While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely. [psychonautwiki.org]

Abstract Anesthesia arguably provides one of the only systematic ways to study the neural correlates of global consciousness/unconsciousness. [ncbi.nlm.nih.gov]

[…] heart attack and died, potentially unrelated. 2015-03-02, Aaron Dunford, 22, Brighton UK - cronic user, B12 deficiency, presumed asphyxia. 2014-02-06, Jordan Guise, 21, France - unknown cause of death. 2013-05-17, Ali Mirza, 19, Claremont CA USA - found unconscious [justsayn2o.com]

Because the gas reduces anxiety and coordination before causing unconsciousness, it may be impossible to escape from such a situation even if you realise your mistake. [drugscience.org.uk]

Commonly reported effects in laboring women include: detachment, dizziness, euphoria, fatigue, hallucinations, hazy memory of events, headache, nightmares, pleasure, relaxation, sedation, and a sense of warmth. [mamanatural.com]

Acute exposure: The signs and symptoms of acute exposure to nitrous oxide include dizziness, difficult breathing, headache, nausea, fatigue, and irritability. [web.archive.org]

[…] symptoms such as headache, blurred vision, vertigo, ataxia, tinnitus, nausea, anorexia, and weakness are not uncommon" with low concentrations of gasoline fumes; and that chronic exposure to gasoline fumes may produce "muscular weakness, listlessness, fatigue [druglibrary.org]

The detonation, the mechanical pounding, actually mechanically erodes or fatigues material out of the piston. [contactmagazine.com]

Google Scholar Crossref Medline ISI McCambridge, J, Winstock, A, Hunt, N. ( 2007 ) 5-year trends in use of hallucinogens and other adjunct drugs among UK dance drug users. Eur Addict Res 13: 57 – 64. [dx.doi.org]

King SB, Smith SC, Hirshfeld JW, Jacobs AK, Morrison DA, Williams DO, Feldman TE, Kern MJ, O'Neill WW, Schaff HV, Whitlow PL, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura [doi.org]

Homocysteine has been linked to endothelial dysfunction and coronary atherosclerosis and this case report highlights one of the dangers of recreational abuse of nitrous oxide. [ncbi.nlm.nih.gov]

An MRI confirmed the absence of pharyngeal haematoma and the absence of thrombosis of the basilar artery. [ncbi.nlm.nih.gov]

Omission of nitrous oxide reduced the odds of postoperative nausea and vomiting by 37%, a reduction in risk of 28%. [doi.org]

Both these agents are known risk factors for postoperative nausea and vomiting (PONV). However, remifentanil and N2O have not been directly compared in a published study. [ncbi.nlm.nih.gov]

A 27-year-old woman was treated in the emergency department for complaints of abdominal pain and inability to urinate for about 12 hours. [ncbi.nlm.nih.gov]

pain, and weight loss" along with "neurological effects such as confusion, ataxia, tremor, paresthesias [itching], neuritis, and paralysis of peripheral and cranial nerves." 28 If Dr. [druglibrary.org]

An MRI confirmed the absence of pharyngeal haematoma and the absence of thrombosis of the basilar artery. [ncbi.nlm.nih.gov]

Fondaparinux was associated with increased risk of catheter thrombosis in PCI. 324 Bivalirudin No benefit in combined outcome was observed when bivalirudin was administered in hospital compared to UFH in patients with non-ST-segment elevation ACS, however [doi.org]

After profound lip numbness, endodontic treatment was performed. Success was defined as the ability to perform endodontic access and instrumentation with no pain or mild pain. [ncbi.nlm.nih.gov]

The use of nitrous oxide/oxygen mixture resulted in a significant reduction in pain when used for photodynamic therapy, botulinum toxin therapy for hyperhidrosis of both the palms and axilla, aesthetic procedures involving various laser procedures, and [ncbi.nlm.nih.gov]

Physical examination was notable for pathologically brisk reflexes in all extremities, generalized flexion contracture of the fingers, decreased sensation in a stocking and glove distribution, and a weakly positive Babinski sign. [ncbi.nlm.nih.gov]

A 17-year-old girl presented to the A&E department with significant neck swelling with associated chest, neck and throat pain. [ncbi.nlm.nih.gov]

When inhaled, nitrous produces a variety of physical effects including: Disorientation (both spatial and time-based) Fixated vision Throbbing or pulsating auditory hallucinations Similarly pulsating visual hallucinations Increased pain threshold Deep [justsayn2o.com]

On very high doses (many repeated inhalations), users often report an “otherworldly” mental state, and may experience visual hallucinations. Be careful! Always remain seated. The greatest risk of using nitrous is injury from falling down. [dancesafe.org]

After a second surgical intervention, the patient became confused. Four months after onset, the patient had paraplegia, severe weakness of the upper limbs, cutaneous anesthesia sparing the head, and confusion. [ncbi.nlm.nih.gov]

Whether other drugs are taken around the same time The following effects may be felt almost immediately and can last for a few minutes: 2,4,5 Euphoria Numbness of the body Sedation Giddiness Uncontrolled laughter Uncoordinated movements Blurred vision Confusion [adf.org.au]

This mental confusion occurs as a result of the nitrous oxide causing Vitamin B12 Malabsorption by depleting the Vitamin B12 stores in the body. [side-effects-site.com]

Not only is this a bit unpleasant but there is a risk of inhaling your own vomit if you are a bit confused or temporarily unconscious. [justsayn2o.com]

Incompatibilities & Reactivities Aluminum, boron, hydrazine, lithium hydride, phosphine, sodium Exposure Routes inhalation, skin and/or eye contact (liquid) Symptoms dyspnea (breathing difficulty); drowsiness, headache; asphyxia; reproductive effects; [cdc.gov]

Headache Saunders et al 16 found no occurrences of headache in a group of 47 patients treated with 50% nitrous oxide or placebo. [doi.org]

Headaches - Although uncommon, a certain subset of people report headaches during the offset of nitrous oxide. [psychonautwiki.org]

Total 1-5 minutes After-effects 15-30 minutes Effects Postive Anxiolytic Euphoria Giggling and laughing Neuroprotection Dream-like state Neutral Analgesia Sound distortion Minor to strong hallucinations & visualizations Negative Neurotoxicity Nausea Headaches [wiki.tripsit.me]

Short-term side effects can include headaches, dizziness and unconsciousness, while long-term, excessive use has been associated with anaemia, incontinence, depleted bone marrow and numbness in fingers and toes. [theweek.co.uk]

A patient who abused nitrous oxide chronically developed ataxia, paresthesia, and urinary retention while self-medicating with cyanocobalamin. [ncbi.nlm.nih.gov]

A case is reported of prolonged and intensive nitrous oxide abuse that resulted in the development of a peripheral neuropathy. [ncbi.nlm.nih.gov]

Later reevaluation revealed a steppage gait and foot drop. Electrodiagnostic studies (ie, electromyography and nerve conduction studies) revealed a severe peripheral polyneuropathy. [ncbi.nlm.nih.gov]

Significant investigation results included a low serum vitamin B12 concentration, mild macrocytosis and raised serum homocysteine concentration. [ncbi.nlm.nih.gov]

In erythroid precursors, macrocytosis and ineffective erythropoiesis occur. Severe neurological impairment, usually subacute combined system degeneration, occurs in cobalamin deficiency. [emedicine.com]

Patient-administered nitrous oxide/oxygen provides safe and effective analgesia for percutaneous liver biopsy: A randomized placebo-controlled trial. Am J Gastroentol 2001 ; 96 : 1553 –7. Saunders BP, Elsby B, Boswell AM, et al. [doi.org]