Edit concept Question Editor Create issue ticket

Organic Brain Syndrome

OBS


Presentation

  • All three presented with high-grade fever and twilight state, and were admitted to our hospital. After admission, delirium developed in all three.[ncbi.nlm.nih.gov]
  • In the present study, the increased mortality was related to the severity of OBS but apparently independent of coexisting physical illness, again supporting the argument that OBS represents pathological as distinct from physiological aging.[ncbi.nlm.nih.gov]
  • RESULTS: Of the 52 patients, 23% presented delirium. These patients were older than the control group, 73.5 /- 4.2 and 69.3 /- 5.9 years, respectively (mean /- SD, p 0.01), and had more frequently a history of previous stroke (p 0.05).[ncbi.nlm.nih.gov]
  • The present clinical investigations demonstrated that the spontaneous restitution of the alcoholic OBS was significantly augmented and accelerated by modafinil. 4. Psychometric tests did not show significant intergroup differences.[ncbi.nlm.nih.gov]
  • The present data confirm previous predictions about the encephalotropic and psychotropic properties of piridoxilate; these predictions were based on pharmaco-EEG trials in the elderly that suggested vigilance-improving qualities of piridoxilate.[ncbi.nlm.nih.gov]
Skin Lesion
  • Systemic mastocytosis is a disease characterized by an excessive accumulation of mast cells, and associated with skin lesions, flushing, diarrhea, tachycardia, and psychiatric manifestations.[ncbi.nlm.nih.gov]
  • Abstract Systemic mastocytosis is a disease characterized by an excessive accumulation of mast cells, and associated with skin lesions, flushing, diarrhea, tachycardia, and psychiatric manifestations.[ncbi.nlm.nih.gov]
Delusion
  • See also substance-induced disorders. organic delusional syndrome a term used in a former system of classification, denoting an organic mental syndrome characterized by delusions caused by a specific organic factor and not associated with clouding of[medical-dictionary.thefreedictionary.com]
  • Influence of previous psychiatric history on hallucinations and delusions in OBS Again, none of these associations proved significant.[annals-general-psychiatry.biomedcentral.com]
  • Both may be marked by illusions, hallucinations, delusions, or disturbances of perceptions, mood, behavior, cognitive capacity, or personality. WHY: Delirium can occur with rheumatic fever or cerebral vasculitis.[sideeffects.embl.de]
  • Other medications, such as risperidone or quetiapine, may also be used to help behavioral problems such as hallucinations, delusions, or agitation.[medicineonline.com]
Aggressive Behavior
  • Medications may be needed to reduce aggressive behaviors typical of some of the conditions in this category. None Cognitive Disorder's[psychnet-uk.com]
  • Medicines may be needed to reduce aggressive behaviors that can occur with some of the conditions. Outlook (Prognosis) Some disorders are short-term and treatable. But many are long-term or get worse over time.[ufhealth.org]
  • Medicines may be needed to reduce aggressive behaviors that can occur with some of the conditions. Some disorders are short-term and reversible. But many are long-term or get worse over time.[medlineplus.gov]
Visual Hallucination
  • Visual hallucinations in consultation-liaison neuropsychiatry . Acta Neuropsychiatrica, Vol. 19, Issue. 06, p. 330.[cambridge.org]
  • Cross-tabulations reported p 0.919, p 0.770, p 0.336 respectively for visual hallucinations, auditory hallucinations and delusions. E.[annals-general-psychiatry.biomedcentral.com]
  • For example, people with Lewy body dementia often have long-lasting visual hallucinations. Some forms of dementia also tends to affect people younger than others and progress faster.[medbroadcast.com]
Impulsivity
  • ., emotional instability, marked apathy, or impaired impulse control, caused by a specific organic factor and not associated with delirium, prominent mood disturbance, delusions, or hallucinations.[medical-dictionary.thefreedictionary.com]
  • […] impaired insight and judgment and loss of affect; memory impairment is often the most prominent initial symptom, and others include increasing rigidity of thought; restricted interests; easy distractibility; lack of initiation; speech disturbances; loss of impulse[medi-info.com]
