The present study provides the first proteomic analysis to address the molecular mechanisms by which OvES products interact with host cells, and Sheds light on the cellular processes involved in O. viverrini-induced CCA. [researchonline.jcu.edu.au]

Clinical Presentation Most infections are asymptomatic. Most pathologic manifestations result from inflammation and intermittent obstruction of the biliary ducts. [cdc.gov]

The present study elucidates the transcriptomes of C. sinensis and O. viverrini using a platform based on next-generation (high throughput) sequencing and advanced in silico analyses. [ncbi.nlm.nih.gov]

• Fishing

  The size of the node reflects the number of raw fish dishes consumed in the household; bigger nodes represent higher raw fish dishes richness With regard to the social determinants of raw fish dish sharing (who receives versus who provides fish dishes [idpjournal.biomedcentral.com]

  In Ban Phai, Thailand, only one subgroup occurred, hosted by two different fish species. Both subgroups occurred in fish from That Luang, Lao PDR, but were represented to very different degrees among the fish hosts there. [eprints.gla.ac.uk]

  Abstract Opisthorchis viverrini, a carcinogenic fish borne fluke, requires freshwater snails and fish as intermediate hosts. Opisthorchiasis is endemic in parts of Southeast Asia, including Central and South Vietnam. [pubmed.ncbi.nlm.nih.gov]

  The frequencies of eating fish did not differ between cases and controls. However, cases ate raw fish more frequently than controls (5.1 vs 1.2 times monthly). [ncbi.nlm.nih.gov]

• Chronic Infection

  The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. [omictools.com]

  (fever, facial edema, lymphadenopathy, arthralgias, rash, and eosinophilia) and involvement may extend to pancreatic duct in chronic cases Differential Diagnosis Helminth infections Cestodes (Tapeworms) Taenia saginata Taenia solium (Cysticercosis) Diphyllobothrium [wikem.org]

  The greatest impact is through the malignant cancer ( = cholangiocarcinoma) that these parasites induce in chronically infected people. [ncbi.nlm.nih.gov]

• Fever

  In addition, infections due to Opisthorchis felineus may present an acute phase resembling Katayama fever (schistosomiasis), with fever, facial edema, lymphadenopathy, arthralgias, rash, and eosinophilia. [cdc.gov]

  […] infection predisposes to cholangitis, cholcystitis, cholangiocarcinoma (rare) Clinical Features Mild: dyspepsia, diarrhea, abdominal pain, constipation Moderate: hepatomegaly, malnutrition Felineus species may have an acute phase: alike to schistosomiasis (fever [wikem.org]

• Weakness

  Weak to negligible bands of H. taichui were produced when mixed in ratios of less than 1∶1 with O. viverrini ( Fig. 1B ). [doi.org]

  Included references were evaluated to determine weaknesses in study design in terms of limitations, risk of bias, choice of study population, definition of CCA cases, matching of controls, sample size, and statistical methods to assess the overall quality [idpjournal.biomedcentral.com]

  University of Michigan Press, Vol. 61, H. 4, S. 763-783. doi: 10.1307/mmj/1353098512. edoc Blanc, J. und Lamy, S. (2012) «Weak Fano threefolds obtained by blowing-up a space curve and construction of Sarkisov links», Proceedings of the London Mathematical [math.unibas.ch]

• Hypertension

  For example, in Thailand, the top four causes of death in the year 2004 were heart disease, diabetes, hypertension, and cancer [7]. [doi.org]

  Schistosoma mekongi can cause liver (eg, advanced liver fibrosis and portal hypertension) and spleen morbidity [ 6 ]. The current study included 1 group of patients coinfected with S. mekongi and O. viverrini. [academic.oup.com]

  A similar extension can be made for diabetes, hypertension, and heart disease. [frontiersin.org]

• Heart Disease

  For example, in Thailand, the top four causes of death in the year 2004 were heart disease, diabetes, hypertension, and cancer [7]. [doi.org]

  A similar extension can be made for diabetes, hypertension, and heart disease. [frontiersin.org]

• Hepatomegaly

  The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis and cholelithiasis. [ncbi.nlm.nih.gov]

  […] significance May have acute infectious phase Source of mild and moderate GI disease Chronic infection predisposes to cholangitis, cholcystitis, cholangiocarcinoma (rare) Clinical Features Mild: dyspepsia, diarrhea, abdominal pain, constipation Moderate: hepatomegaly [wikem.org]

  With infections of longer duration, the symptoms can be more severe, and hepatomegaly and malnutrition may be present. In rare cases, cholangitis, cholecystitis, and chlolangiocarcinoma may develop. [cdc.gov]

• Jaundice

  The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis and cholelithiasis. [ncbi.nlm.nih.gov]

  Opisthorchis viverrini infection is associated with hepatobiliary morbidity, such as hepatomegaly, jaundice, cholecystitis, cholangitis, and cholangiocarcinoma, a fatal bile duct cancer [ 3 ]. [doi.org]

