Presentation
CASE PRESENTATION: A 34-year-old white man with type 1 diabetes mellitus presented to our hospital with severe, rapidly progressive bilateral neovascular glaucoma following coronary artery bypass graft surgery. [ncbi.nlm.nih.gov]
Entire Body System
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Weight Loss
Weight loss was 5.7 kg. Intraocular pressure decreased markedly during hemodialysis (beginning: 53 mm Hg; ending: 14 mm Hg). [ncbi.nlm.nih.gov]
He denied weight loss, fatigue, anorexia, chest pain, shortness of breath, mouth ulcers, fevers, nausea, or vomiting. [webeye.ophth.uiowa.edu]
Common acute symptoms include: abdominal pain or cramps, diarrhea, fever, jaundice, skin rash, vomiting, weight loss. [zdoc.site]
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Cat Scratch
Review of the clinical, laboratory, photographic, and angiographic records of a patient with cat scratch disease associated with central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss. [ncbi.nlm.nih.gov]
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Pseudotumor
Unilateral exophthalmos associated with an inflammatory pseudotumoral process in a woman with insulin-dependent diabetes diagnosed 30 years earlier is reported. [ncbi.nlm.nih.gov]
Respiratoric
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Aspiration
Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. [ncbi.nlm.nih.gov]
Aqueous humor was collected by means of anterior chamber paracentesis performed with a 30-gauge needle and the volume of the aspirated aqueous humor samples was about 100μL. [journals.plos.org]
Skin
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Xanthoma
Generalized eruptive xanthomas were found on the back and extremities. Extreme dyslipidemia (serum cholesterol 1311 mg/dl and triglycerides 6356 mg/dl) and diabetes mellitus (fasting plasma glucose 325 mg/dl and HbA1 c 12.1%) were first diagnosed. [ncbi.nlm.nih.gov]
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Eruptions
Generalized eruptive xanthomas were found on the back and extremities. Extreme dyslipidemia (serum cholesterol 1311 mg/dl and triglycerides 6356 mg/dl) and diabetes mellitus (fasting plasma glucose 325 mg/dl and HbA1 c 12.1%) were first diagnosed. [ncbi.nlm.nih.gov]
Eyes
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Retinal Pigmentation
The principle causes of advanced exudative retinopathy are severe breakdown of the blood-retinal barrier due to diabetes mellitus and altered retinal pigment epithelium lipid metabolism. [ncbi.nlm.nih.gov]
Since the outer photoreceptor–retinal pigment epithelium complex accounts for the majority of total retinal oxygen consumption, PRP may decrease retinal oxygen demand by destroying this outer layer. [aao.org]
Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells. Curr Eye Res 2008;33(2):199-203. . [webeye.ophth.uiowa.edu]
Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells. Exp Eye Res. 2004;79(4):465–76. PubMed View Article Google Scholar Tolentino MJ, et al. [journalretinavitreous.biomedcentral.com]
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Chemosis
Early posttreatment complications included hyphema, fibrin's exudation, chemosis. Cyclocryotherapy is usefull and accessible method for control of intensive pain in neovascular glaucoma. [ncbi.nlm.nih.gov]
Clinical presentation include: conjunctival hyperemia, chemosis and/or serosanguineous exudates, pseudomembranous conjunctivitis, bilateral episcleritis, superior limbic keratoconjunctivitis or cicatricial conjunctivitis. [zdoc.site]
Psychiatrical
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Suggestibility
Although no large, prospective, randomized trials have been performed to date, the growing body of knowledge suggests that anti-VEGF agents are effective at reversing iris and angle neovascularization and lowering intraocular pressure in patients with [ncbi.nlm.nih.gov]
Neurologic
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Headache
Neovascular glaucoma symptoms range from minor vision disturbances to debilitating headaches and total vision loss. A visual field test can detect central and peripheral vision problems caused by glaucoma. [visual-field-software.com]
Stage 1 2 3 Rubsosis iridis Secondary open-angle glaucoma Secondary angle closure glaucoma Symptoms None to mild, redness, pain, photophobia Redness, pain, photophobia, mild headache Acute severe pain, headache, photophobia, nausea or vomitting Pupils [reviewofoptometry.com]
PRESENTATION SYMPTOMS - Sudden pain - Headache ,vomiting - Redness - Watering - Defective vision - Photophobia 8. [slideshare.net]
