Nephritis is a condition, characterized by inflammation of the kidneys, which is majorly caused by infections, autoimmune diseases or exposure to toxins. The kidneys constitute of the glomerulus, interstitial tissue and tubules.
Some of the common symptoms of nephritis include the following :
- Feeling of pain and burning sensation during urination
- Presence of blood and pus in the urine
- Fever accompanied by vomiting
- High blood pressure in individuals who have developed glomerulonephritis
- Pain in the pelvic region, kidneys and or abdomen
- Development of edema in the face, legs and hands due to accumulation of fluid
- Frequency in urge to urinate
- Urine is cloudy in appearance
Entire Body System
- Poor Growth
The several complications involved with kidney failure include uremia, anemia, overload of fluids, electrolyte imbalance, anorexia, sexual dysfunction and poor growth. Autoimmune diseases are the major cause of nephritis. [symptoma.com]
growth Anorexia Endocrine abnormalities Wen YK, Chen ML. [emedicine.medscape.com]
Male patient, 72 years-old, was admitted on hospital service with clinical complaint of asthenia, loss of strength, emaciation, and anosmia. Previous history included type 2 diabetes mellitus. [ncbi.nlm.nih.gov]
Diphtheria-pertussis-tetanus vaccine Management In primary care Take a history - ask about onset of symptoms and uraemic symptoms; look for a clue to an underlying cause - eg, recent streptococcal infection, other infection, multisystem disease. [patient.info]
Jaw & Teeth
- Periorbital Edema
Her physical examination revealed that she had bilateral pitting leg edema and periorbital edema. She was not pale or icteric. She had evidence of mild synovitis of the small joints of the hand bilaterally with no deformities. [ncbi.nlm.nih.gov]
[…] nephritis): Peripheral or periorbital edema Coagulopathy Physical findings Focal and diffuse lupus nephritis – Generalized active SLE with the presence of a rash, oral or nasal ulcers, synovitis, or serositis; signs of active nephritis Active lupus nephritis [emedicine.medscape.com]
This form of oliguria and renal insufficiency usually responds to the release of the obstruction. [emedicine.medscape.com]
Retrieved 2015-06-15. ^ "Oliguria: Background, Etiology, Epidemiology". Medscape. eMedicine. [en.wikipedia.org]
She presented to our hospital with worsening generalized body swelling and oliguria of 1 month's duration. Her physical examination revealed that she had bilateral pitting leg edema and periorbital edema. She was not pale or icteric. [ncbi.nlm.nih.gov]
Various tests would be required for diagnosing the condition of nephritis. These would include the following :
- Laboratory studies: Several laboratory investigations would be required such as blood urea nitrogen levels, urine culture along with urinalysis and complete blood count. Blood tests to analyze levels of electrolyte and creatinine would be done. In addition to these, other laboratory studies include lupus serologies, antiDNAase B, serum IgA measurement, measurement of components C3 and C4, antistreptolysin and cellular antineutrophil cytoplasmic antibody. These tests would help detect infection in general and also give insights about presence of a bacterial infection  .
- Biopsy: Biopsy of the kidney would be required when the patient shows signs of edema, proteinuria, hypertension and hematuria.
- Imaging: Imaging studies such as CT scan of the abdomen and pelvic region is indicated to check for signs of infection. In addition to this, renal ultrasonography is done to rule out other conditions of tumor, kidney stones, renal artery stenosis and hematuria.
Low to normal BP Polyuria 2nd to NDI Typically seen with chronic K+ depletion (< 3.0 mEq/L) Minimal proteinuria Majority have reduced eGFR and azotemia Severity of renal impairment correlated with duration and degree of potassium depletion Associated: hyponatremia [renalandurologynews.com]
Hyperkalemia, hyponatremia, and metabolic acidosis C. Hypokalemia, hypernatremia, and metabolic alkalosis D. Hypokalemia, hyperchloremia, and metabolic acidosis 2. What is the most common type of uveitis present in patients with TINU Syndrome? A. [docsity.com]
Medications, infectious agents like chlamydia, and a certain Chinese herb by the name of "Goreisan", have all been considered potential suspects. [verywellhealth.com]
As described above, other infections that have been associated with granulomatous AIN include fungi (histoplasmosis, coccidioidomycosis), bacteria ( Brucella, Chlamydia ), spirochetes ( Francisella, Treponema ), and parasites ( Leishmania, Toxoplasma [uptodate.com]
Acute tubulo-interstitial nephritis with uveitis (TINU syndrome) in a patient with serologic evidence for chlamydia infection. Klin Wochenschr 1990; 68 : 971–975 [ PubMed ] 62. Grefer J, Santer R, Ankermann T, et al. [ncbi.nlm.nih.gov]
Nephron 1985 ; 40 : 108 – 110 61 Acute tubulo-interstitial nephritis with uveitis (TINU syndrome) in a patient with serologic evidence for chlamydia infection. [academic.oup.com]
- Legionella Pneumophila
pneumophila, collagen vascular diseases (e.g., sarcoidosis), streptococcal infections, and transplant rejection. [healthcommunities.com]
The primary goal of treatment would be to correct the underlying disease condition that is causing nephritis. For this, medications and certain home care measurement would be required to treat the condition. Medications such as antibiotics are required if bacterial infections are the source of the problem. If autoimmune reactions are the cause, then various immunosupressants would be administered.