  • ., explosive temper outbursts, sudden crying, etc.) and impairment in impulse control; OR Loss of measured intellectual ability of at least 15 I.Q. points or overall impairment index clearly within the severely impaired range on neuropsychological testing[disability-benefits-help.org]
  • The Patients Patient 1: A 38 year old mate technician was admitted with loss of impulse control, emotional liability and disordered thinking.[benzo.org.uk]
Psychiatric Manifestation
  • It is important for psychiatrists to be aware that mental status changes can represent psychiatric manifestations of mastocytosis, a readily treatable medical disorder.[ncbi.nlm.nih.gov]
Confusion
  • That D-amphetamine was critical to the resulting marked diminution in confusion, paranoia, and deficit in short term memory was confirmed by the occurrence of a relapse coincident with placebo administration as part of a double blind evaluation.[ncbi.nlm.nih.gov]
  • Both patients had intellectual impairment and memory loss punctuated by periods of confusion, tremulousness, clumsiness, difficulty in walking, and myoclonic jerks.[ncbi.nlm.nih.gov]
  • Subjects experienced a reduction in depression and confusion and an increase in vigor. This evidence of an increase in vigor was supported behaviorally by a delay in the onset of increased latency in reaction time.[ncbi.nlm.nih.gov]
  • A 68-year-old woman, who was treated with 5-fluorouracil (5-FU) intravenous therapy weekly for variable periods following hemicolectomy for adenocarcinoma of the cecum, had at least two well-described episodes of mental confusion, disorientation, and[ncbi.nlm.nih.gov]
  • […] signs and symptoms including problems with attention, concentration, memory, confusion, anxiety, and depression caused by transient or permanent dysfunction of the brain.[medical-dictionary.thefreedictionary.com]
Personality Change
  • For example, some people who experience traumatic brain injuries undergo personality changes in addition to experiencing neurological symptoms like difficulty walking or speaking.[wisegeek.com]
  • Instead, people with subcortical dementia can experience behavior and personality changes, resulting in socially inappropriate and unusual actions. Some forms of dementia are progressive, which means that they get worse over time.[nmihi.com]
  • changes, including agitation and irritability impaired ability to orient the body to the surrounding space a loss of interest in activities that were previously pleasurable loss of bowel and bladder control Sometimes individuals will wander.[medicineonline.com]
  • Unable to plan a meal or balance a check book Inability to use objects correctly Progression of Dementia Phase 2 Progression of difficulty interacting in social situations Personality changes Irritability Rigidity Perseveration (repeating of meaningless[quizlet.com]
  • Dementia and delirium are the cause of the confusion, orientation, cognition or alertness impairment. [9] Therefore, these symptoms require more attention because hallucinations, delusions, amnesia, and personality changes are the result.[en.wikipedia.org]
Apathy
  • ., emotional instability, marked apathy, or impaired impulse control, caused by a specific organic factor and not associated with delirium, prominent mood disturbance, delusions, or hallucinations.[medical-dictionary.thefreedictionary.com]
  • Dementia in Pick's disease ( G31.0 ) A progressive dementia, commencing in middle age, characterized by early, slowly progressing changes of character and social deterioration, followed by impairment of intellect, memory, and language functions, with apathy[apps.who.int]
Slurred Speech
  • Physical symptoms: Restlessness , Tremor ,Ataxia ,Slurred speech ,Incontinance. Behavior disturbance – wandering ,aggressive outbursts Predisposing factors: Age—any age- common in young children and elderly pts( dementia).[slideshare.net]
Decreased Attention Span
  • attention span Disorganized thinking Rambling, incoherent speech Decreased LOC Illusions, hallucinations, or other perceptual disturbances Disorientation Memory impairment Disturbances of sleep/wake cycles Sudden increase in confusion Physical and/or[quizlet.com]

