Edit concept Question Editor Create issue ticket

Nonsteroidal Antiinflammatory Drug

NSAID%27s Toxicity


Presentation

  • Abstract The aim of the present study was to determine the prevalence of Helicobacter pylori infection in a group of patients hospitalized at the clinic of rheumatology who presented peptic ulcers and erosions associated with nonsteroidal antiinflammatory[ncbi.nlm.nih.gov]
  • The inverse association with regular continuing use was present across age and gender and for both colon and rectal carcinoma. Similar inverse associations were present for regular continuing use of aspirin and nonaspirin NSAIDs.[ncbi.nlm.nih.gov]
  • A case of NSAID-induced colonic stricture leading to large bowel obstruction and secondary cecal perforation (previously unreported) is presented.[ncbi.nlm.nih.gov]
  • The case of a 61-year-old man who gradually developed similar inflammatory changes in the ascending colon during prolonged intake of a slow-release form of diclofenac is presented, and the literature on nonsteroidal antiinflammatory drug-induced intestinal[ncbi.nlm.nih.gov]
  • The present case suggests that binge drinking may be a potential risk factor for ARF in the presence of NSAIDs.[ncbi.nlm.nih.gov]
Fatigue
  • In addition, some people taking NSAIDs have experienced asthma attacks, bleeding, fatigue, headache, insomnia, low neutrophil levels, urticaria ( hives ), vertigo and seizures.[drugs.com]
  • Common side effects of prescription NSAIDs may include: dizziness headache nausea diarrhea excess gas constipation extreme weakness or fatigue dry mouth. Serious, but rare, side effects of prescription NSAIDs may include: Allergic reaction.[familydoctor.org]
  • Hyperkalemia symptoms include nausea, fatigue, tingling... SAPHO Syndrome SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO syndrome is an eponym for the combination of...[medicinenet.com]
  • […] urine Severe stomach pain Blood or material that looks like coffee grounds in vomit (bleeding may occur without warning symptoms like pain) Blurred vision Wheezing, trouble breathing, or unusual cough Chest pain, rapid heartbeat, palpitations Acute fatigue[my.clevelandclinic.org]
Anemia
  • Small intestine inflammation and bleeding (enteropathy) due to NSAIDs must be considered in the evaluation of anemia in patients with arthritis.[ncbi.nlm.nih.gov]
  • […] are currently taking any other medications (including over-the-counter medications) and/or herbal or dietary supplements If you are pregnant, planning to become pregnant, or are breast-feeding If you have problems taking any medications If you have anemia[my.clevelandclinic.org]
  • 34 ] Sex, age, calendar year, body mass index, HF, hypertension, diabetes, antihypertensive use, oral steroid use, NSAID use, and consultant visits and hospitalizations in the previous year Leonard 2012 [ 6 ] Hospitalized in prior 30 days, ever past anemia[bmcnephrol.biomedcentral.com]
Congestive Heart Failure
  • Other heart-related side effects such as high blood pressure, congestive heart failure, and palpitations have also been reported.[drugs.com]
  • heart failure Asthma that gets worse when taking aspirin Pregnancy in the third trimester History of stroke or heart attack If you are 65 years of age or older Simultaneous use with certain medications such as warfarin (Coumadin ), clopidogrel (Plavix[my.clevelandclinic.org]
  • heart failure, Diabetes, Hyperlipidemia, Hypertension, Osteoarthritis, Rheumatoid arthritis, Peptic ulcer/ GERD, PVD, Valvular disease), hospitalization (last 30 days, previous year), drug use (ACEi or ARBs, Beta-blockers, Diuretics, Oral anticoagulants[bmcnephrol.biomedcentral.com]
Weight Loss
  • Hypernatremia was found in 3% and was associated with a mean weight loss. Postrace serum sodium concentration varied inversely with percent weight change. Runners using any NSAID were more likely to become hyponatremic.[ncbi.nlm.nih.gov]
  • Before these symptoms, he had an undefined abdominal process with diarrhea, weight loss, and diffuse edema, which resolved spontaneously without reaching a diagnosis.[ncbi.nlm.nih.gov]
  • Three patients had an initial illness characterized by diarrhea, profound weight loss, and hypoalbuminemia. Intestinal radiology at this stage ranged from subtle changes to those of Crohn's disease. Three patients underwent surgery.[ncbi.nlm.nih.gov]
Hypoxemia
  • The goal of this study was to determine whether PPHN is associated with fetal exposure to: (1) tobacco and marijuana smoking (ie, contributors to fetal hypoxemia), (2) consumption of aspirin and other nonsteroidal antiinflammatory drugs (ie, inhibitors[ncbi.nlm.nih.gov]
