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Nonallergic Interstitial Nephritis

Nephritis Interstitial Non Allergic


Presentation

  • Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty.[books.google.com]
  • Major teaching points are reinforced by the presentation of 20 problem cases for the reader's diagnosis. The book also details the general management of the patient with renal failure and the treatment of various causative diseases.[books.google.de]
  • In mild cases, the clinical presentation may consist of subtle tubular function abnormalities, such as Fanconi syndrome (ie, aminoaciduria, glycosuria, renal tubular acidosis). Patients may present with rash and hematuria.[emedicine.medscape.com]
  • Abstract Acute interstitial nephritis due to drugs commonly presents as acute renal failure and may be commoner than is presently realized.[annals.org]
Decreased Renal Function
  • Introduction Decreasing renal function can result in the accumulation of metabolic waste products (eg, urea, creatinine), electrolyte and acid–base abnormalities, and fluid retention.[dovepress.com]

Workup

  • Intravenous pyelography: Once widely used, this technique seldom plays a role in the workup of kidney diseases Quantitative determination of urine protein in modern medicine.[slideshare.net]
  • In retrospect, after careful investigation including the ethylenediaminetetraacetic acid (EDTA) lead mobilization test (see Workup), many patients presumed to have either gouty nephropathy or hypertensive nephrosclerosis are discovered to have lead nephropathy[emedicine.medscape.com]
  • Hemolytic-uremic syndrome IgA nephropathy The following 4 renal syndromes commonly mimic the early stage of acute glomerulonephritis: Anaphylactoid purpura with nephritis Chronic glomerulonephritis with an acute exacerbation Idiopathic hematuria Familial nephritis Workup[sites.google.com]
  • An allergy workup is normally recommended 1 to 6 months after the reaction. It may comprise skin tests and in vitro tests. The sensitivity of these tests is probably low, but the specificity is good – which makes a positive result valuable.[waojournal.biomedcentral.com]
Creatinine Increased
  • The RIFLE ( R isk, I njury, F ailure, L oss, E nd-stage) criteria for acute kidney injury, 7 - 9 which defines this syndrome based on glomerular filtration rate (ie, serum creatinine increase) and weight-dependent urine output criteria.[jaoa.org]
Abnormal Renal Function
  • renal function Frequency not reported : Interstitial nephritis, renal failure, allergic/non-allergic glomerulonephritis, nephrotic syndrome, non-oliguric renal failure, renal papillary necrosis, tubulointerstitial nephritis [ Ref ] Psychiatric Rare ([drugs.com]
Human Herpesvirus 6
  • Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms. Arch Dermatol. 2001;137:301–4. 15. Lang DM, Alpern MB, Visintainer PF, Smith ST.[aafp.org]
  • PubMed Google Scholar Tamagawa-Mineoka R, Katoh N, Nara T: DRESS syndrome caused by teicoplanin and vancomycin, associated with reactivation of human herpesvirus-6. Int J Dermatol. 2007, 46: 654-655. 10.1111/j.1365-4632.2007.03255.x.[waojournal.biomedcentral.com]

Treatment

  • Apply the latest best practices through new and updated treatment algorithms. Find therapeutic drug information more easily with guidance incorporated into each chapter.[books.google.com]
  • The book also details the general management of the patient with renal failure and the treatment of various causative diseases.[books.google.de]
  • This comprehensive textbook provides a broad reveiw of kidney diseases with regards to symptoms, investigation and treatment.[books.google.de]

Prognosis

  • Prognosis depends on the underlying disease and the overall health of the patient. Occurrence of cardiopulmonary or neurologic complications worsens the prognosis.[sites.google.com]
  • The PROGNOSIS is, on the whole, good, still bearing in mind the necessity of guarded prognosis in all renal diseases as above indicated.[meridianinstitute.com]
  • […] progress to chronic renal failure Treatment Drugs Removal of offending drug is 1st line of therapy Steroid therapy may improve recovery of renal function, especially if started early Supportive measures for acute renal insufficiency and renal failure Prognosis[basicmedicalkey.com]
  • The prognosis and pathogenesis of severe lupus glomerulonephritis. Nephrol Dial Transplant. 2008;23:1298-306. [ PubMed link ] ).[kidneypathology.com]
  • 25%, or serum creatinine x1.5 injury: GFR decrease by 50%, or creatinine x2 failure:GFR decreased by 75%, or serum creatinine x3 loss: complete loss of function for 4 weeks end-stage kidney disease 3 months RIFLE is useful for correlating suggesting prognosis[sharinginhealth.ca]

