Important EU Safety Information HUMIRA is contraindicated in patients with active tuberculosis or other severe infections such as sepsis, and opportunistic infections and in patients with moderate to severe heart failure (NYHA class III/IV). [prnewswire.com]

[…] efficacy 14 The MUST study demonstrated that long-term systemic therapy for uveitis leads to infections requiring treatment in 72.3% of subjects 18 Short-term use of systemic corticosteroids is associated with an increased risk of adverse events, including sepsis [rethinkuveitis.com]

Discontinue HUMIRA if a patient develops a serious infection or sepsis. Reported infections include: Active tuberculosis (TB), including reactivation of latent TB. [humirapro.com]

Summary of Safety Information Contradictions HUMIRA is contraindicated in patients with serious infection (sepsis etc.), active tuberculosis, a history of hypersensitivity to any of the ingredients of HUMIRA, a current or past history of demyelinating [eisai.com]

CONGESTIVE HEART FAILURE Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully. [humirapro.com]

and congestive heart failure. [eisai.com]

In case of bilateral sarcoidosis, relapsing polychondritis or TINU syndrome, MTX was recommended along with systemic steroids. [ard.bmj.com]

He was diagnosed as having systemic mastocytosis at the age of 4 months, at which time he presented with diarrhea, hepatosplenomegaly, and typical skin lesions. [healio.com]

Important EU Safety Information HUMIRA is contraindicated in patients with active tuberculosis or other severe infections such as sepsis, and opportunistic infections and in patients with moderate to severe heart failure (NYHA class III/IV). [prnewswire.com]

CONGESTIVE HEART FAILURE Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully. [humirapro.com]

and congestive heart failure. [eisai.com]

About Dry Eye Syndrome Dry Eye Syndrome is a common inflammatory disease characterized by insufficient moisture and lubrication over the anterior surface of the eye. [finance.yahoo.com]

eye syndrome clinical trial, expected in Q3 of this year Source text for Eikon: Further company coverage: [businessinsider.com]

He was diagnosed as having systemic mastocytosis at the age of 4 months, at which time he presented with diarrhea, hepatosplenomegaly, and typical skin lesions. [healio.com]

The most frequently reported adverse events across all indications included respiratory infections, injection site reactions, headache and musculoskeletal pain. [prnewswire.com]

Evidence suggests that toxic chemicals known as aldehydes are formed in patients with noninfectious anterior uveitis and may be partially responsible for the inflammation in the disease. [aldeyra.com]

In our case, the irrelevant systemic work-up and the absence of mast cells in the anterior chamber paracentesis cytological examination might suggest that the patient’s uveitis related to autoimmunity. [healio.com]

The Phase 2 results in NAU released in May 2016 and presented at ARVO suggest that ADX-102 is also active in autoimmune disease. [finance.yahoo.com]

Sudden bilateral loss of vision suggests VKH syndrome or sympathetic ophthalmia. Panuveitis Presents with any combination of the above symptoms. [patient.info]

Pooled findings regarding safety outcomes suggest increased risks of post- implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy. Read the full abstract... [cochrane.org]

"Based on positive results from our phase 2 clinical trial announced last year, we are excited to commence phase 3 clinical testing of our novel aldehyde trap, ADX-102, in noninfectious anterior uveitis," Todd C. [eyewiretoday.com]

"Based on positive results from our Phase 2 clinical trial announced last year, we are excited to commence Phase 3 clinical testing of our novel aldehyde trap, ADX-102, in noninfectious anterior uveitis," commented Todd C. [finanznachrichten.de]

“It’s an exciting time because biologics are just exploding, and there are so many potential therapeutic targets that we are learning to interfere with in various ways,” said Dr. [aao.org]

Table 1 Current systemic infections agents as causes of active uveitis VZV (n 14) Mycobacterium tuberculosis (n 21) Ascaris lumbricoides (n 2) Candida albicans (n 22) CMV (n 5) Chlamydia trachomatis (n 10) Filaria (n 2) Aspergillus fumigatus (n 2) Other [ojrd.biomedcentral.com]