Nausea
  • A 44-year-old-male visited our out-patient department with symptoms of nausea, vomiting, and general weakness that had developed over the previous 2 weeks. He had history of medication, nonsteroidal anti-inflammatory drugs.[ncbi.nlm.nih.gov]
  • The most common side effects are: vomiting, nausea, constipation, diarrhea, reduced appetite, headache, dizziness, rash, and drowsiness. NSAIDs also may cause swelling of the arms and legs due to the retention of fluid from their renal effects.[rxlist.com]
  • Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys.[drugs.com]
  • The most common treatment-related adverse events for tramadol/APAP were somnolence (6.5%), nausea (4.6%), and constipation (3.3%). Mean tramadol/APAP dose was 4.1 tablets (154 mg tramadol/ 1332 mg APAP).[ncbi.nlm.nih.gov]
  • Case Presentation A 43-year-old white man presented with a 3- to 4-day history of severe headaches, nausea, confusion, and photophobia. One week earlier he had been started on oral naproxen, 500 mg, twice daily for tension headaches.[mdmag.com]
Vomiting
  • A 44-year-old-male visited our out-patient department with symptoms of nausea, vomiting, and general weakness that had developed over the previous 2 weeks. He had history of medication, nonsteroidal anti-inflammatory drugs.[ncbi.nlm.nih.gov]
  • He denied urticaria, difficulty breathing, fever, abdominal pain, vomiting, and diarrhea.[ncbi.nlm.nih.gov]
  • The most common side effects are: vomiting, nausea, constipation, diarrhea, reduced appetite, headache, dizziness, rash, and drowsiness. NSAIDs also may cause swelling of the arms and legs due to the retention of fluid from their renal effects.[rxlist.com]
  • Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys.[drugs.com]
  • GIT:  Aspirin and released salicylic acid irritate gastric mucosa, cause epigastric distress, nausea and vomiting.  It also stimulates CTZ. 7. Urate excretion:  Aspirin in high dose reduces renal tubular excretion of urate 17 18. 8.[slideshare.net]
Constipation
  • The most common side effects are: vomiting, nausea, constipation, diarrhea, reduced appetite, headache, dizziness, rash, and drowsiness. NSAIDs also may cause swelling of the arms and legs due to the retention of fluid from their renal effects.[rxlist.com]
  • Gastrointestinal side effects that may occur include bloating, diarrhea, constipation, irritation of the lining of the stomach, nausea or vomiting. NSAIDs may also affect kidney function and reduce how quickly blood flows through the kidneys.[drugs.com]
  • The most common treatment-related adverse events for tramadol/APAP were somnolence (6.5%), nausea (4.6%), and constipation (3.3%). Mean tramadol/APAP dose was 4.1 tablets (154 mg tramadol/ 1332 mg APAP).[ncbi.nlm.nih.gov]
  • Constipations disturb blood circulation. Irrational diet: lack of vitamins, eating fast-food without any beverage can also lead to varicose veins among young women.[varicose-default.zcpa.info]
Abdominal Pain
  • He reported a history of recurrent episodes of colic abdominal pain during the past 25 years; he underwent three surgical operations for this condition.[ncbi.nlm.nih.gov]
  • He denied urticaria, difficulty breathing, fever, abdominal pain, vomiting, and diarrhea.[ncbi.nlm.nih.gov]
  • Most NSAID ingestions are asymptomatic or are associated with only minimal gastrointestinal (GI) symptoms, such as nausea, emesis, abdominal pain, and GI bleeding. Hepatic injury resulting in increased liver enzymes and liver failure can occur.[pedsinreview.aappublications.org]
  • COX-2 inhibitors are not without side effects, which can include abdominal pain, nausea, and indigestion. Antacids or a fatty meal can limit the body's ability to absorb and use COX-2 inhibitors, so do not take them together.[orthoinfo.aaos.org]
  • Research has shown that women with dysmenorrhoea have high levels of prostaglandins, hormones known to cause cramping abdominal pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs that act by blocking prostaglandin production.[cochrane.org]
Dyspepsia
  • Of a group of 4,256 hospitalized patients receiving therapy with NSAIDs, 221 patients with persistent dyspepsia underwent endoscopic examination of the upper segment of the gastrointestinal tract.[ncbi.nlm.nih.gov]
  • Indigestion (Dyspepsia, Upset Stomach Pain) Symptoms, Relief Remedies, Medicine Indigestion (dyspepsia) can be caused by diseases or conditions that involve the gastrointestinal (GI) tract, and also by some...[medicinenet.com]
