Fatigue, problems with sleep, headaches, stupor, slurred speech, and anemia are also found in chronic lead poisoning. • A "lead hue" of the skin with pallor • ]Burton line • Children with chronic poisoning may refuse to play or may have hyperkinetic or [slideshare.net]

These symptoms may consist of twitching during REM sleep but may also include other types of simple motor movements and sleep talking or yelling. 30-31 Day time somnolence and fatigue are rare because gross sleep architecture and the sleep-wake cycle [bjmp.org]

In general, these diseases have typical symptoms, such as, weakness, fatigue, motor impairment, ataxia, dysphagia, urinary complications, sensory loss, depression, cognitive decline, sleep disorders, among others [8-16]. [jneuro.com]

We describe a female infant with the above core features in whom an initial rapid neurological deterioration and associated transient left ventricular hypertrophy and liver dysfunction was followed by relative clinical stability after ten months of age [ncbi.nlm.nih.gov]

This female patient died at the age of 72 years after an approximately 20-year history of peculiar posture with progressive head drooping (Kubisagari) and lordosis (bowed posture), parkinsonism, dysphonia and slight muscle wasting of the face, tongue, [ncbi.nlm.nih.gov]

Here we present a case referred to a "first-episode" psychosis clinic with socio-occupational decline, auditory hallucinations and paranoid ideation who subsequently exhibited a rapid, severe cognitive and behavioral decline. [ncbi.nlm.nih.gov]

Here we present a case referred to a "first-episode" psychosis clinic with socio-occupational decline, auditory hallucinations and paranoid ideation who subsequently exhibited a rapid, severe cognitive and behavioral decline. [ncbi.nlm.nih.gov]

A clinical pattern of neonatal-onset intractable seizure, profound developmental delay, muscular hypotonia, hypsarrhythmia, and no focal abnormality of brain MRI should prompt initiation of molecular genetic analysis of SYNJ1. [ncbi.nlm.nih.gov]

Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia. [ncbi.nlm.nih.gov]

Clinical findings Cerebellar ataxia. Location Cerebellum and connecting tracts. Motor neuron disease Examples Amyotrophic lateral sclerosis, spinobulbar muscle atrophy (Kennedy’s disease), spinal muscular atrophy. Clinical findings Motor weakness. [medical-dictionary.thefreedictionary.com]

striatonigral degeneration), there is only parkinsonism, but in others, often called parkinson-plus syndromes, there is parkinsonism plus signs of cerebellar ataxia (e.g., olivopontocerebellar atrophy), orthostatic hypotension (e.g., Shy-Drager syndrome [jci.org]

Fatigue, problems with sleep, headaches, stupor, slurred speech, and anemia are also found in chronic lead poisoning. • A "lead hue" of the skin with pallor • ]Burton line • Children with chronic poisoning may refuse to play or may have hyperkinetic or [slideshare.net]

These disorders include epilepsy, Alzheimer disease and dementia, stroke, migraine and other headache disorders, multiple sclerosis, Parkinson's disease, neuroinfections, brain tumours, traumatic disorders of the nervous system due to head trauma, and [imedpub.com]

The most common symptoms of brain tumors are: headaches seizures numbness or tingling in your arms or legs nausea vomiting changes in personality difficulty with movement or balance changes in your hearing, speech, or vision The type of treatment you’ [healthline.com]

Differentiating features White matter disorders Gray matter disorders Cerebellar signs Early,prominent late Fundal examination May show optic atrophy Retinal degeneration EEG Diffuse delta slowing Epileptic form discharges EMG Slowed nerve conduction [slideshare.net]

These two subjects were diagnosed with MSA of the cerebellar subtype based on the presence of cerebellar signs plus dysautonomic features (e.g., orthostatic hypotension, urinary incontinence and erectile dysfunction). [journals.plos.org]

The brain MRI is normal and EEG showed hypsarrhythmia. The diagnosis was achieved via whole-genome sequencing which showed homozygous mutation in SYNJ1 (c.709C T, p.Gln237*). [ncbi.nlm.nih.gov]

We describe a female infant with the above core features in whom an initial rapid neurological deterioration and associated transient left ventricular hypertrophy and liver dysfunction was followed by relative clinical stability after ten months of age [ncbi.nlm.nih.gov]