Symptoma

Non-Infectious Anterior Uveitis

Non-Infectious Iridocyclitis

Case Report A 10-year-old boy presented in October 2003 with a 2-week history of redness, pain, and photophobia in both eyes. [healio.com]

May 17 (Reuters) - Aldeyra Therapeutics Inc * Presents noninfectious anterior uveitis Phase 2 clinical trial data * Aldeyra Therapeutics - data demonstrated ADX-102 activity comparable to standard-of-care topical ocular corticosteroids in reducing anterior [businessinsider.com]

The Phase 2 results in NAU released in May 2016 and presented at ARVO suggest that ADX-102 is also active in autoimmune disease. [finance.yahoo.com]

Poster Presentations Other orphan diseases FRI0602 National recommendations on the use of immunomodulatory drugs in patients with non-infectious non-malignant anterior uveitis G Espinosa 1, S Muñoz-Fernandez 2, JM García Ruiz de Morales 3, JM Herreras [ard.bmj.com]

Download citation file: Ris (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager ARVO (1962-2015); The Authors (2016-present) Supplements Abstract Purpose Non-infectious uveitis (NIU) can cause visual impairment and as a result may incur [iovs.arvojournals.org]

  • Sepsis

    Important EU Safety Information HUMIRA is contraindicated in patients with active tuberculosis or other severe infections such as sepsis, and opportunistic infections and in patients with moderate to severe heart failure (NYHA class III/IV). [prnewswire.com]

    […] efficacy 14 The MUST study demonstrated that long-term systemic therapy for uveitis leads to infections requiring treatment in 72.3% of subjects 18 Short-term use of systemic corticosteroids is associated with an increased risk of adverse events, including sepsis [rethinkuveitis.com]

    Discontinue HUMIRA if a patient develops a serious infection or sepsis. Reported infections include: Active tuberculosis (TB), including reactivation of latent TB. [humirapro.com]

    Summary of Safety Information Contradictions HUMIRA is contraindicated in patients with serious infection (sepsis etc.), active tuberculosis, a history of hypersensitivity to any of the ingredients of HUMIRA, a current or past history of demyelinating [eisai.com]

  • Congestive Heart Failure

    CONGESTIVE HEART FAILURE Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully. [humirapro.com]

    and congestive heart failure. [eisai.com]

  • Relapsing Polychondritis

    In case of bilateral sarcoidosis, relapsing polychondritis or TINU syndrome, MTX was recommended along with systemic steroids. [ard.bmj.com]

  • Hepatosplenomegaly

    He was diagnosed as having systemic mastocytosis at the age of 4 months, at which time he presented with diarrhea, hepatosplenomegaly, and typical skin lesions. [healio.com]

  • Heart Failure

    Important EU Safety Information HUMIRA is contraindicated in patients with active tuberculosis or other severe infections such as sepsis, and opportunistic infections and in patients with moderate to severe heart failure (NYHA class III/IV). [prnewswire.com]

    CONGESTIVE HEART FAILURE Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully. [humirapro.com]

    and congestive heart failure. [eisai.com]

  • Dry Eyes

    About Dry Eye Syndrome Dry Eye Syndrome is a common inflammatory disease characterized by insufficient moisture and lubrication over the anterior surface of the eye. [finance.yahoo.com]

    eye syndrome clinical trial, expected in Q3 of this year Source text for Eikon: Further company coverage: [businessinsider.com]

  • Skin Lesion

    He was diagnosed as having systemic mastocytosis at the age of 4 months, at which time he presented with diarrhea, hepatosplenomegaly, and typical skin lesions. [healio.com]

  • Musculoskeletal Pain

    The most frequently reported adverse events across all indications included respiratory infections, injection site reactions, headache and musculoskeletal pain. [prnewswire.com]

  • Suggestibility

    Evidence suggests that toxic chemicals known as aldehydes are formed in patients with noninfectious anterior uveitis and may be partially responsible for the inflammation in the disease. [aldeyra.com]

    In our case, the irrelevant systemic work-up and the absence of mast cells in the anterior chamber paracentesis cytological examination might suggest that the patient’s uveitis related to autoimmunity. [healio.com]

    The Phase 2 results in NAU released in May 2016 and presented at ARVO suggest that ADX-102 is also active in autoimmune disease. [finance.yahoo.com]

    Sudden bilateral loss of vision suggests VKH syndrome or sympathetic ophthalmia. Panuveitis Presents with any combination of the above symptoms. [patient.info]

    Pooled findings regarding safety outcomes suggest increased risks of post- implant surgery for cataract and high intraocular pressure compared with standard-of-care therapy. Read the full abstract... [cochrane.org]

  • Excitement

    "Based on positive results from our phase 2 clinical trial announced last year, we are excited to commence phase 3 clinical testing of our novel aldehyde trap, ADX-102, in noninfectious anterior uveitis," Todd C. [eyewiretoday.com]

    "Based on positive results from our Phase 2 clinical trial announced last year, we are excited to commence Phase 3 clinical testing of our novel aldehyde trap, ADX-102, in noninfectious anterior uveitis," commented Todd C. [finanznachrichten.de]

    “It’s an exciting time because biologics are just exploding, and there are so many potential therapeutic targets that we are learning to interfere with in various ways,” said Dr. [aao.org]

