Presentation
We present a case of AIP exacerbated by nortriptyline. [ncbi.nlm.nih.gov]
Entire Body System
- Unconsciousness
[…] pain or tightness clumsiness cold, clammy skin confusion decreased awareness or responsiveness decreased urine output dilated neck veins extreme tiredness or weakness fainting fast, slow, or irregular heartbeat fast, weak pulse increased or excessive unconscious [mayoclinic.org]
Skin
- Papule
CASE REPORT: The patient presented with photosensitivity and erythematous, well-defined, oval papules and patches, with fine collarettes of scale on the dorsal hands, upper arms, and trunk. [ncbi.nlm.nih.gov]
Neurologic
- Dysautonomia
International Nortriptyline In the US, Nortriptyline (nortriptyline systemic) is a member of the drug class tricyclic antidepressants and is used to treat Burning Mouth Syndrome, Cyclic Vomiting Syndrome, Depression, Diabetic Peripheral Neuropathy, Dysautonomia [drugs.com]
- Dysarthria
As for the safety profiles, the nortriptyline group scored a significantly higher incidence of adverse events such as dysarthria or orthostatic dizziness, as well as increased heart rate. [ncbi.nlm.nih.gov]
Treatment
The period of treatment was two months and the frequency and intensity of headache attacks of the 30 days pre-treatment period were compared with the frequency of headaches in the treatment period. [ncbi.nlm.nih.gov]
Prognosis
The findings of this study by Sackeim et al are hence more applicable to patients with a poor prognosis, such as those who are severely ill or medication resistant, for whom ECT may have been prescribed as a (relatively) last resort. [ebmh.bmj.com]
In addition, smoking cessation can reduce symptoms of cough and sputum production, decrease airway reactivity, and improve long-term prognosis. [aafp.org]
The use of CNS depressants may worsen the prognosis. The administration of barbiturates for control of convulsions alleviates an increase in the cardiac work load but should be undertaken with caution to avoid potentiation of respiratory depression. [healthyplace.com]
Smoking cessation has also been shown to reduce the rate of decline in forced expiratory volume in 1 second in smokers with COPD. 1 - 6 Furthermore, it improves the long-term prognosis 7 and reduces the symptoms of cough and sputum production 8 and airways [doi.org]
Lymphatic microvessel density in epithelial ovarian cancer: its impact on prognosis. [harekrishnaforex.com]
Etiology
Year introduced: 1968(1965) PubMed search builder options Subheadings: administration and dosage adverse effects analogs and derivatives analysis antagonists and inhibitors blood cerebrospinal fluid chemical synthesis chemistry economics etiology immunology [ncbi.nlm.nih.gov]
Epidemiology
Design, Epidemiologic Research The form and structure of analytic studies in epidemiologic and clinical research. Design, Epidemiological Research The form and structure of analytic studies in epidemiologic and clinical research. [healthdictionary.info]
Care, Antonius Deusinglaan 1, 9713AV, Groningen, The Netherlands. [email protected] 2 Groningen Institute of Pharmacy, University of Groningen, Unit of Pharmacoepidemiology & Pharmacoeconomics, Groningen, The Netherlands. [email protected] 3 Department of Epidemiology [ncbi.nlm.nih.gov]
Epidemiology 2011; 22 6:836-844. [Context Link] 3. Peeters W, van den Brande R, Polinder S, Brazinova A, Steyerberg EW, Lingsma HF, et al. Epidemiology of traumatic brain injury in Europe. Acta Neurochir (Wien) 2015; 157 10:1683-1696. [nursingcenter.com]
Breslau NKilbey MMAndreski P Nicotine withdrawal symptoms and psychiatric disorders: findings from an epidemiologic study of young adults. Am J Psychiatry. 1992;149464- 469 Google Scholar 5. Hurt RDSachs DPLGlover ED et al. [dx.doi.org]
Discussion We provide proof-of-concept from basic, clinical, and epidemiologic studies that blockage of the cardiac sodium channel by therapeutic dosages of a non-cardiac drug (nortriptyline) may be critical and cause life-threatening arrhythmias. [doi.org]
Pathophysiology
The pathophysiology of TTS, a variant of myocardial stunning, is still incompletely understood but could be related to sympathetic overstimulation. The possibility of TTS following toxic exposure is discussed. [ncbi.nlm.nih.gov]
For Suggests clinical disorders or settings where the test may be helpful Monitoring serum concentration during therapy Evaluating potential toxicity The test may also be useful to evaluate patient compliance Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]
"Depression and sleep: pathophysiology and treatment". Dialogues in Clinical Neuroscience. 8 (2): 217-26. PMC 3181772. PMID 16889107. ^ a b Kennedy SH (Mar 1997). [popflock.com]
Prevention
Abstract Few trials have evaluated combination of two or more drugs in the preventive treatment of migraine. [ncbi.nlm.nih.gov]
Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial. [ebmh.bmj.com]