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Night Blindness


Presentation

  • This is contrary to the standing opinion and present problems regarding the integrity of the retina.[ncbi.nlm.nih.gov]
  • The possibility that vitamin A deficiency may be contributing to anaemia present in pregnancy should also be considered.[ncbi.nlm.nih.gov]
  • The present familial case suggests that BAFME may also be a disease of the calcium channel that is present in the retina and the central nervous system (CNS). Copyright 2002 BEA Trading Ltd. Published by Elsevier Science Ltd. All rights reserved.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Ophthalmology, University Hospital of Crete, Crete, Greece. tasosanastasakis@gmail.com Abstract A 69-year-old male patient presented to our department with a 3-month history of nyctalopia.[ncbi.nlm.nih.gov]
  • Abstract Night blindness and optic neuropathy were the presenting symptoms of an iatrogenic malabsorption syndrome in a 64-year old female.[ncbi.nlm.nih.gov]
Bulimia
  • It might be especially relevant in certain socioeconomic situations and eating disorders such as bulimia or anorexia nervosa.[ncbi.nlm.nih.gov]
Steatorrhea
  • Abstract A 59-year-old man presented with a 3-month history of night blindness and a 9-month history of steatorrhea. Both symptoms had appeared after he had begun taking methyltestosterone.[ncbi.nlm.nih.gov]
Salt Craving
  • We report on three boys, of Indian origin, with Dent's disease that presented at an early age (1-4 years), with polyuria, polydipsia, salt craving, recurrent vitamin A-responsive night blindness, hypophosphataemic rickets, hypercalciuria and low molecular[ncbi.nlm.nih.gov]
Night Blindness
  • The seasonal pattern for night blindness roughly parallels that for scurvy and for diarrheal diseases. The peak season for night blindness incidence was summer, and the next highest season was spring.[ncbi.nlm.nih.gov]
  • Acquired Causes Most of the acquired causes of night blindness (night blindness which is not present since birth and does not have a genetic basis), generally fall into the category of progressive night blindness.[web.archive.org]
  • Multivariate logistic regression was used to identify socioeconomic, demographic, and pregnancy-related factors associated with maternal night blindness. RESULTS: Women reported night blindness in 687 (5.2%) of 13,171 pregnancies.[ncbi.nlm.nih.gov]
  • RESULTS: The prevalence of gestational night blindness was 9·9 %.[ncbi.nlm.nih.gov]
  • The Se concentration was inversely associated with the risk of night blindness in both genders. These results add to an increasing body of evidence that Se is a protecting element for night blindness.[ncbi.nlm.nih.gov]
Polyuria
  • We report on three boys, of Indian origin, with Dent's disease that presented at an early age (1-4 years), with polyuria, polydipsia, salt craving, recurrent vitamin A-responsive night blindness, hypophosphataemic rickets, hypercalciuria and low molecular[ncbi.nlm.nih.gov]
Ataxia
  • Symptoms include retinopathy, polyneuropathy, ataxia, and deafness. They are variable and rarely recognized before adulthood. The authors report the case of a 14-year-old girl diagnosed because of night blindness.[ncbi.nlm.nih.gov]
  • The patient had suffered from mental retardation, epilepsy, and mild cerebellar ataxia. Corrected visual acuity was 20/30 in the right eye and 20/25 in the left. Goldmann perimetry showed no scotoma but slight depression with internal isoptors.[ncbi.nlm.nih.gov]
Cerebellar Ataxia
  • The patient had suffered from mental retardation, epilepsy, and mild cerebellar ataxia. Corrected visual acuity was 20/30 in the right eye and 20/25 in the left. Goldmann perimetry showed no scotoma but slight depression with internal isoptors.[ncbi.nlm.nih.gov]

