All the patients presented with inflammatory subcutaneous nodules. The patients with WCD presented with systemic manifestations and cutaneous atrophy. [pesquisa.bvsalud.org]

It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs. [en.wikipedia.org]

On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

Based on Lever's Histopathology of the Skin, Ninth Edition, this full-color atlas presents an algorithmic pattern recognition approach to differential diagnosis of skin diseases. [books.google.de]

• Fever

  Angioedema/diagnosis, Fever/etiology, Panniculitis, Nodular Nonsuppurative/complications, Panniculitis, Nodular Nonsuppurative/diagnosis, Panniculitis/etiology, Adult, Angioedema/etiology, Diagnosis, Differential, Fatal Outcome, Fever/drug therapy, Glucocorticoids [pesquisa.bvsalud.org]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  The fever persists as long as there are nodules present. These nodules may be painless, particularly if small, or tender, especially when large. The overlying skin is red and raised but is not attached to the subcutaneous. .. [nejm.org]

  No history of skin nodules or unknown origin fever was suffered during childhood or youth. [wjgnet.com]

  Then all available areas were treated by x-ray, with prompt disappearance of the lesions, disappearance of fever, and a return of blood FULL TEXT [annals.org]

• Malaise

  In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. [rarediseases.info.nih.gov]

  The name is descriptive of the process, which is characterized by recurrent attacks of malaise and fever of varying degrees, associated with subcutaneous nodules (localized inflammation of the panniculus adiposus). [jamanetwork.com]

  Nodular panniculitis is associated with acute systemic symptoms such as fever, general malaise and abdominal pain. [dermnetnz.org]

  It is often associated with recurring episodes of fever, malaise, fatigue, joint pain and the mechanism remains unknown. Ehman F, Harth M, Spouge AR: Christian disease with severe polyarthritis and polyosteitis. J Rheumatol 29(5):1102, 2002. [accessanesthesiology.mhmedical.com]

• Fatigue

  It is often associated with recurring episodes of fever, malaise, fatigue, joint pain and the mechanism remains unknown. Ehman F, Harth M, Spouge AR: Christian disease with severe polyarthritis and polyosteitis. J Rheumatol 29(5):1102, 2002. [accessanesthesiology.mhmedical.com]

  Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue. [icd.codes]

  You might also have body-wide symptoms, such as: fatigue fever general sick feeling (malaise) joint and muscle pain abdominal pain nausea and vomiting weight loss bulging of the eye These symptoms can come and go. [healthline.com]

  Therefore, the disease is characterized in most of the patients by the development of painful subcutaneous nodules, usually located in limbs and torso; systemic symptoms and signs such as relapsing fever episodes, fatigue and polyarthralgia are also frequent [wjgnet.com]

  A 53-year-old male presented with a 2.5-year history of painful subcutaneous nodules on his trunk and limbs, accompanied by fever, night sweats, fatigue and malaise. [pesquisa.bvsalud.org]

• Abdominal Pain

  In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later. [rarediseases.info.nih.gov]

  It is usually asymptomatic, but may cause abdominal pain, bloating, distension and diarrhea. [wjgnet.com]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  The upper extremities, buttocks, abdominal wall, breasts, and face can also be involved. In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. [orpha.net]

• Nausea

  Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. WCD can present as a severe systemic illness. [orpha.net]

  CASE REPORT We present a 61-year-old patient who presented to an outside hospital with sudden onset of acute abdominal pain, nausea, and vomiting lasting for two days. [pancreas.imedpub.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  You might also have body-wide symptoms, such as: fatigue fever general sick feeling (malaise) joint and muscle pain abdominal pain nausea and vomiting weight loss bulging of the eye These symptoms can come and go. [healthline.com]

  Nausea, vomiting, abdominal pain, weight loss, hepatomegaly, and additional systemic features may also occur. The key pathologic finding on microscopy is a nodular inflammatory pattern of the fat lobules. [emedicine.com]

• Enophthalmos

  Of these, four presented initially with proptosis, representing early stages of inflammation, and two subsequently developed enophthalmos, representing late, inactive stage of the disease. [pesquisa.bvsalud.org]

• Arthralgia

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. [orpha.net]

  Myalgias and arthralgias may also occur. The etiology of Weber-Christian syndrome is unknown. Figure 19–7 Local exposure to cold ... [accesspediatrics.mhmedical.com]

• Myalgia

  Weber-Christian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain. [accessanesthesiology.mhmedical.com]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Myalgia, unspecified site M79.11 Myalgia of mastication muscle M79.12 Myalgia of auxiliary muscles, head and neck M79.18 Myalgia, other site M79.2 Neuralgia and neuritis, unspecified M79.3 Panniculitis, unspecified M79.4 Hypertrophy of (infrapatellar [icd10coded.com]

  The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38°C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present. [e-ijd.org]

  In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months. [orpha.net]