Individuals with nephritis should give special considerations to their diet and their activity profile. Sodium and fluid restriction would be required if the patient is suffering from hypertension as the underlying condition. Along with this, a high carbohydrate diet would also be recommended for a short period in order to prevent breakdown of body protein. Calcium supplementation would also be indicated to maintain the normal serum calcium levels . Individuals are also advised against carrying out strenuous activity; however, they are permitted to undertake daily light activities.
Prognosis of the condition is favorable with prompt initiation of treatment. However, failure to do so can cause damage to the organs, causing kidney failure. In such cases, individuals may require dialysis for filtering off the wastes from the body. Mortality due to nephritis in children is found to be higher in cases when there is development of complications. The several complications involved with kidney failure include uremia, anemia, overload of fluids, electrolyte imbalance, anorexia, sexual dysfunction and poor growth .
Autoimmune diseases are the major cause of nephritis. Following this, the condition can also occur due to infections and exposure to toxins. Individuals suffering from systemic lupus erythematosus are at an increased risk of developing nephritis. There have been instances, where nephritis can also be caused by heredity. However, such cases are rare and nephritis is majorly caused either by infections or autoimmune diseases. A kind of nephritis, known as athletic nephritis occurs as a result of excessive strenuous exercises. Such a type of condition gives rise to cylindruria, proteinuria and hematuria .
The exact incidence of nephritis across the globe is unknown. Based on the statistics given by Center for Disease Control and Prevention, it was reported that approximately 39,480 people die due to nephritis in US each year. In addition, kidney disease was ranked 9th as the leading cause of mortality amongst the US population .
Kidneys form an important organ of the body, responsible for maintain water and electrolyte balance, regulate acid-base concentration, and filtering off metabolic wastes. These bean-shaped organs process about 200 quarts of blood everyday and remove excess water and waste products from the body. Conditions interfering with the normal functioning of the kidneys are infections and underlying disease conditions.
These factors promote development of inflammation of the organ which can further lead to kidney damage. In addition to infection and disease conditions, individuals can also develop nephritis if they have undergone surgical procedures of the kidneys or are allergic to certain medications .
Certain practices can help prevent the onset of infections which would in a way avoid the onset of nephritis. Healthy living and appropriate water consumption can help keep the bladder clean and also avoid infections. Alcohol consumption and smoking are known to cause damage to the kidney and should therefore be avoided. Certain fruits and vegetables act as natural diuretics and should be made a part of daily diet. These consist of grapes and coconut water.
There are three types of nephritis, interstitial nephritis, glomerulonephritis and pyelonephritis. In interstitial nephritis, the area between the renal tubules undergoes inflammation. In the condition of glomerulonephritis, the filtering units of the kidneys, the glomeruli, get inflamed. Pyelonephritis occurs as a result of infection of the bladder, favoring development of inflammation of the kidneys. Nephritis, if not treated on time can turn severe, leading to development of several complications such as kidney damage .
- Definition: Nephritis is a condition, wherein the kidneys undergo inflammation usually either due to infections or autoimmune diseases. Such a type of condition should be promptly treated in order to avoid development of kidney damage.
- Cause: The various causative factors for nephritis include bacterial infections, autoimmune diseases, and allergic reactions to antibiotics and or surgical procedures of the kidney. All these factors can trigger an inflammatory response, giving rise to nephritis.
- Symptoms: Individuals with nephritis suffer from pain during urination, frequency in urge to urinate, pain in the abdomen and pelvic region, fever as well as vomiting. Affected individuals also experienced swelling in the arms and legs due to accumulation of fluids and also pass out blood in urine.
- Diagnosis: The various diagnostic procedures employed include blood tests, blood culture, urinalysis, urine culture, complete blood count and serology tests. In addition, kidney biopsy would be required in individuals who suffer from hematuria, edema, proteinuria and hypertension.
- Treatment: Antibiotic medications form the basis of treatment regime. Dietary restrictions along with fluid control would also be done in order to correct the condition of nephritis.
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