Treatment

  • KEYWORDS: Cuban treatment; Soviet Union treatment; dubious RP treatments; historical RP treatments; night blindness; retinitis pigmentosa (RP)[ncbi.nlm.nih.gov]
  • Despite the normal serum vitamin A levels, the patient was instructed to commence treatment with high doses of oral vitamin A supplements.[ncbi.nlm.nih.gov]
  • Future treatments may include retinal transplant, artificial retinal implants, and stem-cell treatment of the genetic defect.[web.archive.org]
  • Isotretinoin is an effective and increasingly popular treatment for acne vulgaris.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis : guarded to poor. Pathogenesis Etiology Inherited in the Appaloosa by, as yet, an unidentified pattern - thought to be either autosomal recessive, or sex-linked recessive, with the defect on the X chromosome.[vetstream.com]
  • This content is for informational purposes only and does not substitute for formal and individualized diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed medical professional.[healdove.com]
  • Prognosis In Oguchi disease the visual prognosis is good in absence of progression of symptoms.[orpha.net]
  • Kidney disease has an onset in the first decade and its progression often defines the survival prognosis. Renal transplantation can be lifesaving when nephronophthisis develops. Psychomotor delays have been reported but are uncommon.[disorders.eyes.arizona.edu]
  • ., 2001 Melastatin expression and prognosis in cutaneous malignant melanoma. J. Clin. Oncol. 19 : 568 –576. D uvoisin, R. M., C. W. M organs and W. R.[dx.doi.org]

Etiology

  • However, the etiology of this unique form of unilateral night blindness remains obscure.[ncbi.nlm.nih.gov]
  • Pathogenesis Etiology Inherited in the Appaloosa by, as yet, an unidentified pattern - thought to be either autosomal recessive, or sex-linked recessive, with the defect on the X chromosome.[vetstream.com]
  • Etiology Oguchi disease is caused by mutations in the SAG gene coding for arrestin located on chromosome 2q37(Oguchi type 1) or by mutations in the GRK1 gene that codes for the rhodopsin kinase located on the chromosome 13q34 (Oguchi type 2).[orpha.net]
  • It is possible that the downregulation of TRPM1 in the retina of LP/LP horses is the etiology of CSNB. TRPM1 may play a role in neural transmission in the retina through changing cytosolic free Ca 2 levels in the retinal ON bipolar cells.[dx.doi.org]

Epidemiology

  • ORPHA:1390 Synonym(s): Hunter-Thompson-Reed syndrome Prevalence: Inheritance: - Age of onset: Childhood ICD-10: Q87.8 OMIM: - UMLS: - MeSH: - GARD: - MedDRA: - Summary Epidemiology It has been described in two brothers.[orpha.net]
  • Summary Epidemiology Oguchi disease is a very rare condition with approximately 50 cases described in the literature to date.[orpha.net]
  • Dali, Alfred Sommer; Night Blindness During Pregnancy and Subsequent Mortality among Women in Nepal: Effects of Vitamin A and β-Carotene Supplementation, American Journal of Epidemiology , Volume 152, Issue 6, 15 September 2000, Pages 542–547, Download[academic.oup.com]
  • The study senior author, a professor of epidemiology at the London School of Hygiene & Tropical Medicine, Juan Casas, says, we all need to cut down on alcohol intake as much as we can.[punchng.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of acne. Cutis. 2005; 76 (2 Suppl):4–7. [ PubMed ] 2. Harris EW, Loewenstein JI, Azar D. Vitamin A deficiency and its effects on the eye. Int Ophthalmol Clin. 1998; 38 :155–61. [ PubMed ] 3. Danby FW.[ncbi.nlm.nih.gov]
  • Pathophysiology A congenital, non-progressive disease which produces visual disturbance in reduced light conditions, probably due to a defect in neural transmission from the photoreceptor cell to the bipolar and Muller cells.[vetstream.com]
  • A case of CADASIL presenting as schizophreniform organic psychosis has been reported. [6] Pathophysiology [ edit ] The underlying pathology of CADASIL is progressive hypertrophy of the smooth muscle cells in blood vessels .[en.wikipedia.org]

Prevention

  • Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.[ncbi.nlm.nih.gov]
  • Proper intake of vitamin A is one preventive measure against night blindness. If the problems originates from other medical conditions, it can be prevented only if the specific condition that leads to night blindness is preventable.[ic.steadyhealth.com]
  • Night Blindness PreventionPrevention is better than cure”, isn’t it? In most cases, night blindness can be prevented by taking proper care of one’s health.[healthguidance.org]
  • This case emphasizes the importance of monitoring vitamin levels in cystic fibrosis to detect deficiency and prevent long-term consequences, and it highlights the challenges encountered during the course of night blindness treatment.[ncbi.nlm.nih.gov]
  • CONCLUSION: Negative ERG may prevent misdiagnosis of malingering for patients with CSNB with normal fundal appearance in the military.[ncbi.nlm.nih.gov]

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