All the patients presented with inflammatory subcutaneous nodules. The patients with WCD presented with systemic manifestations and cutaneous atrophy. [pesquisa.bvsalud.org]

On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

Based on Lever's Histopathology of the Skin, Ninth Edition, this full-color atlas presents an algorithmic pattern recognition approach to differential diagnosis of skin diseases. [books.google.de]

[…] characteristics of thirteen patients with Weber-Christian panniculitis. 61 31402393 2019 2 Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report. 61 Somalanka S...Baikunje S 31122958 2019 3 Weber-Christian disease presenting [malacards.org]

It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs. [en.wikipedia.org]

• Fever

  Angioedema/diagnosis, Fever/etiology, Panniculitis, Nodular Nonsuppurative/complications, Panniculitis, Nodular Nonsuppurative/diagnosis, Panniculitis/etiology, Adult, Angioedema/etiology, Diagnosis, Differential, Fatal Outcome, Fever/drug therapy, Glucocorticoids [pesquisa.bvsalud.org]

  Weber-Christian disease — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 14055 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = ped eMedicineTopic = 2429 MeshID = Weber Christian disease is a skin disease characterized by relapsing fever [translate.academic.ru]

  Then all available areas were treated by x-ray, with prompt disappearance of the lesions, disappearance of fever, and a return of blood FULL TEXT [annals.org]

  The fever persists as long as there are nodules present. These nodules may be painless, particularly if small, or tender, especially when large. The overlying skin is red and raised but is not attached to the subcutaneous. .. [nejm.org]

  It is characterized by fever, arthritis, and the sudden onset of a severe cutaneous rash. The rash consists of an asymmetric distribution of bluish-red, tender papules that usually occur on the arms, legs, face or neck. [accessanesthesiology.mhmedical.com]

• Inflammation

  She did not have any condition or disease previously reported to be associated with nodular nonsuppurative inflammation. The nodular panniculitis in this patient appears to be a new complication of small-bowel bypass surgery. [ncbi.nlm.nih.gov]

  Inflammation of subcutaneous fat, form of panniculitis. Erythema nodosum is the most common form of panniculitis (inflammation of the subcutaneous fat). [diki.pl]

  This recurring inflammation in the fat layer of the skin was first described by Victor Pfeiffer, German physician in 1892. Unknown. [accessanesthesiology.mhmedical.com]

  It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs. [en.wikipedia.org]

• Pain

  Erythema Nodosum: Belongs to a group of skin disorders characterized by painful nodules most often affecting the lower extremities. [accessanesthesiology.mhmedical.com]

  In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. [rarediseases.info.nih.gov]

  Pain in forearm M79.631 Pain in right forearm M79.632 Pain in left forearm M79.639 Pain in unspecified forearm M79.64 Pain in hand and fingers M79.641 Pain in right hand M79.642 Pain in left hand M79.643 Pain in unspecified hand M79.644 Pain in right [icd10coded.com]

  […] visceral pain, regional pain, and low back pain. [books.google.es]

  Recurrent episodes of livid, painful, subcutaneous nodules on both lower extremities with consecutive soft tissue atrophy developed in a 57-year-old woman with previously undiagnosed primary biliary cirrhosis (PBC) and Hashimoto's thyroiditis. [ncbi.nlm.nih.gov]

• Malaise

  In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. [rarediseases.info.nih.gov]

  The name is descriptive of the process, which is characterized by recurrent attacks of malaise and fever of varying degrees, associated with subcutaneous nodules (localized inflammation of the panniculus adiposus). [jamanetwork.com]

  Nodular panniculitis is associated with acute systemic symptoms such as fever, general malaise and abdominal pain. [dermnetnz.org]

  It is often associated with recurring episodes of fever, malaise, fatigue, joint pain and the mechanism remains unknown. Ehman F, Harth M, Spouge AR: Christian disease with severe polyarthritis and polyosteitis. J Rheumatol 29(5):1102, 2002. [accessanesthesiology.mhmedical.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

• Fatigue

  It is often associated with recurring episodes of fever, malaise, fatigue, joint pain and the mechanism remains unknown. Ehman F, Harth M, Spouge AR: Christian disease with severe polyarthritis and polyosteitis. J Rheumatol 29(5):1102, 2002. [accessanesthesiology.mhmedical.com]

  Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue. [icd.codes]

  You might also have body-wide symptoms, such as: fatigue fever general sick feeling (malaise) joint and muscle pain abdominal pain nausea and vomiting weight loss bulging of the eye These symptoms can come and go. [healthline.com]

  A 53-year-old male presented with a 2.5-year history of painful subcutaneous nodules on his trunk and limbs, accompanied by fever, night sweats, fatigue and malaise. [pesquisa.bvsalud.org]

  Therefore, the disease is characterized in most of the patients by the development of painful subcutaneous nodules, usually located in limbs and torso; systemic symptoms and signs such as relapsing fever episodes, fatigue and polyarthralgia are also frequent [wjgnet.com]

• Abdominal Pain

  It is usually asymptomatic, but may cause abdominal pain, bloating, distension and diarrhea. [wjgnet.com]

