Symptoma

Normokalemic Periodic Paralysis

NormoKPP

METHODS: A thorough clinical, electrophysiologic, and molecular study was performed of four unrelated families who presented with periodic paralysis. [ncbi.nlm.nih.gov]

Treatment of TPP is not well established and must be individualized to each presentation. [westjem.com]

Conclusion: Periodic paralysis can present with initial symptoms of thyrotoxicosis associated with normokalemia. [endocrine-abstracts.org]

Two pitfalls are present for the student, however. First, the abnormalities are superimposed on a changing, developing brain, not a rather static, mature organ. [books.google.com]

Acronym NKPP Synonyms Periodic paralysis eukalemic Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. [uniprot.org]

  • Multiple Organ Dysfunction Syndrome

    organ dysfunction syndrome, and much more. [books.google.com]

  • Camping

    الصفحة 362 - Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases [books.google.com]

  • Excessive Daytime Sleepiness

    An individual with sporadic hyperPP and excessive daytime sleepiness with multiple sleep-onset REM periods has been reported. Symptoms were improved by a diuretic that decreased serum potassium concentration [ Iranzo & Santamaria 1999 ]. [ncbi.nlm.nih.gov]

  • Eating Frequently

    frequent meals rich in carbohydrates and low in potassium and by avoiding fasting, strenuous activity, and exposure to cold. [6] Symptoms of individuals who are normokalemic during attacks may be improved by exercising. [9] Last updated: 9/12/2012 If [rarediseases.info.nih.gov]

  • Salt Craving

    craving * Intense thirst * Stomach pains * Hypotonia * Hypoactive tendon reflexes Causes - Normokalemic periodic paralysis 1. [checkorphan.org]

  • Increased Appetite

    She also presented to weight loss, increased appetite, and heat intolerance for the last 2 months. She denied any previous disease history or medication. In physical examination, her thyroid gland was minimal enlarged diffusely and non tender. [endocrine-abstracts.org]

  • Loss of Appetite

    She also presented to weight loss, increased appetite, and heat intolerance for the last 2 months. She denied any previous disease history or medication. In physical examination, her thyroid gland was minimal enlarged diffusely and non tender. [endocrine-abstracts.org]

  • Failure to Thrive

    Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy. [ncbi.nlm.nih.gov]

  • Metallic Taste

    Diamox (It made me sick and left a metallic taste in my mouth) "I mix up high THC and high CBD strains. At the moment I only smoke Cannabis since it's hard to get high quantities for an affordable price here to make oil, without getting arrested. [cannabisoilsuccessstories.com]

  • Masseter Spasm

    Prevention of secondary complications: During surgery, avoid use of depolarizing anesthetic agents (including potassium, suxamethonium, and anticholinesterases) that aggravate myotonia and can result in masseter spasm and stiffness of respiratory and [ncbi.nlm.nih.gov]

  • Heart Block

    Complete heart block during potassium therapy in thyrotoxic periodic paralysis. J Emerg Med. 2013;44(1):61-4. 7. Kung AWC. Thyrotoxic periodic paralysis: a diagnostic challenge. J Clin Endocrinol Metabol. 2006;91(7):2490-5. 8. Lin SH, Lin YF. [westjem.com]

  • Uremia

    Muscle 801 447 813 Disorders of Muscle Membranes The Periodic 817 360 828 The Anatomical Basis for Cardiac Rhythm 831 Summary 871 Malabsorption Syndromes 901 510 906 Mechanisms of Calcium Absorption 919 365 937 511 940 CHAPTER 44 Cystic Fibrosis 941 Uremia [books.google.com]

  • Involuntary Movements

    movements and generalized epilepsy associated with two novel mutations in SCN4A gene. ( 25193600 ) Cao L....Hong D. 2014 6 Enhanced slow inactivation of the human skeletal muscle sodium channel causing normokalemic periodic paralysis. ( 24682880 ) Wu [malacards.org]

    Sensory system was intact with no involuntary movements. Other systems were normal. [casereports.in]

  • Cerebellar Sign

    Neurological assessment demonstrated intact cranial nerves, absence of cerebellar signs, and preserved upper extremity motor and sensory exams. [westjem.com]

  • Limb Weakness

    Hyperkalemic periodic paralysis (hyperPP) is characterized by attacks of flaccid limb weakness (which may also include weakness of the muscles of the eyes, throat, and trunk), hyperkalemia (serum potassium concentration 5 mmol/L) or an increase of serum [ncbi.nlm.nih.gov]

Clinical Testing and Workup Because potassium levels may be reduced during an episode of periodic paralysis, a blood test to determine the serum potassium levels during an episode can be helpful in diagnosing the disorder in some cases. [rarediseases.org]

