This report presents the first case in which the clinical features of DICER1 syndrome appear in combination with well-differentiated fetal adenocarcinoma of the lung. [ncbi.nlm.nih.gov]

Discussion The Chinese family presented hereditary predisposition to PTC, but currently the genetic incline to fPTC is unknown. [bmcendocrdisord.biomedcentral.com]

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

• Deepening of Voice

  A 14-year-old female presented with intermittent abdominal pain, deepening of voice and amenorrhoea for 4 months. [ncbi.nlm.nih.gov]

Otherwise incidental finding of thyroid nodules found on the inpatient service can be deferred to outpatient workup and management. [clinicaladvisor.com]

If any changes occur, then further workup is indicated. Evidence-based answers from the Family Physicians Inquiries Network [mdedge.com]

Although the risk of cancer is small, it is the main reason for workup of these lesions. Measurement of thyroid-stimulating hormone can identify conditions that may cause hyperfunctioning of the thyroid. [aafp.org]

[…] in a young individual (often diagnosed due to routine screening of newborns for congenital hypothyroidism) Radiologic evaluation includes thyroid ultrasound and scintiscan Correlation of clinical signs with laboratory and ancillary tests Laboratory workup [pathologyoutlines.com]

This thoroughly updated edition includes an introduction to risk assessment and screening and results of recent clinical trials and their implications for treatment and prevention. [books.google.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

If repeat aspirations fail to provide an adequate specimen, close follow-up or surgery (particularly if the nodule is solid) should be considered.9 Treatment Options for Patients with Multinodular Goiters Several treatment modalities are available for [touchendocrinology.com]

Treatment of toxic multinodular goiter: Comparison of radioiodine and long-term methimazole treatment. (Abstract) Treatment of toxic multinodular goiter: Comparison of radioiodine and long-term methimazole treatment. [tripdatabase.com]

This can be done with: Ultrasound Thyroid scan Barium swallow X-ray Treatment Nontoxic goiters usually grow very slowly. They may not cause any symptoms. In this case, they do not need treatment. [winchesterhospital.org]

[…] but may be seen incidentally CT may be useful for fully characterising the extent of substernal (retrosternal) goitre an enlarged and heterogeneous thyroid gland suggests the diagnosis, which is confirmed by ultrasound or scintigraphy Treatment and prognosis [radiopaedia.org]

Follicular cancer occurs in an older age group (40–60 years), arises as a single tumour, metastasises by the bloodstream, and has a worse prognosis than papillary cancer, with 10 year survival rates around 75%. [surgwiki.com]

Support Groups: Expectations (prognosis): A goiter is a benign (harmless) process. A simple goiter may disappear on its own, or may become large. [uclahealth.org]

Abstract: Iodine deficiency is the most important etiological factor for euthyroid endemic goiter. However, family and twin pair studies also indicate a genetic predisposition for euthyroid simple goiter. [edoc.mdc-berlin.de]

Besides iodine deficiency as the most important etiological factor (2), environmental factors, age, and sex, a genetic predisposition for goiter development could also be observed. [academic.oup.com]

Pathophysiology The histopathology varies with the etiology and duration of the goiter. [ocw.tufts.edu]

Etiology Multinodular goiter (MNG) loci have been identified on chromosome 14q and on chromosome Xp22 and 3q26. Germline mutations in DICER1 (chromosome 14q31) have been found in familial MNG-1, with and without ovarian Sertoli-Leydig cell tumors. [unboundmedicine.com]

[…] atrophy type 4 Pseudohypoaldosteronism type 2E Synonym(s): - FMNG - Familial MNG Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare oncologic disease Classification (ICD10): - Endocrine, nutritional and metabolic diseases - Epidemiological [csbg.cnb.csic.es]

Epidemiology The most common cause of pediatric goiter in the United States is chronic lymphocytic thyroiditis. The prevalence of goiter in the United States is 3–7%, although the incidence is much higher in regions of iodine deficiency. [unboundmedicine.com]

Epidemiologically ascertained risk factors are ionizing radiation, the presence of thyroid adenoma, multinodular goiter (MNG) and family history of thyroid cancer, and personal history of goiter or thyroid nodule. [iasj.net]

Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg. 2006;135(3):451-457. Bonora E, Tallini G, Romeo G. Genetic predisposition to familial nonmedullary thyroid cancer J Oncol. 2010;2010:385206. [journals.sfu.ca]

EPIDEMIOLOGY A Japanese study showed that patients on treatment for hyperthyroid Graves’ disease are almost twice as likely to develop type 2 diabetes than members of the general population, are less likely to have been overweight, and are less likely [diapedia.org]

Pathophysiology The histopathology varies with the etiology and duration of the goiter. [ocw.tufts.edu]

Role of emotional stress in the pathophysiology of Graves' disease”. 《Eur. J. Endocrinol.》 168 (1): R13–18. doi:10.1530/EJE-12-0539. PMID 23027804. Stathopoulos, P.; Gangidi, S.; Kotrotsos, G.; Cunliffe, D. [ko.wikipedia.org]

[Review] Endocrine. 2020 Apr 17 [Online ahead of print]Führer DE Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. [unboundmedicine.com]

Etiology and pathophysiology Thyroid hormones affect the function of virtually all organ systems of the body; these are critical determinants of brain and somatic development in infants and of metabolic activity in adults. [intechopen.com]

This thoroughly updated edition includes an introduction to risk assessment and screening and results of recent clinical trials and their implications for treatment and prevention. [books.google.com]

Prevention: The use of iodized table salt prevents endemic goiter. [uclahealth.org]

The use of iodized salt in the United States prevents a lack of iodine in the diet. [medlineplus.gov]

The efficacy of levothyroxine suppressive therapy in preventing recurrence of goiter growth after partial thyroidectomy is less clear. [touchendocrinology.com]

Management Iodine supplementation is perhaps the simplest and cheapest of all remedies and it prevents a condition that has devastating consequences; it is sobering that iodine deficiency still persists. [enetmd.com]