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2.1
Organ Transplantation
Grafting Organ

Images

WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, CC BY-SA 3.0

Presentation

Herein, we present the management of a liver transplantation recipient who presented with AML and comprehensively review the relevant literature. [ncbi.nlm.nih.gov]

Entire Body System

  • Surgical Procedure

    Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the transplanted organ, and the intensity and type of immunosuppressive therapy. [ncbi.nlm.nih.gov]

    Organ specific: Kidney, Liver, Pancreas, Heart, Lung (orden de organos cambiado) – Indications and Waiting List – Organ evaluation and surgical procedure (techniques and surgical complications) – Postoperative management and medical follow up (early/late [tpm-dti.com]

    Liver Transplantation We provide specialized liver transplantation care, as well as other surgical procedures. Lung Transplantation We provide expert evaluation and transplant surgery for people who are candidates for lung transplantation. [nyulangone.org]

    Named “domino” because of the three, sequential surgical procedures, the delicate operations are rare enough that only18 were reportedly done in the U.S. in 2002. _______________________________________________________________________ WHO: The first patient [web.archive.org]

  • Pathologist

    Diagnosis and treatment of acute antibody-mediated rejection (AMR) of a transplanted organ requires close collaboration between clinicians, pathologists, and clinical immunologists. [en.auh.dk]

    If transplantation therapy is to be more widely adopted it will be crucial to have a global capacity to train and educate specialist surgeons, physicians, pathologists, nurses, donor and transplant coordinators and allied health professionals. [web.archive.org]

    A general British wariness about the abuse of body parts dates from a scandal at the Alder Hey children's hospital in Liverpool where Dick van Velzen, a Dutch pathologist, cut thousands of parts from children who died between 1988 and 1994, without their [economist.com]

    The biopsy specimens were stained with hematoxylin and eosin and were examined by pathologists with expertise in cardiac-transplant biopsies, who assessed them according to the criteria of the International Society for Heart and Lung Transplantation. [doi.org]

    Histological evaluation was performed by the local pathologist according to the Banff scheme [ 13 ]; rejection episodes were considered if they occurred during the first year after transplantation. [ndt.oxfordjournals.org]

  • Malaise

    A 37-year-old woman presented with malaise, upper abdominal pain and fever seven months after renal transplantation. She was seronegative for cytomegalovirus (CMV) and had received a kidney from a seropositive donor. [ncbi.nlm.nih.gov]

Gastrointestinal

  • Vomiting

    Patient was admitted with irregular fever, severe headache, nausea and vomiting in the department of Nephrology on July 2007. After admission patient was thoroughly evaluated and clinically found features of meningitis. [ncbi.nlm.nih.gov]

    Symptoms may include fever, rash, jaundice, vomiting, diarrhea, abdominal pain, weight loss, and increased risk of infections. These reactions can be fatal. [msdmanuals.com]

  • Nausea

    Patient was admitted with irregular fever, severe headache, nausea and vomiting in the department of Nephrology on July 2007. After admission patient was thoroughly evaluated and clinically found features of meningitis. [ncbi.nlm.nih.gov]

    If rejection occurs soon after transplantation, symptoms may include fever, chills, nausea, fatigue, and sudden changes in blood pressure. [msdmanuals.com]

    Rejection medications may have side effects of increased blood pressure, headaches, diarrhea, and nausea. Also, because rejection medications weaken the immune system, it can be hard for liver transplant patients to fight infections. [slideshare.net]

    Six patients were readmitted once after transplantation: 2 for an elevated creatinine level (1 of whom was diagnosed as having rejection), 1 after a rise in the IgG isoagglutinin titer for multiple days of inpatient plasmapheresis, 1 for severe nausea [dx.doi.org]

Psychiatrical

  • Fear

    This is largely due to fear of transmitting the pathogenic organisms to the immunosuppressed recipient. [ncbi.nlm.nih.gov]

    They fear that donors may drop out once their relative or friend has received a kidney, if there is a delay before they give their own organ, bringing the domino arrangement to a halt. [northernstar.com.au]

    Most people were fearful or uncomfortable with thoughts of death—particularly their own—and consequently did not contemplate organ donation. [law.jrank.org]

    Such a law would ensure that fear of job loss is not the reason that a willing donor does not donate, without unduly burdening private employers with mandates they may not be able to fulfill. [bioethicsarchive.georgetown.edu]

