However, 3 years later, he presented with recurrent visible haematuria. [ncbi.nlm.nih.gov]

We present a case of a patient affected by a nested variant of urothelial carcinoma of urinary bladder to whom a radical cystoprostatectomy was performed and adjuvant chemotherapy was given. [pesquisa.bvsalud.org]

Comment Here Reference: Nested urothelial carcinoma Board review style question #2 A 65 year old man with flank pain and hematuria presents with bladder wall thickening on MRI. Transurethral resection of bladder tumor is performed (see above image). [pathologyoutlines.com]

J Urol (Paris) 95:45–47 CAS Google Scholar Rosser CJ, Salton JW, Izawa JI, et al (2003) Clinical presentation and outcome of high-grade urinary bladder leiomyosarcoma in adults. [link.springer.com]

• Pain

  Comment Here Reference: Nested urothelial carcinoma Board review style question #2 A 65 year old man with flank pain and hematuria presents with bladder wall thickening on MRI. Transurethral resection of bladder tumor is performed (see above image). [pathologyoutlines.com]

  One year later, she was admitted to hospital for the worsening abdominal pain. She had a computed tomography (CT) scan which revealed multiple intra-abdominal and peritoneal nodules consistent with metastatic disease. [ncbi.nlm.nih.gov]

• Asymptomatic

  An 83-year-old woman who presented with asymptomatic visible haematuria underwent transurethral resection of bladder tumour, which on histological examination was reported to be an invasive urothelial carcinoma (pT2). [ncbi.nlm.nih.gov]

• Hematuria

  Comment Here Reference: Nested urothelial carcinoma Board review style question #2 A 65 year old man with flank pain and hematuria presents with bladder wall thickening on MRI. Transurethral resection of bladder tumor is performed (see above image). [pathologyoutlines.com]

While the neoplastic cells exhibit low-grade histological features, the growth pattern is widely infiltrative conferring this neoplasia a bad prognosis even if a radical treatment is performed. [pesquisa.bvsalud.org]

Treatment Radical surgical resection is the treatment of choice [6]. 3.6. Macroscopic Features Quite often there is no evidence of a clearly defined tumour. 3.7. [ncbi.nlm.nih.gov]

While the neoplastic cells exhibit low-grade histological features, the growth pattern is widely infiltrative conferring this neoplasia a bad prognosis even if a radical treatment is performed. [pesquisa.bvsalud.org]

These variants of urothelial carcinoma have varied biological behaviours but small cell carcinoma of the urinary bladder is a very aggressive tumour with very poor prognosis. [ncbi.nlm.nih.gov]

Lab Med 2007;131:1725, Pathol Res Pract 2009;205:508, Anal Quant Cytol Histol 2011;33:340, Pol J Pathol 2014;65:74, Urology 2007;69:778.e15) Less than 1% of reported urothelial carcinomas (Eur Urol Focus 2020;6:653) Sites Renal pelvis, ureter, bladder Etiology [pathologyoutlines.com]

J Urol 116(1):41–42 CAS PubMed Google Scholar Kantor AF, Hartge P, Hoover RN, Fraumeni Jr JF (1988) Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder. [link.springer.com]

[…] unspecified Other, unspecified urinary organs C68.0 - malignant neoplasm of urethra C68.1 - malignant neoplasm of paraurethral glands C68.8 - malignant neoplasm of overlapping sites of urinary organs C68.9 - malignant neoplasm of urinary organ, unspecified Epidemiology [pathologyoutlines.com]

Epidemiology Nested variant of urothelial carcinoma usually occurs in men who are older than 60 years which is similar to the occurrence of classic urothelial carcinoma [6]. 3.3. [ncbi.nlm.nih.gov]