Etiology

  • General guidelines for differentiating the etiology of acute kidney injury (ie, prerenal vs renal) using laboratory studies. Figure 3.[jaoa.org]
  • , or systemic etiology, as such a description is beyond the scope of this article.[sites.google.com]
  • […] appearance: envelope shaped Etiology -methanol -ethanol -ethylene glycol -Crohn's disease **fat malabsorption so fat stays in gut and binds to calcium and so oxalate doesnt have calcium to bind iwth Uric Acid crystals -etiology Etiology: -tumor lysis[quizlet.com]
  • , findings common to tubulointerstitial nephritides of other etiologies.[slideshare.net]
  • If sepsis is the etiology of the patient's AKI, then sepsis should be sequenced as the principal diagnosis with AKI as a secondary diagnosis, Yelton says.[blr.hcpro.com]

Epidemiology

  • Epidemiology [ edit ] Interstitial nephritis is uncommon ( acute kidney injury of unknown cause. [2] While it can occur in patients of all ages, it is more common in elderly patients, perhaps due to increased exposure to drugs and other triggering causes[en.wikipedia.org]
  • "Epidemiological studies have revealed an excess prevalence of scleroderma (progressive systemic sclerosis) among workers exposed to silica in mining and stone-cutting trades.[haz-map.com]
  • Epidemiology and risk factors Hypersensitivity reactions to anti-TB drugs are reported in 1-5% of patients.[waojournal.biomedcentral.com]
  • Epidemiology AKI occurring in the community (CA-AKI) is relatively uncommon. It accounts for 1% of hospital admissions in the United States. 5 However, its true incidence is likely unknown.[dovepress.com]
  • […] chr. transplant rejection Neoplasia ( myeloma, amyloidosis, leukemia) Atherosclerotic kidney diseases Metabolic ( hyperCa,potassium depletion, cystinosis) Genetics( Alport sy, medullary cystic diseases Miscellaneous ( Balkan endemic nephropathy) 25 Epidemiology[slideplayer.com]
Sex distribution
Age distribution

Pathophysiology

  • Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices.[books.google.com]
  • Cascade of events involved in the pathophysiology of acute kidney injury. (Copyright 2004 by American Society for Clinical Investigation. Reproduced with permission of American Society for Clinical Investigation.[jaoa.org]
  • The pathophysiology of renal involvement in leprosy is illustrated in Fig. 1. Pathophysiology of renal involvement in leprosy. AKI acute kidney injury; CKD chronic kidney disease.[ncbi.nlm.nih.gov]
  • Because the pathophysiology of both is poorly understood, these conditions tend to be included under the generic term of chronic transplant nephropathy. Most kidney transplant patients have a stable course with mild impairment of renal function.[emedicine.medscape.com]
  • […] lead to acute tubular necrosis include radiographic contrast agents, aminoglycosides, vancomycin, amphoteracin B, cyclosporine, statins, acyclovir, methotrexate, NSAIDs, COX-2 inhibitors, cisplatin, ethylene glycol, and ACE inhibitors. return to top Pathophysiology[sharinginhealth.ca]

Prevention

  • Dense granules (calcium and ATP) Alpha granules(lots of ****) Urea prevents plateletes from degranulating and releasing all this stuff GET: superficial bleeding (platelet bleeding) Tx for uremia induced bleeding Give them DDAVP(desmopresin) -causes the[quizlet.com]
  • Your doctor can make changes that do a better job preventing or reducing your symptoms.[qa.virinchihospitals.com]
  • Prevention: avoid excessive use of NSAID 23 Principal mechanism in acute tubulointerstitial nephritis Hypersensitive reaction to drugs (penicillin, NSAID, sulfa drugs) Infection (viral, bacterial, parasitic) often associated with obstruction or reflux[slideplayer.com]
  • Often, the disorder can't be prevented. Avoiding or reducing your use of medicines that can cause this condition can help reduce your risk. If needed, your provider will tell you which medicines to stop or reduce.[medlineplus.gov]
  • Switching to a D-sorbitol-stabilized formulation may prevent toxicity ( 124 ).[abdominalkey.com]

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