    Many people who hear the myth probably dismiss it, but it is possible that some believe it and decide against organ donation out of needless fear." Reference: Organ Procurement and Transplantation Network at www.optn.org/about/myths. [transweb.org]

Neurologic

  • Confusion

    A 55-year-old male presented 6 months post cadaveric renal transplant with headache, fever and confusion. Neuroimaging was unremarkable, but an electroencephalogram was consistent with diffuse encephalopathy. [ncbi.nlm.nih.gov]

    Without an established transplantation system, and with cultural norms opposed to organ donation, some degree of confusion surrounding transplantation is to be expected. But the problems in China are worse than shortages and confusion. [thenewatlantis.com]

    In short, managing medications after transplant surgery can be complex and confusing. Selecting a good pharmacy and getting to know your pharmacist can help you understand your medications and manage your medication schedule. [organdonor.gov]

    Then they vanished away all confused. There was a friar which was fellow of S. [fordham.edu]

  • Forgetful

    Does Western capitalism make us forget that altruism is possible? Further studies are needed to explore these issues. Conclusion This exploratory study describes views on altruism offered by a sample of French and Quebec transplant physicians. [bmcresnotes.biomedcentral.com]

    And I cried with an high cry of mine heart: O in pace, O in id ipsum, O thou that sayst I shall sleep in that same and take rest, thou art the same, for thou art not changed, and in thee is rest, forgetting all labours. [fordham.edu]

Workup

For example, a status code of "pretransplant workup in progress" indicates the patient is interested in transplantation (step B complete). [doi.org]

However, the transplantation process involves a series of steps related to medical suitability, interest in transplantation, pretransplant workup, and movement up a waiting list to eventual transplantation. [ncbi.nlm.nih.gov]

Patients donating a kidney underwent a standard workup, including computed tomographic urography, blood work, urinalysis, medical history intake, and physical examination. [dx.doi.org]

Treatment

Autoimmune hemolytic anemia usually occurs within the first year and has been attributed to immunosuppressive treatment, infections, or underlying post-transplant lymphoproliferative disorder. [ncbi.nlm.nih.gov]

Prognosis

Prognosis of head and neck cancer arising in solid organ transplantation recipients is proven to have poor prognosis. [ncbi.nlm.nih.gov]

It is however, widely accepted that the prognosis for heart failure in adults is improving and the new treatments for adult heart failure are beginning to permeate into paediatrics. [doi.org]

The cancer would probably return in the new organ, the doctors told De Leon, 50, a construction superintendent who cried when he learned of his prognosis. [sfgate.com]

Etiology

The etiology of post-transplantation ARI is poorly understood, with only isolated clinical cases being reported, most imputed to drug toxicity. [ncbi.nlm.nih.gov]

What This Study Adds: This study of pediatric solid organ transplant recipients identifies an elevated risk of numerous cancer types in addition to non-Hodgkin’s lymphoma and provides evidence for a key role of Epstein-Barr virus in the etiology of most [pediatrics.aappublications.org]

In a series of 84 HCV-coinfected liver transplant recipients in Spain, 64% experienced at least 1 infection (largely non-OIs) and 43% developed severe infections, which proved fatal in 19%.(12) Infectious etiologies were bacterial in 45%, and fungal in [hivinsite.ucsf.edu]

Epidemiology

We reviewed medical, laboratory and epidemiological records at our hospital, and the literature concerning cases of organ-transmitted WNV infections and WNV screening of organ donors in Italy and worldwide. [ncbi.nlm.nih.gov]

Pathophysiology

Transplantation decision-making in aHUS has evolved over this time with expanding knowledge of pathophysiology and genetics, alongside refined plasma exchange and anticoagulation protocols and improved centre experience. [ncbi.nlm.nih.gov]

Current Status of Islet Transplantation 40.1 Introduction 40.2 The Burden of Type 1 Diabetes Mellitus 40.3 Pathophysiology of Type 1 Diabetes Mellitus 40.4 Standard Management of Patients with Type 1 Diabetes 40.5 Indications to Islet Transplantation [elsevier.com]

Prevention

Prophylaxis against bacterial, viral, and fungal infections is often used to prevent infection from common pathogens during high-risk periods. [ncbi.nlm.nih.gov]

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