Nodular Malignant Melanoma

NodularMelanomaEvolution

Skin Tumors-P6251257

Presentation

Moreover, these very few examples present a totally different appearance pattern compared to the one we examined.[ncbi.nlm.nih.gov]
The authors present the case of a patient with a pigmented tumoural lesion on the left shoulder clinically thought to represent nodular malignant melanoma, but whose histopathology revealed a pigmented form of eccrine poroma.[revista.spdv.com.pt]
Melanoma at this site is often thick by the time of presentation and is therefore usually associated with a poor prognosis.[es.slideshare.net]
Nodular melanoma presents as a rapidly enlarging lump (over several weeks to months).[dermnetnz.org]

FISH with c-MYC and centromere eight specific probes revealed that the tumor, in contrast to unaffected skin, was characterized by a gain in copy numbers of the c-MYC gene.[ncbi.nlm.nih.gov]

A light-colored or non-pigmented NM lesion may escape detection because the appearance is not alarming, however an ulcerated and/or bleeding lesion is common.[en.wikipedia.org]
Definition / general Traditional considered most common type of melanoma (50 - 75%) but lentigo maligna may actually be more common in patients with extensive sun exposure ( J Am Acad Dermatol 2008;58:1013 ) Recently diagnosed tumors are thinner with less ulceration[pathologyoutlines.com]
The ulceration was present in 22.3% of cases and prevailed in thick melanomas as well in nodular subtype. Most patients present at stage IA. There was progression to metastatic disease in 20 patients.[ncbi.nlm.nih.gov]
The histopathology analysis disclosed an asymmetric and compound melanocytic lesion, with nodular configuration, exophytic and endophytic, with a thickness of 2.5 mm and epidermal ulceration.[scielo.conicyt.cl]
It is measured vertically in millimetres from the top of the granular layer (or base of superficial ulceration ) to the deepest point of tumour involvement.[dermnetnz.org]

Pigmented MM should be differentiated from conditions like seborrheic keratosis, basal cell carcinoma, dermatofibroma, and thrombosed capillary angioma. Non-melanotic MM may mimic pyogenic granuloma and sarcoma.[scielo.conicyt.cl]

Our study suggests that important cytometric differences exist between Spitz nevi and nodular melanoma, and that these could be exploited to develop cytometry into an adjunctive clinical technique.[ncbi.nlm.nih.gov]
Although the metastasis and arrhythmia might be just coincidence, extensive and selective invasion of the right atrial wall, as well as the association in time of neoplastic dissemination with the appearance of the arrhythmias, suggests a cause-effect[revespcardiol.org]
Exposure to ultraviolet (UV) light from the sun is thought to cause most melanomas, but there's evidence to suggest that some may result from sunbed exposure.[nhs.uk]

Available treatments for select sites include adoptive T cell therapies and dendritic cell vaccines.[doi.org]
The treatment of choice of lentigo maligna is surgical excision if the lesion is small. Radiation therapy is frequently the treatment of choice in the elderly with an extensive lesion.[bccancer.bc.ca]
Treating melanoma The main treatment for melanoma is surgery, although your treatment will depend on your circumstances. If melanoma is diagnosed and treated at an early stage, surgery is usually successful.[nhs.uk]
Surgery is the most effective treatment of MM in early stage, and lymphadenectomy may be needed.[scielo.conicyt.cl]
Further treatment depends mainly on the Breslow thickness of the lesion.[dermnetnz.org]

Nodular malignant melanoma accounts for 20% of melanocytic malignant tumors and is associated with a relatively poor prognosis.[ncbi.nlm.nih.gov]
Since NM tends to grow in depth more quickly than it does in width, and can occur in a place that did not have a previous lesion, the prognosis is often worse because it takes longer for a person to be aware of the changes.[en.wikipedia.org]
Interestingly, the predominant location of MM in men was similar to that often observed in black people, with poorer prognosis and higher mortality rate than among women 7. Figure 1.[scielo.conicyt.cl]
Melanoma at this site is often thick by the time of presentation and is therefore usually associated with a poor prognosis.[es.slideshare.net]
Prognosis also is related to the type of melanoma.[emedicine.medscape.com]

Agents/therapeutic use Kidney Transplantation* Lymphatic Metastasis Male Melanoma/etiology* Melanoma/pathology Melanoma/secondary Melanoma/surgery Neoplasms, Multiple Primary/etiology* Neoplasms, Multiple Primary/pathology Neoplasms, Multiple Primary[ncbi.nlm.nih.gov]
(See Etiology and Workup.)[emedicine.medscape.com]

The cure depends on early diagnosis and understanding melanoma epidemiology is of great importance for the implementation of programs of primary prevention and early detection.[ncbi.nlm.nih.gov]
[…] factors : Extensive sun exposure during childhood, family history of melanoma, large numbers of benign nevi and dysplastic nevi Recommended to evaluate vertical growth phase as prognostic factor for thin ( 0.76 mm) tumors ( Am J Surg Pathol 2003;27:717 ) Epidemiology[pathologyoutlines.com]
Malignant melanoma in solid transplant recipients: collection of database cases and comparison with surveillance, epidemiology, and end results data for outcome analysis. Arch Dermatol . 2011 Jul. 147(7):790-6. [Medline] .[emedicine.medscape.com]

Sex distribution

Age distribution

The cure depends on early diagnosis and understanding melanoma epidemiology is of great importance for the implementation of programs of primary prevention and early detection.[ncbi.nlm.nih.gov]
Preventing melanoma Melanoma isn't always preventable, but you can reduce your chances of developing it by avoiding getting sunburned (even going pink in the sun).[nhs.uk]
Study Calls Into Question Sunscreen in Melanoma Prevention. Medscape Medical News. Available at . November 4, 2016; Accessed: November 9, 2016. US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Ebell M, et al.[emedicine.medscape.com]