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Nitroglycerin

Glyceryl Trinitrate


Presentation

  • Thus, the present manuscript describes a hitherto unrecognized pathway of GTN bioactivation in bovine and porcine blood vessels.[ncbi.nlm.nih.gov]
  • The present study aimed to compare the efficacy of nicorandil versus nitroglycerin for alleviation of angina symptoms in slow flow patients.[ncbi.nlm.nih.gov]
  • These values were present in a 29.8% (n   100) and a 47.1% (n   158), of the total lesions. Scatter plots showed a better correlation and agreement points with Pd/Pa-NTG than resting baseline Pd/Pa.[ncbi.nlm.nih.gov]
  • We report a case of PAN presenting with severe abdominal pain successfully treated with nitroglycerin.[ncbi.nlm.nih.gov]
  • We present two patients with allergic contact dermatitis and review the existing bibliography.[ncbi.nlm.nih.gov]
Hyperthermia
  • Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143, USA. rosenm@anesthesia.ucsf.edu Abstract We report the administration of two anesthetics to a patient potentially at risk for malignant hyperthermia[ncbi.nlm.nih.gov]
Sleep Apnea
  • METHODS: Prospectively collected transesophageal echocardiography recordings from 13 patients with obstructive sleep apnea were retrospectively analyzed for the presence or absence of LBA during resting respiration and during Valsalva strain.[ncbi.nlm.nih.gov]
Severe Abdominal Pain
  • We report a case of PAN presenting with severe abdominal pain successfully treated with nitroglycerin.[ncbi.nlm.nih.gov]
Hypotension
  • Dexmedetomidine or nitroglycerin was used as the hypotensive drug for each group. All patients underwent hypotensive anesthesia and surgery according to standard protocol.[ncbi.nlm.nih.gov]
  • The pooled OR of mortality, readmission, and hypotension showed that no significant difference was found in both drugs (P   0.05), with the absence of heterogeneity.[ncbi.nlm.nih.gov]
  • Caution in MI or CHF, alcohol use, increased ICP (eg, head trauma, cerebral hemorrhage; potential contraindication), hyperthyroidism, hypertrophic cardiomyopathy, increased IOP, postural hypotension, volume depletion, low systolic BP Severe hypotension[reference.medscape.com]
  • Riociguat; coadministration may cause hypotension Narrow angle glaucoma (controversial: may not be clinically significant) Hypersensitivity Symptomatic hypotension, uncorrected hypovolemia, increased intracranial pressure (head trauma, cerebral hemorrhage[reference.medscape.com]
Tachycardia
  • These concentrations produced no disturbance of the patient's state of consciousness and no serious haemodynamic effects appeared except for a tachycardia in relation to peripheral vasodilatation.[ncbi.nlm.nih.gov]
  • Nitroglycerin's most common side effects are headache, facial flushing, head throbbing, fainting, hypotension, tachycardia, and syncope.[ncbi.nlm.nih.gov]
  • ) Burden Not at all hard to take Dosage: As needed Cost: 25 monthly Apr 28, 2012 (Started Sep 04, 1995) Effectiveness Major (for myocardial ischemia) Side effects Severe (headache on right side of head, ventricular tachycardia) Burden A little hard to[patientslikeme.com]
  • Dyspnea, tachypnea, and tachycardia subsided for 1 to 2 hours, allowing to reduce NTG infusion to 2 to 4 mg h ¹.[ncbi.nlm.nih.gov]
  • […] during acute anginal episodes Nitro tablets are inactivated by light, air and moisture and must be kept in amber glass containers with tight-fitting lids Alcohol will accentuate vasodilating and hypotensive effects Adverse Reactions: Headache Hypotension Tachycardia[orangecountyfl.net]
Orthostatic Hypotension
  • Dosage may need to be reduced temporarily. • Drug may cause orthostatic hypotension.[glowm.com]
  • Because of this reason, this category of patients also experiences condition called orthostatic hypotension.[omicsonline.org]
  • hypotension reported when calcium channel blockers and organic nitrates used in combination Nitroglycerin at higher dosages may interfere with anticoagulant effect of heparin; intravenous nitroglycerin can induce heparin resistance[reference.medscape.com]
  • Contraindications • Hypersensitivity to drug, other organic nitrates, nitrites, or adhesives (transdermal form) • Angle-closure glaucoma • Orthostatic hypotension • Hypotension or uncorrected hypovolemia (I.V. form) • Early MI (S.L. form) • Increased[medical-dictionary.thefreedictionary.com]
Flushing
  • The current standard of care for maintaining catheter patency includes flushing the CL with saline or heparin. Neither agent has any antimicrobial activity. Furthermore, heparin may enhance staphylococcal biofilm formation.[ncbi.nlm.nih.gov]
  • Nitroglycerin's most common side effects are headache, facial flushing, head throbbing, fainting, hypotension, tachycardia, and syncope.[ncbi.nlm.nih.gov]
  • Cost: 25 monthly 0 helpful marks Dec 16, 2012 (Started Oct 27, 2012) Effectiveness Major (for angina pain) Burden Not at all hard to take Dosage: As needed Advice & Tips: No headaches, though get light headed and slightly flushed with taking it.[patientslikeme.com]
  • […] episodes Nitro tablets are inactivated by light, air and moisture and must be kept in amber glass containers with tight-fitting lids Alcohol will accentuate vasodilating and hypotensive effects Adverse Reactions: Headache Hypotension Tachycardia Dizziness Flushing[orangecountyfl.net]
  • SIDE EFFECTS CNS: Headache, dizziness, flushing, nausea and vomiting. Cardiovascular: Hypotension, reflex tachycardia. Nitroglycerin (Nitro-Bid Ointment) DOSAGE Adult: 1 inch of 2% ointment topically for transdermal absorption.[jointemsprotocols.com]
Headache
  • Sobrero first noted the 'violent headache' produced by minute quantities of NG on the tongue. 2. Constantin Hering, in 1849, tested NG in healthy volunteers, observing that headache was caused with 'such precision'.[ncbi.nlm.nih.gov]
  • Dec 12, 2014 (Started Nov 20, 2007) Effectiveness Major (for heart attack (myocardial infarction)) Side effects Moderate (headaches) Burden Not at all hard to take Dosage: As needed Advice & Tips: Please take it if you really need to and only when you[patientslikeme.com]
  • Drawbacks of therapy include not only side effects such as headache, resistance, and development of tolerability to nitrates but also free radical production.[ncbi.nlm.nih.gov]
  • The patient did not experience the typical side effects of headache, asymptomatic decrease in blood pressure, hypotension, palpitations or dizziness that can be associated with administration of nitroglycerin.[ncbi.nlm.nih.gov]
  • Nitroglycerin's most common side effects are headache, facial flushing, head throbbing, fainting, hypotension, tachycardia, and syncope.[ncbi.nlm.nih.gov]

