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Ofloxacin


Presentation

  • Here we present the first reported case of bilateral iliopsoas tendon rupture associated with prolonged ciprofloxacin use. This older woman presented with non-traumatic, sudden onset hip pain which was diagnosed as a right iliopsoas rupture on MRI.[doi.org]
  • Abstract A case of severe bacteremic pneumococcal pneumonia which developed in a patient with lung cancer, who was taking ofloxacin for chemoprophylaxis, is presented. Pneumonia resolved well with intravenous penicillin G.[ncbi.nlm.nih.gov]
  • RMP resistance was present in 2.6% of new and 15.1% of previously treated patients in Tamil Nadu.[ncbi.nlm.nih.gov]
  • A patient with drug-induced toxic pustuloderma is presented.[ncbi.nlm.nih.gov]
  • If a temporal association of use of a drug having the potential to cause hallucinations is present, mere withdrawal of the drug causes complete improvement in the symptoms.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration.[dbpedia.org]
  • ALSO AVAILABLE: Ofloxacin is also available for intravenous administration in the following configurations: FLOXIN (ofloxacin injection) I.V. IN SINGLE-USE VIALS (10 mL) containing a concentrated solution with the equivalent of 400 mg of ofloxacin.[druglib.com]
  • ., “Tissue Concentrations of Enrofloxacin and Ciprofloxacin in Anesthetized Dogs Following Single Intravenous Administration,” Veterinary Therapeutics, Vol. 2, No. 2, 2001, pp. 120-128. [ 13 ] M. N.[doi.org]
  • Levofloxacin is rapidly and essentially completely absorbed after oral administration, with a plasma concentration profile over time that is essentially identical to that obtained from intravenous administration of the same amount over 60 minutes.[en.wikipedia.org]
  • Tissue distribution of ciprofloxacin following oral and intravenous administration. Infection 1985;13:78-81. [ PUBMED ] 22. Dan M, Golomb J, Gorea A, Braf Z, Berger SA.[ijp-online.com]
Constitutional Symptom
  • Patients receiving ofloxacin should be monitored for constitutional symptoms suggestive of this complication even though the risk of such complication may be minimal.[ncbi.nlm.nih.gov]
Metallic Taste
  • Minor incidences of nausea, gastritis, metallic taste were reported in 7.42%, 7.14%, and 5.85% of patients respectively. No serious adverse events were reported which led to withdrawal of patient from the study.[ncbi.nlm.nih.gov]
Hypersalivation
  • The most remarkable phenomena were spitting and profuse swearing; other features were echolalia, echopraxia, orofacial and limb automatisms, hypersalivation, and amnesia for the episode on recovery.[ncbi.nlm.nih.gov]
Thrombosis
  • Inappropriate use of fluoroquinolone (Levofloxacin/Tavanic) resulting in partial Achilles tendon rupture complicated by deep venous thrombosis Authors' affiliations A M Meyers, Division of Nephrology, Department of Medicine, Charlotte Maxeke Johannesburg[cmej.org.za]
  • A 51-year-old woman was referred with suspicion of deep vein thrombosis 8 days after successful aorto-coronary bypass surgery. On clinical examination a mild swelling of the calves with little pitting oedema were found.[ncbi.nlm.nih.gov]
  • […] hyposthenuria, hematuria, pyuria Post-Marketing Adverse Events Additional adverse events, regardless of relationship to drug, reported from worldwide marketing experience with quinolones, including ofloxacin: Clinical Cardiovascular System: cerebral thrombosis[rxlist.com]
Corneal Deposit
  • To report six cases of corneal deposits after administration of topical ofloxacin in the treatment of bacterial keratitis.[ncbi.nlm.nih.gov]
Dry Skin
  • Approximately 12 hours after ingestion, the patient was admitted to the hospital in a delirious state with extreme mydriasis and warm and dry skin.[ncbi.nlm.nih.gov]
Encephalopathy
  • To describe the association between the use of the fluoroquinolone ofloxacin in an elderly man and an unusual acute encephalopathy with characteristics suggestive of Tourette's syndrome.[ncbi.nlm.nih.gov]
  • Gemifloxacin-associated neurotoxicity presenting as encephalopathy. Ann Pharmacother 2009; 43 :782–4. 10.1345/aph.1L621 [ PubMed ] [ CrossRef ] [ Google Scholar ] 52. Guven EO, Balbay D, Kilciler M.[ncbi.nlm.nih.gov]
Echolalia
  • The most remarkable phenomena were spitting and profuse swearing; other features were echolalia, echopraxia, orofacial and limb automatisms, hypersalivation, and amnesia for the episode on recovery.[ncbi.nlm.nih.gov]
Echopraxia
  • The most remarkable phenomena were spitting and profuse swearing; other features were echolalia, echopraxia, orofacial and limb automatisms, hypersalivation, and amnesia for the episode on recovery.[ncbi.nlm.nih.gov]

Workup

Foam Cell
  • Because the biopsy specimen showed foam cells, histiocytes, epithelioid cells, many Mycobacterium leprae and no giant cells, the diagnosis of borderline-lepromatous (BL) type was made.[ncbi.nlm.nih.gov]

