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Non-Syndromic Orofacial Cleft

Cleft Lip with or without Cleft Palate Non-Syndromic 1


Presentation

  • Acronym OFC15 Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.[uniprot.org]
  • This question is at present under investigation.[jmg.bmj.com]
  • The aim of the present work is to review the current literature regarding genetics of NSCL/P, focusing on the multiple methods of genetic investigation. Furthermore, genes and genetic loci best-supported as involved in NSCL/P are discussed.[iris.unito.it]
  • A tendency towards a significant deviation was also present for the G/G homozygotes at rs481931 over-transmitted for NSCLO (Z 1.84 and P 0.066) and NSCLP (Z 1.76 and P 0.078).[omicsonline.org]
Low Set Ears
  • Any major abnormalities or syndromes detected during the screening were excluded. [18] Patients with one minor anomaly such as low-set ears, hypertelorism, clinodactyly, and single palmar crease were included.[jclpca.org]
  • Patients with minor anomaly such as low-set ears, hypertelorism, clinodactyly and single palmar crease were included.[bmcgenet.biomedcentral.com]

Treatment

  • Though comprehensive treatment for OFC is now available universally, an increased emphazis on cosmesis and prenatal diagnosis (PND) by ultrasonography has lead to evidence of elective termination of pregnancy.[ijoms.com]
  • It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice .[uniprot.org]
  • Abstract To evaluate the relation between health-related quality of life (QOL), in a large representative group of adolescents with non-syndromic orofacial clefts.724 non-syndromic patients with an orofacial cleft who had finished their surgical treatment[infona.pl]

Prognosis

  • Prognosis of facial growth in patients with unilateral complete clefts of the lip, alveolus and palate. J Craniomaxillofac Surg . 29 , 198-204 (2001). Parsons, K. J., Andreeva, V., James Cooper, W., Yelick, P. C., Craig Albertson, R.[jove.com]

Etiology

  • Although numerous studies have been published addressing the genetic etiology of CL/P, this factor remains incompletely understood.[lirias.kuleuven.be]
  • The etiologies of NSOCs were multifactorial, with a combination of both genetic and environmental risk factors.[omicsonline.org]
  • Notably, mutations in IRF6 were first discovered to be etiologic in autosomal-dominant clefting syndrome (Van der Woude syndrome); subsequently, the causative role of this gene has been identified also for NSCL/P and independently replicated across the[iris.unito.it]
  • Marazita Original Investigation First Online: 04 January 2017 1.1k Downloads 24 Citations Abstract Nonsyndromic orofacial clefts (OFCs) are a heterogeneous group of common craniofacial birth defects with complex etiologies that include genetic and environmental[link.springer.com]
  • Etiology and Genetic Counseling No distinct etiology of orofacial clefts is known.[consultant360.com]

Epidemiology

  • In fact, during the past two decades, a series of epidemiologic studies have also revealed the role of alcohol in determining NS OFC.[oapublishinglondon.com]
  • Nieuwenhuijsen MJ, Dadvand P, Grellier J, Martinez D, Vrijheid M (2013) Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies.[journals.plos.org]
  • Epidemiological studies on the frequency of clefts in Europe and world-wide. J Craniomaxillofac Surg 2006;34:1-2. Go to original source... Go to PubMed... Wehby GL, Cassell CH.[biomed.papers.upol.cz]
  • Laboratory of Congenital Malformation Epidemiology Oswaldo Cruz Institute, FIOCRUZ Rio de Janeiro Brazil 9. Department of Epidemiology, Institute of Public Health University of Southern Denmark Odense Denmark 10.[link.springer.com]
  • Epidemiology underpinning research in the aetiology of orofacial clefts. Orthod Craniofac Res. 2007;10(3):114–120. Bell JC, Raynes-Greenow C, Bower C, Turner RM, Roberts CL, Nassar N.[colombiamedica.univalle.edu.co]
Sex distribution
Age distribution

Prevention

  • Bronkhorst Department of Cariology and Preventive Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Rajendra Prasad A.B.[infona.pl]
  • Prevention It is necessary to understand genetic and environmental causes of syndromic and non-syndromic OFCs in order to prevent them. Having an understanding of multifactorial a etiology helps direct attention toward prevention.[article.sciencepublishinggroup.com]
  • Factors Vitamin B12 Folic acid Literature sources : Maternal dietary B vitamin intake “Folate intake Folic acid on prevention of orofacial cleft Complications Feeding problems Psychosocial issues Infections (otitis media, pneumonia, bronchopneumonia)[flipper.diff.org]
  • […] in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p CONCLUSIONS: DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention[ncbi.nlm.nih.gov]
  • Prevention and protecting against having an infant with NSOFC could be possible through understanding the associated risk factors.[journals.plos.org]

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