Oculodentodigital dysplasia (ODD dysplasia) syndrome may be inherited in an autosomal dominant or autosomal recessive manner. The typical clinical findings in this syndrome depend on the type of inheritance, with multiple organ systems being afflicted, namely the head, eyes, mouth cavity, skin, skeletal, and nervous system .
Patients with the autosomal dominant form of ODD dysplasia are usually born with microphthalmia with or without microcephaly. The other common ocular findings include glaucoma, strabismus, iris atrophy, micro cornea, epicanthic folds, a narrow palpebral fissure and atrophy of the eye  .
The dental problems occurring in patients with ODD dysplasia include small teeth predisposed to caries due to insufficient enamel. Irregular teeth, missing teeth, and early tooth loss are the other findings.
A slender nose with narrow and/or underdeveloped nostrils is another typical finding. Cleft lip or palate may also be observed.
A major sign of ODD dysplasia syndrome is the syndactyly between the fourth and the fifth fingers and/or the fourth and the fifth toes. Apart from being pathologically connected, the fingers and toes may also be unusually bent (camptodactyly).
Signs and symptoms in the autosomal recessive form of ODD dysplasia are typically more severe. The eyes are extremely small and slender, with the interpupillary distance wider than normal. Some patients may even go completely blind. The skeletal changes are more pronounced and the bones of the skull, lower jaw, and the collar bone show an abnormal thickening.
ODD dysplasia must be distinguished from several other conditions presenting with similar symptoms. Foremost among these is the oro-cranio-digital syndrome, an autosomal recessive condition characterized by numerous abnormalities such as microcephaly, cleft lip and/or palate and growth retardation. This disorder is extremely rare and shows a slight female preponderance.
Amelogenesis imperfecta is another rare congenital condition in which defective formation of the tooth enamel results in the teeth being more sensitive to extremes of temperature. Early tooth loss with frequent dental infections are the other common clinical features.
A group of hereditary conditions, termed the ectodermal dysplasias, may also be a cause for defective enamel formation, with missing teeth and hair problems being the usual presenting features. Other organs derived from the ectodermal germ layer, most notably the skin, are also routinely affected.
Saethre-Chotzen syndrome is an autosomal dominant disorder, characterized by various malformations of the head, skeleton, and skin of the fingers and toes that may present with mental retardation.
Entire Body System
Proportionate Short Stature
We report a case of a 6-year-old male who presented with dysmorphic facial features (short palpebral fissure, thin nose with hypoplastic alae nasi, and flat face), bilateral syndactyly, abnormal dentition, and proportionate short stature with growth hormone [ncbi.nlm.nih.gov]
Jaw & Teeth
Progressive Loss of Vision
Described here is the case of a 21-year-old male who presented to the ophthalmology outpatient department with a complaint of bilateral progressive loss of vision since childhood. [ncbi.nlm.nih.gov]
Case Report A 21-year-old male presented to the ophthalmology outpatient department of our institute with a complaint of bilateral progressive loss of vision since childhood. [ijo.in]
Small Palpebral Fissures
The distance between the inner canthi and the medial orbital walls in three patients we studied suggests that previous reports of hypertelorism may have been illusions resulting from microcornea, small palpebral fissures, and variably present epicanthus [ncbi.nlm.nih.gov]
2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre Syndrome Pili Torti and Developmental Delay Pilodental Dysplasia with Refractive Errors Poikiloderma with Neutropenia Polyposis, Skin Pigmentation, Alopecia, and [nfed.org]
Chronic cheilitis and perléche are common, whereas hair and nail dystrophy, scarring alopecia, dental anomalies and heat intolerance are less frequent. [sajr.org.za]
SYNDROME Albinism Deafness Syndrome Aldred Syndrome Alice in Wonderland Syndrome Alien Hand Syndrome ALKURAYA-KUCINSKAS SYNDROME Allan-Herndon-Dudley syndrome Allanson Pantzar McLeod Syndrome allergic cutaneous vasculitis Aloi Tomasini Isaia Syndrome Alopecia [rgd.mcw.edu]
[…] bones Persistent pupillary membrane Macrodontia of permanent maxillary central incisor Fifth finger distal phalanx clinodactyly 4-5 finger syndactyly 2-4 toe cutaneous syndactyly Hydrocephalus Abnormality of dental morphology Respiratory insufficiency Alopecia [mendelian.co]
(Hu et al. 2013) (6) Palmoplantar keratoderma and congenital alopecia 1 (104100) .0023 Palmoplantar keratoderma and congenital alopecia 1 (104100) [GJA1, GLY8VAL] (rs864309644) (RCV000185623) (Wang et al. 2015) (7) Eythrokeratoderma variabilis et progressiva [syndromefinder.ncchd.go.jp]
