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Neurodegenerative Disorder

Degenerative Disease of Nervous System Unspecified


Presentation

  • Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia.[ncbi.nlm.nih.gov]
Fatigue
  • These symptoms may consist of twitching during REM sleep but may also include other types of simple motor movements and sleep talking or yelling. 30-31 Day time somnolence and fatigue are rare because gross sleep architecture and the sleep-wake cycle[bjmp.org]
  • In general, these diseases have typical symptoms, such as, weakness, fatigue, motor impairment, ataxia, dysphagia, urinary complications, sensory loss, depression, cognitive decline, sleep disorders, among others [ 8 - 16 ].[jneuro.com]
Anemia
  • Abstract A female case of developmental arrest, early-onset seizures, retinal pigmentary degeneration, progressive central nervous symptoms and peripheral neuropathy, associated with progressive renal dysfunction, anemia and nephrotic syndrome, was presented[ncbi.nlm.nih.gov]
Short Stature
  • Additionally, tremor ophthalmologic abnormalities, sensory deficits, short stature, hypogonadism, elevated cerebrospinal fluid protein, and absent or prolonged somatosensory evoked potentials were seen in some relatives.[ncbi.nlm.nih.gov]
Respiratory Insufficiency
  • Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia.[ncbi.nlm.nih.gov]
Failure to Thrive
  • Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia.[ncbi.nlm.nih.gov]
Lordosis
  • This female patient died at the age of 72 years after an approximately 20-year history of peculiar posture with progressive head drooping (Kubisagari) and lordosis (bowed posture), parkinsonism, dysphonia and slight muscle wasting of the face, tongue,[ncbi.nlm.nih.gov]
Auditory Hallucination
  • Here we present a case referred to a "first-episode" psychosis clinic with socio-occupational decline, auditory hallucinations and paranoid ideation who subsequently exhibited a rapid, severe cognitive and behavioral decline.[ncbi.nlm.nih.gov]
Paranoid Ideation
  • Here we present a case referred to a "first-episode" psychosis clinic with socio-occupational decline, auditory hallucinations and paranoid ideation who subsequently exhibited a rapid, severe cognitive and behavioral decline.[ncbi.nlm.nih.gov]
Psychomotor Retardation
  • Neuroimaging studies identified progressive global CNS tissue loss presenting early in life, associated with microcephaly, seizures, and psychomotor retardation; based on this, we named the condition Autosomal Recessive Cerebral Atrophy (ARCA).[ncbi.nlm.nih.gov]
Cerebellar Ataxia
  • Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia.[ncbi.nlm.nih.gov]
  • Clinical findings Cerebellar ataxia. Location Cerebellum and connecting tracts. Motor neuron disease Examples Amyotrophic lateral sclerosis, spinobulbar muscle atrophy (Kennedy’s disease), spinal muscular atrophy. Clinical findings Motor weakness.[medical-dictionary.thefreedictionary.com]
  • ., striatonigral degeneration), there is only parkinsonism, but in others, often called parkinson-plus syndromes, there is parkinsonism plus signs of cerebellar ataxia (e.g., olivopontocerebellar atrophy), orthostatic hypotension (e.g., Shy-Drager syndrome[jci.org]
Headache
  • The most common symptoms of brain tumors are: headaches seizures numbness or tingling in your arms or legs nausea vomiting changes in personality difficulty with movement or balance changes in your hearing, speech, or vision The type of treatment you’[healthline.com]
Motor Disturbances
  • Abstract Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor disturbance, cognitive loss, and psychiatric manifestations.[ncbi.nlm.nih.gov]

Workup

Hypsarrhythmia
  • The brain MRI is normal and EEG showed hypsarrhythmia. The diagnosis was achieved via whole-genome sequencing which showed homozygous mutation in SYNJ1 (c.709C T, p.Gln237*).[ncbi.nlm.nih.gov]
Ventricular Hypertrophy
  • We describe a female infant with the above core features in whom an initial rapid neurological deterioration and associated transient left ventricular hypertrophy and liver dysfunction was followed by relative clinical stability after ten months of age[ncbi.nlm.nih.gov]

