Symptoma

Oral Mucositis

In the present study, despite the elevated number of patients that presented grade 3 mucositis (white coating) at the end of laser therapy, this finding is probably related to the healing process of the lesions, since there were no associated symptoms [scielo.br]

Odynophagia was present in 55.7% (n 73) of patients with glutamine and in 77.9% (n 102) of those without it (p 0.0001). [scielo.isciii.es]

In patients undergoing chemotherapy at standard doses, oral mucositis generally presents as grades 1 and 2 rather than grades 3 and 4. [touchoncology.com]

OM initially presents as erythema and soreness, followed by painful ulcerations. 1,3,6 These symptoms follow the pathophysiology, which has been described to include 5 phases: initiation, upregulation and activation of second messengers, signal amplification [cancertherapyadvisor.com]

Stomatitis can include oral ulceration, xerostomia, altered taste and taste loss, oral sensitivity, and oral pain with or without lesions being clinically present. r Pathophysiology Oral mucositis The mucosal lining of the mouth is a prime target for [eviq.org.au]

  • Anemia

    […] and weight loss of more than 5% (60%) compared with patients without OM (6%; P .01 and 17%; P .001, respectively). 7 Severe OM that results in swallowing impairment and/or pain that prevents oral intake results in weight loss, anorexia, malnutrition, anemia [cancertherapyadvisor.com]

    Examples for supportive care conditions are myelosuppression, anemia, oral and intestinal mucositis, thromboembolic disease, infections, nausea and vomiting, diarrhea, fatigue and pain. [karger.com]

  • Localized Pain

    pain treatment for head and neck cancer patients with oral mucostis Medical condition: Oral pain due to oral mucositis in head and neck cancer patients which are undergoing radiation therapy Disease: Version SOC Term Classification Code Term Level 17.1 [clinicaltrialsregister.eu]

    Local pain therapies such as viscous lidocaine and magic mouthwash have limited benefits. 33,34 Although they provide pain relief, it is very fleeting as the lidocaine wears away after only a few minutes. [touchoncology.com]

  • Dysphagia

    OM results in pain (69%), opioid use (53%), dysphagia (56%), weight loss requiring feeding tube placement and hospitalization (15%), and modification of treatment (11%-16%). 4 One study demonstrated that patients with OM were significantly more likely [cancertherapyadvisor.com]

    Oral mucositis in its early stages presents with erythema, mild pain, and mild dysphagia that is manageable with over-the-counter medications. [touchoncology.com]

    Improvement of critical conditions related to severe oral mucositis and radiation therapy, especially dysphagia, nausea and vomiting in both Validive groups.. No significant difference in efficacy observed between Validive 50 μg and 100 μg groups.. [onxeo.com]

    Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients. Support Care Cancer 2015;23:3249-3255. [karger.com]

    The oral lesions lead to a considerably decreased quality of life in these patients, due to dysphagia (difficulty in feeding) with solid and liquid food, dysarthria (poor coordination of the speech muscles) and odynophagia (pain or burning sensation on [spandidos-publications.com]

  • Periodontitis

    Clinicians, researchers and those involved in oral and periodontal medicine should join hand in hand in persuit of understanding and developing treatment strategies for treatment of inflammatory conditions like OM in oncology. [journal.waocp.org]

    The preliminary periodontal treatment is also indicated to eliminate potential sites of infection, since chronic periodontal disease is associated with an increased number of microorganisms in the periodontal pockets. [spandidos-publications.com]

    Patients with pulpal disease from dental caries or trauma, periodontal disease, and low-grade soft-tissue infections (especially those associated with partially erupted third molars) are at increased risk for bacteremia due to oral viridans streptococci [emedicine.medscape.com]

    You will want to rinse your mouth frequently with antiseptic mouth rinses, such as Peridex or Periogard, to prevent periodontal (gum) infections and inflammation. [oralcancerfoundation.org]

    […] patient’s age and diagnosis, the level of oral hygiene during therapy, and genetic factors. 5,6,8 Risk Factors Patient-related factors such as age, gender, genetic factors (increased proinflammatory cytokine expression), preexisting poor oral hygiene, periodontal [uspharmacist.com]

  • Aphthous Stomatitis

    The oral ulcerations resemble aphthous stomatitis, and their pathogenesis is not well understood. [eviq.org.au]

    stomatitis in otherwise healthy patients. [emedicine.medscape.com]

    In view of a clinical aphtoid aspect, a similarity between mIAS and recurrent aphthous stomatitis (RAS) has been proposed. [jomos.org]

    stomatitis ( Al‐Dasooqi 2013 ; Boers‐Doets 2013 ; Peterson 2015 ). [cochranelibrary.com]

  • Aphthous Ulceration

    Like aphthous ulcers, these are confined to the nonkeratinized tissues and have a quicker onset compared with classic mucositis. [emedicine.medscape.com]

  • Trismus

    Radiation therapy of the head and neck frequently causes acute and late oral toxicities, including mucositis, trismus due to fibrosis, impaired or lost saliva production (xerostomia), and xerostomia-related radiation dental caries ( cavities ). 1-6 Oral [oncologynurseadvisor.com]

  • Skin Ulcer

    Topical manuka honey for MRSA-contaminated skin ulcers. Palliat Med 2006 ; 20 : 557. van den Berg, AJ, van den Worm, E, van Ufford, HC, Halkes, SB, Hoekstra, MJ, Beukelman, CJ. [cambridge.org]

[…] oral mucositis are the following: World Health Organization (WHO) Oral Toxicity Scale: Combines both objective and functional elements into a single score National Cancer Institute Common Toxicity Criteria (NCI CTC): Scores functional elements only See Workup [emedicine.medscape.com]

