Symptoma

Onchocerca Volvulus

Site-directed mutagenesis of the three cysteines present in the OvEC-SOD shows that enzyme activity is markedly reduced in the Cys-192 mutant. [ncbi.nlm.nih.gov]

Taylor * Present address: Department of Biological Sciences, Njala University College, University of Sierra Leone, PMB Freetown, Sierra Leone. [doi.org]

  • Camping

    All NS children were in IDP camps and that the majority (25/45) had spent 5 years in the IDP camps before onset of nodding. [panafrican-med-journal.com]

    The following proteins and other compounds of O. volvulus were expressed in the cells of the neoplasms: glutathione S-transferase 1, lysosomal aspartic protease, cAMP-dependent protein kinase, alpha-enolase, aspartate aminotransferase, ankyrin E1, tropomyosin [ncbi.nlm.nih.gov]

  • Intermittent Fever

    The child had general body pruritic rash and intermittent fever. Although the child's skin snip on re-examination five weeks later was also positive, the fever had gradually subsided. [ncbi.nlm.nih.gov]

  • Muscle Weakness

    Abstract Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. [ncbi.nlm.nih.gov]

    Box 166, Gulu, Uganda Abstract Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. [panafrican-med-journal.com]

  • Stroke

    Stroke, National Institutes of Health, Bethesda, MD 20892, USA. 3 Clinical Proteomics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. 4 Microarray Core Facility, National Human Genome [ncbi.nlm.nih.gov]

    Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. 3 Clinical Proteomics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. 4 Microarray Core Facility, National [stm.sciencemag.org]

    An initial broad stroke approach identified as a potential drug target any O. volvulus protein belonging to the same gene family in this database as a human protein annotated as a drug target in ChEMBL. [nature.com]

  • Atonic Seizures

    Abstract Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. [ncbi.nlm.nih.gov]

    Box 166, Gulu, Uganda Abstract Nodding Syndrome (NS) is a childhood neurological disorder characterized by atonic seizures, cognitive decline, school dropout, muscle weakness, thermal dysfunction, wasting and stunted growth. [panafrican-med-journal.com]

  • Trichinella Spiralis

    The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis : a comparison with Caenorhabditis elegans. Invert Neurosci. 7, 219–226 (2007). 30. Dent, J. A., Smith, M. M., Vassilatis, D. K. & Avery, L. [nature.com]

    The cys-loop ligandgated ion channel gene family of Brugia malayi and Trichinella spiralis : a comparison with Caenorhabditis elegans. Invert Neurosci. 2007; 7 :219–226. [ PubMed ] [ Google Scholar ] 30. Dent JA, Smith MM, Vassilatis DK, Avery L. [ncbi.nlm.nih.gov]

  • Entamoeba Histolytica

    Entamoeba histolytica antigens (EhAg) strongly activated pro-inflammatory MIP-1 alpha/CCL3 and MIP-1 beta/CCL4 responses of similar magnitude in mothers, children and neonates alike. [ncbi.nlm.nih.gov]

  • Neisseria Gonorrhoeae

    A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae, J Exp Med, 1998, vol. 187 (pg. 743 - 52 ) 14. [doi.org]

  • Borrelia Burgdorferi

    Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates, Int Immunopharmacol, 2001, vol. 1 (pg. 393 - 401 ) 46. [doi.org]

The initial microfilarial density influenced post-treatment densities at all the time-points. [ncbi.nlm.nih.gov]

The prognosis (outcome) depends on how quickly the infection is recognized and treated. The prognosis is good if the disease is adequately treated and the patient makes their follow-up appointments and treatments. [medicinenet.com]

Abstract Nodding syndrome is an epileptic disorder of unknown etiology that occurs in children in East Africa. [ncbi.nlm.nih.gov]

Active epilepsy was defined as a patient who presented with at least 2 unprovoked seizures of unknown etiology in the last 12 months. [idpjournal.biomedcentral.com]

Indeed, 270,000 individuals are blind from this etiology worldwide. [scielo.br]

Author information 1 Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom. [ncbi.nlm.nih.gov]

It is the authors' view that ( OV may perhaps be a biological agent with some links to NS and particularly when other mechanisms such as observed above can explain its roles in the pathophysiology of Nodding Syndrome [ 3 - 6 ]. [panafrican-med-journal.com]

Despite these efforts, onchocerciasis remains the second leading infectious cause of blindness worldwide. [4] Pathophysiology O volvulus microfilariae mature into larvae in the gut of blackflies of the genus Simulium. [emedicine.medscape.com]

Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 3 Vector Control Division, Uganda Ministry of Health, Kampala, Uganda. 4 Ethiopian Public Health Institute, Addis Ababa, Ethiopia. [ncbi.nlm.nih.gov]

Priest, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: [email protected] [ajtmh.org]

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