The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment. Copyright © 2014 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

• Fatigue

  A 14-year-old male patient presented with a nonproductive cough, weight loss, fatigue, and malaise. [ncbi.nlm.nih.gov]

  […] predominance Corresponding ICD-10 Codes C81.0 Hodgkin's disease, lymphocytic predominance Corresponding ICD-10-CM Codes (U.S. only) C81.0 Nodular lymphocyte predominant Hodgkin lymphoma (effective October 01, 2015) Signs and Symptoms Drenching night sweats Fatigue [seer.cancer.gov]

  It is sometimes accompanied by symptoms such as fever, weight loss, fatigue, and night sweats. An obsolete term referring to hodgkin lymphoma. [icd9data.com]

  There may be non-specific symptoms such as fever, fatigue, swollen lymph nodes that are not painful, and unintended weight loss The diagnosis of Nodular Lymphocyte-Predominant Hodgkin Lymphoma may be established through a biopsy of the affected lymph [dovemed.com]

  If your child has Hodgkin lymphoma, the following symptoms may be present: Swollen (but not sore) lymph nodes in the neck, chest, armpit or groin Extreme fatigue Loss of appetite Weight loss Fever Night sweats Itchy skin How is Hodgkin lymphoma treated [stjude.org]

• Parotid Mass

  The patient was found to have a parotid mass, which was diagnosed as NLPHL, and a thymic mass diagnosed as cHL, of nodular sclerosis subtype concurrently. The lesion in the parotid showed features typical of NLPHL by morphology and immunophenotype. [ncbi.nlm.nih.gov]

• Lacrimation

  CT scan of the orbits with and without contrast demonstrated homogenous enhancement of the left lacrimal gland. Examination was notable for left hypoglobus and proptosis. [ncbi.nlm.nih.gov]

• Suggestibility

  By immunohistochemistry, CD8 T-cells from HPS2 NLPHL contained an increased amount of perforin (Prf) + suggesting a defect in the release of this granules-associated protein. [ncbi.nlm.nih.gov]

• Scalp Mass

  In late 2011, he presented to Georgetown University Hospital for evaluation of a new posterior scalp mass. [hematologyandoncology.net]

• Generalized Tonic-Clonic Seizure

  We report a case of Hodgkin lymphoma in a 25-year-old male patient who had been treated with diphenylhydantoin sodium for generalized tonic clonic seizures for 15 years. [ncbi.nlm.nih.gov]

Subsequent workup confirmed stage II A, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) involving the neck. The large atypical cells were positive for CD20, CD45, and CD30. [hematologyandoncology.net]

Biopsy of the mass and a thorough staging workup revealed Stage IA NLPHL. The patient received external beam radiation therapy (EBRT) of 40 Gy in 20 fractions to the mantle field. He was followed annually for 13 years without evidence of disease. [omicsonline.org]

• Anterior Mediastinal Mass

  Case 2 was a 28-year-old woman who underwent surgical resection of an anterior mediastinal mass. The histology and microenvironment of both specimens resembled those of nodular lymphocyte predominant Hodgkin lymphoma. [ncbi.nlm.nih.gov]

Treatment at disease recurrence should be chosen on the basis of various factors, including histology at relapse, time to relapse, extent of disease at relapse, and prior treatment. [ncbi.nlm.nih.gov]

Advanced stage has a poor prognosis. 3-5% of case progress to large B cell lymphoma, although if localised this retains a good prognosis. [e-immunohistochemistry.info]

Transformation from an NLPHL to a T/HRBCL can occur and is associated with a worsening of the prognosis. Here is described a case of a 16-year-old boy who presented with an NLPHL with features of T/HRBCL. [ncbi.nlm.nih.gov]

Treatment and prognosis Prognosis depends on stage as well as several other factors such as age, serological markers (ESR), presence of B symptoms, and histological tumor subtype: nodular lymphocyte predominant: best prognosis lymphocyte depleted: worse [radiopaedia.org]

An extensive diagnostic work up was performed to rule out infectious etiologies. Biopsies of the lymph node and lung tissue were diagnostic of nodular lymphocyte predominant Hodgkin lymphoma. [ncbi.nlm.nih.gov]

Although the association between diphenylhydantoin therapy and the development of immunosuppression and lymphoma is well-documented, the role of the drug in the etiology of these disorders is still controversial. [ijpmonline.org]

[…] interleukins (IL) 4, 6, 8, 10, and 12; and soluble IL-2 receptor (sCD25) have been recorded in patients with HLH in combination with impaired/absent natural killer (NK) cell activity. 3 The aforementioned parameters can aid in distinguishing this syndrome from etiologies [gotoper.com]

(Etiology) The exact cause of Nodular Lymphocyte-Predominant Hodgkin Lymphoma is not known. [dovemed.com]

KEYWORDS: Chemotherapy; Epidemiology; Nodular lymphocyte predominant Hodgkin lymphoma; Outcome; Radiotherapy [ncbi.nlm.nih.gov]

[…] rash or itchy skin Splenomegaly Weight loss (for no known reason) Diagnostic Exams Erythrocyte sedimentation rate Immunophenotyping Progression and Transformation Advanced stages have unfavorable prognosis Disease develops slowly with frequent relapses Epidemiology [seer.cancer.gov]

Hodgkin's paragranuloma Lukes and Butler: Lymphocytic and/or histiocytic (L&H) predominance Hodgkin's disease Kiel group: nodular paragranuloma Rye: Lymphocytic predominance Hodgkin's disease REAL: Nodular lymphocyte predominance Hodgkin's disease Epidemiology [e-immunohistochemistry.info]

"A 20-year population-based study on the epidemiology, clinical features, treatment, and outcome of nodular lymphocyte predominant Hodgkin lymphoma". Ann Hematol. 95 (3): 417–423. doi : 10.1007/s00277-015-2578-6. PMC 4742486. [en.wikipedia.org]

Whether the pathophysiology of phenytoin-induced pseudo-lymphoma is similar remains unknown. [1] It is suggested that periodic examination of patients receiving diphenylhydantoin for lymphadenopathy may be useful in detecting early aberrations of the [ijpmonline.org]

Thus, no indication was found that the tumor cells of the three types of lymphomas show a disease-specific gene expression pattern, which would have supported a distinct pathogenesis and pathophysiology of the tumor cells. [journals.plos.org]

However, rituximab alone is not sufficient to prevent relapses after first- or second-line treatment. [karger.com]

The exact cause of Nodular Lymphocyte-Predominant Hodgkin Lymphoma is unknown, and hence, no guidelines exist for the prevention of this type of cancer. [dovemed.com]

In order to prevent damage to the kideny from radiotherapy and to reduce treatment-related toxicity, the patient was treated only with ABVD adjuvant chemotherapy following a laparoscopic left adrenalectomy. [spandidos-publications.com]

Different MHC I molecules are up-regulated between two- and fivefold in L&H cells (unpublished data), which may prevent the elimination of these cells by NK cells. CD59 (3.6-fold up-regulated) inhibits the formation of the membrane attack complex. [jem.rupress.org]