NAFLD is now present in 17% to 33% of Americans, has a worldwide distribution, and parallels the frequency of central adiposity, obesity, insulin resistance, metabolic syndrome and type 2 diabetes. NASH could be present in one third of NAFLD cases. [ncbi.nlm.nih.gov]

Data are presented as means and 95% CI. [doi.org]

• Fatigue

  Due to progressive fatigue, he underwent an orthotopic liver transplantation complicated by a 36-kg weight gain. Sixteen months posttransplantation, a liver biopsy revealed the recurrence of NASH. [ncbi.nlm.nih.gov]

  However, some have fatigue, malaise, or right upper quadrant abdominal discomfort. Hepatomegaly develops in about 75% of patients. [merckmanuals.com]

  Diabet Med 25, 221 – 227. 91 Newton, JL, Jones, DE, Henderson, E, et al. ( 2008 ) Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or [doi.org]

• Hematemesis

  A 67-year-old woman was admitted with hematemesis due to the rupture of esophageal varices. Her varices were treated by endoscopic ligation and endoscopic sclerotherapy. Her medical history was unremarkable. [ncbi.nlm.nih.gov]

• Impulsivity

  Francisca Velázquez-Marín, Pilar Sainz de Baranda, Florentina Guzmán-Aroca, Carmen Fernández-Hernández, Ernesto Doménech-Abellán, Dolores Abellán-Rivero, Guadalupe Ruiz-Merino, Juan Madrid-Conesa and Manuel Canteras-Jordana, Acoustic radiation force impulse [doi.org]

  The EASL suggest using fibrosis tests such as elastometry, acoustic radiation force impulse imaging and serum biomarkers in order to reduce the number of biopsies. [en.wikipedia.org]

• Insomnia

  Saiyu Tanaka, Kento Imajo, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Kazuyuki Kanemasa, Kazuaki Chayama, Yoshito Itoh, Toshikazu Yoshikawa, Toshiji Saibara, Kazuma Fujimoto and Atsushi Nakajima, The association of insomnia [doi.org]

This delay in diagnosis is illustrated in our case of a 53-year-old man who presented with hepatic hydrothorax and ascites, whose workup revealed cirrhosis due to NAFLD. [dx.doi.org]

Patients with high serum titers of autoantibodies and other features suggesting autoimmune liver disease (eg, very high aminotransferases or high globulin levels) should undergo a more thorough workup for autoimmune liver disease. [emedicine.com]

Thomas Jensen, Amanda Wieland, Melanie Cree-Green, Kristen Nadeau and Shelby Sullivan, Clinical workup of fatty liver for the primary care provider, Postgraduate Medicine, 10.1080/00325481.2019.1546532, (1-12), (2018). [doi.org]

Due to the lack of effective pharmacological treatments available for NAFLD, lifestyle modifications such as following a healthy diet, vigorous physical activity, and weight reduction remain the first line of treatment for NAFLD. [ncbi.nlm.nih.gov]

Lifestyle modification is the foundation of treatment for patients with nonalcoholic steatosis. [doi.org]

We identified 34 studies comprising 368,569 unique patients that characterized disparities in NAFLD prevalence, severity, or prognosis. [ncbi.nlm.nih.gov]

Expert commentary : This meta-analysis indicated that for NAFLD patients, obesity (according to ethnic-specific BMI cut-off points to define obesity) could predict a worse long-term prognosis. [doi.org]

While NAFLD is believed to be associated with metabolic risk factors such as obesity, diabetes, and dyslipidemia, its etiology remains largely unknown and the development or co-existence of NAFLD in patients with insulinoma has not been investigated. [ncbi.nlm.nih.gov]

As a result, specialty societies, including the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver, have developed guidance on the epidemiology, diagnosis, and treatment of NAFLD and NASH [ncbi.nlm.nih.gov]

This article will explore and evaluate our current understanding of NAFLD in childhood and adolescence and how it differs from adult NAFLD, in terms of its epidemiology, pathophysiology, natural history, diagnosis and clinical management. [ncbi.nlm.nih.gov]

A planned complete nutritional combination addressing specific needs and helping to prevent the progression of NAFLD is the need of the hour to avert people from ending up with complications. [ncbi.nlm.nih.gov]