Treatment

  • The aim of this study was to evaluate the effectiveness and safety of topical nitroglycerin 0.2% in the treatment of CNH.[ncbi.nlm.nih.gov]
  • One of 11 patients (9%) did not respond completely and surgical treatment was performed. Two of 11 patients (18.1%) stopped the treatment because of headache.[ncbi.nlm.nih.gov]
  • Medical treatment becomes a more difficult challenge in the late stage. Treatment regimens for stage III RSD have been largely unsuccessful, and their benefits infrequently maintained.[ncbi.nlm.nih.gov]
  • Acute antihypertensive treatment options can be limited in this setting by monitoring requirements of intravenous medications and patients' inability to take oral medications.[ncbi.nlm.nih.gov]
  • Abstract Variant angina usually responds to conventional treatment with nitrates and calcium antagonists.[ncbi.nlm.nih.gov]

Etiology

  • Abstract Topical nitroglycerin ointment has been studied in the laboratory as a possible treatment for impotence of various etiologies.[ncbi.nlm.nih.gov]
  • A final diagnosis of a cardiac etiology for chest pain was found in 18% of the patients in the study.[mdedge.com]

Epidemiology

  • […] of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. 3 Department of Cardiovascular Surgery, Tokyo Yamate Medical Center, 3-22-1 Hyakuninncho, Shinjuku-ku, Tokyo, 169-0073, Japan. 4 Department of Epidemiology[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Our experimental design overlaps with a large spectrum of processes present in migraine pathophysiology, and it can be a useful experimental model for drug screening.[ncbi.nlm.nih.gov]
  • We discuss the possible pathophysiologic mechanisms by which nitroglycerin might exacerbate ischemia in patients with non-stenotic ectasia, and we present supporting data from other sources.[ncbi.nlm.nih.gov]
  • Author information 1 Biomaterials Science Center, Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland. 2 Nanomedicine Research and Education Center, Institute of Pathophysiology, Semmelweis University Budapest, Hungary; SeroScience[ncbi.nlm.nih.gov]
  • BACKGROUND AND OBJECTIVES: Laparoscopic surgery offers the advantages of minimally invasive surgery; however, pneumoperitoneum and the patient's position induce pathophysiological changes that may complicate anesthetic management.[ncbi.nlm.nih.gov]
  • The methodology described here has great potential for future pathophysiological studies.[ncbi.nlm.nih.gov]

Prevention

  • This study will clarify whether NSAIDs plus nitroglycerin can prevent PEP.[ncbi.nlm.nih.gov]
  • Although several agents have been studied for use in the prevention of nitrate tolerance, none are currently recommended owing to a paucity of supportive clinical data.[ncbi.nlm.nih.gov]
  • Abstract In cases of purpura fulminans (PF), various treatments have been used to prevent the cutaneous involvement and extensive skin necrosis that can be both disfuguring and debilitating.[ncbi.nlm.nih.gov]
  • Abstract Temporary asystole induced with adenosine or electrically induced ventricular fibrillation has previously been proposed to prevent hypertension during transluminal placement of thoracic endovascular stent-grafts.[ncbi.nlm.nih.gov]
  • We evaluated the safety and efficacy of a novel nonantibiotic catheter lock solution for the prevention of CLABSI.[ncbi.nlm.nih.gov]

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