We review neonatal seizures and hypocalcemia and present the case of a 6-day-old male infant who presented to a tertiary pediatric emergency department with seizure-like episodes. [ncbi.nlm.nih.gov]

• Myopathy

  Rarely, phosphofructokinase deficiency manifests in infancy as congenital myopathy and arthrogryposis with fatal outcome. [ncbi.nlm.nih.gov]

• Infantile-Onset Seizures

  Most had KCNQ2 mutations, but two families had SCN2A mutations, which are normally associated with a mixed picture of neonatal and infantile onset seizures. [ncbi.nlm.nih.gov]

• Neonatal Hypotonia

  Neonatal hypotonia, seizures beginning at 5 days, and severe retardation were noted in a girl with normal karyotype and biochemical evidence of impaired adrenal function. [ncbi.nlm.nih.gov]

It is a benign syndrome, but its diagnosis requires a workup to eliminate other potentially more serious epileptic syndromes during this period. [medlink.com]

• Multifocal Epileptiform Discharges

  More multifocal epileptiform discharges in EEG, more abnormal neuroimaging findings, and higher incidence of future developmental delay were noted in the group with later epilepsy. [ncbi.nlm.nih.gov]

• Hypsarrhythmia

  All were born at term and discharged home without seizures or concern of encephalopathy, but developed infantile spasms with hypsarrhythmia (or modified hypsarrhythmia) between the ages of 4 and 6 months. [ncbi.nlm.nih.gov]

• White Matter Lesions

  matter lesions on DWI, particularly around 5 days of life. [ncbi.nlm.nih.gov]

• Liver Biopsy

  biopsy specimen were present in normal number and appeared enlarged. [ncbi.nlm.nih.gov]

The objective of this study was to evaluate the efficacy and safety of lidocaine as second-line treatment of neonatal seizures in infants following benzodiazepine treatment but without previous treatment with phenobarbital. [ncbi.nlm.nih.gov]

This KCNQ2 mutation has implications for diagnosis and prognosis of familial neonatal seizures. [ncbi.nlm.nih.gov]

Prognosis depends on the etiology, seizure type, neurological examination at discharge and EEG. Long term neurodevelopmental follow up is essential for babies with neonatal seizures. [ncbi.nlm.nih.gov]

Better understanding of the risk of post-neonatal epilepsy based on etiology is emerging with new epidemiological studies. [ncbi.nlm.nih.gov]

Epidemiology The prevalence of neonatal seizures is approximately 1-5%. The overall incidence is 3 per 1,000 live births (57 to 132 per 1,000 live births in pre-term infants) [ 2 ]. Etiology The etiology of neonatal seizures is diverse. [omicsonline.org]

In the following article, the authors discuss many issues related to this syndrome, including etiology, pathogenesis and pathophysiology, epidemiology, and differential diagnosis. [medlink.com]

EPIDEMIOLOGY- INDIA(NNPD;2002-03)  Incidence : 10.3 per 1000 live births  The incidence is high in PRETERM neonates (2 fold), VLBW( 4 fold) compared to TERM neonates.  Term neonates- 8.4  Preterm neonates-20.8  VLBW-36.1 6. [slideshare.net]

the Departments of Epidemiology (A.D.S., S.A., Z.W., J.C.G., N.P.) and Statistics and Probability (Z.W., J.C.G.), Michigan State University, East Lansing; and Pharmakon Laboratories, Pittsburgh (B.M.). Address reprint requests to Dr. [nejm.org]

Both are expressed in the brain, and although mutations have not been associated with epilepsy, we propose a pathophysiologic mechanism by which the combination of molecular changes may cause seizures. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

In the following article, the authors discuss many issues related to this syndrome, including etiology, pathogenesis and pathophysiology, epidemiology, and differential diagnosis. [medlink.com]

Although many seizures may be prevented by careful attention to metabolic changes and the neonate's overall condition, those that cannot be prevented may require pharmacologic treatment. [ncbi.nlm.nih.gov]

Hospital for Sick Children Health A-Z Search a complete list of child health articles expand_more View All Drug A-Z Search a list of articles about medications expand_more View All Learning Hubs Browse a complete list of content groups Healthy Living & Prevention [aboutkidshealth.ca]

Because several causes of seizures in newborns require rapid recognition and treatment to prevent further injury, early recognition is important. Seizures in newborns frequently have more subtle clinical manifestations than in older children. [neoreviews.aappublications.org]