  In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. [rarediseases.info.nih.gov]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  The upper extremities, buttocks, abdominal wall, breasts, and face can also be involved. In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. [orpha.net]

• Nausea

  Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. WCD can present as a severe systemic illness. [orpha.net]

  CASE REPORT We present a 61-year-old patient who presented to an outside hospital with sudden onset of acute abdominal pain, nausea, and vomiting lasting for two days. [pancreas.imedpub.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  You might also have body-wide symptoms, such as: fatigue fever general sick feeling (malaise) joint and muscle pain abdominal pain nausea and vomiting weight loss bulging of the eye These symptoms can come and go. [healthline.com]

  Nausea, vomiting, abdominal pain, weight loss, hepatomegaly, and additional systemic features may also occur. The key pathologic finding on microscopy is a nodular inflammatory pattern of the fat lobules. [emedicine.com]

• Arthralgia

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. [orpha.net]

  Myalgias and arthralgias may also occur. The etiology of Weber-Christian syndrome is unknown. Figure 19–7 Local exposure to cold ... [accesspediatrics.mhmedical.com]

• Myalgia

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  Myalgia, unspecified site M79.11 Myalgia of mastication muscle M79.12 Myalgia of auxiliary muscles, head and neck M79.18 Myalgia, other site M79.2 Neuralgia and neuritis, unspecified M79.3 Panniculitis, unspecified M79.4 Hypertrophy of (infrapatellar [icd10coded.com]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. [orpha.net]

• Back Pain

  […] visceral pain, regional pain, and low back pain. [books.google.es]

• Musculoskeletal Pain

  The fourth section provides in-depth coverage of specific painful conditions—neuropathic pain syndromes, psychological contributions to pain, vascular, cutaneous, and musculoskeletal pains, pain due to cancer, acute pain, pain in special populations, [books.google.es]

• Subcutaneous Nodule

  From Wikidata Jump to navigation Jump to search cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin Relapsing febrile nodular nonsuppurative panniculitis (disorder) Weber - Christian disease [wikidata.org]

  Recurrent episodes of livid, painful, subcutaneous nodules on both lower extremities with consecutive soft tissue atrophy developed in a 57-year-old woman with previously undiagnosed primary biliary cirrhosis (PBC) and Hashimoto's thyroiditis. [ncbi.nlm.nih.gov]

  — A 33 year old white man first noted, early in March 1945, a red, tender, subcutaneous nodule in the left inguinal region. Two weeks later two similar nodules developed on the buttocks. [jamanetwork.com]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber–Christian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin.It is a type of panniculitis. It is a rare disease seen in females 30–60 years of age. [en.wikipedia.org]

• Erythema

  Article En | MEDLINE | ID: mdl-27060919 Crohn Disease/complications, Edema/etiology, Erythema Nodosum/complications, Erythema Nodosum/diagnostic imaging, Panniculitis, Nodular Nonsuppurative/complications, Panniculitis, Nodular Nonsuppurative/diagnostic [pesquisa.bvsalud.org]

  Histologically, erythema nodosum represents the prototype of septal panniculitis. [basicmedicalkey.com]

  Erythema Nodosum Support Group http://health.groups.yahoo.com/group/er ... sum_Group/ The website for the group Is Erythema Nodosum http://www.geocities.com/erythema_nodos ... _Page.html ............ [lymphedemapeople.com]

  Erythema nodosum. Dermatol Clin 2008;26:425-38. 22. Gilchrist H, Patterson JW. Erythema nodosum and erythema induratum (nodular vasculitis): Diagnosis and management. Dermatol Ther 2010;23:320-7. 23. Schwartz RA, Nervi SJ. [ijdpdd.com]

  Granulomatous mastitis, erythema nodosum, and oligoarthritis in a pregnant woman. Breast J 2008;14:588-90. Salesi M, Karimifar M, Salimi F, Mahzouni P. A case of granulomatous mastitis with erythema nodosum and arthritis. [archivesofrheumatology.org]

• Skin Disease

  Caption = DiseasesDB = 14055 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = ped eMedicineTopic = 2429 MeshID = Weber Christian disease is a skin disease characterized by relapsing fever and panniculitis … Wikipedia Weber-Christian disease [translate.academic.ru]

  A dictionary of medical eponyms Related people Frederick Parkes Weber Henry Asbury Christian Victor Pfeifer A skin disease characterized by relapsing fever and panniculitis, and development of crops of painful subcutaneous fatty nodules, resulting in [whonamedit.com]

  Based on Lever's Histopathology of the Skin, Ninth Edition, this full-color atlas presents an algorithmic pattern recognition approach to differential diagnosis of skin diseases. [books.google.de]

  Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Overview Weber-Christian disease is a skin disease characterized by relapsing fever and panniculitis. [wikidoc.org]

• Ulcer

  In some cases, the nodules can ulcerate and leak an oily, yellow discharge. [dermnetnz.org]

  She was evaluated since childhood because recurrent urinary tract infections, amigdalytis and oral aphtoid ulcers. [wjgnet.com]

