Presentation
Apart from pruritus, patients may present with a burning or cold sensation, tingling, surface numbness, tenderness and foreign body sensation. Additionally, patients often present with hyperpigmented skin at the site of symptoms. [pubmed.ncbi.nlm.nih.gov]
Entire Body System
- Pain
Eur J Pain. 2016;20(1):24–31. Publ. en ligne du 28 sept. 2015. [PubMed] [Google Scholar] 49. Van Laarhoven AI, van der Sman-Mauriks IM, Donders AR, Pronk MC, van de Kerkhof PC, Evers AW. [ncbi.nlm.nih.gov]
Pain Pract. 2016;16(5):E90–1. 10.1111/papr.12436 - DOI - PubMed Alcántara F, Feito M, Albizuri F, Beato M, De Lucas R. Notalgia paresthetica and multiple endocrine neoplasia syndrome 2a: a case report. [pubmed.ncbi.nlm.nih.gov]
- Amyloidosis
The differential diagnosis includes post-infiammatory pigmentation, neurodermatitis, fixed drug eruption and macular amyloidosis. [cab.unime.it]
Skin
- Pruritus
A diagnostic approach to pruritus. Am Fam Physician. 2011;84(2):195–202. [PubMed] [Google Scholar] 7. Greco PJ, Ende J. Pruritus : a practical approach. J Gen Intern Med. 1992;7(3):340–9. [PubMed] [Google Scholar] 8. [ncbi.nlm.nih.gov]
Keywords: Hyperesthesia; Notalgia; Paresthesia; Pruritus. [pubmed.ncbi.nlm.nih.gov]
Topical treatment with capsaicin improved pruritus and paresthetic sensations. Notalgia parestesica. [iris.unimore.it]
Massey Medicine Neurology 1978 Notalgia paresthetica affects the posterior rami of several spinal nerves (arising from thoracic segments T2 to T6), causing pruritus, burning, and dysesthesias, and examination reveals hypesthesia. [semanticscholar.org]
- Hyperpigmentation
Fig. 2 Bilateral hyperpigmentation in a 59-year-old patient with notalgia paresthetica. Similar articles General features and treatment of notalgia paresthetica. Pérez-Pérez LC. Pérez-Pérez LC. Skinmed. 2011 Nov-Dec;9(6):353-8; quiz 359. [pubmed.ncbi.nlm.nih.gov]
Neurologic
- Dysesthesia
Massey Medicine Neurology 1978 Notalgia paresthetica affects the posterior rami of several spinal nerves (arising from thoracic segments T2 to T6), causing pruritus, burning, and dysesthesias, and examination reveals hypesthesia. [semanticscholar.org]
- Hypesthesia
Massey Medicine Neurology 1978 Notalgia paresthetica affects the posterior rami of several spinal nerves (arising from thoracic segments T2 to T6), causing pruritus, burning, and dysesthesias, and examination reveals hypesthesia. [semanticscholar.org]
Treatment
To date, no well-defined treatment has been found, although many treatment modalities have been reported with varying success, usually providing only temporary relief. Keywords: Hyperesthesia; Notalgia; Paresthesia; Pruritus. [pubmed.ncbi.nlm.nih.gov]
Low-dose doxepin for treatment of pruritus in patients on hemodialysis. Iran J Kidney Dis. 2007;1(1):34–7. [PubMed] [Google Scholar] 42. Matsuda KM, Sharma D, Schonfeld AR, Kwatra SG. Gabapentin and pregabalin for the treatment of chronic pruritus. [ncbi.nlm.nih.gov]
Topical treatment with capsaicin improved pruritus and paresthetic sensations. Notalgia parestesica. [iris.unimore.it]
Etiology
Massey Medicine, Psychology Seminars in neurology 1998 The clinical features, etiologies, laboratory findings, and management of the common sensory mononeuropathies including meralgia paresthetica, cheiralgia parestchetica, notalgia parerhetica, gonyalgia [semanticscholar.org]
The etiology of this condition is still poorly understood, although a number of hypotheses have been described. [pubmed.ncbi.nlm.nih.gov]
Pruritic dermatoses : overview of etiology and therapy. Am J Med. 2002;113(Suppl 9A):25S–33S. [PubMed] [Google Scholar] 27. Lavery MJ, Stull C, Kinney MO, Yosipovitch G. Nocturnal pruritus: the battle for a peaceful night’s sleep. [ncbi.nlm.nih.gov]
Pathophysiology
Pathophysiology and clinical aspects of pruritus. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine. 8 édition. New York, NY: McGraw-Hill; 2012. pp. 1146–57. [ncbi.nlm.nih.gov]
Prevention
Atopic eczema prevention programs—a new therapeutic concept for secondary prevention. Dermatol Psychosom. 2000;1:138–47. [Google Scholar] 11. Staab D, Von Rueden U, Kehrt R, Erhart M, Wenninger K, Kamtsiuris P, et al. [ncbi.nlm.nih.gov]