• Subcutaneous Nodule

  From Wikidata Jump to navigation Jump to search cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin Relapsing febrile nodular nonsuppurative panniculitis (disorder) Weber - Christian disease [wikidata.org]

  Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis. [medical-dictionary.thefreedictionary.com]

  Weber–Christian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin.It is a type of panniculitis. It is a rare disease seen in females 30–60 years of age. [en.wikipedia.org]

  Recurrent episodes of livid, painful, subcutaneous nodules on both lower extremities with consecutive soft tissue atrophy developed in a 57-year-old woman with previously undiagnosed primary biliary cirrhosis (PBC) and Hashimoto's thyroiditis. [ncbi.nlm.nih.gov]

  — A 33 year old white man first noted, early in March 1945, a red, tender, subcutaneous nodule in the left inguinal region. Two weeks later two similar nodules developed on the buttocks. [jamanetwork.com]

• Subcutaneous Mass

  Subcutaneous fat necrosis in panniculitis may present as a complex mass with mural nodules, an isoechoic mass, a hypoechoic solid mass, or an anechoic cystic mass with posterior acoustic enhancement or shadowing (Fernando et al. 2003 ; Cho and Park 2013 [springerplus.springeropen.com]

• Left Pleural Effusion

  Chest computed tomography showed left pleural effusion and mediastinitis. He developed painful red subcutaneous nodules in his bilateral lower extremities. [pesquisa.bvsalud.org]

• Multiple Pulmonary Nodules

  Agents/therapeutic use, Male, Middle Aged, Multiple Pulmonary Nodules/diagnosis, Multiple Pulmonary Nodules/etiology, Panniculitis, Nodular Nonsuppurative/complications, Panniculitis, Nodular Nonsuppurative/diagnosis, Positron Emission Tomography Computed [pesquisa.bvsalud.org]

All cultures were sterile, however a 15-d meropenem treatment was performed. [wjgnet.com]

Our patient improved rapidly following cyclosporine A and corticosteroid treatment. [bmcmusculoskeletdisord.biomedcentral.com]

Other effective treatments for WCD may be described in the future. [pesquisa.bvsalud.org]

1 Analysis of the clinical characteristics of thirteen patients with Weber-Christian panniculitis. 61 31402393 2019 2 Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report. 61 Somalanka S...Baikunje S 31122958 [malacards.org]

Treatment of this condition during the second trimester of pregnancy can be challenging. [e-ijd.org]

The disease course varies, and prognosis depends on which organs are affected, the severity of organ involvement, and the response to therapy. [emedicine.medscape.com]

So, early diagnosis and treatment are very important for the prognosis of breast panniculitis. [spandidos-publications.com]

The prognosis depends upon the severity of the renal disease http://www.geocities.com/SoHo/Gallery/6 ... ulitis.htm ............ [lymphedemapeople.com]

The etiology and pathogenesis of nodular nonsuppurative panniculitis is still unknown. Frequently, the disease occurs in patients with autoimmune disorders. [ncbi.nlm.nih.gov]

Weber-Christian disease or Pfeifer-Weber-Christian disease or idiopathic relapsing febrile nodular non-suppurative panniculitis was initially defined as a rare inflammatory disorder of unknown etiology affecting subcutaneous adipose tissue inter alia [radiopaedia.org]

Etiology unknown. Pfeiffer in 1892 first described multiple areas of atrophy in subcutaneous fatty tissue; Weber in 1925 called it "relapsing, non-suppurative panniculitis." Christian in 1928 pointed out its febrile character. Bibliography V. [whonamedit.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Summary Epidemiology Nodular non-suppurative panniculitis, known as Weber-Christian disease (WCD) prevalence is unknown. It occurs more often in adult women (approximately 75% of reported cases). [orpha.net]

SNPs for PPIA No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene - elite association - COSMIC cancer census association via MalaCards Relevant External Links for PPIA Genetic Association Database (GAD) PPIA Human Genome Epidemiology [genecards.org]

Because the etiology is unknown, Weber-Christian disease is often referred to as idiopathic lobular panniculitis. [7, 8] Epidemiology Frequency United States Ambiguity surrounding Weber-Christian disease versus other closely related conditions makes it [emedicine.com]

Pathophysiology Weber-Christian disease is a classic skin condition that features recurring inflammation in the subcutaneous fat layer of the skin. [emedicine.com]

The exact pathophysiology is becoming clear but not entirely understood. [pancreas.imedpub.com]

No review of the literature is here included, as this has been done recently. 2, 3 Our case is reported because it showed that, although cortisone apparently caused the disappearance of fever, it did not prevent the appearance of new lesions. [annals.org]

FNP-BC is a member of the following medical societies: American Association of Nurse Practitioners, American College Health Association, American Nurses Association, American Professional Society on the Abuse of Children, International Society for the Prevention [emedicine.com]

The authors successfully treated him with an antiproliferative agent, mycophenolate mofetil, which resulted in preventing him from having further episodes. [pesquisa.bvsalud.org]