Patients’ treatment time was consistent throughout a 6/7-week course, and mucositis survey was self-reported weekly during treatment, providing a unique resource for this study. [cancerres.aacrjournals.org]

TREATMENT OPTIONS Despite the high incidence of oral mucositis, impact on patients’ quality of life and treatment plan implementation, and economic costs, there are few treatment options. [oncologynurseadvisor.com]

And additional research showed that treating cancer patients with KGF before cancer treatment had a strong protective effect, limiting the damage cancer treatments can inflict on the rapidly dividing cells of the mouth. [cancer.gov]

Oral mucositis often happens around a week after you begin treatment. A sore mouth usually gets better once you finish your treatment for lymphoma and your blood counts return to the levels they were at before you had treatment. [lymphoma-action.org.uk]

“Most importantly, [patients] will not have to discontinue treatment,” Arany said. “People discontinue treatment because they can’t handle the oral mucositis. They are not eating well. Their overall immunity is down. [oncnursingnews.com]

Due to its high incidence and clinical significance in patient prognosis, several studies were conducted to investigate the treatment and prevention of oral mucositis ( 11, 18 – 20 ). [spandidos-publications.com]

Severe OM consequences are serious and may include: Interruption of treatment Interruptions in radiotherapy caused by severe OM can seriously compromise the otherwise good prognosis for tumor control in many of these patients. [galeratx.com]

Prognosis of oral mucositis The outlook for OM in the long-term is reasonably good as most lesions resolve within 2-4 weeks of stopping chemotherapy or radiation. [healthengine.com.au]

Prognosis Chemotherapy-induced oral mucositis is a self-limiting condition. [emedicine.medscape.com]

Oral mucositis is a common complication of some malignancies treatment, causing therapeutic modifications due to patient's debilitation, which often interferes with the prognosis of the disease. [scielo.br]

Oral mucositis occurs independently of oral mucosal infections of viral and fungal etiology, but it may be exacerbated by such concomitant infections. [emedicine.medscape.com]

Potential trauma may be caused by two etiologies. First one is the mechanical trauma which consists by the damages of foods, drinks, dentures or teeth, or even opening the mouth when mucous membranes are dry and stuck together. [omicsonline.org]

Palanianppan N, Owadally W, Evans M: Epidemiology and etiology of head and neck cancers. In Practical Clinical Oncology. 2nd Edition. Hanna L, Crosby T, Macbeth F. Cambridge University Press, UK. 2015. Reference Source 7. [f1000research.com]

In 2011, the FDA cleared episil oral liquid for the management and relief of pain of oral lesions with various etiologies, including oral mucositis/stomatitis which may be caused by chemotherapy or radiation therapy. [en.wikipedia.org]

Rettig EM, D'Souza G: Epidemiology of head and neck cancer. Surg Oncol Clin N Am. 2015; 24 (3): 379–96. PubMed Abstract 6. Palanianppan N, Owadally W, Evans M: Epidemiology and etiology of head and neck cancers. [f1000research.com]

Epidemiology of mucositis induced by mTOR inhibitors Mucositis is one of the most common and limiting toxicities caused by mTOR inhibitors. [jomos.org]

These studies focus on the effects of the different treatment options for OM and are not primarily epidemiological studies or HRQoL studies of OM. [karger.com]

Epidemiology Frequency Some degree of oral mucositis occurs in approximately 40% of patients who receive cancer chemotherapy. [emedicine.medscape.com]

Perspectives on Cancer Therapy-Induced Mucosal Injury: Pathogenesis, Measurement, Epidemiology, and Consequences for Patients. Cancer. 2004; 100 (S9):1995–2025. [ PubMed ] [ Google Scholar ] 14. Sonis ST, Peterson RL, Edwards LJ, et al. [ncbi.nlm.nih.gov]

[…] demonstrated that 56% of children experienced any grade OM, and 39% and 8.3% experienced grade 2 or grade 4 OM, respectively. 5 Presentation OM initially presents as erythema and soreness, followed by painful ulcerations. 1,3,6 These symptoms follow the pathophysiology [cancertherapyadvisor.com]

Stomatitis can include oral ulceration, xerostomia, altered taste and taste loss, oral sensitivity, and oral pain with or without lesions being clinically present. r Pathophysiology Oral mucositis The mucosal lining of the mouth is a prime target for [eviq.org.au]

Because this toxicity clusters with dermatologic toxicities, rather than GI (as is the case with conventional mucositis) toxicities, this suggests that the underlying pathophysiology is likely very different. [emedicine.medscape.com]

Advances in molecular biology have provided greater insight into the pathophysiology of this condition. [touchoncology.com]

Pathophysiology Mucosal cells have a high capacity of cellular turnover which is the cause of irradiation sensitivity. [omicsonline.org]

There are few clinical trials in the literature proving any kind of treatment or prevention methods to be effective. [mdpi.com]

Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis. Ann Oncol 2008;19:1644-9. [ Crossref ] [ PubMed ] Papas AJE, Sobel S, Olsen TO. Effects of preventive regimen on oral mucositis. J Dent Res IADR 1981;544:940. [cco.amegroups.com]

Oral-disease prevention in children with cancer: Testing preventive protocol effectiveness. Medicina Oral 2001;6(5): 326-334. Tomlinson T, Gibson F, Treister N, Baggott C, Judd P, Hendershot E et al. [hsj.gr]

Different strategies are used to try and prevent this condition, and the review of trials found that some of these are effective. [cochrane.org]

This new regulatory approval for gelX is the first for a medical product to be used for both the treatment and prevention of oral mucositis in cancer patients. [bmgpharma.com]