlm.nih.gov]

• Infantile-Onset Seizures

  Most had KCNQ2 mutations, but two families had SCN2A mutations, which are normally associated with a mixed picture of neonatal and infantile onset seizures. [ncbi.nlm.nih.gov]

It is a benign syndrome, but its diagnosis requires a workup to eliminate other potentially more serious epileptic syndromes during this period. [medlink.com]

• Multifocal Epileptiform Discharges

  More multifocal epileptiform discharges in EEG, more abnormal neuroimaging findings, and higher incidence of future developmental delay were noted in the group with later epilepsy. [ncbi.nlm.nih.gov]

• White Matter Lesions

  BACKGROUND AND AIMS: Some full-term neonates presenting seizures show diffusion-restricted lesions in the cerebral white matter on brain diffusion-weighted imaging (DWI). [ncbi.nlm.nih.gov]

• Liver Biopsy

  biopsy specimen were present in normal number and appeared enlarged. [ncbi.nlm.nih.gov]

The objective of this study was to evaluate the efficacy and safety of lidocaine as second-line treatment of neonatal seizures in infants following benzodiazepine treatment but without previous treatment with phenobarbital. [ncbi.nlm.nih.gov]

This KCNQ2 mutation has implications for diagnosis and prognosis of familial neonatal seizures. [ncbi.nlm.nih.gov]

PROGNOSIS  Focal clonic seizures carry the best prognosis.  Myoclonic seizures carry the worst prognosis in terms of neurodevelopmental outcome and seizure recurrence.  Seizures due to SAH and late onset hypocalcemia carry best prognosis in terms of [slideshare.net]

Prognosis depends on the etiology, seizure type, neurological examination at discharge and EEG. Long term neurodevelopmental follow up is essential for babies with neonatal seizures. [ncbi.nlm.nih.gov]

Epidemiology The prevalence of neonatal seizures is approximately 1-5%. The overall incidence is 3 per 1,000 live births (57 to 132 per 1,000 live births in pre-term infants) [ 2 ]. Etiology The etiology of neonatal seizures is diverse. [omicsonline.org]

In the following article, the authors discuss many issues related to this syndrome, including etiology, pathogenesis and pathophysiology, epidemiology, and differential diagnosis. [medlink.com]

EPIDEMIOLOGY- INDIA(NNPD;2002-03)  Incidence : 10.3 per 1000 live births  The incidence is high in PRETERM neonates (2 fold), VLBW( 4 fold) compared to TERM neonates.  Term neonates- 8.4  Preterm neonates-20.8  VLBW-36.1 6. [slideshare.net]

"Epidemiology and aetiology of neonatal seizures". Seminars in Fetal & Neonatal Medicine. 18 (4): 185–91. doi : 10.1016/j.siny.2013.05.008. PMID 23746578. ^ Van Hove JL, Lohr NJ (November 2011). [en.wikipedia.org]

the Departments of Epidemiology (A.D.S., S.A., Z.W., J.C.G., N.P.) and Statistics and Probability (Z.W., J.C.G.), Michigan State University, East Lansing; and Pharmakon Laboratories, Pittsburgh (B.M.). Address reprint requests to Dr. [nejm.org]

Both are expressed in the brain, and although mutations have not been associated with epilepsy, we propose a pathophysiologic mechanism by which the combination of molecular changes may cause seizures. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

In the following article, the authors discuss many issues related to this syndrome, including etiology, pathogenesis and pathophysiology, epidemiology, and differential diagnosis. [medlink.com]

Although many seizures may be prevented by careful attention to metabolic changes and the neonate's overall condition, those that cannot be prevented may require pharmacologic treatment. [ncbi.nlm.nih.gov]

Because several causes of seizures in newborns require rapid recognition and treatment to prevent further injury, early recognition is important. Seizures in newborns frequently have more subtle clinical manifestations than in older children. [neoreviews.aappublications.org]

Treating the cause of seizures is critical to preventing further brain damage. [abclawcenters.com]