Presentation
We present possibilities of differential diagnosis. [ncbi.nlm.nih.gov]
Entire Body System
- Pain
Instruct the patient on the effective use of the pain scale and to request pain medication before the pain escalates to an intolerable level. [medical-dictionary.thefreedictionary.com]
[…] subgroups, with and without preoperative pain, and reported that in patients without preoperative pain, CPB significantly reduced pain scores and delayed or prevented the subsequent onset of pain (P In our meta‐analysis there were no major complications [doi.org]
Abdominal pain. Pancreatic cancer can cause a dull ache in the upper abdomen radiating to the back. The pain may come and go. Back pain. Bloating. [webmd.com]
Celiac plexus block, to control cancer pain. This is done by a skilled anesthesiologist/pain specialist and is usually reserved in the cases of patients who have unremitting pain not well-controlled by narcotics and other pain medicines. [cancersupportivecare.com]
- Weight Loss
loss Gastrinomas (excess gastrin ): abdominal pain, stomach ulcers that can bleed, reflux, weight loss Somatostatinomas (excess somatostatin): diarrhea, weight loss, abdominal pain, foul-smelling fatty stools VIPomas (excess vasoactive intestinal peptide [webmd.com]
The presenting symptoms were abdominal pain, fever, or weight loss. Abdominal CT scans showed low-density round masses at the pancreas head or body with/without lymphadenopathy. [ncbi.nlm.nih.gov]
They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. Also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. [icd9data.com]
Symptoms can include tummy pain, weight loss, and feeling and being sick (nausea and vomiting). Solid pseudopapillary neoplasm Solid pseudopapillary neoplasms grow mostly in the body and tail of the pancreas. [pancreaticcancer.org.uk]
- Surgical Procedure
In addition, a small amount of blood will be collected at the time of the EUS or surgical procedure. [clinicaltrials.gov]
Virginia Mason is a very high volume hospital for the surgical treatment of pancreatic neoplasms and cancer. The surgical procedure will depend on the location of the IPMN within the pancreas. [virginiamason.org]
Surgical procedures depended on the location and extension of the tumor. [scielo.br]
For non-functional tumours, the indication for surgery is based on the risk of cancer which is related to the size of the tumour, and also on the risk profile of the patient as well as the risks associated with the surgical procedure required. [singhealth.com.sg]
For example, patients with pancreatic cancer who received the Whipple surgical procedure in one study (from a very experienced Johns Hopkins team) were reported as having a 21% five-year survival rate, with a median survival of 15.5 months. [pancreatica.org]
- Weakness
Symptoms of MEN-1, include fatigue, muscle weakness or pain, constipation, kidney stones and thinning of the bones and generally appear in individuals in their 30’s and 40’s. [pancreaticcanceraction.org]
Progression In patients where a cure is not possible, progression of the disease may be accompanied by progressive weakness, weight loss, and pain. [pancreatic.org]
Symptoms of pancreatic cancer include: Diarrhea Dark urine and clay-colored stools Fatigue and weakness Sudden increase in blood sugar level (diabetes) Jaundice (a yellow color in the skin, mucous membranes, or white part of the eyes) and itching of the [nlm.nih.gov]
[…] with pancreatic cancer results in ~20x risk 8 hereditary syndromes 6 HNPCC familial breast cancer familial atypical multiple mole melanoma (FAMMM) hereditary pancreatitis ataxia-telangiectasia Peutz-Jeghers syndrome Perhaps surprisingly there is only a weak [radiopaedia.org]
- Fishing
Choose whole-grain breads, pastas, and cereals instead of refined grains, and eat fish, poultry, or beans instead of processed meat and red meat. [web.archive.org]
Gastrointestinal
- Abdominal Pain
Abdominal pain. Pancreatic cancer can cause a dull ache in the upper abdomen radiating to the back. The pain may come and go. Back pain. Bloating. [webmd.com]
The patients, two women and a man, whose ages ranged from 63 to 70 years, complained of abdominal pain attributed to chronic pancreatitis in two patients. The patient with the largest tumor also had symptoms of gastric outlet obstruction. [ncbi.nlm.nih.gov]
- Diarrhea
Consistent or worsening discomfort, nausea, vomiting, or diarrhea are also disconcerting. If you feel something's not right, see your doctor. [webmd.com]
The most common adverse reactions in patients receiving erlotinib hydrochloride were diarrhea and rash. Grade 3/4 rash and diarrhea occurred in 9 percent and 6 percent, respectively. [web.archive.org]
which can cause low blood pressure (hypotension), flushing, diarrhea, unintended weight loss, and diabetes. [rarediseases.org]
Abstract VIPomas are rare pancreatic endocrine tumors (PETs), detected in 1 in 10 million people per year and usually present as a constellation of well-defined clinical features characterized by watery diarrhea, hypokalemia, and achlorhydria (WDHA). [tgc.amegroups.com]
- Abdominal Mass
CONCLUSIONS: The treatment is surgical and the most common clinical presentation is abdominal mass. Distal pancreatectomy with splenectomy was the most frequently performed surgery for its treatment. [ncbi.nlm.nih.gov]
