Presentation
Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia. [ncbi.nlm.nih.gov]
Similarly, the authors' review of the literature revealed that patients with concurrent rheumatic disease and movement disorders rarely presented with Parkinson disease. [rheumatologyadvisor.com]
Entire Body System
- Disability
Multiple sclerosis (MS) is the most common neurological disorder leading to permanent disability in young adults in the developed world. [ncbi.nlm.nih.gov]
We are also performing research relevant to other conditions with altered brain function, such as: Studying normal brain development and how this is altered in intellectual disability syndromes. [wehi.edu.au]
- Falling
PSP-Parkinsonism (PSP-P) is characterized by prominent early parkinsonism (tremor, limb bradykinesia, axial and limb rigidity) rather than falls and cognitive change. [orpha.net]
17), and Pick disease fall into the category of the tauopathies ( 10 ). [jci.org]
Advanced disease is associated with emergence of feature such as freezing, falling and neuropsychological dysfunction. Nonpharmacologic treatments like exercise are fundamental elements of patients' management. [ncbi.nlm.nih.gov]
It can also cause impaired balance resulting in falls. It is frequently associated with emotional symptoms such as anxiety, depression and apathy. [neuronup.com]
Alcoholic dementia Alcoholics have higher risk of dementia and brain atrophy Not sure if alcohol toxicity directly causes dementia or increases risk of other causes Lesions include Trauma, including chronic subdural hematomas (high risk of falls) Vascular [youtube.com]
- Fatigue
In general, these diseases have typical symptoms, such as, weakness, fatigue, motor impairment, ataxia, dysphagia, urinary complications, sensory loss, depression, cognitive decline, sleep disorders, among others [8-16]. [jneuro.com]
Fatigue, problems with sleep, headaches, stupor, slurred speech, and anemia are also found in chronic lead poisoning. • A "lead hue" of the skin with pallor • ]Burton line • Children with chronic poisoning may refuse to play or may have hyperkinetic or [slideshare.net]
These symptoms may consist of twitching during REM sleep but may also include other types of simple motor movements and sleep talking or yelling. 30-31 Day time somnolence and fatigue are rare because gross sleep architecture and the sleep-wake cycle [bjmp.org]
- Asymptomatic
[…] significant neuronal loss is lacking, some other pathological features of neurodegeneration, such as the presence of Lewy bodies, so typical of PD, and neurofibrillary tangles (NFTs) and senile plaques, so typical of AD, can be detected in brains of asymptomatic [ncbi.nlm.nih.gov]
Gastrointestinal
- Nausea
Adverse effects Frequent and trouble some Dose related and reversible Nausea and vomiting Occurs in almost every patient Hypotension 1/3 patient experience. [slideshare.net]
The most common symptoms of brain tumors are: headaches seizures numbness or tingling in your arms or legs nausea vomiting changes in personality difficulty with movement or balance changes in your hearing, speech, or vision The type of treatment you’ [healthline.com]
Many side-effects for the most common drugs associated with Parkinson’s and Alzheimer’s cause vomiting, nausea, digestive issues, and decreased appetite, just to name a few. [solcbd.com]
- Vomiting
Affected infants who are normal at birth develop poor feeding and vomiting in the 1st wk of life; lethargy and coma may ensue within a few days. • Physical examination reveals hypertonicity and muscular rigidity with severe opisthotonos. [slideshare.net]
The most common symptoms of brain tumors are: headaches seizures numbness or tingling in your arms or legs nausea vomiting changes in personality difficulty with movement or balance changes in your hearing, speech, or vision The type of treatment you’ [healthline.com]
Many side-effects for the most common drugs associated with Parkinson’s and Alzheimer’s cause vomiting, nausea, digestive issues, and decreased appetite, just to name a few. [solcbd.com]
- Failure to Thrive
Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia. [ncbi.nlm.nih.gov]
• More than 90% show postnatal growth failure 26. [slideshare.net]
Psychiatrical
- Behavior Disorder
“Mark Mahowald is the clinical sleep specialist who first discovered REM sleep behavior disorder and he is quite right in saying that some percentage of patients with REM sleep behavior disorder go on to develop Parkinson disease or similar disorders, [journals.lww.com]
