ARF presenting with hyperkalemia, hyperuricemia and hyperphosphatemia should lead to further work up for occult haematological malignancy. We describe two cases of lymphoma presenting with ARF secondary to spontaneous TLS. [ncbi.nlm.nih.gov]

Xanthogranulomatous pyelonephritis (XGP) can present with weight loss, anemia, leukemoid reaction, and generalized debility; there may be no signs or symptoms referable to the urinary tract. [scholars.northwestern.edu]

• Weight Loss

  Xanthogranulomatous pyelonephritis (XGP) can present with weight loss, anemia, leukemoid reaction, and generalized debility; there may be no signs or symptoms referable to the urinary tract. [scholars.northwestern.edu]

  Abstract Xanthogranulomatous pyelonephritis (XGP) can present with weight loss, anemia, leukemoid reaction, and generalized debility; there may be no signs or symptoms referable to the urinary tract. [ncbi.nlm.nih.gov]

  Patients with cancer of unknown primary site demonstrate common characteristics and present with general complaints such as anorexia, weight loss, etc. Multiple sites of involvement are shown in more than 50% of patients with occult primary tumors. [aboutcancer.com]

  A 38-year-old, previously healthy, male smoker of 10 pack-years who has never used anorectics complained of a 3-months history of a flu-like syndrome with dyspnoea, dry cough, fever and unintentional weight loss. [openres.ersjournals.com]

• Anemia

  Xanthogranulomatous pyelonephritis (XGP) can present with weight loss, anemia, leukemoid reaction, and generalized debility; there may be no signs or symptoms referable to the urinary tract. [scholars.northwestern.edu]

  Abstract Xanthogranulomatous pyelonephritis (XGP) can present with weight loss, anemia, leukemoid reaction, and generalized debility; there may be no signs or symptoms referable to the urinary tract. [ncbi.nlm.nih.gov]

  Philadelphia: Saunders Elsevier [ CR ] [ PM ] [ EČ ][ GS ] Loughlin, K.R., Gittes, R.F., Partridge, D., Stelos, P. (1987) The relationship of lactoferrin to the anemia of renal cell carcinoma. [scindeks.ceon.rs]

• Fatigue

  Cella D, Kallich J, McDermott A, Xu X: The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol 2004;15:979. [karger.com]

  Adenocarcinoma metastatic to unspecified site Cancer Cancer in childbirth Cancer in pregnancy Cancer metastatic to bone Cancer metastatic to ovary Cancer metastatic to parotid gland Cancer metastatic to vagina Cancer of unknown primary Cancer related fatigue [icd10data.com]

  […] patients with newly diagnosed cancer are found to have cancer without an identifiable primary site, despite exhaustive tests.[1] Presentation Most patients present with advanced-stage cancers and therefore usually have symptoms of malaise, weakness, fatigue [patient.info]

  Unexplained shortness of  Pain or tenderness -the pain is breath usually in 1 leg and may only  Chest pain and/or palpitations be present when standing or walking  Anxiety and/or sweating  Warm skin  Coughing/coughing up blood  Red or discolored skin  Fatigue [slideshare.net]

  Throughout the whole period he felt increasing fatigue and had an episode of fainting. Just four days before the current symptoms started he had arrived from a vacation in Ecuador, during which his right upper limb had become swollen, red and hot. [scielo.mec.pt]

• Malaise

  Case report A 33-year-old patient presented with a six months history of dyspnoea, general malaise, weight loss, ascites and ankle oedema. Chest X-ray demonstrated bilateral pleural effusions. [academic.oup.com]

  Wales about 4% of patients with newly diagnosed cancer are found to have cancer without an identifiable primary site, despite exhaustive tests.[1] Presentation Most patients present with advanced-stage cancers and therefore usually have symptoms of malaise [patient.info]

• Parotid Mass

  MATERIALS AND METHODS: A case series of 4 patients with occult parotid malignancies presenting with acute-onset unilateral facial paralysis is reported. RESULTS: Initial imaging on all 4 patients did not demonstrate a parotid mass. [ncbi.nlm.nih.gov]

• Hepatomegaly

  Chest examination revealed scattered crackles over bases and a firm hepatomegaly 4 cm below coastal margin. Investigations revealed normal CBC. The ESR was further elevated to 71 mm in the first hour. [consultant360.com]

• Musculoskeletal Pain

  METHODS: Bone scans of 491 patients with new or recurrent complaints of musculoskeletal pain and no previously known malignancy were retrospectively reviewed. [ncbi.nlm.nih.gov]

• Right Shoulder Pain

  During that time her right shoulder pain spontaneously resolved. However she then developed new onset right wrist pain, swelling, and erythema. X-ray revealed moderate degenerative changes. [hindawi.com]

• Urticaria

  […] oral SSC, lung, kidney Chest breast, lung, mela- noma Extremities melanoma, breast, lung, renal, intestinal Umbilicus (Sister Mary Joseph's nodule) stomach, colon, ovary, kidney, breast Back lung 12. pruritus petechiae, ecchymoses pallor ichthyosis urticaria [slideshare.net]

• Oscillopsia

  We report a case of primary position downbeating nystagmus due to an occult breast carcinoma in a 57-year-old woman with progressive oscillopsia and truncal ataxia. Acute nausea and vomiting precipitated hospitalization. [ncbi.nlm.nih.gov]

• Downbeat Nystagmus

  Primary position downbeating nystagmus is an uncommon manifestation of an occult malignancy. [ncbi.nlm.nih.gov]

