Presentation
Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. [books.google.com]
In mild cases, the clinical presentation may consist of subtle tubular function abnormalities, such as Fanconi syndrome (ie, aminoaciduria, glycosuria, renal tubular acidosis). Patients may present with rash and hematuria. [emedicine.medscape.com]
Abstract Acute interstitial nephritis due to drugs commonly presents as acute renal failure and may be commoner than is presently realized. [annals.org]
Presentation on theme: "Tubulointerstitial nephritis Lívia Jánoskuti. Definition Kidney diseases that involve structures in the kidney outside the glomerulus Tubules and/ or. [slideplayer.com]
Urogenital
- Renal Injury
Hyperemesis Acute Renal Failure Cardiorenal syndrome Carfilzomib-Indiced Renal Injury CFHR5 nephropathy Charcot–Marie–Tooth Disease with Glomerulopathy Chinese Herbal Medicines and Nephrotoxicity Cherry Concentrate and Acute Kidney Injury Cholesterol [kidney.nyc]
[…] last authored: Jan 2012, David LaPierre last reviewed: Introduction Acute renal injury, or acute renal failure, is the abrupt drop in glomerular filtration rate (GFR) sufficient to lead to retention of creatinine, urea, and other wastes, and the perturbation [sharinginhealth.ca]
Abscess Renal Agenesis Renal Arcuate Vein Microthrombi-Associated Acute Kidney Injury Renal Artery Aneurysm Renal Artery Stenosis Renal Cell Cancer Renal Cyst Renal Hypouricemia with Exercise-induced Acute Renal Failure Renal Infarction Renal Osteodystrophy [thekaiganfoundation.com]
injury are other renal complications of these drugs. [1], [7], [8], [10] First-generation NSAIDs are non-specific inhibitors of both COX-1 and COX-2 forms of cyclo-oxygenase enzyme. [3] New-generation NSAIDs are supposed to have fewer side-effects due [sjkdt.org]
This lesion is associated with three different processes: direct toxic injury, ischemic injury from renal hypoperfusion and pigmenturia. Direct toxicity accounts for approximately 35% of all cases of acute tubular necrosis." [haz-map.com]
- Incontinence
Tubular Dysgenesis Immune Complex Tubulointerstitial Nephritis Due to Autoantibodies to the Proximal Tubule Brush Border Tumor Lysis Syndrome Uremia Uremic Optic Neuropathy Ureteritis Cystica Ureterocele Urethral Caruncle Urethral Stricture Urinary Incontinence [thekaiganfoundation.com]
The lesion involving the sphincteric center of the bladder; the paralytic incontinence; the imperfect vesical innervation and paresis of the walls from over distention; the spasmodic incontinence due to over action of the compressor muscle of the bladder [meridianinstitute.com]
Workup
Intravenous pyelography: Once widely used, this technique seldom plays a role in the workup of kidney diseases Quantitative determination of urine protein in modern medicine. [slideshare.net]
In retrospect, after careful investigation including the ethylenediaminetetraacetic acid (EDTA) lead mobilization test (see Workup), many patients presumed to have either gouty nephropathy or hypertensive nephrosclerosis are discovered to have lead nephropathy [emedicine.medscape.com]
Hemolytic-uremic syndrome IgA nephropathy The following 4 renal syndromes commonly mimic the early stage of acute glomerulonephritis: Anaphylactoid purpura with nephritis Chronic glomerulonephritis with an acute exacerbation Idiopathic hematuria Familial nephritis Workup [sites.google.com]
An allergy workup is normally recommended 1 to 6 months after the reaction. It may comprise skin tests and in vitro tests. The sensitivity of these tests is probably low, but the specificity is good – which makes a positive result valuable. [waojournal.biomedcentral.com]
Serum
- Hyponatremia