A 61 year old patient admitted to the Internal Medicine Ward 3 at Coimbra University Hospital presents with a volumous intra-abdominal mass in the left hypochondrium and microcytic anemia. [rihuc.huc.min-saude.pt]
[…] pain and a palpable, non-tender, upper abdominal mass Also symptoms related to an intra-abdominal mass effect, such as discomfort, nausea, vomiting and early satiety Radiology description Well circumscribed, encapsulated, heterogeneous pancreatic lesion [pathologyoutlines.com]
- Constipation
Figures and Tables - Analysis 1.6 Comparison 1 CPB versus analgesic therapy, Outcome 6 Adverse effects: constipation. Comparison 1. [doi.org]
These narcotics can cause a fair amount of drowsiness, confusion (particularly in older patients), and constipation, so the simultaneous regular use of stool softeners should be encouraged while patients are taking narcotics. [cancersupportivecare.com]
Laxatives : Various over-the-counter and prescription medicines can help relieve constipation. [webmd.com]
Question the patient as to the presence of any nausea and vomiting (especially that worsens after eating), anorexia, flatulence, diarrhea, constipation, or unusual fatigue. [medical-dictionary.thefreedictionary.com]
Liver, Gall & Pancreas
- Hepatomegaly
Physical examination may reveal jaundice, temporal wasting, peripheral lymphadenopathy, hepatomegaly, and ascites. [ncbi.nlm.nih.gov]
Patients presenting with or developing advanced intra-abdominal disease may have ascites, a palpable abdominal mass, hepatomegaly from liver metastases, or splenomegaly from portal vein obstruction. [emedicine.medscape.com]
Depression Migratory thrombophlebitis (ie, Trousseau sign) and venous thrombosis: May be the first presentation Palpable gallbladder (ie, Courvoisier sign) Developing, advanced intra-abdominal disease: Presence of ascites, a palpable abdominal mass, hepatomegaly [emedicine.com]
Musculoskeletal
- Back Pain
This pain is described as severe, gnawing, and radiating to the middle of the back. Pain can also be epigastric or in the right upper quadrant if bile duct obstruction is present. [web.archive.org]
Unexplained weight loss, abdominal pain, nausea, vomiting. Back pain is another one, because the pancreas is very posterior in the body. [scientificamerican.com]
Abdominal pain. Pancreatic cancer can cause a dull ache in the upper abdomen radiating to the back. The pain may come and go. Back pain. Bloating. [webmd.com]
pain, dyspepsia, and unexplained weight loss, as well as the classic presentation of painless jaundice The majority of pancreatic cancer is incurable at presentation 1 2 Whether or not pancreatic cancer is deemed curable, current surgical, endoscopic [dx.doi.org]
Psychiatrical
- Fear
Assess the specific feelings and fears of the patient and family as well as the support systems available and previous coping strategies. [medical-dictionary.thefreedictionary.com]
Pancreatic cancer is a much feared disease due to its notoriously late presentation, early metastases and poor survival rates. [patient.info]
Learn more about coping with the fear of recurrence. If the cancer does return after the original treatment, it is called recurrent cancer. [cancer.net]
However, a third of patients with pancreatic cancer have locally advanced cancer involving adjacent structures such as blood vessels which are not usually removed because of fear of increased complications after surgery. [doi.org]
Neurologic
- Irritability
This is because tobacco smoke contains harmful chemicals and toxins that can cause irritation and inflammation within your body's organs and tissues. [web.archive.org]
During this process, patients can be misdiagnosed with other gastrointestinal diseases, such as irritable bowel syndrome or Crohn's disease. [medscape.com]
Wang LH, Fang XC, Pan GZ: Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut 2004;53:1096–1101. [karger.com]
- Tingling
Tingle SJ, Severs GR, Goodfellow M, Moir JA, White SA. NARCA: A novel prognostic scoring system using neutrophil-albumin ratio and Ca19-9 to predict overall survival in palliative pancreatic cancer. J Surg Oncol. 2018 Sep 9. [Medline]. [emedicine.com]
- Stroke
Too much sugar of any kind not only adds pounds, but is also a key culprit in diabetes, heart disease and stroke, according to the American Heart Association. [healthzone.ca]
Mars Stroke Horizontal Mars Stroke Vertical medkit Meh Mercury Microchip microphone Microphone Slash minus Minus Circle Minus Square Mobile Phone Alternate Mobile Money Bill Alternate Moon Motorcycle Mouse Pointer Music Neuter Newspaper Medical Notes [gesundheitsrebell.de]
Other newly recognized severe adverse reactions observed with the erlotinib hydrochloride/gemcitabine combination included stroke, syncope, microangiopathic anemia with thrombocytopenia, myocardial infarction/ischemia, arrhythmias, renal insufficiency [web.archive.org]
Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 2003 ; 34 : 47 –52. (22) Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988–1994. [dx.doi.org]
May nakausap akong isang kababayan natin na kalalabas lang ng hospital Mild Stroke. Kwento niya natatakot siya baka bigla siya atakihin ulit at matuluyan, dahil lagi daw siya ini stress ng Amo para mag give Up siya. [findglocal.com]
Urogenital
