A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. [books.google.com]

Gerard A, Sarrot-Reynauld F, Liozon E, et al.: Neurologic presentation of Whipple disease: Report of 12 cases and review of the literature. Medicine (Baltimore) 2002, 81 :443–457. [link.springer.com]

Uveitis, retinitis, optic neuritis and papilloedema may be found. 80 percent of the reported cases of neuro-Whipple had associated systemic symptoms or signs but many patients are presenting without concurrent intestinal manifestation. [ncbi.nlm.nih.gov]

The presentation of OMM is pathognomonic for Whipple’s disease and thus can aid in quickly making a diagnosis. [eyewiki.aao.org]

Dementia - Present in more than 50% of patients with CNS-WD Psychiatric illness (ie, depression; hypomania; anxiety; psychosis, mostly with delusional content; change in personality) - Present in almost 50% of patients Ophthalmoplegia - Present in 50% [emedicine.medscape.com]

In most patients, differentiating between these etiologies requires a systematic and at times protracted workup. [prognosisapp.com]

Nevertheless, at the present time, culture is not a suitable tool for routine diagnostic purposes in the workup of possible Whipple’s disease. [oncohemakey.com]

Mahnel R, Marth T: Progress, problems, and perspectives in diagnosis and treatment of Whipple’s disease. Clin Exp Med 2004, 3 :39–43. This is a review of current recommendations for diagnosis and treatment of Whipple’s disease. [link.springer.com]

Extensively updated to reflect advancements in the field, this fifth edition covers new imaging modalities such as pediatric neuroimaging, spinal fluid examination, neurophysiology, as well as the treatment and management of epilepsy, ADHD, infections [books.google.com]

Most agree that initial treatment with a combination of parenteral penicillin and streptomycin for at least 14 days is appropriate, thereafter cotrimoxazole orally 3 times a day for at least one and probably for two years. [ncbi.nlm.nih.gov]

Treatment Antibiotics are primary treatment for Whipple disease. For many years, Whipple disease was considered a fatal primary metabolic disorder, but current treatment greatly improves a patient's chances of survival. [medicalnewstoday.com]

If you relapse during treatment, your doctor may change your antibiotics. Treatment for standard cases In most cases, Whipple's disease therapy begins with 14 days of intravenous (IV) ceftriaxone (Rocephin). [tipdisease.com]

(Outcomes/Resolutions) The prognosis of Whipple’s Disease Lymphadenopathy is based on the severity of the underlying bacterial infection In general, the prognosis of Whipple’s Disease is excellent with appropriate antibiotic treatment Without treatment [dovemed.com]

If treated properly and promptly with antibiotics, the prognosis is generally good. References 1. [prognosisapp.com]

Prognosis: The prognosis for this disease so treated is excellent, and most patients are cured. Occasional patients may relapse when antibiotics are discontinued, necessitating their reinstitution. [enotes.tripod.com]

These include the following: Weight loss Brain damage Nutritional deficiencies Heart valve damage caused by endocarditis Relapse of symptoms caused by drug resistance Whipple Disease Prognosis Following treatment, the likely outcome or prognosis for Whipple [hxbenefit.com]

In most patients, differentiating between these etiologies requires a systematic and at times protracted workup. [prognosisapp.com]

To the Editor: The clinical spectrum of Whipple disease has widely expanded since its etiologic agent, Tropheryma whipplei, was isolated in 2000 ( 1 ). [wwwnc.cdc.gov]

He had a history of a short-lasting arthritis of left ankle, unknown etiology recurring episodes of fever and one episode of persistent high fever and lymphadenopathy for which he was referred to an outpatient clinic; at that time, laboratory examinations [benthamopen.com]

Myorhythmia: Phenomenology, Etiology, and Treatment. Movement Disorders 2015;30(2):171–179. doi:10.1002/mds.26093. 7.0 7.1 Fenollar, F., Puéchal, X., Raoult, D. January 2007. "Whipple's disease". [eyewiki.aao.org]

Infectious etiology was suspected and PENICILLIN administered... without finding any germ! But of course it worked -empirically- for a few months. [thenakedscientists.com]

Genotyping studies done in Europe, Africa and Asia showed high genetic diversity with no correlation between genotypes and clinical features, but contributed to a better understanding of the epidemiology of the disease. [mayoclinic.pure.elsevier.com]

EPIDEMIOLOGY: Interestingly, Whipple’s disease occurs about six times more commonly in men than in women. The disease tends to occur in late middle age. [neuropathologyblog.blogspot.com]

EPIDEMIOLOGY Classical Whipple’s disease with intestinal involvement is a rare entity. [oncohemakey.com]

A small epidemiologic study from western Switzerland calculated the incidence of Whipple’s disease to be approximately 0.4 per million of the population per year. 16 A similar incidence of 0.4 per million per year was estimated for Germany. 17 An epidemiologic [clinicalgate.com]

Genotyping in Whipple's disease may, however, be useful in epidemiological studies. Edited by: K. E. Weaver The GenBank/EMBL/DDBJ accession numbers for the HVGS marker sequences of T. whipplei are given in Table 1 T1. [mic.microbiologyresearch.org]

In addition, the genome contains a family of genes predicted to encode an unusual set of variable surface-associated proteins likely involved in pathogenesis and pathophysiology [ 3 ]. [academic.oup.com]

Delineating these mechanisms will facilitate our understanding of the pathophysiology and heterogeneity of saccadic disorders. [journal.frontiersin.org]

Bacteria adhesion to a thrombogenic surface can assist in the pathophysiology and explain thromboembolic events associated with infection [ 10, 13 ]. Risk factors for venous thrombosis are well defined in medical reports. [karger.com]

Furthermore, the exact pathophysiology is poorly understood, though it is suspected that damage is caused by direct bacterial replication, more so than the associated host's immune response with inflammatory damage. 6 Histologic specimens of WD from the [ajnr.org]

Pathophysiology Of Neurological Manifestations Cyanocobalamin mediates two important enzymatic reactions in humans. [ispub.com]

Whipple's disease is a rare, infectious condition that prevents the small intestine from properly absorbing nutrients. [ddc.musc.edu]

Currently, there’s no known way to prevent Whipple’s disease. Whipple’s disease prevents your body from properly absorbing nutrients. Because of this, it affects many different parts of the body and is associated with a variety of symptoms. [healthline.com]

Prevention Until now, there is no known way to prevent Whipple disease. However, practicing good hygiene, for example, regular hand-washing, can reduce the risk. [medicalnewstoday.com]

It is still not clear if mild or moderate B12 deficiency can cause dementia and whether supplementation of the diet with B12 can prevent or delay the onset of dementias like Alzheimer's disease. [ispub.com]

Much of this research is aimed at learning more about these disorders and finding ways to prevent, treat, and, ultimately, cure them. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. [my.clevelandclinic.org]