Hypercalcemia Hyperkalemia Hypermagnesemia Hypernatremia Hyperoxaluria Hyperphosphatemia Hypocalcemia Hypocomplementemic Urticarial Vasculitic Syndrome Hypokalemia, Hypokalemia-induced renal dysfunction Hypokalemic Periodic Paralysis Hypomagnesemia Hyponatremia [kidney.nyc]
Kidney (Renal Fusion) Hunner's Ulcer Hyperaldosteronism Hypercalcemia Hyperkalemia Hypermagnesemia Hypernatremia Hyperoxaluria Hyperphosphatemia Hypocalcemia Hypokalemia, Hypokalemia-induced renal dysfunction Hypokalemic Periodic Paralysis Hypomagnesemia Hyponatremia [thekaiganfoundation.com]
[…] hematocrit decreased, thrombocytopenic purpura, disseminated intravascular coagulation, neutropenia, autoimmune hemolytic anemia, eosinophilia, platelet aggregation inhibition [ Ref ] Metabolic Rare (less than 0.1%): Hyperglycemia Frequency not reported : Hyponatremia [drugs.com]
- Hypermagnesemia
Kidney Disease High Blood Pressure and Kidney Disease HIV-Associated Nephropathy (HIVAN) HNF1B-related Autosomal Dominant Tubulointerstitial Kidney Disease Horseshoe Kidney (Renal Fusion) Hunner's Ulcer Hyperaldosteronism Hypercalcemia Hyperkalemia Hypermagnesemia [thekaiganfoundation.com]
Nephropathy (HIVAN) HNF1B-related Autosomal Dominant Tubulointerstitial Kidney Disease Horseshoe Kidney (Renal Fusion) Hunner's Ulcer Hydrophilic Polymer Emboli Hydroxychloroquine-induced Renal Phospholipidosis Hyperaldosteronism Hypercalcemia Hyperkalemia Hypermagnesemia [kidney.nyc]
- Abnormal Renal Function
Common (1% to 10%): Abnormal renal function Frequency not reported : Interstitial nephritis, renal failure, allergic/non-allergic glomerulonephritis, nephrotic syndrome, non-oliguric renal failure, renal papillary necrosis, tubulointerstitial nephritis [drugs.com]
- Creatinine Increased
*A threefold increase in serum creatinine or a serum creatinine level ≥ 4.0mg/dL with an acute rise > 0.5 mg/dL indicates renal failure. †Likewise, anuria for 12 hours indicates renal failure. Figure 1. [jaoa.org]
- Creatinine Increased
*A threefold increase in serum creatinine or a serum creatinine level ≥ 4.0mg/dL with an acute rise > 0.5 mg/dL indicates renal failure. †Likewise, anuria for 12 hours indicates renal failure. Figure 1. [jaoa.org]
Treatment
Apply the latest best practices through new and updated treatment algorithms. Find therapeutic drug information more easily with guidance incorporated into each chapter. [books.google.com]
Quick treatment often leads to a full recovery. Sometimes interstitial nephritis causes permanent damage to the kidneys before you can be diagnosed. This damage requires treatment as well. [healthline.com]
Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest 1991;99(6):1330-1335. 4. Sontag SJ, Hirschowitz BI, Holt S, et al. [hon.ch]
This comprehensive textbook provides a broad reveiw of kidney diseases with regards to symptoms, investigation and treatment. [books.google.de]
Prognosis
Prognosis depends on the underlying disease and the overall health of the patient. Occurrence of cardiopulmonary or neurologic complications worsens the prognosis. [sites.google.com]
The PROGNOSIS is, on the whole, good, still bearing in mind the necessity of guarded prognosis in all renal diseases as above indicated. [meridianinstitute.com]
The prognosis and pathogenesis of severe lupus glomerulonephritis. Nephrol Dial Transplant. 2008;23:1298-306. [ PubMed link ] ). [kidneypathology.com]
[…] progress to chronic renal failure Treatment Drugs Removal of offending drug is 1st line of therapy Steroid therapy may improve recovery of renal function, especially if started early Supportive measures for acute renal insufficiency and renal failure Prognosis [basicmedicalkey.com]
or serum creatinine x1.5 injury: GFR decrease by 50%, or creatinine x2 failure:GFR decreased by 75%, or serum creatinine x3 loss: complete loss of function for > 4 weeks end-stage kidney disease >3 months RIFLE is useful for correlating suggesting prognosis [sharinginhealth.ca]
