In the present case, longstanding constipation could have resulted in IND-like colon changes or IND could have been the cause of chronic constipation. The patient presented with megacolon and received surgical treatment. [ncbi.nlm.nih.gov]

The number of giant ganglia was significantly higher in infants presenting ganglia with signs of immaturity (P<0.01). [nature.com]

The signs and symptoms, particularly those related to bowel habits, present at the time of IND-B diagnosis (before beginning treatment) and the treatments undergone will also be recovered. [journals.lww.com]

The diffuse form of IND type B (16% patients) usually presents with chronic pseudoobstruction. In the remaining patients with rectocolonic dysplasia initial symptoms are constipation with pseudo-HSCR presentation. Symptoms usually start in infancy. [czytelniamedyczna.pl]

• Short Stature

  The first was characterized by NID B, intestinal malrotation, and congenital short bowel, the second by NID B, short stature, mental retardation, and facial dysmorphism. [en.wikipedia.org]

  There is also a report of two siblings with IND, mental retardation, dysmorphic features, hearing loss and short stature (13). Additional anomalies are more often observed in cases with diffuse IND (80%). [czytelniamedyczna.pl]

• Asymptomatic

  The patient was discharged on postoperative day 10 and during a 2-year follow-up has remained asymptomatic with normal bowel motility. The WCS score is 8 points, showing a significant difference compared to 20 points preoperatively. [ncbi.nlm.nih.gov]

• Pathologist

  a diagnosis of intestinal neuronal dysplasia type B depends on the presence of at least 20% giant ganglia, with more than eight neurons among 25 submucosal ganglia analyzed.11, 12 The histopathological analysis was performed jointly by two medical pathologists [nature.com]

• Abdominal Pain

  On the last admission, the patient presented with megacolon, abdominal pain and X-ray finding of bowel obstruction. [ncbi.nlm.nih.gov]

  […] fecaloma, presence of abdominal distension, presence of bloody stools, presence of abdominal pains, and need for enemas. [journals.lww.com]

• Vomiting

  She was admitted to hospital at 5 months because of a history of chronic constipation (she passed a hard stool with difficulty, every 4-5 days), loss of appetite, vomiting, and failure to thrive. She weighed 6700 g (10 th percentile). [czytelniamedyczna.pl]

  Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction.[3,15] In some cases, these symptoms may begin in the first days of life with a delay in meconium elimination, abdominal distension, vomiting [journals.lww.com]

• Abdominal Distension

  distension, presence of bloody stools, presence of abdominal pains, and need for enemas. [journals.lww.com]

  Clinical examination revealed significant abdominal distension with palpable faeces-filled loops of bowel. There was presence of stool in the ampulla on rectal examination. [czytelniamedyczna.pl]

• Failure to Thrive

  She was admitted to hospital at 5 months because of a history of chronic constipation (she passed a hard stool with difficulty, every 4-5 days), loss of appetite, vomiting, and failure to thrive. She weighed 6700 g (10 th percentile). [czytelniamedyczna.pl]

• Loss of Appetite

  She was admitted to hospital at 5 months because of a history of chronic constipation (she passed a hard stool with difficulty, every 4-5 days), loss of appetite, vomiting, and failure to thrive. She weighed 6700 g (10 th percentile). [czytelniamedyczna.pl]

• Suggestibility

  These data suggest a strong correlation between IND and intestinal development.[4] Diagnosis[edit] This section is empty. You can help by adding to it. [en.wikipedia.org]

  Mitochondrial DNA analysis of an intestinal biopsy of patient 1 showed heteroplasmy consisting of a normal 16.5-kb band and an approximately 28-kb band, suggestive of a duplication. [journals.sagepub.com]

  Gálvez et al. [ 12 ] suggested that enteric nervous system dysplasia, including histological features of neuronal intestinal dysplasia, could be induced by chronic intestinal obstruction. [ncbi.nlm.nih.gov]

  They also concluded that familial recurrence of associated IND-Malrotation-Short Bowel Syndrome suggests the possible presence of an autosomal recessive mode of inheritance. [czytelniamedyczna.pl]

• Confusion

  It can often be confused for Hirschsprung's disease, as both have similar symptoms.[1] Presentation[edit] IND can be grouped into NID A and NID B, with the "A" form affecting the sympathetic innervation, and the "B" version affecting the parasympathetic [en.wikipedia.org]

  This difficulty in exact estimation of the frequency of IND results from the considerable confusion regarding the essential diagnostic criteria. [czytelniamedyczna.pl]

These patients will be divided into 2 groups according to the type of treatment that they previously received: 29 patients in the surgical treatment group and 34 patients in the conservative treatment group. [journals.lww.com]

(November 2017) Treatment[edit] Conservative treatment involves the long term use of laxatives and enemas, and has limited success. [en.wikipedia.org]

The patient presented with megacolon and received surgical treatment. [ncbi.nlm.nih.gov]

Similar results of the efficacy of conservative treatment in the majority of patients with IND were recorded by Ure etal. (23). [czytelniamedyczna.pl]

The analysis will be performed according to a classification of clinical prognosis as proposed by Tran et al[31] (Fig. 2). [journals.lww.com]

The role of genetic factors in etiology in that disorder is also suggested by two reports of IND in monozygotic twins (10,16). The procedure of choice in diagnosis of IND is a rectal biopsy. [czytelniamedyczna.pl]

Epidemiology of congenital innervation defects of the distal colon. Virch Arch (A). 1992; 420 171-177 28 Meier-Ruge W, Schmidt P C, Stoss F. Intestinal neuronal dysplasia and its morphometric evidences. [thieme-connect.com]

Epidemiology of congenital innervation defects of the distal colon. Virchows Arch A Pathol Anat Histopathol 1992;420:171–7. Cited Here [7]. Milla PJ, Smith VV. Intestinal neuronal dysplasia. J Pediatr Gastroenterol Nutr 1993;17:356–7. [journals.lww.com]

Epidemiology of congenital innervation defects of the distal colon. Virchows Arch A 1992;420:171–177. Article CAS Google Scholar Munakata K, Fukuzawa M, Nemoto N. [nature.com]

The main diagnostic criteria, the underlining pathophysiology and the recommended therapeutic approach of this rare entity are extensively reviewed. [ncbi.nlm.nih.gov]

The main diagnostic criteria, the underlining pathophysiology and the recommended therapeutic approach of this rare entity are extensively reviewed. © 2014 S. [karger.com]

The intestine uses peristalsis to push its contents toward the anus; people with IND have a problem with the motor neurons that lead to the intestine, inhibiting this process and thus preventing digestion. [en.wikipedia.org]