Diagnostic criteria for REM Behavior Disorder (ICSD-2: ICD-9 code: 327.42) 1 A. [bjmp.org]
OBJECTIVE: To estimate the risk for developing a defined neurodegenerative syndrome in a large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up. [ncbi.nlm.nih.gov]
Introduction REM sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behaviors associated with REM sleep without muscle atonia [1], [2], [3]. [journals.plos.org]
Examples of non-motor symptoms include: apathy, depression, constipation, sleep behavior disorders, loss of sense of smell and cognitive impairment. In idiopathic Parkinson’s disease, progression tends to be slow and variable. [parkinson.org]
Neurologic
- Cognitive Impairment
ONDRI has set out to examine both differences and similarities between neurodegenerative diseases such as: Alzheimer’s disease (AD), mild cognitive impairment (MCI), Parkinson’s disease (PD), vascular cognitive impairment (VCI), frontotemporal dementia [braininstitute.ca]
Emerging diagnoses (37.4%) were dementia with Lewy bodies (DLB) in 29 subjects, Parkinson disease (PD) in 22, multiple system atrophy (MSA) in two, and mild cognitive impairment (MCI) in 12. [ncbi.nlm.nih.gov]
- Cerebellar Ataxia
Characteristic presentations are failure to thrive, cerebellar ataxia, respiratory insufficiency, and hypotonia or hypertonia. [ncbi.nlm.nih.gov]
Ataxic Examples Friedrich’s ataxia, spinocerebellar degeneration, dentatorubropallidoluysial atrophy. Clinical findings Cerebellar ataxia. Location Cerebellum and connecting tracts. [medical-dictionary.thefreedictionary.com]
In some (e.g., striatonigral degeneration), there is only parkinsonism, but in others, often called parkinson-plus syndromes, there is parkinsonism plus signs of cerebellar ataxia (e.g., olivopontocerebellar atrophy), orthostatic hypotension (e.g., Shy-Drager [jci.org]
- Personality Change
Frontotemporal dementia (aka Pick’s disease) Asymmetric atrophy of frontal and temporal lobes; spares parietal protein More prominent personality changes, including apathy, disinhibition, loss of emotional control Earlier onset and faster progression [youtube.com]
The Stages of Alzheimer’s Disease Mild Moderate Severe Memory Loss Language Problems Mood and Personality Changes Diminished Judgement Behavioral, Personality Changes Unable to Learn or Recall New Information Long-Term Memory Affected Wandering, Agitation [slideshare.net]
Symptoms of Alzheimer’s disease include disruptive memory loss, confusion about time or place, difficulty planning or executing tasks, poor judgment, and personality changes. [courses.lumenlearning.com]
Symptoms commonly include psychiatric problems, lack of coordination, and personality changes. Prion disorders progress rapidly and there are very limited treatment options. [journeywithparkinsons.com]
- Mild Cognitive Impairment
Emerging diagnoses (37.4%) were dementia with Lewy bodies (DLB) in 29 subjects, Parkinson disease (PD) in 22, multiple system atrophy (MSA) in two, and mild cognitive impairment (MCI) in 12. [ncbi.nlm.nih.gov]
Low Scam Awareness May Indicate Alzheimer Disease Risk in Seniors Low scam awareness is associated with an increased risk for Alzheimer disease and mild cognitive impairment among older adults. [neurologyadvisor.com]
ONDRI has set out to examine both differences and similarities between neurodegenerative diseases such as: Alzheimer’s disease (AD), mild cognitive impairment (MCI), Parkinson’s disease (PD), vascular cognitive impairment (VCI), frontotemporal dementia [braininstitute.ca]
- Headache
Fatigue, problems with sleep, headaches, stupor, slurred speech, and anemia are also found in chronic lead poisoning. • A "lead hue" of the skin with pallor • ]Burton line • Children with chronic poisoning may refuse to play or may have hyperkinetic or [slideshare.net]
These disorders include epilepsy, Alzheimer disease and dementia, stroke, migraine and other headache disorders, multiple sclerosis, Parkinson's disease, neuroinfections, brain tumours, traumatic disorders of the nervous system due to head trauma, and [imedpub.com]
The most common symptoms of brain tumors are: headaches seizures numbness or tingling in your arms or legs nausea vomiting changes in personality difficulty with movement or balance changes in your hearing, speech, or vision The type of treatment you’ [healthline.com]