Etiology
or systemic etiology, as such a description is beyond the scope of this article. [sites.google.com]
General guidelines for differentiating the etiology of acute kidney injury (ie, prerenal vs renal) using laboratory studies. Figure 3. [jaoa.org]
[…] appearance: envelope shaped Etiology -methanol -ethanol -ethylene glycol -Crohn's disease **fat malabsorption so fat stays in gut and binds to calcium and so oxalate doesnt have calcium to bind iwth Uric Acid crystals -etiology Etiology: -tumor lysis [quizlet.com]
findings common to tubulointerstitial nephritides of other etiologies. [slideshare.net]
If sepsis is the etiology of the patient's AKI, then sepsis should be sequenced as the principal diagnosis with AKI as a secondary diagnosis, Yelton says. [blr.hcpro.com]
Epidemiology
Epidemiology [ edit ] Interstitial nephritis is uncommon ( acute kidney injury of unknown cause. [2] While it can occur in patients of all ages, it is more common in elderly patients, perhaps due to increased exposure to drugs and other triggering causes [en.wikipedia.org]
"Epidemiological studies have revealed an excess prevalence of scleroderma (progressive systemic sclerosis) among workers exposed to silica in mining and stone-cutting trades. [haz-map.com]
Epidemiology and risk factors Hypersensitivity reactions to anti-TB drugs are reported in 1-5% of patients. [waojournal.biomedcentral.com]
Determining the epidemiology and etiology of acute renal failure (ARF) has been problematic. In 2002, the Acute Dialysis Quality Initiative (ADQI) workgroup met and proposed a consensus definition. [dovepress.com]
[…] chr. transplant rejection Neoplasia ( myeloma, amyloidosis, leukemia) Atherosclerotic kidney diseases Metabolic ( hyperCa,potassium depletion, cystinosis) Genetics( Alport sy, medullary cystic diseases Miscellaneous ( Balkan endemic nephropathy) 25 Epidemiology [slideplayer.com]
Pathophysiology
Cascade of events involved in the pathophysiology of acute kidney injury. (Copyright 2004 by American Society for Clinical Investigation. Reproduced with permission of American Society for Clinical Investigation. [jaoa.org]
Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. [books.google.com]
The pathophysiology of renal involvement in leprosy is illustrated in Fig. 1. Pathophysiology of renal involvement in leprosy. AKI = acute kidney injury; CKD = chronic kidney disease. [ncbi.nlm.nih.gov]
Because the pathophysiology of both is poorly understood, these conditions tend to be included under the generic term of chronic transplant nephropathy. Most kidney transplant patients have a stable course with mild impairment of renal function. [emedicine.medscape.com]
The pathophysiology of nephrotoxicity is not well understood. [slideshare.net]
Prevention
Dense granules (calcium and ATP) Alpha granules(lots of ****) Urea prevents plateletes from degranulating and releasing all this stuff GET: superficial bleeding (platelet bleeding) Tx for uremia induced bleeding Give them DDAVP(desmopresin) -causes the [quizlet.com]
Your doctor can make changes that do a better job preventing or reducing your symptoms. [qa.virinchihospitals.com]
Prevention: avoid excessive use of NSAID 23 Principal mechanism in acute tubulointerstitial nephritis Hypersensitive reaction to drugs (penicillin, NSAID, sulfa drugs) Infection (viral, bacterial, parasitic) often associated with obstruction or reflux [slideplayer.com]
Often, the disorder can't be prevented. Avoiding or reducing your use of medicines that can cause this condition can help reduce your risk. If needed, your provider will tell you which medicines to stop or reduce. [medlineplus.gov]
Switching to a D-sorbitol-stabilized formulation may prevent toxicity ( 124 ). [abdominalkey.com]