Treatment

  • In a small clinical trial of cannabis oil, all patients showed demonstrative results in the treatment of their behavioral and psychoactive dementia.[solcbd.com]
  • Cross-talk between basic and clinical researchers can lead to new treatment opportunities.[neurosciences.ucsd.edu]
  • Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies.[books.google.com]
  • That the two disorders are localized at the extremes of excitability, is supported by their opposing treatments: convulsant neuroleptics and anti-epileptic anti-depressants.[ncbi.nlm.nih.gov]
  • Caregiver education Counseling Special Programs Comprehensive Diagnostic Services Services to Physicians Consultation on complicated cases Second opinions Evaluation of patient conditions Special treatment procedures Short-term and long-term management[umm.edu]

Prognosis

  • Each hypothesis explains some of the phenomena associated with schizophrenia and it is probable that many variables described in these hypotheses interact to produce a disorder characterized by heterogeneous symptomatology, progression and prognosis.[ncbi.nlm.nih.gov]
  • You will learn about the biology of neurodegeneration, the clinical symptoms, course and prognosis. Particular attention will be paid to symptoms of mental and cognitive disorder, their diagnosis and management.[birmingham.ac.uk]
  • ONDRI: Ontario Neurodegenerative Disease Research Initiative The overall mission of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) is to catalyze advances in neurodegenerative disease research that improve diagnosis, prognosis, care[braininstitute.ca]
  • Prognosis In acute and idiopathic chronic RBD, the prognosis with treatment is excellent. In the secondary chronic form, prognosis parallels that of the underlying neurologic disorder.[bjmp.org]

Etiology

  • In the last 10 years insights concerning the etiology, diagnosis and pathogenesis of these diseases have come from research carried out by Chinese neuroscientists.[ncbi.nlm.nih.gov]
  • Scientists and physicians are working out the genetics, biochemistry, etiology (the cause of a disease), and pathogenesis [chapter and verse (i.e., story) of how a disease develops] of neurodegenerative disorders.[journeywithparkinsons.com]
  • Evidence for an Infectious Etiology in Alzheimer’s Disease By Brian Balin, Christine Hammond, C. Scott Little, Denah Appelt and Susan Hingley 1943 Open access peer-reviewed 3.[intechopen.com]
  • Etiology PSP is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69).[orpha.net]

Epidemiology

  • Additionally, challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented.[ncbi.nlm.nih.gov]
  • […] and cognition, including PSP and CBD Objectives Know about developments in the understanding of the genetic and molecular basis of neurodegenerative disorders Know about the most affective approaches in palliative care Understand current views of the epidemiology[bna.org.uk]
  • Summary Epidemiology Prevalence is conservatively estimated at about 1/16,600. Clinical description PSP usually manifests during the sixth or seventh decade of life.[orpha.net]
Sex distribution
Age distribution

Pathophysiology

  • Although a number of hypotheses have been proposed in an attempt to explain the pathophysiology of schizophrenia no single theory seems to account for all facets of the disease.[ncbi.nlm.nih.gov]
  • Our research unit “Molecular Pathophysiology of Neurodegenerative Disorders” has investigated the molecular pathogenesis of abnormal protein accumulation in the nervous system in neurodegenerative diseases to facilitate the analyses of pathogenic substances[ura.sec.tsukuba.ac.jp]
  • […] α-Synuclein as a Therapeutic Target Conclusions Chapter 3: Neuroinflammation as a therapeutic target in neurodegenerative diseases Abstract Introduction Glial Cells in CNS Development, Homeostasis, and Pathology Chronic Neuroinflammation as a Common Pathophysiological[elsevier.com]

Prevention

  • An adequate N-3 diet will probably prevent most psychotic episodes and prove that neurodegenerative disorder with dementia is also to a large extent not only preventable but avoidable.[ncbi.nlm.nih.gov]
  • Brain injuries can never be fully prevented.[books.google.com]
  • Verubecestat, Atabecestat Not Beneficial for Preventing Alzheimer Disease Use of the orally administered β-site amyloid precursor protein-cleaving enzyme 1 inhibitors, verubecestat and atabecestat, does not prevent clinical progression to Alzheimer disease[neurologyadvisor.com]
  • […] of research from basic experimental studies, cell/stem cell and animal models to clinical studies using an array of methods with the aims to understand the disease mechanisms, develop tools for early diagnosis and to find strategies for treatment and prevention[ki.se]

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