Prophylactic treatment with thiazide diuretics is highly effective in preventing attacks in hyperKPP. However, the efficacy and safety of such diuretics in normoKPP remain unclear. [ncbi.nlm.nih.gov]

CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. [diseaseinfosearch.org]

The treatment of TTP is not well defined. Traditionally, potassium repletion has been the mainstay of treatment. [westjem.com]

Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. [books.google.com]

Treatment for periodic paralysis. Cochrane Database Syst Rev. January 2008; 23(1): S. L. Venance et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006; 129:8-17. [rarediseases.info.nih.gov]

Prognosis - Normokalemic periodic paralysis Not supplied. Treatment - Normokalemic periodic paralysis Not supplied. Resources - Normokalemic periodic paralysis Not supplied. [checkorphan.org]

Family history Timing Intensity History of administration of certain drugs Clinical examination Differential Diagnosis Laboratory investigations Serum K CPK and serum myoglobin ECG EMG Nerve conduction studies Provocative Testing Muscle biopsy Treatment Prognosis [slideshare.net]

Severe prognosis in a large family with hypokalemic periodic paralysis. Muscle Nerve. 2003;27:165–9. 13. Mutation analysis of two patients with hypokalemic periodic paralysis and suspected malignant hyperthermia. Muscle Nerve. 2004;30:114–7. [revistas.fucsalud.edu.co]

Parents should talk to their children’s physician and medical team about their specific case, associated symptoms and overall prognosis. [rarediseases.org]

Prognosis Most patients learn to prevent their attacks well enough that no significant deterioration in the quality of life occurs. Strenuous exercise must be avoided, however. Attacks often lessen in severity and frequency during middle age. [medical-dictionary.thefreedictionary.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Evaluation of the etiology of the thyrotoxic state should also be undertaken with treatments targeting the underlying cause. Graves’ disease remains the most common precipitating cause, as was seen in our patient. [westjem.com]

Thyroid disease may present first with neurological complications or else may occur concurrently in patients suffering other neurological disorders, particularly those with an autoimmune etiology. [scinapse.io]

(including hypokalemic periodic paralysis and thyrotoxic periodic paralysis, and other “Channelopathies” or “Membranopathies) Pathophysiology Epidemiology Primary or familial periodic paralysis Secondary periodic paralysis Conventional classification [slideshare.net]

Twenty patients with periodic paralysis were evaluated and the aspects studied included epidemiological data, clinical manifestations, ancillary tests, treatment and evolution. [scielo.br]

[…] impact childhood development Monday, 28 January 2019 0 comments 4 Gene mutations in paediatric epilepsies cause NMDA‐pathy, and phasic and tonic GABA‐pathy Friday, 25 January 2019 0 comments 2 Subacute sclerosing panencephalitis: clinical phenotype, epidemiology [icnapedia.org]

The pathophysiology of neurological disorders in childhood is based on the same principles of the organization, structure, and function of the nervous sys tem as apply to adults. Two pitfalls are present for the student, however. [books.google.com]

The presentation is most commonly seen in Asian men and is usually associated with hypokalemia, which is believed to play a role in the underlying pathophysiology. The diagnosis is usually not made in the emergency department (ED). [westjem.com]

(including hypokalemic periodic paralysis and thyrotoxic periodic paralysis, and other “Channelopathies” or “Membranopathies) Pathophysiology Epidemiology Primary or familial periodic paralysis Secondary periodic paralysis Conventional classification [slideshare.net]

Br J Anaesth 1980; 52: 153–64Ellis, FR Miller J, Katz RL: Muscle diseases, Anesthesia and Uncommon Disease: Pathophysiologic and Clinical Correlations, 2nd edition. Edited by Katz J, Benumof J, Kadis LB. [anesthesiology.pubs.asahq.org]

Prophylactic treatment with thiazide diuretics is highly effective in preventing attacks in hyperKPP. However, the efficacy and safety of such diuretics in normoKPP remain unclear. [ncbi.nlm.nih.gov]

[…] kidneys or GI tract or due to accidental ingestion of absorbable barium salts that block K channels, reducing the egress of K from the muscles, evoking systemic hypokalemia or hyperkalemia, which may be associated with renal or adrenal insufficiency Prevention [checkorphan.org]

The goals of treatment are to relieve acute symptoms and prevent further attacks. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI. [diseaseinfosearch.org]

[…] subunit of a sodium channel in muscle cell membranes, closely linked to the growth hormone gene GH1 Clinical Early onset, most intense in males in whom paralytic attacks follow strenuous exercise, affecting the legs and eyelids; hyperkalemia may be prevented [medical-dictionary.thefreedictionary.com]