  Today, the more frequent associations include streptococcal infections, sarcoidosis, ulcerative colitis and Crohn’s disease, Sweet’s syndrome, Behçet’s disease, menstruation, pregnancy, estrogens and the oral contraceptive, cat scratch disease and various [basicmedicalkey.com]

  The most important conditions that are heralded or attended by erythema nodosum are such infections as streptococcal upper-respiratory infections, ulcerative colitis, histoplasmosis, coccidioidomycosis, tuberculosis, syphilis, and leprosy. [accesspediatrics.mhmedical.com]

• Eruptions

  Caused by Protozoa 204 Zoonoses 211 RatBite Fever 216 Dermatomycoses 219 Diagnosis of Mycoses 222 Onychomycosis 236 Systemic Mycoses 244 Epizoonoses 248 Cimicosis 251 Ticks 260 Diseases Caused by Worms 262 Annelida Ringlet or Bristle Worms 270 Drug Eruptions [books.google.com]

  A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. [connects.catalyst.harvard.edu]

  Beschreibung: A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. [hon.ch]

• Suggestibility

  […] histology and immunopathology recognised to be clearly definable and separate entities comprising: lupus panniculitis cytophagic histiocytic panniculitis α 1 -antitrypsin deficiency factitial panniculitis traumatic panniculitis calciphylaxis Most authors suggest [radiopaedia.org]

  The rosette-like pattern, the primary degenerative alteration of the fat cells and the progression of the lesion all suggest insufficient blood supply. Inflammation is secondary and appears only occasionally. [link.springer.com]

  The kidney biopsy also suggested parenchymal involvement by W-CD disease, with supportive ultrastructural findings. [pesquisa.bvsalud.org]

  Many etiological factors including local irritation, oral contraceptive use, viruses, parasites, mycotic diseases, hyperprolactinemia, diabetes mellitus, smoking, alpha-1 antitrypsin deficiency, and autoimmunity have been suggested in pathogenesis of [archivesofrheumatology.org]

  Rather, the sonography report suggested inflammatory lesions. This result suggested the breast lesion was inflammation. [spandidos-publications.com]

Other effective treatments for WCD may be described in the future. [pesquisa.bvsalud.org]

All cultures were sterile, however a 15-d meropenem treatment was performed. [wjgnet.com]

1 Analysis of the clinical characteristics of thirteen patients with Weber-Christian panniculitis. 61 31402393 2019 2 Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report. 61 Somalanka S...Baikunje S 31122958 [malacards.org]

Our patient improved rapidly following cyclosporine A and corticosteroid treatment. [bmcmusculoskeletdisord.biomedcentral.com]

Treatment of this condition during the second trimester of pregnancy can be challenging. [e-ijd.org]

The disease course varies, and prognosis depends on which organs are affected, the severity of organ involvement, and the response to therapy. [emedicine.medscape.com]

So, early diagnosis and treatment are very important for the prognosis of breast panniculitis. [spandidos-publications.com]

The prognosis depends upon the severity of the renal disease http://www.geocities.com/SoHo/Gallery/6 ... ulitis.htm ............ [lymphedemapeople.com]

The etiology and pathogenesis of nodular nonsuppurative panniculitis is still unknown. Frequently, the disease occurs in patients with autoimmune disorders. [ncbi.nlm.nih.gov]

Etiology unknown. Pfeiffer in 1892 first described multiple areas of atrophy in subcutaneous fatty tissue; Weber in 1925 called it "relapsing, non-suppurative panniculitis." Christian in 1928 pointed out its febrile character. Bibliography V. [whonamedit.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Abstract Relapsing febrile nodular non-suppurative panniculitis is an uncommon disease of unknown etiology. In a review article Beerman 1 found 83 reported cases. [annals.org]

Summary Epidemiology Nodular non-suppurative panniculitis, known as Weber-Christian disease (WCD) prevalence is unknown. It occurs more often in adult women (approximately 75% of reported cases). [orpha.net]

SNPs for PPIA No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene - elite association - COSMIC cancer census association via MalaCards Relevant External Links for PPIA Genetic Association Database (GAD) PPIA Human Genome Epidemiology [genecards.org]

Because the etiology is unknown, Weber-Christian disease is often referred to as idiopathic lobular panniculitis. [7, 8] Epidemiology Frequency United States Ambiguity surrounding Weber-Christian disease versus other closely related conditions makes it [emedicine.com]

Pathophysiology Weber-Christian disease is a classic skin condition that features recurring inflammation in the subcutaneous fat layer of the skin. [emedicine.com]

The exact pathophysiology is becoming clear but not entirely understood. [pancreas.imedpub.com]

No review of the literature is here included, as this has been done recently. 2, 3 Our case is reported because it showed that, although cortisone apparently caused the disappearance of fever, it did not prevent the appearance of new lesions. [annals.org]

FNP-BC is a member of the following medical societies: American Association of Nurse Practitioners, American College Health Association, American Nurses Association, American Professional Society on the Abuse of Children, International Society for the Prevention [emedicine.com]

The authors successfully treated him with an antiproliferative agent, mycophenolate mofetil, which resulted in preventing him from having further episodes. [pesquisa.bvsalud.org]