  • Though tolerability of celecoxib is better than traditional NSAIDs, still abdominal pain, dyspepsia and mild diarrhoea are the common side effects.[slideshare.net]
Hypertension
  • There was a statistically significant relationship between NSAID usage and having hypertension (p 0.013, OR 2.064, 95% CI 1.16 - 3.65). 78 of the antihypertensive and 88% of the analgesic/NSAIDs users explained the purpose of the drug usage properly.[ncbi.nlm.nih.gov]
  • A 68-year-old African-American man with no known drug allergies and a history of hypertension, benign prostatic hypertrophy, diverticulosis, and gout arrived at the clinic with swelling of the lips and tongue three days after he started taking naproxen[ncbi.nlm.nih.gov]
  • A history of hypertension (OR 2.0, 95% CI 1.2-3.2), longer NSAID exposure (OR 1.3, 95% CI 1.2-1.4), and more physician visits/year (OR 1.1, 95% CI 1.0-1.2) were significantly associated with serum creatinine testing.[ncbi.nlm.nih.gov]
  • OBJECTIVE: Prenatal causation of persistent pulmonary hypertension of the newborn (PPHB) is suggested by a specific pattern of pulmonary vascular remodeling observed immediately after birth in some infants with fatal PPHN.[ncbi.nlm.nih.gov]
  • NSAIDs may reduce the benefit of drugs used for treating hypertension because NSAIDs may increase blood pressure.[rxlist.com]
Hypotension
  • Orthostatic Hypotension Orthostatic hypotension symptoms include: LightheadednessWeaknessBlurred vision Syncope or passing out Causes of...[medicinenet.com]
Blurred Vision
  • vision Wheezing, trouble breathing, or unusual cough Chest pain, rapid heartbeat, palpitations Acute fatigue, flu -like symptoms Jaundice Photosensitivity (greater sensitivity to light) Change in strength on one side is greater than the other, trouble[my.clevelandclinic.org]
Tinnitus
  • Decreased hearing or ringing in the ears (also called tinnitus). Jaundice (the yellowing of the skin and the whites of the eyes). Abdominal cramping. Heartburn. Indigestion.[familydoctor.org]
  • .  CNS side effects include headache, dizziness, blurring of vision, tinnitus and depression.  Rashes, itching and other hypersensitivity phenomena are infrequent.  They are not to be prescribed to pregnant woman and should be avoided in peptic ulcer[slideshare.net]
Urticaria
  • Studies, review articles, and commentaries on aspirin-induced asthma and aspirin- or NSAID-induced urticaria/angioedema were included in the review.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Oral challenges can reliably predict long-term NSAID tolerability in patients with previous adverse reactions to other drugs of this class, except for patients with chronic urticaria.[ncbi.nlm.nih.gov]
  • He denied urticaria, difficulty breathing, fever, abdominal pain, vomiting, and diarrhea.[ncbi.nlm.nih.gov]
  • In addition, some people taking NSAIDs have experienced asthma attacks, bleeding, fatigue, headache, insomnia, low neutrophil levels, urticaria ( hives ), vertigo and seizures.[drugs.com]
  • There are four presentations recognised: patients with an atopic tendency – urticaria is the usual presentation, rarely involving the airways. 80% of intolerant-to- NSAID patients are atopic. in non-atopics, urticaria and anaphylactic reactions, or urticaria[dermnetnz.org]
Photosensitivity
  • Photosensitivity to ketoprofen: mechanisms and pharmacoepidemiological data. Drug Safety 2000; 22: 339-349. Dermatology. Ed. Bolognia, J et al. 2nd edition 2007. Mosby Cousin F, Philips K, Favier B, Bienvenu J, Nicolas JF. Drug-induced urticaria.[dermnetnz.org]
  • […] material that looks like coffee grounds in vomit (bleeding may occur without warning symptoms like pain) Blurred vision Wheezing, trouble breathing, or unusual cough Chest pain, rapid heartbeat, palpitations Acute fatigue, flu -like symptoms Jaundice Photosensitivity[my.clevelandclinic.org]
Panic Attacks
  • Arcoxia 60 mg prospect arcoxia 120 mg kaina 4 stars based on 15 reviews I felt less depressed and did not feel prone to panic attacks that I had been having prior to starting this medication Buying Accutane From Canada Comprimate filmate de 60 mg biconvexe[rnci.clicfrance.fr]
Renal Insufficiency
  • Miscellaneous adverse effects and contraindications  May decrease the glomerular filtration rate, particularly in patients with renal insufficiency.  Occasionally produce mild hepatitis  Prolong bleeding time.  Aspirin irreversibly inhibits platelet[slideshare.net]

