Herein we present a case of a previously healthy 55-year-old man who presented with leg weakness and was found to have diffuse involvement of his spinal cord by neurosarcoidosis. He was treated with steroids and recovered completely. [ncbi.nlm.nih.gov]

People may have weakness in their arms and legs, and difficulty walking or controlling their urine or bowels. [ufhealth.org]

Our case demonstrates the importance of considering isolated neurosarcoidosis as a potential underlying etiology of painful ophthalmoplegia, even without systemic manifestation of the disease. [ncbi.nlm.nih.gov]

Yes I'm using it now and does help with my pain. I think it helps better for pain than the hydromorphone Yes I have isolated cardiac sarc (nowhere else) for Reply cont'd. [inspire.com]

Pain medication Inflammation of certain nerves can be painful and may be treated with pain medication. Pain medication may include narcotic drugs, which can also cause side effects, such as nausea, dry mouth, and sleepiness. [medicalnewstoday.com]

In neurosarcoidosis fatigue is a core symptom, but little is known about the relevance of fatigue on cognitive functions in this disease. Previous results in healthy subjects suggest that fatigue strongly affects cognitive control processes. [ncbi.nlm.nih.gov]

Symptoms vary as any part of the nervous system can be affected, but they may include fatigue, excessive thirst, dizziness, headaches, loss of vision or sense of smell, speech impairment, loss of movement in any body part and nausea. [independent.ie]

Symptoms of neurosarcoidosis vary widely and may include: Facial palsy Muscle weakness and wasting Numbness in various parts of the body Excessive thirst Fatigue Headache Seizures Lethargy Fever Memory loss Hallucinations Irritability/agitation Depression [diseases.emedtv.com]

We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 31, 2019 [patientslikeme.com]

People may have weakness in their arms and legs, and difficulty walking or controlling their urine or bowels. [medlineplus.gov]

People may have weakness in their arms and legs, and difficulty walking or controlling their urine or bowels. In some cases, the spinal cord is so severely affected that both legs are paralyzed. [nlm.nih.gov]

A 27-year-old male was admitted to our hospital with a history of unconsciousness and convulsion 1 month ago, which was suspected as a seizure. [ncbi.nlm.nih.gov]

The most frequent features were headaches, visual failure, ataxia and vomiting. [jnnp.bmj.com]

Clinical Presentation Case 1 A 25 years male presented to Emergency Department with complaint of headache and altered consciousness for 3 days; he has nausea, vomiting without visual or behavioral problem. [omicsonline.org]

[…] inappropriate ADH secretion and the systemic findings of sarcoidosis was observed. 9 In a study investigating the relationship between sarcoidosis and pituitary mass, a patient diagnosed with pulmonary and ophthalmic sarcoidosis was presented with fatigue and vomiting [reumatologiaclinica.org]

CASE REPORT A 23-year-old Japanese man was transferred to our hospital because of progressive consciousness disturbances with vomiting. [surgicalneurologyint.com]

Symptoms vary as any part of the nervous system can be affected, but they may include fatigue, excessive thirst, dizziness, headaches, loss of vision or sense of smell, speech impairment, loss of movement in any body part and nausea. [independent.ie]

Clinical Presentation Case 1 A 25 years male presented to Emergency Department with complaint of headache and altered consciousness for 3 days; he has nausea, vomiting without visual or behavioral problem. [omicsonline.org]

Pain medication may include narcotic drugs, which can also cause side effects, such as nausea, dry mouth, and sleepiness. Narcotic pain medication can also be habit-forming and is usually only prescribed in the short term. [medicalnewstoday.com]

One patient was taking methotrexate only briefly and was changed to azathioprine because of severe nausea. [jamanetwork.com]

Five months later, the patient presented to the outside hospital with a headache, nausea, vomiting, ataxia, dizziness, and blurred vision. [nnjournal.net]

A 37-year-old man presented with dysphagia to solids and liquids, dysphonia, fatigue and 50 lb weight loss over 2 months. [ncbi.nlm.nih.gov]