Urinalysis Infectious workup (eg, depending on presentation, toxoplasma, Lyme disease, HIV, VDRL. Laboratory tests on a sample of aqueous or vitreous may be helpful where infection or malignancy is suspected. [patient.info]

  • Candida

    Table 1 Current systemic infections agents as causes of active uveitis VZV (n 14) Mycobacterium tuberculosis (n 21) Ascaris lumbricoides (n 2) Candida albicans (n 22) CMV (n 5) Chlamydia trachomatis (n 10) Filaria (n 2) Aspergillus fumigatus (n 2) Other [ojrd.biomedcentral.com]

They include specific recommendations on patients with non-infectious, non-neoplastic AU, as well as different treatment lines. [ncbi.nlm.nih.gov]

Researchers observed 16 treatment failures in 60 patients (27 percent) in the adalimumab group versus 18 treatment failures in 30 patients (60 percent) in the placebo group (hazard ratio, 0.25; 95 percent confidence interval [CI], 0.12 to 0.49; P About [firstwordpharma.com]

[…] patients who have failed standard treatments. [prnewswire.com]

They include specific recommendations on patients with non-infectious, non-neoplastic UA, as well as different treatment lines. [ard.bmj.com]

A good prognosis can be expected for those who undergo appropriate treatment. The condition does not usually lead to permanent blindness Complications, such as glaucoma and cataract, can worsen the prognosis. [dovemed.com]

Juvenile arthritis-associated uveitis: visual outcomes and prognosis. Can J Ophthalmol. 2004;39:614-20. Murphy CC, Greiner K, Plskova J, et al. [rarediseases.org]

However, when disease is not detected early enough, or when providers who are unfamiliar or uncomfortable dealing with uveitis fail to refer to a specialist, complications are much more prevalent and prognosis usually worse. [mersi.com]

[ edit ] The prognosis is generally good for those who receive prompt diagnosis and treatment, but serious complication including cataracts, glaucoma, band keratopathy, macular edema and permanent vision loss may result if left untreated. [en.wikipedia.org]

Prognosis Anterior uveitis can be a self-limiting condition. The factors determining which cases will resolve without intervention are unclear. [patient.info]

It has been shown to contribute to the etiology of T-cell-mediated autoimmune diseases through the upregulation of type 2 anti-inflammatory T helper cells and the suppression of type 1 T helper cells. [eye.hms.harvard.edu]

Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. [utmb.influuent.utsystem.edu]

There might be as many as 85 different etiologies for uveitis, noted C. Stephen Foster, MD, FACS, FACR, founder and president of the Ocular Immunology and Uveitis Foundation in Waltham, MA. [clinicaladvisor.com]

Summary The management of uveitis is challenging because of its protean etiologies and its manifestations, both ocular and systemic. [touchophthalmology.com]

Table 2 summarizes the most common etiologies of uveitis cases and their anatomical distribution. [ojrd.biomedcentral.com]

We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet's disease, Vogt-Koyanagi-Harada [utmb.influuent.utsystem.edu]

Epidemiology and course of disease in childhood uveitis. Ophthalmology. 2009 Aug;116(8):1544-1551. 6 Bhat, P.V., MD; Goldstein, D.A., MD. Pediatric Anterior Uveitis. Available at: . [firstwordpharma.com]

Epidemiology and course of disease in childhood uveitis. Ophthalmology. 2009 Aug;116(8):1544-1551. [5] Bhat, P.V., MD; Goldstein, D.A., MD. Pediatric Anterior Uveitis. Available at: . [prnewswire.com]

Antidepressants: risk of fractures Healthcare professionals should be aware of epidemiological data showing a small increased risk of fractures associated with the use of TCAs and SSRIs, and should take this risk into account in their... [evidence.nhs.uk]

Clinical trial data on these and other potential therapies will enhance understanding of the pathophysiology of NIU of the posterior segment, and one or more of these agents may in the future provide additional therapeutic options for patients. n Steven [retinatoday.com]

Non-neoplastic: retinitis pigmentosa intraocular foreign body juvenile xanthogranuloma retinal detachment Neoplastic: retinoblastoma lymphoma malignant melanoma leukemia reticulum cell sarcoma Pathophysiology [ edit ] Immunologic factors [ edit ] Onset [en.wikipedia.org]

Some ocular syndromes can give rise to anterior or posterior uveitis. [ 7 ] Pathophysiology [ 2, 8 ] Uveitis is the eye's response to a wide range of intraocular inflammatory diseases of infectious, traumatic, genetic or autoimmune aetiology. [patient.info]

Except for patients with TINU, etanercept was not recommended because current evidence does not support the use of it to prevent AU flares. [ard.bmj.com]

Seeking proper treatment for an autoimmune disease or infection can help to prevent uveitis. Uveitis in otherwise healthy people is difficult to prevent since the cause isn’t known. [healthline.com]

Alternatively, antibodies against the cytokine receptor can prevent circulating cytokines from binding to the receptor, inhibiting the inflammatory response. [touchophthalmology.com]

Anterior Uveitis Treatments Anterior uveitis may be treated by: Taking eye drops that dilate the pupil to prevent muscle spasms in the iris and ciliary body (see diagram). [nei.nih.gov]