• Flushing

  […] further large-scale epidemiological surveys to be carried out in Southeast Asia, which will shed further light on the distribution of these liver flukes in human and snail intermediate hosts with the advantage that targets for more arduous anthelmintic flushing [doi.org]

• Fracture

  It remains uncertain whether hatching in this species is mediated through mechanical fracture of the eggshell or by digestion with specific digestive enzymes. [bioone.org]

• Suggestibility

  Various reports have suggested that this parasite may represent a species complex, with genetic structure in the region perhaps being dictated by geographical factors and different species of intermediate hosts. [eprints.gla.ac.uk]

  Both food sharing and eating practices are potentially important factors in FTB, suggesting an important role for the social ecology of disease transmission in these rural communities. [ncbi.nlm.nih.gov]

Nimer Assy, Gattas Nasser, Agness Djibre, Zaza Beniashvili, Saad Elias and Jamal Zidan, Characteristics of common solid liver lesions and recommendations for diagnostic workup, World Journal of Gastroenterology, 10.3748/wjg.15.3217, 15, 26, (3217), (2009 [doi.org]

• Fasciola Hepatica

  hepatica Fasciolopsis buski Opistorchis viverrini Schistosoma spp Schistosomiasis Chlonorchis sinensis Paragonimus spp. [wikem.org]

  Two paralogous proteins have been partially characterized in the genus Fasciola, Fasciola hepatica TP16.5, a novel tegumental antigen in human fascioliasis and, recently F. gigantica DM9-1, a parenchymal protein with structural similarity to nematode [ncbi.nlm.nih.gov]

  High worm-burden reductions were obtained with these drugs in rodents with acute or chronic infections of Schistosoma japonicum, S. mansoni, Clonorchis sinensis, Fasciola hepatica and Opisthorchis viverrini. [doi.org]

  […] gigantica, Fasciola hepatica, Opisthorchis felineus, and Opisthorchis viverrini), lung flukes (Paragonimus spp.), and intestinal flukes (e.g., Echinostoma spp., Fasciolopsis buski, and the heterophyids). [typeset.io]

“Firstly we aim to develop treatments or a vaccine to prevent liver fluke infection, which in turn will dramatically reduce the incidence of liver cancer in Thailand and surrounding countries. [outbreaknewstoday.com]

4) O. viverrini infection, NDMA, and treatment with PZQ (ODP), and 5) uninfected, untreated control. [ncbi.nlm.nih.gov]

In the short term this would be beneficial to the human host, but the repeated wounding and healing over decades could lead to this form of cancer, which has a dismal prognosis.” “Our work on this project is two-fold,” he said. [outbreaknewstoday.com]

It has long latency, is invasive, metastasizes and has a dismal prognosis. [grantome.com]

BACKGROUND/AIM: Early detection of disease is a pivotal factor for determining prognosis and clinical outcome of patients with cancer. [ncbi.nlm.nih.gov]

The epicenter of this disease is located in northeast Thailand, where high a prevalence of opisthorchiasis coexists with a high incidence of cholangiocarcinoma (CHCA), a major primary carcinoma of the liver with a very poor prognosis. [content.sciendo.com]

HER2 has been shown to have a significant role in the cell proliferation process, therefore, cancer with high expression of HER2 has a poor prognosis such as in breast cancer and gastric cancer. [dovepress.com]

Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. [ncbi.nlm.nih.gov]

It is associated with a number of hepatobiliary diseases and the evidence strongly indicates that liver fluke infection is the major etiology of cholangiocarcinoma. [koreascience.or.kr]

Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. Moreover, both… CONTINUE READING [semanticscholar.org]

Although data from Cambodia, Laos and Vietnam are rare, data from Thailand often show wide-ranging variability in epidemiological parameters, including human morbidity and the prevalence and incidence of CCA. [ncbi.nlm.nih.gov]

Part 1: Epidemiology and etiology. J Gastroenterol Hepatol. 2002; 17:1049-55. 2. Nithikathkul C. Liver flukes. Com Dis J. 2000; 26:274-8. 3. [content.sciendo.com]

Ongoing research suggests the potential for beneficial therapies emanating from pathophysiological investigation of granulins, including anti-tumor action and promotion of wound healing ( 7, 29, 30 ). [frontiersin.org]

These data, together with transcriptomic data for F. hepatica [46], contribute to a growing resource and a significant foundation for future comparative genomic, proteomic, metabolomic and pathophysiological investigations of liver flukes and the diseases [doi.org]

This study indicates that people realize that eradication of the liver fluke needs a continuous people participation for O. viverrini prevention and control in their communities. [ncbi.nlm.nih.gov]

“Firstly we aim to develop treatments or a vaccine to prevent liver fluke infection, which in turn will dramatically reduce the incidence of liver cancer in Thailand and surrounding countries. [outbreaknewstoday.com]