Treatment

  • Thus, oxiracetam seems to have no effect in the treatment of organic brain syndrome.[ncbi.nlm.nih.gov]
  • Side effects were observed more frequently under active treatment and were characterized by temporary headaches.[ncbi.nlm.nih.gov]
  • EMD 21657 treatment was interrupted because of side effects (increased aggressiveness, rash) in 2 cases.[ncbi.nlm.nih.gov]
  • Longer treatment periods and further specifications with regard to the aetiopathology and degree of cognitive impairment are recommended for further clinical studies of this promising compound.[ncbi.nlm.nih.gov]
  • Abstract Evaluation of treatment modalities, including pharmacotherapy, for organic brain syndrome (OBS) has been difficult because of sampling and methodological problems, and comparisons of research studies are all but impossible.[ncbi.nlm.nih.gov]

Prognosis

  • Outlook (Prognosis) Some disorders are short-term and treatable. But many are long-term or get worse over time. Possible Complications People with neurocognitive disorder often lose the ability to interact with others or function on their own.[ufhealth.org]
  • Drug withdrawal Dose 1—1.5 mg daily orally 1 hour a day of 0.8% I/V Risk of dependence Prognosis: Depends on causative condition Commonest out come—complete recovery MR 12% DRUGS CAUSING DELIRIUM: Tranqulizer and hypnotics—Barbsiturate,Benzodiazepine,[slideshare.net]
  • Many of the cases are long-term, and there is not as much of a set and defined prognosis.[en.wikipedia.org]
  • Determining their varied presentations may help in earlier detection, better management, and, assessing prognosis and outcome.[annals-general-psychiatry.biomedcentral.com]

Etiology

  • The term was sometimes used as a synonym of organic mental syndrome. organic mental syndrome former term for a constellation of psychological or behavioral signs and symptoms associated with brain dysfunction of unknown or unspecified etiology, grouped[medical-dictionary.thefreedictionary.com]
  • Diagnostic Tests The diagnosis of delirium is based on the clinical presentation, particularly the fluctuation of symptoms with periods of lucidity, and a history of one or more etiologic agents.[medi-info.com]
  • […] and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Until now, there is no evidence for etiologic and pathophysiologic mechanisms. However, at the present time the acute psychoorganic syndrome is considred to be a stressinduced cerebral dysregulation.[thieme-connect.com]
  • Differential diagnosis of EOD is complicated by the fact that symptoms may be more variable in younger patients than in the elderly, due to different etiologies (McMurtray, Clark, Christine, & Mendez, 2006; Fadil et al., 2009), lack of awareness about[asha.org]

Epidemiology

  • Comparison of a screening test and a reference test in epidemiologic studies. I. Indices of agreement and their relation to prevalence . American Journal of Epidemiology 83 , 586 – 592 . Cicchetti , D V. ( 1976 ).[journals.cambridge.org]
  • A 3-Site Epidemiologic Study. J General Intern Med. 1998, 13 (4): 234-242. 10.1046/j.1525-1497.1998.00073.x. View Article Google Scholar Huang SC: Characteristics and Outcome of Delirium in Psychiatric Inpatients.[annals-general-psychiatry.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • Alcoholic organic brain disease may result from two interacting pathophysiological processes: nutritional (thiamine) deficiency and ethanol neurotoxicity.[ncbi.nlm.nih.gov]
  • Therefore in the organic brain syndrome there seems to exist a pathophysiological dysfunction of brain barriers in addition of the neural damage.[ncbi.nlm.nih.gov]
  • "Alcoholic organic brain disease: nosology and pathophysiologic mechanisms". Prog. Neuropsychopharmacol. Biol. Psychiatry. 10 (2): 147–64. doi : 10.1016/0278-5846(86)90069-2. PMID 2875490. a b c Rogers, M. P; Bloomingdale, K; Murawski, B.[en.wikipedia.org]
  • Disease Process The pathophysiology of organic mental syndromes is not yet understood.[medi-info.com]
  • Drugs and alcohol abuse – predispose to delirium more readily Pathophysiology: The cerebral dysfunction lie in brain stem reticular formation , thalamic nuclei mainly mid line. This leads to disturbance in arousal ,attention ,wake sleep cycle.[slideshare.net]

Prevention

  • Thus, the vast majority of those diagnosed as being without OBS at about the age of 80 years remained asymptomatic in subsequent years, supporting the view that OBS is not a necessary concomitant of old age, but the result of disease for which prevention[ncbi.nlm.nih.gov]
  • , schedules, memory books, name tags); encouragement to do familiar, repetitive routines; safety precautions to prevent wandering; use of adult day care, respite care, or home care to relieve caregiver; family support groups and counseling; prevention[medi-info.com]
  • To prevent atherosclerosis, don't smoke, eat a diet low in fat, exercise regularly and reduce stress whenever possible. Ask your doctor about preventive steps to take.[nmihi.com]
  • Expert information on promising new treatments, practical coping strategies for caregivers, and the latest on prevention of Alzheimer's disease.[healthcentral.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!