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Nodular Nonsuppurative Panniculitis

Weber-Christian disease


Presentation

  • It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs.[en.wikipedia.org]
  • On presentation, patient's temperature was just above 38 C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present.[e-ijd.org]
  • Parkes Weber, and subsequently read his report in the British Journal of Dermatology and Syphilis. 1 The name he used intrigued me; now, with a title for my report, it seemed appropriate to present my observations before the Association of American Physicians[doi.org]
  • It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person. Disclaimer: Whonamedit? does not give medical advice.[whonamedit.com]
Fever
  • The fever persists as long as there are nodules present. These nodules may be painless, particularly if small, or tender, especially when large. The overlying skin is red and raised but is not attached to the subcutaneous . . .[nejm.org]
  • Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis.[medical-dictionary.thefreedictionary.com]
  • - A dictionary of medical eponyms Related people Frederick Parkes Weber Henry Asbury Christian Victor Pfeifer A skin disease characterized by relapsing fever and panniculitis, and development of crops of painful subcutaneous fatty nodules, resulting in[whonamedit.com]
  • Abstract DEFINITION Relapsing, febrile, nodular, nonsuppurative panniculitis is a title that defines a disease, which is characterized by recurrent episodes of fever ranging as high as 104 F., and by the formation of single to multiple crops of tender[insights.ovid.com]
Malaise
  • In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later.[rarediseases.info.nih.gov]
  • The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38 C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present.[e-ijd.org]
  • Malaise, fever, and arthralgias often occur. Nausea, vomiting, abdominal pain, weight loss, hepatomegaly, and additional systemic features may also occur. The key pathologic finding on microscopy is a nodular inflammatory pattern of the fat lobules.[emedicine.com]
  • Nodular panniculitis is associated with acute systemic symptoms such as fever, general malaise and abdominal pain.[dermnetnz.org]
  • In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months.[orpha.net]
Recurrent Pleural Effusion
  • K...Payer J 2018 3 Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease. ( 28352826 ) Laperuta P...Di Crescenzo VG 2016 4 Ocular Inflammation: Can It Be a Sign of Activity of Weber-Christian Disease[malacards.org]
  • 1 Weber-Christian disease presenting with lung nodules dramatically improved with corticosteroid therapy: one case report and literature review. ( 26224252 ) 2018 2 Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian[malacards.org]
Abdominal Pain
  • In most people, this condition is associated with fever, a general feeling of ill health ( malaise ), muscle pain, and/or abdominal pain. These symptoms may subside after a few days or weeks and may recur weeks, months, or years later.[rarediseases.info.nih.gov]
  • Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis.[medical-dictionary.thefreedictionary.com]
  • In most cases, it is associated with fever, malaise, myalgia, arthralgia and abdominal pain. [1] On histological examination, fat lobules are replaced by neutrophils, lymphocytes, and histiocytes in the early stages and by macrophages and fibrotic tissue[e-ijd.org]
  • Nausea, vomiting, abdominal pain, weight loss, hepatomegaly, and additional systemic features may also occur. The key pathologic finding on microscopy is a nodular inflammatory pattern of the fat lobules.[emedicine.com]
  • In most cases WCD is associated with fever, malaise, myalgia, arthralgia, and abdominal pain. Nausea, vomiting, weight loss, and hepatomegaly may occur. The disease tends to recur at intervals of weeks or months.[orpha.net]
Hairy Tongue
  • Tongue 808 Anginas 818 686 822 Diseases of the Glans Penis and the Prepuce 823 Diseases of the Glans Penis and the Prepuce 826 Balanitis and Balanoposthitis 827[books.google.com]
Angioedema
  • […] with weber-christian disease. ( 25391077 ) Saleh M...Speeg-Schatz C 2009 13 Weber and Christian of Weber-Christian disease. ( 18401882 ) Haubrich WS 2008 14 Weber-Christian disease presenting with intractable fever and periorbital swelling mimicking angioedema[malacards.org]
  • […] with weber-christian disease. ( 25391077 ) Saleh M...Speeg-Schatz C 2009 12 Weber and Christian of Weber-Christian disease. ( 18401882 ) Haubrich WS 2008 13 Weber-Christian disease presenting with intractable fever and periorbital swelling mimicking angioedema[malacards.org]
Myalgia
  • Clinical findings Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis.[medical-dictionary.thefreedictionary.com]
  • The patient further complained of malaise, nausea, bone pain, myalgia, and arthralgia. On presentation, patient's temperature was just above 38 C. Palpable left axillary lymphadenopathy was noted. No hepatomegaly or splenomegaly was present.[e-ijd.org]
  • Weber-Christian disease. ( 8168588 ) Leibovici V...Lax E 1994 42 Cultivation of Borrelia burgdorferi from the blood and a subcutaneous lesion of a patient with relapsing febrile nodular nonsuppurative panniculitis. ( 1538171 ) Viljanen M.K....Kalimo H. 1992 43 Myalgia[malacards.org]
  • Weber-Christian disease. ( 8439847 ) Ishida T...Mitomo M 1993 44 Cultivation of Borrelia burgdorferi from the blood and a subcutaneous lesion of a patient with relapsing febrile nodular nonsuppurative panniculitis. ( 1538171 ) Viljanen M.K....Kalimo H. 1992 45 Myalgia[malacards.org]
  • Myalgia, unspecified site M79.11 Myalgia of mastication muscle M79.12 Myalgia of auxiliary muscles, head and neck M79.18 Myalgia, other site M79.2 Neuralgia and neuritis, unspecified M79.3 Panniculitis, unspecified M79.4 Hypertrophy of (infrapatellar[icd10coded.com]
Neglect
  • […] following medical societies: American Association of Nurse Practitioners, American College Health Association, American Nurses Association, American Professional Society on the Abuse of Children, International Society for the Prevention of Child Abuse and Neglect[emedicine.com]
  • […] medical societies: American Association of Nurse Practitioners , American College Health Association , American Nurses Association , American Professional Society on the Abuse of Children , International Society for the Prevention of Child Abuse and Neglect[emedicine.medscape.com]