[…] nerve involvement (particularly common) 5 facial nerve palsy endocrine features of hypothalamic/pituitary sarcoidosis 7 diabetes insipidus SIADH hyperprolactinemia hypothyroidism hypoadrenalism seizures variable weakness, paresthesias and dysarthria/dysphagia [radiopaedia.org]

Seizures 132/965 (14) Rheumatological 99/469 (21) Nausea 11/84 (13) Otorhinolaryngeal 43/469 (9) Diplopia 41/361 (11) Hepatic 37/469 (8) Micturition abnormalities 23/206 (11) Cardial 26/469 (6) Dysarthria 36/413 (9) Constitutional symptoms 106/469 (23) Dysphagia [bmcneurol.biomedcentral.com]

Other symptoms include hypoacusia, tinnitus, dizziness, trigeminal neuralgia, and dysphagia. Eventually the clinical picture will be that of Tolosa-Hunt or Garcin syndrome 5. [scielo.br]

Guillain-Barré syndrome variant: presenting with myalgias and acute facial diplegia. Mil Med. 2008 ;173(5): 507 – 508. Google Scholar Crossref Medline ISI 18. Elias, MK, Mateen, FJ, Weiler, CR. [journals.sagepub.com]

A 23-year-old African American man presented to our emergency department with diplopia, which was worsened on left horizontal gaze. On the day of admission, he had a witnessed seizure. [ncbi.nlm.nih.gov]

CASE REPORT A 61-year-old man with a history of hypertensive cerebellar hemorrhage visited our hospital because of diplopia and fever. The diplopia was recognized when he gazed at the right side and disappeared with monocular vision. [surgicalneurologyint.com]

Macarie 4 REZUMAT Introducere: Boala cronică de rinichi (BCR) poate More information Radiology of Multiple Sclerosis September 2000 Radiology of Multiple Sclerosis Patricia Bachiller, Harvard Medical School Year-IV Our Patient 40 y.o. woman with baseline diplopia [docplayer.net]

Other brainstem symptoms typical of MS include ataxia, painless diplopia, facial numbness, and trigeminal neuralgia in a young patient. Hyperacute or insidious onset of brainstem symptoms is unlikely to indicate MS. [mdedge.com]

Symptoms of Neurosarcoidosis with involvement of parts of the brain and cranial nerves: Decreased hearing Disorientation and confusion Delirium Dizziness and vertigo Dementia or memory impairment Abnormal sensation of movement Visual impairment with double [epainassist.com]

Subsequently, chloroquine at a dose of 150 mg b.i.d/day was added with regular monitoring of visual impairment. [neurologyindia.com]

Sensory abnormalities 138/484 (29) Caucasian 461/739 (62) Hypaesthesia 39/174 (22) African 218/739 (29) Paraesthesia 69/334 (21) Other 27/739 (4) Neuropathic pain 25/216 (12) Unknown 33/739 (4) Gait abnormalities 128/466 (28) Presentation of disease Visual [bmcneurol.biomedcentral.com]

The optic and auditory nerves can also become involved, causing vision and hearing impairments. It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior. [ninds.nih.gov]

Some symptoms include facial muscle weakness, vision and hearing impairments, and changes in mood and behavior. Common symptoms reported by people with neurosarcoidosis Reports may be affected by other conditions and/or medication side effects. [patientslikeme.com]

The optic and auditory nerves can also become involved, causing vision and hearing impairments. [houghton.moneomed.com]

The second is a 36-year-old woman with rapid-onset horizontal diplopia, left mixed severe sensorineural hearing loss (SNHL) and tinnitus, diffuse leptomeningeal enhancement on MRI, and progressive palsy of the left CNs IV, VI, VII, IX, X and XI, with [ncbi.nlm.nih.gov]

Patient and observation A 46-year-old lady with no significant medical history, was referred to our department after a 7 months history of gradually worsening bilateral hearing loss without tinnitus, vertigo or aural discharge. [panafrican-med-journal.com]

Weakness of jaw muscles and muscle twitch Loss of sight or defects in visual perception Impaired taste and smell Sensorineural deafness (“brain deaf”), tinnitus and vertigo Involuntary tongue movements causing speech abnormalities and problems with swallowing [healthhype.com]

