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Old Age


Presentation

  • Ten studies presented results for the association between use of any AED and any fall/injurious fall.[ncbi.nlm.nih.gov]
  • This report describes an unusual case of patent ductus arteriosus, presenting in old age. The patient is the oldest living female with patient ductus reported thus far in the medical literature.[ncbi.nlm.nih.gov]
  • Diagnosis in the present case was delayed. It is hoped that reemphasis of this aspect of tuberous sclerosis will lead to a prompt diagnosis in similar cases.[ncbi.nlm.nih.gov]
  • Crusted (Norwegian) scabies, which is a hyperinfestation variant of scabies, is very contagious and can present as other dermatoses, thus delaying the correct diagnosis and management.[ncbi.nlm.nih.gov]
  • Neurosyphilis can present with psychiatric symptoms. The late form can occur in old age with psychosis, paranoid delusions, affective disorders or cognitive impairment.[ncbi.nlm.nih.gov]
Hypertension
  • The left to right shunt could have caused an increase in the blood flow and pulmonary hypertension, intensified by the vascular alterations in the region.[ncbi.nlm.nih.gov]
  • In another 5 patients (17.8%) we found atrial fibrillation, fast rhythm (2 with chronic obstructive lung disease, 2 with hypertension and 1 in post M.I.) which explained their symptomatology.[ncbi.nlm.nih.gov]
  • It is suggested that her longevity was helped by being female, with a moderate degree of mental handicap and a degree of weight control which reduced the problems of diabetes and hypertension.[ncbi.nlm.nih.gov]
  • Hypertension in old age should not be considered a ‘normal part of aging’. Approximately 30-40% of all people over 65 have high blood pressure. Blood pressure control also increases life expectancy and the quality of life among elderly people.[tensoval.com]
  • Older ethnic and racial minorities have a higher prevalence of obesity, diabetes and hypertension, as well as an earlier onset of chronic illness, than White older adults.[apa.org]
Cyanosis
  • This hypertension probably became intense to the point of reversing the direction of the shunt, from the right to the left, characterizing a probable Eisenmenger syndrome, responsible for the patient's dyspnea and cyanosis.[ncbi.nlm.nih.gov]
Hemianopsia
  • It was hypothesized that repeated left-rotational stress due to homonymous hemianopsia loaded to the atlantoaxial joint caused abnormal laxity of the joint.[ncbi.nlm.nih.gov]
Eruptions
  • Two residents of different old-age homes presented with hyperkeratotic skin eruptions, which later proved to be crusted scabies. In both cases, the scabies was initially misdiagnosed as eczema.[ncbi.nlm.nih.gov]
Psychiatric Symptoms
  • We conclude that neurosyphilis is a relevant differential diagnosis in patients developing severe psychiatric symptoms in old age.[ncbi.nlm.nih.gov]
Tonic-Clonic Seizure
  • The subject presented with mental state changes (confusion and agitation), hyperreflexia, diaphoresis, nausea, vomiting, fever, and a general tonic-clonic seizure which developed soon after an increase in the trazodone dose.[ncbi.nlm.nih.gov]
Homonymous Hemianopsia
  • It was hypothesized that repeated left-rotational stress due to homonymous hemianopsia loaded to the atlantoaxial joint caused abnormal laxity of the joint.[ncbi.nlm.nih.gov]
Disturbance of Consciousness
  • Old age, disturbance of consciousness, moderate to severe electroencephalogram abnormality, hydrocephalus, remarkable increase of protein ( 236 mg/dL) and white blood cell counts ( 243 /μL) in cerebral spinal fluid were associated with poor prognosis.[ncbi.nlm.nih.gov]

Workup

  • Essentials of a diagnostic workup. Alzheimer's Association. . Accessed Dec. 19, 2012. Nowrangi MA. Epidemiology, assessment and treatment of dementia. Psychiatric Clinics of North America. 2011;34:275. Alternative treatments.[web.archive.org]
  • Anthony Rostain says, "When an older adult comes in looking for an ADHD evaluation, he or she deserves the same workup as anyone else at any age." You can’t treat the condition without a diagnosis.[additudemag.com]
Electroencephalogram Abnormal
  • Old age, disturbance of consciousness, moderate to severe electroencephalogram abnormality, hydrocephalus, remarkable increase of protein ( 236 mg/dL) and white blood cell counts ( 243 /μL) in cerebral spinal fluid were associated with poor prognosis.[ncbi.nlm.nih.gov]

