Tumors of the liver include benign tumors such as hepatic adenomas, hemangiomas and focal nodular hyperplasia and malignant neoplasms such as hepatocellular carcinoma, cholangiocarcinoma, hemangioblastoma, angiosarcoma, hemangioendothelioma and mesenchymal tumors.
Presentation
HCC presents a variable appearance at CT and MRI. [scielo.br]
How do liver abscesses present? Multiple abscesses tend to present more acutely and single ones more indolently. Liver symptoms: Right upper quadrant pain, tenderness, hepatomegaly, possible palpable mass. [brainscape.com]
The most common presentation is an asymptomatic mass. Patients may also present with abdominal pain, nausea, vomiting, weight loss, and/or fever. [cancertherapyadvisor.com]
Typically presenting with mass effect or incidentally on imaging, MCN-L is considered a premalignant transformation, requiring resection. [academic.oup.com]
This is justified, since the clinical presentations differ. [nature.com]
Liver, Gall & Pancreas
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Hepatomegaly
ALP isoenzyme test (Medical Encyclopedia) Ascites (Medical Encyclopedia) Diet - liver disease (Medical Encyclopedia) Hepatic encephalopathy (Medical Encyclopedia) Hepatomegaly (Medical Encyclopedia) Liver disease (Medical Encyclopedia) Liver scan (Medical [icdlist.com]
Most are asymptomatic, but some cause hepatomegaly, right upper quadrant discomfort, or intraperitoneal hemorrhage. Most are detected incidentally on ultrasound or other scans (in Imaging Tests of the Liver and Gallbladder ). [msdmanuals.com]
] [3] Clinical features Usually asymptomatic apart from symptoms of the underlying disease (mostly cirrhosis or hepatitis ) Metastasis is uncommon and usually only occurs in advanced stages Possible symptoms in advanced disease Weight loss, cachexia Hepatomegaly [amboss.com]
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Hepatic Mass
Kinnard MF, Alavi A, Rubin RA, Lichtenstein GR: Nuclear imaging of solid hepatic masses. Semin Roentgenol 1995, 30 :375–395. PubMed CrossRef Google Scholar 62. Ault GT, Wren SM, Ralls PW, et al. : Selective management of hepatic adenomas. [link.springer.com]
In addition, if there is a need to definitively characterize a hepatic mass, MRI is generally more sensitive and specific, with no associated radiation dose. [5] References [ edit ] Ariff, B; Lloyd, CR; Khan, S; Shariff, M; Thillainayagam, AV; Bansi, [en.wikipedia.org]
Preoperative imaging studies are the key to diagnosis in the evaluation of cystic hepatic mass, which differential diagnosis includes simple cysts, echinococcal cysts, liver abscesses, cystic degeneration of a liver neoplasm and liver metastases (5). [scielo.isciii.es]
Like other more widely described hepatic masses, MCAs can cause symptoms such as abdominal pain, nausea, vomiting, and jaundice from mass effect. [frontiersin.org]
mass CEA, CA 19-9, liver markers (below) Liver tumor markers may be useful in patients with risk factors; however, further studies are needed to confirm role AFP AFP-L3 – more specific than AFP Des-gamma-carboxy-prothrombin (DCP) – more specific than [arupconsult.com]
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Hepatic Friction Rub
Occasionally, a hepatic friction rub or bruit develops. Occasionally, systemic metabolic complications, including hypoglycemia, erythrocytosis, hypercalcemia, and hyperlipidemia, occur. These complications may manifest clinically. [merckmanuals.com]
Workup
Workup [ edit ] Upon discovery of a liver tumor, the main issue in the workup is to determine whether the tumor is benign or malignant. Many imaging modalities are used to aid in the diagnosis of malignant liver tumors. [en.wikipedia.org]
Hepatic adenomas are most often diagnosed as a result of imaging done for unrelated pathology or following workup of a palpable abdominal mass (30% patients) [ 88 ]. [intechopen.com]
The upright chest radiograph is the ideal primary diagnostic study in the evaluation of hemothorax (see Workup). [emedicine.medscape.com]
The combination of Hep Par 1 and MOC-31 will allow for the diagnosis of hepatocellular carcinoma in most cases and will guide the selection of immunohistochemical markers for further workup. [archivesofpathology.org]
Biopsy
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Hepatocellular Carcinoma
We therefore developed a quantitative immunohistochemical assay and monitored epoxide hydrolase expression in hepatocellular carcinomas (HCC, n 20), cholangio-cellular carcinomas (CCC, n 2) and liver metastases (n 57) of tumours of various origins, and [ncbi.nlm.nih.gov]
Tumors of the liver include benign tumors such as hepatic adenomas, hemangiomas and focal nodular hyperplasia and malignant neoplasms such as hepatocellular carcinoma, cholangiocarcinoma, hemangioblastoma, angiosarcoma, hemangioendothelioma and mesenchymal [symptoma.com]
Expert consensus of the Standardized diagnosis and treatment for Hepatocellular carcinoma. J Clin Hepatol. 2009; 12 (5) 13. Zhang X, Zhou L, Chen B, Hu S, Wachtel MS, Frezza EE. [hepatmon.com]
Aflatoxin B1 acts synergistically with hepatitis B virus in causing hepatocellular carcinoma. [scienceopen.com]
Treatment
The treatment-related complication rate was 11.4 %. There was no treatment-related death. [aetna.com]