Combination of odontodysplasia, poor oral hygiene, and parental neglect can lead to extensive destruction of tooth structure and the treatment options become limited. [ncbi.nlm.nih.gov]
Second, neurological symptoms can be easily neglected if the diagnosis of ODDD is made by physicians with other specialties, especially when the symptoms are subtle. [e-jmd.org]
Additional findings consisted of gaze palsy and squinting (28), bladder and bowel disturbances (21), visual loss (20) and blindness (4), hearing loss (15), ataxia (11), nystagmus (9), muscle weakness (5) and paresthesias (3). [ncbi.nlm.nih.gov]
Pyramidal Tract Signs
We found a novel GJA1 mutation (W25C) as the possible causative gene in this sporadic ODDD patient with neurological features of motor deficits by pyramidal tract signs, and sensory deficits due to peripheral nerve disturbance. [ncbi.nlm.nih.gov]
Loss of Speech
Neurological symptoms are not universally seen, but about 30% of the patient population has been diagnosed with neurological problems that include conductive hearing loss, dysarthria (speech articulation problems), neurogenic bladder (voiding problems [ncbi.nlm.nih.gov]
A proper diagnosis rests on the identification of the typical clinical features of ODD dysplasia. However, the symptoms and their severity vary from case to case and hence, the recognition of this disorder based primarily on its clinical manifestations is not always apparent. When ODD dysplasia is suspected, the diagnosis can be confirmed by certain molecular tests. The defective gene is situated on 6q chromosome and genetic mapping studies may help to further elucidate the precise location of the mutation   .
Early diagnosis with a proper treatment plan and meticulous oral hygiene program helps eliminate the necessity of multiple tooth extractions. [ncbi.nlm.nih.gov]
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]
Treatment Currently, there is no cure for oculodentodigital dysplasia. Since the disorder displays itself physically, you may forego testing or treatment for the condition. However, complications may arise if you ignore symptoms. [0755szzc.com]
These findings expand the neurologic phenotype and prognosis and underscore the importance of counseling families with oculodentodigital dysplasia about the possibility of neurologic involvement. [ncbi.nlm.nih.gov]
Diagnosis and Prognosis: The diagnosis is based on the unique combination of bone and eye findings in the presence of typical facial features. It usually requires the collaborative efforts of geneticists, pediatricians and ophthalmologists. [disorders.eyes.arizona.edu]
For initial management, we advised the patient to undergo cataract surgery with intraocular lens implantation in both eyes with guarded visual prognosis. [ijo.in]
Etiology ODDD is caused by heterozygous mutations in the GJA1 gene (6q22-q23), which encodes the gap junction protein connexin 43 (Cx43). Over 40 causative mutations have been identified. [orpha.net]
Smith's Recognizable Patterns of Human Malformation has long been known as the source to consult on multiple malformation syndromes of environmental and genetic etiology as well as recognizable disorders of unknown cause. [libreriauniversitaria.it]
Summary Epidemiology To date, approximately 250 cases have been described worldwide (the majority of whom were white individuals). Clinical description The disease is characterized by wide intra- and interfamilial phenotypic variability. [orpha.net]
Chapters on epidemiology, embryology, non-syndromic hearing loss, and syndromic forms of hearing loss have all been updated with particular attention to the vast amount of new information on molecular mechanisms, and chapters on clinical and molecular [books.google.ro]
but new cases do arise through novel mutations. The mutation has high penetrance and variable expression, which means that nearly all people with the gene show signs of the condition, but these signs can range from very mild to very obvious. Epidemiology [en.wikipedia.org]
This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. [books.google.ro]
Spastic hypertonia and movement disorders: pathophysiology, clinical presentation, and quantification. [ncbi.nlm.nih.gov]
To prevent this syndrome from being overlooked, awareness of possible symptoms is necessary. Early recognition can prevent blindness, dental problems and learning disabilities. [ncbi.nlm.nih.gov]
Be sure to brush regularly to prevent tooth decay, cavities, and gum disease. Consult an orthodontist to correct issues with your bite. [0755szzc.com]
Preventive procedures like caries control, topical fluorides, pit and fissure sealants, and preventive resin restorations should be initiated as early as possible. [jisppd.com]
Early recognition of the syndrome is of crucial importance in prevention and treatment of the wide variety of clinical manifestations. The documents contained in this web site are presented for information purposes only. [orpha.net]
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