- Dark Urine
That said, symptoms like unintentional weight loss, persistent loss of appetite, yellowing of the eyes or skin, dark urine, or light-colored stools should always prompt concern. [webmd.com]
Because more than two-thirds of adenocarcinomas occur in the head of the pancreas, abdominal pain, jaundice, pruritus, dark urine, and acholic stools may be presenting symptoms. [ncbi.nlm.nih.gov]
Symptoms of pancreatic cancer include: Diarrhea Dark urine and clay-colored stools Fatigue and weakness Sudden increase in blood sugar level (diabetes) Jaundice (a yellow color in the skin, mucous membranes, or white part of the eyes) and itching of the [nlm.nih.gov]
[…] either diarrhoea or severe constipation jaundice (yellowish skin and eyes, and dark urine). Less common signs include: severe back pain onset of diabetes (10-20% of people with pancreatic cancer develop diabetes). [cancer.org.au]
Workup
Here, we report a 69-year-old male patient with distal pancreatic mass incidentally found during a CT scan workup for a pulmonary nodule suspicious for metastatic prostate adenocarcinoma. [ncbi.nlm.nih.gov]
The aim of this review is to outline the current consensus on definitions, workup and management of BRPC, and also provide a summary of issues that require progress as defined by the International Study Group of Pancreatic Surgery (ISGPS). [dx.doi.org]
Discusses current guidelines in the workup and management of tumors of the exocrine pancreas. Google Scholar 6. Demos TC, et al. Cystic lesions of the pancreas. Am J Roentgenol. 2002;179(6):1375–88. CrossRef Google Scholar 7. Coursey CA, et al. [link.springer.com]
Treatment
The patient made an excellent recovery on anti-tuberculous treatment, and no evidence of a tumor was seen on a CT scan performed 6 months after the initiation of treatment. [ncbi.nlm.nih.gov]
When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. [cancer.gov]
Prognosis
[…] of General Surgery, La Princesa University Hospital, Madrid, Spain. [email protected] Abstract CONTEXT: Colloid carcinoma is considered a distinct type of pancreatic neoplasia with specific histopathological and molecular features, and a better prognosis [ncbi.nlm.nih.gov]
prognosis 1-May-11 – Better Prognosis: 5-FU Combination Therapy [pancreatica.org]
857 genes associated with favourable prognosis. [proteinatlas.org]
You may be curious about your prognosis if you’ve been diagnosed and your stage has been determined. A prognosis is based on information compiled from people who have a similar cancer. Survival statistics may be comforting, or they may be upsetting. [healthline.com]
Etiology
However, it´s etiology still maintain discussions. AIM: To analyze it´s clinical data, diagnosis and treatment. METHODS: A retrospective study of medical records of all patients treated from January 1997 until July 2015. [ncbi.nlm.nih.gov]
Etiology and risk factors The specific risk factors for pancreatic cancer are not as striking as those for other gastrointestinal (GI) malignancies, such as esophageal and gastric carcinomas. [web.archive.org]
The differences in rates of pancreatic cancer among countries, the changes in rates over time, and the increases among migrants moving from low-risk to high-risk areas suggest that other factors may also play an etiologic role. [jnci.oxfordjournals.org]
Epidemiology
[…] of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical [ncbi.nlm.nih.gov]
Conference: 10th Annual ENETS Conference (2013) Category: Epidemiology/Natural history/Prognosis - Descriptive epidemiology Presenting Author: professor Claudio Pasquali #983 Vipomas: Report of Three Cases in Ten Years Introduction: VIPoma is a rare neuroendocrine [enets.org]
Inoue M, Tajima K, Takezaki T et al (2003) Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). [oadoi.org]
Pathophysiology
There have been advances in PNET diagnosis, tumor localization, and therapies in the last decade, and increased understanding of their pathophysiology is likely to be rewarded with new and emerging treatments for PNETs in the not too distant future. [ncbi.nlm.nih.gov]
Bethesda, Md., USA; b Service d'Hépato-Gastroentérologie, CHU de Reims, Hôpital Robert Debré, Reims, France; c University of Florence, Florence, Italy; d Department of Endocrinology, Erasmus MC University, Rotterdam, The Netherlands; e Department of Pathophysiology [doi.org]
Conclusion: There have been advances in PNET diagnosis, tumor localization, and therapies in the last decade, and increased understanding of their pathophysiology is likely to be rewarded with new and emerging treatments for PNETs in the not too distant [oadoi.org]
Prevention
The aim of this study was to review the prevention and treatment of pancreatic fistula as performed by our department. [ncbi.nlm.nih.gov]
Causes, Risk Factors, and Prevention Learn about the risk factors for pancreatic cancer and what you might be able to do to help lower your risk. Early Detection, Diagnosis, and Staging Know the signs and symptoms of pancreatic cancer. [cancer.org]
These tubes are strategically placed during surgery to decompress the stomach and prevent stress on the anastomosis sites. [medical-dictionary.thefreedictionary.com]
Because the outlook is so poor once a person develops pancreatic cancer, it's important to find ways to prevent it. [web.archive.org]