Presentation
The present study elucidates the transcriptomes of C. sinensis and O. viverrini using a platform based on next-generation (high throughput) sequencing and advanced in silico analyses. [ncbi.nlm.nih.gov]
Entire Body System
-
Laboratory Technician
Participants, investigators, and laboratory technicians doing the diagnostic assessments were masked to group assignment, but the investigator administering treatment could have recognised the treatment group based on the number of tablets. [ncbi.nlm.nih.gov]
ACKNOWLEDGMENTS We thank all the study participants, the laboratory technicians for stool sample analysis, Dalouny Bouakhasith and Youthanavanh Vonghachack for assistance in the fieldwork, and Penelope Vounatsou for reviewing the statistical analyses. [jcm.asm.org]
-
Plethora
[…] environment within the liver, and to propose how this parasite evades or modulates host attack; and (iii) to indicate some of the challenges, and, more importantly, the exciting opportunities that the 'omic resources for O. viverrini now provide for a plethora [ncbi.nlm.nih.gov]
Gastrointestinal
-
Regurgitation
Thirty-one ( C. sinensis ) to 42 ( O. viverrini ) days after infection, adult flukes were collected from the bile ducts of hamsters and cultured in vitro to allow the worms to regurgitate caecal contents using an established procedure [46]. [doi.org]
Cardiovascular
-
Thrombosis
It has a modulating effect on the organization of the actin cytoskeleton and may be involved in the pathophysiology of thrombosis or in wound healing [ 48 ]. [doi.org]
Neurologic
-
Excitement
[…] system, how it feeds, survives and protects itself in such a hostile, microaerobic environment within the liver, and to propose how this parasite evades or modulates host attack; and (iii) to indicate some of the challenges, and, more importantly, the exciting [ncbi.nlm.nih.gov]
Some recent genomic, bioinformatic and proteomic studies [29], [41] – [45] indicate unique and exciting prospects to explore key biochemical, physiological and biological pathways in liver flukes, and to predict and prioritize novel drug targets. [doi.org]
-
Headache
The most common adverse events 3 h after treatment in adolescents and adults were vertigo (n 35 [11%]), headache (n 9 [3%]), nausea (n 6 [2%]), and fatigue (n 4 [1%]), and in children were headache (n 3 [2%]), vertigo (n 2 [1%]), and fatigue (n 2 [1%] [ncbi.nlm.nih.gov]
-
Lethargy
A 12-year-old, female, domestic cat (Felis catus) presented with dehydration, emaciation, anorexia, and lethargy. The cat was unresponsive to medical treatment and euthanized; the carcass was submitted for pathological diagnosis. [ncbi.nlm.nih.gov]
Workup
Nimer Assy, Gattas Nasser, Agness Djibre, Zaza Beniashvili, Saad Elias and Jamal Zidan, Characteristics of common solid liver lesions and recommendations for diagnostic workup, World Journal of Gastroenterology, 10.3748/wjg.15.3217, 15, 26, (3217), (2009 [doi.org]
Microbiology
-
Echinococcus Multilocularis
Multiple sequence alignment of the ORFs of OvAE22 with homologues from Schistosoma mansoni (SmRK-I – GenBank AF031557), the hydatid tapeworm Echinococcus multilocularis (TR1 – AJ841786) and human (TGF-β receptor type I – L11695) (A). [doi.org]
Treatment
4) O. viverrini infection, NDMA, and treatment with PZQ (ODP), and 5) uninfected, untreated control. [ncbi.nlm.nih.gov]
Prognosis
BACKGROUND/AIM: Early detection of disease is a pivotal factor for determining prognosis and clinical outcome of patients with cancer. [ncbi.nlm.nih.gov]
It has long latency, is invasive, metastasizes and has a dismal prognosis. [grantome.com]
The epicenter of this disease is located in northeast Thailand, where high a prevalence of opisthorchiasis coexists with a high incidence of cholangiocarcinoma (CHCA), a major primary carcinoma of the liver with a very poor prognosis. [content.sciendo.com]
In the short term this would be beneficial to the human host, but the repeated wounding and healing over decades could lead to this form of cancer, which has a dismal prognosis.” “Our work on this project is two-fold,” he said. [outbreaknewstoday.com]
Etiology
Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. [ncbi.nlm.nih.gov]
Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. Moreover, both… CONTINUE READING [semanticscholar.org]
Epidemiology
Although data from Cambodia, Laos and Vietnam are rare, data from Thailand often show wide-ranging variability in epidemiological parameters, including human morbidity and the prevalence and incidence of CCA. [ncbi.nlm.nih.gov]
Pathophysiology
Ongoing research suggests the potential for beneficial therapies emanating from pathophysiological investigation of granulins, including anti-tumor action and promotion of wound healing ( 7, 29, 30 ). [frontiersin.org]
These data, together with transcriptomic data for F. hepatica [46], contribute to a growing resource and a significant foundation for future comparative genomic, proteomic, metabolomic and pathophysiological investigations of liver flukes and the diseases [doi.org]
Prevention
This study indicates that people realize that eradication of the liver fluke needs a continuous people participation for O. viverrini prevention and control in their communities. [ncbi.nlm.nih.gov]