Treatment

  • Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure.[ncbi.nlm.nih.gov]
  • Complete clearance of the plaques was achieved 3 to 5 months after the initiation of treatment. Some patients experienced postinflammatory hyperpigmentation.[ncbi.nlm.nih.gov]
  • New antimycobacterial agents and combined treatment regimens are being introduced for the treatment of leprosy. Ofloxacin is one such broad spectrum antimicrobial agent.[ncbi.nlm.nih.gov]
  • METHODS: A total of 184 human large traumatic TMPs were randomly assigned to receive epidermal growth factor (EGF) treatment, fibroblast growth factor-2 (FGF-2) treatment, 0.3% (w/v) ofloxacin drops treatment, and conservative observation (only).[ncbi.nlm.nih.gov]
  • 3 Completed Treatment Pneumonia 6 3 Completed Treatment Pneumonia, Bacterial 1 3 Completed Treatment Prostatitis 3 3 Completed Treatment Pyelonephritis / Urinary Tract Infections (UTIs) 1 3 Completed Treatment Sinusitis 1 3 Completed Treatment Skin Diseases[drugbank.ca]

Etiology

  • Drugs such as penicillins, cephalosporins, and sulfonamides are now noted to be the most common etiologic agents of serum sickness-like reactions.[doi.org]
  • In addition to ruling out other possible etiologic factors one by one, we assessed the probability of ofloxacin/levofloxacin-induced rhabdomyolysis by observing the close time relationship between drug administration and the development of symptoms/signs[ncbi.nlm.nih.gov]
  • The etiology of GA is unknown; however, multiple inciting factors have been proposed. Histologically, GA is characterized by foci of degenerative collagen associated with palisading, sometimes infiltrating granulomatous inflammation.[ncbi.nlm.nih.gov]
  • Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.[ncbi.nlm.nih.gov]
  • Conclusions Our case is fascinating given the prior history of rhabdomyolysis establishing a cause–effect relationship of levofloxacin in the etiology of rhabdomyolysis.[ncbi.nlm.nih.gov]

Epidemiology

  • From these, 31 epidemiologically unrelated strains were randomly selected for antimicrobial susceptibility testing to determine the minimum inhibitory concentration (MIC) of four fluoroquinolones and the corresponding quinolone resistance-determining[ncbi.nlm.nih.gov]
  • Articles Corresponding Author E-mail address: hschelle@mail.med.upenn.edu Center for Clinical Epidemiology and Biostatistics and Centers for Education and Research on Therapeutics, Department of Biostatistics and Epidemiology, University of Pennsylvania[doi.org]
  • Weekly Epidemiological Surveillance Report. 1995;26(44):571. Google Scholar 2. Punyaratabandhu P, Sangchai R, Vathanophas K, Athipanyakom S, Varavithya W. Risk factors for childhood diarrhea in an urban community, Bangkok, Thailand.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • The Pigmentary System: Physiology and Pathophysiology. New York: Oxford Univ. Press; 1998. Ozkaya E. Fixed drug eruption: state of the art. J Dtsch Dermatol Ges. Nov 2008;6:181-8 (PubMed). Shiohara T, Mizukawa Y.[ijbcp.com]
  • The pathophysiology of fluoroquinolone-induced tenocyte degeneration involves changes in receptor and signalling proteins as well as apoptosis [ 7 ] and may be accelerated by magnesium deficiency [ 5, 8 ].[ncbi.nlm.nih.gov]
  • […] described in the literature, reports of tendon rupture in association with newer quinolones such as levofloxacin are now emerging. 4, 5 We describe a patient with levofloxacin-induced partial rupture of the Achilles tendon and review the literature, pathophysiology[jabfm.org]
  • Fluoroquinolones are increasingly being recognized as a cause of tendinitis and tendon rupture 8, but the specific pathophysiological mechanisms involved in drug‐induced tendinopathies remain unknown.[ncbi.nlm.nih.gov]
  • […] surveillance data indicating that these medications were associated with subsequent tendonitis and tendon rupture. 4 Several large epidemiological studies have confirmed this association. 5, 6 Secondary cell biology and animal research has elucidated the pathophysiology[bmjopen.bmj.com]

Prevention

  • Competitive binding between cisplatin and 1 to DNA revealed that cisplatin prevents binding of 1. Our experiments revealed that binding of the title complex to DNA occurs also if guanine N7 is protonated.[ncbi.nlm.nih.gov]
  • These antibiotics prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase. By preventing the formation of single-stranded DNA, fluoroquinolones inhibit bacterial replication.[goldbio.com]
  • CONCLUSION: Gatifloxacin was not superior to ofloxacin in preventing failure, but use of gatifloxacin did result in more prompt fever clearance time compared to ofloxacin. TRIAL REGISTRATION: ISRCTN 63006567 (www.controlled-trials.com).[ncbi.nlm.nih.gov]
  • This prevents the bacterial cells from dividing and repairing, thereby killing them. Common side effects of ofloxacin Nausea, Headache, Dizziness, Vomiting, Stomach pain, Diarrhea[1mg.com]
  • Chronic Systolic Heart Failure / Complete atrioventricular heart block / Sick Sinus Syndrome / Syncope 1 3 Recruiting Prevention Leukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes 1 3 Recruiting Prevention Prevention 1 3 Recruiting Supportive[drugbank.ca]

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