Treatment

  • […] as gaps in evidence for old-age pharmacologic treatment.[ncbi.nlm.nih.gov]
  • As a causal antibiotic treatment is possible this infectious disease should be considered seriously in gerontopsychiatric patients.[ncbi.nlm.nih.gov]
  • CONCLUSION: Results suggest similar effects on cognitive symptoms from the use of EGb 761 in the treatment of dementia in AD together with favorable safety compared to donepezil.
.[ncbi.nlm.nih.gov]
  • Both episodes subsided spontaneously when treatment was discontinued.[ncbi.nlm.nih.gov]
  • The administration of psychopharmacas, sedation and anti-sclerotic treatment are recommended.[ncbi.nlm.nih.gov]

Prognosis

  • The good or poor prognosis in the patients was defined, based on Glasgow Outcome Scale System at discharge. Patients with a GOS score less than 5 were defined as "poor prognosis."[ncbi.nlm.nih.gov]
  • TUNEL analysis showed that apoptosis was present in 10% of the cells, thus suggesting that an high number of apoptotic cells may represent an indicator of good prognosis for this malignancy.[ncbi.nlm.nih.gov]
  • Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment[ncbi.nlm.nih.gov]
  • The above recording is an effort to provide guidance on geriatric therapy, prognosis, rehabilitation, possibilities of prevention.[ncbi.nlm.nih.gov]
  • Abstract BACKGROUND: Presence of behavioral and psychological symptoms of dementia (BPSD) is very common in subjects with cognitive impairment, representing an important determinant of disease progression, institutionalization, and worse prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Key messages Heterogenous etiology of dementia, which in old age is usually a clinical diagnosis, may confound the role of long-term risk factors.[ncbi.nlm.nih.gov]
  • Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, et al. (2006) Research agenda for frailty in older adults: toward a better understanding of the physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging[doi.org]

Epidemiology

  • Given current epidemiological trends, geriatricians will be increasingly called upon to diagnose and manage this condition.[ncbi.nlm.nih.gov]
  • Recent epidemiological studies and animal models have clarified the pathological correlation between ventricular contractile dysfunction and PKD1 function.[ncbi.nlm.nih.gov]
  • Depressive symptoms were measured using the eight-item Center for Epidemiologic Studies Depression Scale.[ncbi.nlm.nih.gov]
  • Author information 1 EPIUnit-Instituto de Saúde Pública, Universidade do Porto; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto; INEB-Instituto de Engenharia Biomédica, Universidade do Porto; Department of Clinical Epidemiology[ncbi.nlm.nih.gov]
  • Sara S Strom Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, USA.[nature.com]
Sex distribution
Age distribution

Pathophysiology

  • Unraveling the molecular pathophysiology of myelodysplastic syndromes . J. Clin. Oncol. 29 , 504–515 (2011). 23. Yan, X.J. et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia . Nat.[nature.com]
  • Hubbard, The Pathophysiology of Frailty: Why Sex Is So Important, Journal of the American Medical Directors Association, 10.1016/j.jamda.2017.10.009, 19, 1, (4-5), (2018).[doi.org]

Prevention

  • A disability is any physical or mental condition that prevents the worker from doing substantial work.[legal-dictionary.thefreedictionary.com]
  • Effective implementation of respiratory protection measures has been identified as an effective prevention measure to reduce mortality and morbidity caused by such outbreaks. Yet, relatively little is known about this aspect in these homes.[ncbi.nlm.nih.gov]
  • The above recording is an effort to provide guidance on geriatric therapy, prognosis, rehabilitation, possibilities of prevention.[ncbi.nlm.nih.gov]
  • Modulatory effects of behavioral factors highlight their value as possible prevention targets. The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America.[ncbi.nlm.nih.gov]
  • The team also found that three out of four people don’t realise that they can help prevent dementia through improving their physical health.[dailymail.co.uk]

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