Workup

Colonic Stricture
  • Twelve additional cases of NSAID-induced colonic stricture are reviewed from the literature and its possible pathogenesis is discussed.[ncbi.nlm.nih.gov]

Treatment

  • […] ability in RA, and 60-80% as great as NSAID treatment in reduction in tender joint counts in RA.[ncbi.nlm.nih.gov]
  • However, length of treatment should always be kept as short as possible, with consideration of the specific type of injury, level of dysfunction, and pain.[ncbi.nlm.nih.gov]
  • The aim was to estimate the clinical important interactions for PU presented by comedication in Japanese RA outpatients on long-term NSAID treatment.[ncbi.nlm.nih.gov]
  • Fifty-eight treatment arms met our inclusion criteria and were available for analysis. Twenty-five treatment arms evaluated a nonsteroidal antiinflammatory drug (NSAID) in placebo control trials and 33 in comparative trials.[ncbi.nlm.nih.gov]
  • The management and treatment of these patients were decided by their treating rheumatologists.[ncbi.nlm.nih.gov]

Prognosis

  • Since there is no proven treatment for the GIN yet, we can carefully suggest that moderate to high dosage corticosteroid can be helpful for prognosis in case of acute granulomatous interstitial nephritis of patients with AKI.[ncbi.nlm.nih.gov]
  • Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines,...[medicinenet.com]

Etiology

  • As long as we can carefully exclude infectious diseases as the cause of granulomatous lesion, acute granulomatous interstitial nephritis can be treated with steroid regardless of the etiologies.[ncbi.nlm.nih.gov]
  • Abstract There is evidence for a role of inflammation in the etiology of lower urinary tract symptoms (LUTS), raising the possibility that use of nonsteroidal antiinflammatory drugs (NSAIDs) may inhibit the development or progression of LUTS.[ncbi.nlm.nih.gov]
  • […] effects Cell Survival/drug effects Cells, Cultured DNA Replication/drug effects Disease Models, Animal Female Humans Ibuprofen/administration & dosage* Indomethacin/administration & dosage* Ketorolac/administration & dosage* Male Ossification, Heterotopic/etiology[ncbi.nlm.nih.gov]
  • .  Acetaminophen is recommended as a substitute for children with fever of unknown etiology. 28 29.[slideshare.net]

Epidemiology

  • Abstract The authors performed a systematic review to summarize the epidemiologic evidence on the association between use of nonsteroidal antiinflammatory drugs (NSAIDs) and the risk of dementia.[ncbi.nlm.nih.gov]
  • OBJECTIVE: Epidemiological studies suggest nonsteroidal antiinflammatory drug (NSAID) and aspirin use is associated with a modest increase in bone mineral density of the hip and lumbar spine.[ncbi.nlm.nih.gov]
  • To reduce inconsistency between the study outcomes, future epidemiological studies on NSAID use and prostate cancer risk should assess the indications for NSAID usage.[ncbi.nlm.nih.gov]
  • BACKGROUND: Animal experiments and epidemiologic data have suggested that the use of nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the incidence of large bowel carcinoma.[ncbi.nlm.nih.gov]
  • Many epidemiologic studies exploring this association lacked sufficient power to draw definitive conclusions. We conducted a metaanalysis to examine the effect of NSAID use on the risk of lung cancer.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of aseptic meningitis is uncertain, and there are probably multiple mechanisms involved. The condition has been observed in all age-groups and can occur after the use of a wide spectrum of pharmacologic agents.[mdmag.com]
  • Consequently, an appreciation for the risk factors and pathophysiology of NSAID-induced renal function abnormalities is required for optimal use of these drugs.[ncbi.nlm.nih.gov]

Prevention

  • STUDY DESIGN: Data were from the National Birth Defects Prevention Study, a multisite population-based, case-control study of risk factors for birth defects.[ncbi.nlm.nih.gov]
  • Because the benefit of NSAIDs in preventing dementia or cognitive impairment was 50% in studies with prevalent dementia cases, declined to 20% in studies with incident dementia cases, and was absent in studies where cognitive decline was used as the endpoint[ncbi.nlm.nih.gov]
  • Abstract Nonsteroidal antiinflammatory drugs (NSAIDs) may play a role in breast cancer prevention; however, breast cancer subtypes and lifestyle/host factors may influence their impact.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Chronic NSAID ingestion does not seem to prevent gallstones in arthritis patients; in these patients gallstone disease is associated with classic risk factors (female gender and age).[ncbi.nlm.nih.gov]
  • A multicenter, double-blind, placebo-controlled trial was conducted to evaluate the efficacy of misoprostol in preventing gastrointestinal toxicity in elderly patients ( or 65 years) given nonsteroidal antiinflammatory agents for no more than ten days[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!