[…] may present with the following manifestations: impaired taste, blindness, blurry vision, double vision, visual field defects, pupillary abnormalities, dry or sore eyes, slurred speech, impaired swallowing, hoarseness, vertigo, sensorineural deafness, tinnitus [jneurology.com]

The first is a 39-year-old man with a history of progressively worsening hearing loss, followed by visual loss, delusions, agitation, ataxia, and musical auditory hallucinations, diffuse leptomeningeal enhancement on MRI with a normal serum angiotensin-converting [ncbi.nlm.nih.gov]

A 22-year-old man was referred to the endocrinology service with profound weight gain, polyuria and lethargy. [ncbi.nlm.nih.gov]

Signs and symptoms of CNS involvement can include polyuria, polydipsia, obesity, impotence, amenorrhea, confusion/amnesia (short and long term memory), meningitis, and seizures (focal seizures). [encyclopedia.com]

Due to hypothalamic-pituitary involvement, diabetes insipidus related symptoms like polydipsia and polyuria can occur. [reumatologiaclinica.org]

* Urinary incontinence. * Bowel incontinence. * Unable to dress himself. * Unable to write. * Unable to walk. * Depression * Short-term memory loss. * Anxiety. * Focal seizures. * Swelling legs. * Irregular diabetes (although he is monitored constantly [inspire.com]

Case 2 25-year-old male presented to Emergency Department with decreased vision, recurrent bilateral lower limbs weakness, and urinary incontinence, On Neurological examination, patient has power 3/5, exaggerated reflexes in lower limbs with Up-going [omicsonline.org]

There were no sensory deficits, and the patient did not complain of fecal or urinary incontinence. Head CT demonstrated bilateral frontal and right suboccipital approach ventricular catheters and a decompressed ventricular system. [nnjournal.net]

Meningeal involvement may cause focal nodular enhancement that can simulate common cranial base tumors. [ncbi.nlm.nih.gov]

Meningeal involvement can take the form of either an acute aseptic meningitis or a chronic meningitis. Meningeal mass lesions also can develop. [authorstream.com]

Common manifestations include leptomeningeal inflammation with seizures, headache, cranial nerve palsies, hydrocephalus, or focal neurological deficits with white matter lesions or mass lesions. [ncbi.nlm.nih.gov]

In the remaining three cases headache was the only neurological symptom found in association with systemic features of sarcoidosis, and had the clinical features of tension-type headache. [ncbi.nlm.nih.gov]

[…] both of the following: a) headache has significantly worsened in parallel with worsening of the neurosarcoidosis b) headache has significantly improved in parallel with improvement in the neurosarcoidosis headache is accompanied by one or more cranial [ichd-3.org]

Stroke is relatively rare, and hemorrhage is much less common than ischemia due to vasculitis. [ncbi.nlm.nih.gov]

Neurosarcoidosis and stroke. Stroke 1990 ; 21 : 152 –53 Brown MM, Thompson AJ, Wedzicha JA, et al. Sarcoidosis presenting with stroke. Stroke 1989 ; 20 : 400 –05 Ketonen L, Oksanen V, Kuuliala I. [ajnr.org]

Peripheral neuropathy is seen in 5-15% of those with neurosarcoidosis. In a series from Johns Hopkins University, 2 of 33 patients with neurosarcoidosis had peripheral neuropathy; of this population, 85% was African American and 15% was white. [emedicine.com]

Keywords: Neurosarcoidosis, sarcoidosis, cranial neuropathy, meningitis, neuroendocrine dysfunction, seizures, peripheral neuropathy, myopathy Abstract: Neurosarcoidosis is an uncommon but potentially serious manifestation of sarcoidosis. [benthamscience.com]

Sarcoid peripheral neuropathy. Neurology 1991;41:1558-61. [ PUBMED ] 13. Nemni R, Galassi G, Cohen M, et al. Symmetric sarcoid polyneuropathy: Analysis of sural nerve biopsy. Neurology 1981;31:1212-23. 14. [neurologyindia.com]

In 2003, she received steroid therapy for one year for the mediastinal mass lesion with a good response. [ncbi.nlm.nih.gov]