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Novobiocin

Crystallinic Acid


Presentation

  • These studies confirmed that the functionality present at the 3-position of the isoflavone plays a critical role in determining Hsp90 inhibition and suggests that the bicyclic ring system present in both novobiocin and derrubone do not share similar modes[ncbi.nlm.nih.gov]
  • Rationale for the preparation of des-noviose novobiocin analogs in addition to their synthesis and biological evaluation are presented herein. Copyright  2011 Elsevier Ltd. All rights reserved.[ncbi.nlm.nih.gov]
  • Abstract In this paper we present a new HPLC method for the determination of novobiocin in human serum.[ncbi.nlm.nih.gov]
  • Abstract We present a rapid and simple method for detecting novobiocin in biologic samples using a methanol-based extraction of the tissue matrix and liquid chromatography with electrospray tandem mass spectrometry (LC-ESI-MS/MS) on positive mode.[ncbi.nlm.nih.gov]
  • The present study explored, whether novobiocin elicits eryptosis.[ncbi.nlm.nih.gov]
Chills
  • For transformation, 10 to 50 μg of plasmid pAM1 was converted to the single-stranded form by incubation at 100 C for 10 min followed by rapid chilling on ice.[doi.org]
Sputum
  • ., nares, rectum, and sputum) were associated with a success rate of 34 of 48 (71%) subjects (P 0.02). Foreign bodies in wounds did not prevent the eradication of MRSA by either regimen.[doi.org]
Nausea
  • Nine patients (35%) failed to tolerate oral antibiotics because of severe nausea and vomiting; 17 patients (65%) were crossed over and considered evaluable.[ncbi.nlm.nih.gov]
  • Nausea, which was a limiting toxicity in other trials of novobiocin, was well controlled with the use of serotonergic antiemetics. Diarrhea was common but mild in most patients.[ncbi.nlm.nih.gov]
  • Nausea Vomiting Diarrhea Anorexia Abdominal distress Jaundice Elevated serum bilirubin Novobiocin may also cause side-effects not listed here. If you notice other side-effects not listed above, contact your doctor for medical advice.[tabletwise.com]
Nausea
  • Nine patients (35%) failed to tolerate oral antibiotics because of severe nausea and vomiting; 17 patients (65%) were crossed over and considered evaluable.[ncbi.nlm.nih.gov]
  • Nausea, which was a limiting toxicity in other trials of novobiocin, was well controlled with the use of serotonergic antiemetics. Diarrhea was common but mild in most patients.[ncbi.nlm.nih.gov]
  • Nausea Vomiting Diarrhea Anorexia Abdominal distress Jaundice Elevated serum bilirubin Novobiocin may also cause side-effects not listed here. If you notice other side-effects not listed above, contact your doctor for medical advice.[tabletwise.com]

Workup

Trypanosoma Cruzi
  • Abstract Inhibitors of the enzyme bacterial topoisomerase II (DNA gyrase) were evaluated for activity against Trypanosoma cruzi (Brazil strain), based on the theoretical need for a topoisomerase II in the replication of the kinetoplast DNA network.[ncbi.nlm.nih.gov]
Salmonella Typhi
  • However, NBG, hektoen enteric, and salmonella-shigella agars failed to differentiate Salmonella typhi from a fecal specimen even after enrichment in selenite F.[ncbi.nlm.nih.gov]

Treatment

  • In six of the seven patients, one or both compounds effected somewhat greater improvement than in the control within 3 weeks of treatment.[ncbi.nlm.nih.gov]
  • A differential response in Topo II activity was also observed after treatment with PMA.[ncbi.nlm.nih.gov]
  • […] per day for 4 days), and novobiocin (4 g/day orally for 7 days) (treatment 2) and autologous marrow support.[ncbi.nlm.nih.gov]
  • […] when compared with that due to treatment with 1.0 micrograms ml-1 aphidicolin alone, while that for 150 micrograms ml-1 novobiocin 1.0 micrograms ml-1 aphidicolin was slightly increased.[ncbi.nlm.nih.gov]
  • Treatment of cell lines with NB disrupts Bcr-Abl /Hsp90 and Bcr-Abl /Hsp70 interactions, resulting in a decreased amount of intracellular Bcr-Abl protein levels.[ncbi.nlm.nih.gov]

Epidemiology

  • Resistance Database gratefully acknowledges recent funding from the Genome Canada & Canadian Institutes of Health Research's Bioinformatics & Computational Biology program, allowing integration of the Antibiotic Resistance Ontology (ARO) with the Genomic Epidemiology[card.mcmaster.ca]
  • Gaynes, Effect of Nurse Staffing and Antimicrobial-Impregnated Central Venous Catheters on the Risk for Bloodstream Infections in Intensive Care Units, Infection Control & Hospital Epidemiology, 10.1086/502160, 24, 12, (916-925), (2015). A.R.[doi.org]
Sex distribution
Age distribution

Prevention

  • Part I: Prevention of Catheter-Related Bloodstream Infections, Journal of Chemotherapy, 10.1179/joc.2003.15.5.419, 15, 5, (419-427), (2013). J.[doi.org]
  • Foreign bodies in wounds did not prevent the eradication of MRSA by either regimen.[doi.org]
  • We found that novobiocin prevents TNF-alpha production by inhibiting translation of the TNF-alpha mRNA.[ncbi.nlm.nih.gov]
  • The aim of this study was to determine the efficacy of novobiocin and rifampin as oral antibiotic prophylaxis for the prevention of catheter-related infection in melanoma patients treated with interleukin-2 (IL-2) plus interferon-alpha and chemotherapy[ncbi.nlm.nih.gov]
  • These results suggest that butyrate and teleocidin induce cell differentiation via distinct signaling pathway and that novobiocin and butyrate can be used as subsidiary drugs in preventing the growth of hepatoma.[ncbi.nlm.nih.gov]

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