Optimal treatment of hepatic abscess. Am Surg. 2008; 74 (2): 178-82[ PubMed ] 28. de Baere T, Risse O, Kuoch V, Dromain C, Sengel C, Smayra T, et al. Adverse events during radiofrequency treatment of 582 hepatic tumors. [hepatmon.com]
In a non cirrhotic liver tumour resection is the treatment of choice, producing similar survival rates to transplantation. Image-guided tumour ablation is now a standard treatment option for patients with early-stage HCC. [brainscape.com]
Using CADLN, a radiologist will be able to compare computer generated volumetric data in serial imaging of the patients over time, that eventually will enable assessing progression or regression of neoplasm growth and help in treatment planning. [ncbi.nlm.nih.gov]
Radiation therapy does not have an established role in the primary treatment of hepatoblastoma or hepatocellular carcinoma but is sometimes used in palliative situations. [cancertherapyadvisor.com]
Prognosis
Therefore, complete excision is recommended, and extensive pathological sampling of these lesions is critical in the determination of prognosis. [journals.lww.com]
Diabetes mellitus and pyogenic liver abscess: risk and prognosis. Clin Infect Dis. 2007; 45 (6): 801[ DOI ][ PubMed ] 35. Azab M, Zaki S, El-Shetey AG, Abdel-Moty MF, Alnoomani NM, Gomaa AA, et al. [hepatmon.com]
Prognosis is usually poor. Other primary liver cancers are uncommon or rare. Diagnosis usually requires biopsy. Prognosis is typically poor. Some cancers, if localized, can be resected. Resection or liver transplantation may prolong survival. [merckmanuals.com]
Prognosis The prognosis depends on success rates of resection in resectable tumors. 5-year survival rates are moderate in low stage tumors but these rates drop below 20-30% in advanced disease. [orpha.net]
Etiology
It is associated with inflammatory disorders and malformations of the ducts, but most cases are of unknown etiology. [ncbi.nlm.nih.gov]
The median survival is approximately 6 months, with 5-year survival of 29 Etiology Possible etiologic factors are much less well established than for HCC, and most cases have no known etiology, but it is clear that disorders that cause chronic inflammation [nature.com]
Hepatitis B and hepatitis C are the most common etiologic agents worldwide in endemic areas but are observed much less often in the United States. [cancertherapyadvisor.com]
Epidemiology
Chapters feature up-to-date information on the basic mechanisms, epidemiological risk factors, screening and surveillance strategies, diagnosis and treatment. [books.google.com]
Epidemiology Fifth most common malignancy worldwide Highest incidence in Southeast Asia and Africa Peak incidence in the US: 70–75 years Peak incidence in Africa and Asia: 30–40 years References: [1] Epidemiological data refers to the US, unless otherwise [amboss.com]
From Wikimedia Commons, the free media repository Jump to navigation Jump to search Radiology: Ultrasound · X-ray · Computed tomography Anatomical pathology: Cytopathology · Gross pathology · Histopathology Other: Epidemiology (Geographic map World) File [commons.wikimedia.org]
The management of the network includes a Scientific Committee, an Executive Board and an Epidemiology and Management Coordinating Centre. [icgc.org]
Pathophysiology
Simple cyst: pathophysiologically they are thought to be congenital. They are of no clinical significance and are often found incidentally. Polycystic liver disease: genetic disease usually associated with mutations of polycystic kidney disease. [brainscape.com]
Etiology The pathophysiology of hepatocellular carcinoma is not well understood. Underlying liver dysfunction is the main predisposing condition (HBV, HCV). [orpha.net]
Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 96. National Cancer Institute website. [medlineplus.gov]
Amyloidosis and bleeding: Pathophysiology, diagnosis, and therapy. none Am J Kidney Dis. 2006; 47 :947–55. [ PubMed ] [ Google Scholar ] 4. Alwitry A, Brackenbury ET, Beggs FD, Soomro I. [ncbi.nlm.nih.gov]
Pathophysiology. Elsevier Health Sciences. pp. 660–. ISBN 978-0-323-29317-4. Farage MA, Neill S, MacLean AB (2009). "Physiological changes associated with the menstrual cycle: a review". [en.wikipedia.org]
Prevention
Related information Information for Health Professionals –Recommendations on Prevention and Screening for Liver Cancer Cancer Prevention Series (7) - Liver Cancer Prevention and Screening The Viral Hepatitis Preventive Service provides detailed information [chp.gov.hk]
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
[…] toxicology conference in MENA region March 21, 2018 News Emory University School of Medicine seniors participate in Match Day 2018 March 16, 2018 News Emory Genetics Metabolic Nutrition Program launches new website for Medical Nutrition Therapy for Prevention [emoryhealthcare.org]
Behind this clinical enthusiasm, however, lies the research to develop the "true technology," in Thomas' words, that will prevent such clinical catastrophies as hepatic metastases. [books.google.ro]
When doctors discover a large adenoma, they may recommend that it be surgically removed to prevent that possibility. [liverfoundation.org]