78763 Phone: (512) 275-2600 Toll-free: 18776 Email: [email protected] Website: http://www.beyondbatten.org Children’s Brain Diseases Foundation 350 Parnassus Avenue Suite 900 San Francisco, CA 94117 USA Phone: (415) 665-3003 Email: [email protected] Epilepsy [rarediseases.org]

Pain medications including opioids and transdermal fentanyl patches have been recommended. Affected children may benefit from occupational, physical, and speech therapy. [rarediseases.org]

CLN1 disease is characterized by delays in reaching developmental milestones (developmental delays), twitching or jerking of muscles (myoclonic jerks), seizures, and mild to moderate intellectual disability. [rarediseases.org]

Infants may fail to gain weight and grow as the expected rate (failure to thrive) and may have diminished muscle tone (hypotonia). They may be restless, irritable and have difficulty sleeping through the night. [rarediseases.org]

They may be restless, irritable and have difficulty sleeping through the night. Some infants exhibit microcephaly, a condition that indicates that a child’s head circumference is smaller than would otherwise be expected based on age and gender. [rarediseases.org]

Specific therapies for affected infants includes anti-seizure medications called anti-convulsants and medications that relax the muscles to treat spasticity. Specific medications may be used to treat anxiety and sleep disorders. [rarediseases.org]