• Truncal Ataxia

  We report a case of primary position downbeating nystagmus due to an occult breast carcinoma in a 57-year-old woman with progressive oscillopsia and truncal ataxia. Acute nausea and vomiting precipitated hospitalization. [ncbi.nlm.nih.gov]

Workup of the first patient found an apical paravertebral mass in the lung; biopsy revealed recurrent breast carcinoma. In the second case, workup found an axillary mass contiguous with the lower brachial plexus. [ncbi.nlm.nih.gov]

Any abnormalities uncovered on this initial workup should be aggressively investigated. [the-hospitalist.org]

This study highlights that thorough history, examination and basic screening investigations (including PSA) should be mandatory for all patients following unprovoked PE – yet for a significant proportion of patients this basic workup may be incomplete [thorax.bmj.com]

• Mural Thrombus

  Initial presentation of a malignant disease as recurrent attacks of lower limb ischaemia due to emboli from a mural thrombus in the descending thoracic aorta is extremely rare. A diagnosis of malignancy may thus easily be overlooked. [ncbi.nlm.nih.gov]

[…] disease, no treatment 45 Pancreatic 52M Proximal DVT Yes CA125 2832 17 No formal staging, metastatic disease, no treatment 19 Pancreatic 57M PE Yes CA125 583, CEA 96 20 No formal staging, metastatic disease, no treatment 65 Lung 85F PE Yes Not done 85 [ashpublications.org]

The pathology, bacteriology, diagnosis, and treatment are reviewed. [scholars.northwestern.edu]

Conclusions: Although CUP patients as a whole have a poor prognosis compared to other metastatic patients of known primary, distinct subsets of CUP patients have similar prognosis. [ascopubs.org]

They have a wide variety of clinical presentations and a poor prognosis in most patients. Patients with occult primary tumors often present with general complaints, such as anorexia and weight loss. [ncbi.nlm.nih.gov]

Occult cancer, unknown primary A malignancy of unknown 1º site or origin that is symptomless, which first manifests itself as metastases or secondary–paraneoplastic phenomena, and usually has a poor prognosis; OPMs are problematic as appropriate therapy [medical-dictionary.thefreedictionary.com]

Accurate prospect of the prognosis could be the strong support for choosing postoperative therapy. [diagnosticpathology.biomedcentral.com]

Harrison St., Suite 855, Chicago, IL 60612, United States. [email protected] Abstract Paraneoplastic syndromes and infection are known causes of autoimmunity, but the etiology of most autoimmune syndromes remains unknown. [ncbi.nlm.nih.gov]

References 1 The etiologic spectrum of constrictive pericarditis, Am Heart J, 1987, vol. 113 (pg. 354 - 360 ) 2 Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy, J Am Coll Cardiol, 2004, vol. 43 (pg. 1445 - 1452 ) [academic.oup.com]

Virchow developed the eponymous triad describing the underlying etiology—hypercoagulability, venous stasis, and endothelial damage [1-3]. [clinicalcorrelations.org]

Cestari DM, Weine DM, Panageas KS, Segal AZ, DeAngelis LM: Stroke in patients with cancer: incidence and etiology. Neurology 2004;62:2025. [karger.com]

Certain clinical, laboratory, and radiological features could help physicians determine stroke etiology early. [journals.plos.org]

Department of Clinical Epidemiology is, however, involved in studies with funding from various companies as research grants to (and administered by) Aarhus University. [nature.com]

Objective/s This review summarises the current knowledge regarding the epidemiology, diagnosis, treatment and care of CUP. Discussion The incidence and mortality rates of CUP are declining in Australia. [racgp.org.au]

New England journal of medicine, 353(23): 2477-90 [ PM ] [ EČ ][ 1 ][ GS ] Collins, S., McKiernan, J., Landman, J. (2006) Update on the epidemiology and biology of renal cortical neoplasms. [scindeks.ceon.rs]

Int Angiol. 25:101–161. 2006. 3 Heit JA: The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol. 28:370–372. 2008. [spandidos-publications.com]

Mechanisms of Clinical Signs is the first consolidated text of its kind; designed to help medical students and junior doctors understand the pathophysiological mechanisms behind clinical signs. [books.google.com]

Pathophysiology of Thrombosis: Poster III| December 3, 2015 Ruochen Li, BA (Hons), MB BChir Ruochen Li, BA (Hons), MB BChir * 1 King's College Hospital NHS Foundation Trust, London, United Kingdom Search for other works by this author on:, Cara Doyle, [ashpublications.org]

Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine. 1977;56:1-37. [ Links ] 15. Varki A. [scielo.mec.pt]

Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation. Thromb Haemost. 2015;113(6):1176-1183. https://www.ncbi.nlm.nih.gov/pubmed/25472800 Stanifer JW. [clinicalcorrelations.org]

Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore). 1977;56(1):1-37. [the-hospitalist.org]

The definite preventative treatment for these cases is early, risk-reducing, bilateral salpingo-oophorectomy (BSO). [ncbi.nlm.nih.gov]

Flack discusses her manuscript "Major Gastrointestinal Bleeding Often Is Caused by Occult Malignancy in Patients Receiving Warfarin or Dabigatran to Prevent Stroke and Systemic Embolism From Atrial Fibrillation" To view manuscript click here http://bit.ly [youtube.com]

The filter is filled with stranded tumor cells, which prevents the hemorrhagic metastasis of malignant cells. [spandidos-publications.com]

Causes, Risk Factors, and Prevention Learn about the possible risk factors for cancer of unknown primary. [cancer.org]