Treatment

  • Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout.[books.google.de]
  • Make informed clinical choices for each patient , from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout.[books.google.ro]
  • Treatment of this condition during the second trimester of pregnancy can be challenging.[e-ijd.org]
  • An unusual occurrence in a 12-year-old child. ( 2361793 ) Sharma BK...Mathur RP 1990 48 Weber-Christian disease producing splenic vein occlusion and bleeding gastric varices: successful treatment with sclerotherapy. ( 2385562 ) Heseltine D...Castle W[malacards.org]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.de]

Prognosis

  • The disease course varies, and prognosis depends on which organs are affected, the severity of organ involvement, and the response to therapy.[emedicine.com]
  • The prognosis of nodular panniculitis is good in patients with only cutaneous involvement. There are frequent remissions and exacerbations of the lesions.[lymphedemapeople.com]

Etiology

  • The etiology and pathogenesis of nodular nonsuppurative panniculitis is still unknown. Frequently, the disease occurs in patients with autoimmune disorders.[ncbi.nlm.nih.gov]
  • Etiology unknown. Pfeiffer in 1892 first described multiple areas of atrophy in subcutaneous fatty tissue; Weber in 1925 called it "relapsing, non-suppurative panniculitis." Christian in 1928 pointed out its febrile character. Bibliography V.[whonamedit.com]
  • Weber-Christian disease or Pfeifer-Weber-Christian disease or idiopathic relapsing febrile nodular non-suppurative panniculitis was initially defined as a rare inflammatory disorder of unknown etiology affecting subcutaneous adipose tissue inter alia[radiopaedia.org]
  • CHRONIC relapsing febrile nodular nonsuppurative panniculitis is a disease of unknown etiology characterized by recurrent fever associated with a nodular nonsuppurative inflammatory process with necrosis of the subcutaneous and sometimes internal fatty[nejm.org]
  • Export Citation: APA/MLA Format Download EndNote Download BibTex MeSH Terms Descriptor/Qualifier: Adipose Tissue / pathology Adult Blood Vessels / pathology Brain / pathology Digestive System / pathology Disseminated Intravascular Coagulation / etiology[biomedsearch.com]

Epidemiology

  • Because the etiology is unknown, Weber-Christian disease is often referred to as idiopathic lobular panniculitis. [7, 8] Epidemiology Frequency United States Ambiguity surrounding Weber-Christian disease versus other closely related conditions makes it[emedicine.com]
  • Summary Epidemiology Nodular non-suppurative panniculitis, known as Weber-Christian disease (WCD) prevalence is unknown. It occurs more often in adult women (approximately 75% of reported cases).[orpha.net]
  • SNPs for PPIA No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene - elite association - COSMIC cancer census association via MalaCards Relevant External Links for PPIA Genetic Association Database (GAD) PPIA Human Genome Epidemiology[genecards.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Weber-Christian disease is a classic skin condition that features recurring inflammation in the subcutaneous fat layer of the skin.[emedicine.com]

Prevention

  • FNP-BC is a member of the following medical societies: American Association of Nurse Practitioners, American College Health Association, American Nurses Association, American Professional Society on the Abuse of Children, International Society for the Prevention[emedicine.com]
  • […] is a member of the following medical societies: American Association of Nurse Practitioners , American College Health Association , American Nurses Association , American Professional Society on the Abuse of Children , International Society for the Prevention[emedicine.medscape.com]
  • Author: Geromanta Baleviciene, MD, Head, Professor, Department of Dermatology, Vilnius University, Medical Faculty, Lithuania Coauthor(s): Robert A Schwartz, MD, MPH, Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive[lymphedemapeople.com]

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