Treatment
In a small clinical trial of cannabis oil, all patients showed demonstrative results in the treatment of their behavioral and psychoactive dementia. [solcbd.com]
Finding the genes responsible for Parkinson’s disease could give scientists a leg up in developing future treatments. Researchers are advancing our understanding of Parkinson’s disease and the therapies for treatment. [brainfacts.org]
Cross-talk between basic and clinical researchers can lead to new treatment opportunities. [neurosciences.ucsd.edu]
Our mission is to advance the development of diagnostic tools and new treatments for patients with neurodegenerative conditions through clinical research. [indd.org]
Prognosis
Each hypothesis explains some of the phenomena associated with schizophrenia and it is probable that many variables described in these hypotheses interact to produce a disorder characterized by heterogeneous symptomatology, progression and prognosis. [ncbi.nlm.nih.gov]
You will learn about the biology of neurodegeneration, the clinical symptoms, course and prognosis. Particular attention will be paid to symptoms of mental and cognitive disorder, their diagnosis and management. [birmingham.ac.uk]
ONDRI: Ontario Neurodegenerative Disease Research Initiative The overall mission of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) is to catalyze advances in neurodegenerative disease research that improve diagnosis, prognosis, care [braininstitute.ca]
Etiology
In the last 10 years insights concerning the etiology, diagnosis and pathogenesis of these diseases have come from research carried out by Chinese neuroscientists. [ncbi.nlm.nih.gov]
Evidence for an Infectious Etiology in Alzheimer’s Disease By Brian Balin, Christine Hammond, C. Scott Little, Denah Appelt and Susan Hingley 1943 Open access peer-reviewed 3. [intechopen.com]
Etiology PSP is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). [orpha.net]
Tabrizi Latest Research and Reviews Research 06 March 2020 | Open Access Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. [nature.com]
Epidemiology
Additionally, challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented. [ncbi.nlm.nih.gov]
[…] and cognition, including PSP and CBD Objectives Know about developments in the understanding of the genetic and molecular basis of neurodegenerative disorders Know about the most affective approaches in palliative care Understand current views of the epidemiology [bna.org.uk]
1 Complementary and alternative medicine for treating amyotrophic lateral sclerosis: A narrative review. 61 31692669 2019 2 Spatial Epidemiology of Sporadic Creutzfeldt-Jakob Disease in Apulia, Italy. 61 Puopolo M...Pocchiari M 31563913 2019 3 [Clinical [malacards.org]
Summary Epidemiology Prevalence is conservatively estimated at about 1/16,600. Clinical description PSP usually manifests during the sixth or seventh decade of life. [orpha.net]
Pathophysiology
Although a number of hypotheses have been proposed in an attempt to explain the pathophysiology of schizophrenia no single theory seems to account for all facets of the disease. [ncbi.nlm.nih.gov]
Published on Aug 24, 2012 http://armandoh.org/ A very introduction to the Pathophysiology of some Neurodegenerative disorder. Song by: Angus and Julia stone - Devils tears WATCH PART II on FACEBOOK!! :::: http://www.facebook.com/ArmandoHasudu... [youtube.com]
Staffan Holmin, Neuroimaging and image-guided vascular interventions Janne Johansson, Biological dementia research Helena Karlström, Alzheimer's disease: focus on gamma-secretase Krister Kristensson, Neurodegenerative disease mechanisms Johan Lundberg, Pathophysiology [ki.se]
Prevention
Brain injuries can never be fully prevented. [books.google.com]
An adequate N-3 diet will probably prevent most psychotic episodes and prove that neurodegenerative disorder with dementia is also to a large extent not only preventable but avoidable. [ncbi.nlm.nih.gov]
Verubecestat, Atabecestat Not Beneficial for Preventing Alzheimer Disease Use of the orally administered β-site amyloid precursor protein-cleaving enzyme 1 inhibitors, verubecestat and atabecestat, does not prevent clinical progression to Alzheimer disease [neurologyadvisor.com]
It also promotes and accelerates exploitation of scientific opportunities, confront barriers to progress and define novel approaches to prevention, intervention, treatment and care. [scitecheuropa.eu]