Symptoms And Signs Of Neovascular Glaucoma Symptoms Sudden eye (ocular) pain Nausea and vomiting Headache Blurring vision Loss of vision. Signs Increased intraocular pressure (ocular hypertension) over 30 mm Hg. [epainassist.com]
Workup
CRVO, diabetic retinopathy, CAOD, and CRAO require systemic workup and appropriate intervention to prevent further complications. [emedicine.medscape.com]
General treatment Diabetes patients require a thorough systemic workup and appropriate intervention to prevent further complications. Tight glycemic control is vital as the onset of NVG in diabetics is associated with glucose control. [oatext.com]
Serum
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Dyslipidemia
Extreme dyslipidemia (serum cholesterol 1311 mg/dl and triglycerides 6356 mg/dl) and diabetes mellitus (fasting plasma glucose 325 mg/dl and HbA1 c 12.1%) were first diagnosed. [ncbi.nlm.nih.gov]
Past medical history is significant for hypertension, dyslipidemia, diabetes, and polycythemia vera. Past ocular history is significant for age related macular degeneration (AMD), cataract extraction and intraocular lens placement in both eyes. [casesjournal.biomedcentral.com]
Microbiology
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Bartonella Henselae
To report a case of Bartonella henselae infection. Observational case report. [ncbi.nlm.nih.gov]
Treatment
OBJECTIVE: To review causes, treatment modalities, and success of neovascular glaucoma treatment in the past five years at Songklanagarind Hospital. [ncbi.nlm.nih.gov]
Prognosis
At the final follow-up, the mean logMAR visual acuity was 3.13 1.24, showing a poor prognosis regardless of whether NVG occurred. CONCLUSIONS: Overall, the prognosis for ocular ischemic syndrome is very poor. [ncbi.nlm.nih.gov]
Generally, NVG carries a very guarded prognosis. Prognosis is highly dependent on diagnosis and treatment of NVG early in its course. The later it is diagnosed the worse the visual prognosis. [theeyeclinicsurgicenter.com]
Each title features more than 250 illustrations throughout and a short succinct format which include: epidemiology and aetiology; history, physical examination; differential diagnosis; laboratory and special examinations; and diagnosis, prognosis and [books.google.es]
Etiology
Etiology is reported for all 310 eyes of 284 patients managed in the department. [ncbi.nlm.nih.gov]
Retinal Vascular Occlusive Disease (RVOD) RVOD was the second most common etiologic factor associated with NVG. [dx.doi.org]
Epidemiology
Conclusions This study updates epidemiologic data on NVG at the beginning of the new century. [ijo.in]
Each title features more than 250 illustrations throughout and a short succinct format which include: epidemiology and aetiology; history, physical examination; differential diagnosis; laboratory and special examinations; and diagnosis, prognosis and [books.google.es]
Keywords: intraocular pressure • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • clinical (human) or epidemiologic studies: outcomes/complications 2010, The Association for Research in Vision and [iovs.arvojournals.org]
An epidemiological study of diabetes mellitus on the Island of Falster, Denmark. Acta Ophthalmol (Copenh) 1983;61:662-672. Kahook M, Shuman J: Chandler and Grant's Glaucoma. Thorofare, Slack, 2013, pp 309-317. [karger.com]
Pathophysiology
Mediators that induce new vessel formation such as the vascular endothelial growth factor-A seem to play a key role in the pathophysiology of this condition. [ncbi.nlm.nih.gov]
PATHOPHYSIOLOGY The underlying pathophysiology of NVG begins with oxygen deprivation, which leads to angiogenesis and neovascularization (NV). [glaucomatoday.com]
The objective of this review is to discuss its etiology, pathophysiology, clinical features and management. [djo.org.in]
Overview Pathophysiology Basic physiological principles References: [4] [5] Open-angle glaucoma Etiology Primary cause unclear Risk factors Age 40 years Increased IOP African descent Diabetes mellitus Familial predisposition Myopia Steroid use Pathophysiology [amboss.com]
Prevention
We report 4 cases using intracameral air injection for the prevention of the tube obstruction of AGV by blood clot. [ncbi.nlm.nih.gov]
Prevention Prevention should be focused on preventing the most common underlying causes of neovascular glaucoma, including retinal vein blockage and diabetic retinopathy. [brightfocus.org]
Antiangiogenic drugs may be used to promote the regression of neovascularization, but generally do not prevent laser photocoagulation and surgical intervention. [fernandez-vega.com]