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Oropharyngeal Carcinoma

Carcinoma of Oropharynx


Presentation

  • Bacteremia due to Erysipelothrix rhusiopathiae is rare; the most common presentation reported in the literature is endocarditis.[ncbi.nlm.nih.gov]
  • See a doctor if any of the following symptoms are present: A sore throat that persists Pain or difficulty with swallowing Unexplained weight loss Voice changes Ear pain A lump in the back of the throat or mouth A lump in the neck Cleveland Clinic News[my.clevelandclinic.org]
Weight Loss
  • See a doctor if any of the following symptoms are present: A sore throat that persists Pain or difficulty with swallowing Unexplained weight loss Voice changes Ear pain A lump in the back of the throat or mouth A lump in the neck Cleveland Clinic News[my.clevelandclinic.org]
  • The possible signs of oropharyngeal cancer are: A sore throat that persists for over 2 weeks Throat pain or difficulty swallowing Unexplained rapid weight loss Voice changes (more hoarse) Ear pain A lump in the back of the throat or mouth A lump in the[en.wikipedia.org]
  • Weight loss for no known reason. Ear pain. A lump in the back of the mouth, throat, or neck. A white patch on the tongue or lining of the mouth that does not go away. Coughing up blood.[cancer.gov]
Fatigue
  • And patients usually suffer severe fatigue during treatment. Although the burns, fatigue, and swallowing problem usually go away after therapy, patients may have another problem for the rest of their lives: dryness of the mouth and throat.[webmd.com]
  • The advantages offered to the surgeon include a three‐dimensional view, 360 robotic arm movement (in restricted spaces with precision of movement), hand tremor filtration and lack of muscle fatigue.[cochranelibrary.com]
Hodgkin Lymphoma
  • For more information about these cancers refer to the American Cancer Society documents, Non-Hodgkin Lymphoma, Non-Hodgkin Lymphoma in Children , and Hodgkin Disease.[web.archive.org]
Sore Throat
  • A few weeks ago Jason found out that his two month long sore throat was in fact a bit of cancer growing on his esophagus. The good news is that it's localized and very much treatable. He gets started later this week.[greendayauthority.com]
  • Signs and symptoms of oropharyngeal cancer include a lump in the neck and a sore throat. These and other signs and symptoms may be caused by oropharyngeal cancer or by other conditions.[cancer.gov]
  • See a doctor if any of the following symptoms are present: A sore throat that persists Pain or difficulty with swallowing Unexplained weight loss Voice changes Ear pain A lump in the back of the throat or mouth A lump in the neck Cleveland Clinic News[my.clevelandclinic.org]
  • The possible signs of oropharyngeal cancer are: A sore throat that persists for over 2 weeks Throat pain or difficulty swallowing Unexplained rapid weight loss Voice changes (more hoarse) Ear pain A lump in the back of the throat or mouth A lump in the[en.wikipedia.org]
Heavy Tobacco Use
  • tobacco use (odds ratio, 2.5; 95% CI, 1.1 to 6.0) after adjustment for age, sex, and alcohol use.[content.nejm.org]
Hemoptysis
  • In October 2012, the patient presented to the Head-Neck ER after episodes of hemoptysis; a lesion was found in the left tonsillar lodge. A biopsy was performed with a result of squamous cell carcinoma with low-grade differentiation.[ncbi.nlm.nih.gov]
Dysphagia
  • Limited data examine these neuropathies after oropharyngeal cancer, particularly as it relates to late radiation-associated dysphagia (late-RAD). Two cases were examined over 4 to 6 years.[ncbi.nlm.nih.gov]
  • […] exposureCertain genetic changes including: P53 mutation and CDKN2A (p16) mutations.High-risk lesions: Erythroplakia Speckled erythroplakia Chronic hyperplastic candidiasisMedium-risk lesions: Oral submucosal fibrosis Syphilitic glossitis Sideropenic dysphagia[en.wikipedia.org]
  • To prevent post-surgical dysphagia in oral or oropharyngeal cancer patients, crico-pharyngeal myotomy and laryngeal suspension are recommended; however, its indication has been controversial.[ci.nii.ac.jp]
  • The primary outcome measure is swallowing function (MD Anderson Dysphagia Inventory) at one year.[cochranelibrary.com]
Odynophagia
  • […] modified by cutting out the consumption of tobacco and alcohol. 36 Clinical manifestations, diagnosis and evaluation Early oropharyngeal tumors are often asymptomatic, but advanced tumors produce local pain, ear ache, cervical lymphadenopathy, trismus, odynophagia[scielo.org.mx]
Periodontitis
  • ., periodontitis), it may serve as a surrogate for chronic infection and inflammation, which may be important in the pathogenesis of cancer.[content.nejm.org]

Treatment

  • Treatment Options by Stage For information about the treatments listed below, see the Treatment Option Overview section.[cancer.gov]
  • Keep in mind that all cancer treatments have side effects, both short term and long term, but it is the MD Anderson physicians’ goal to factor in the effect of each treatment on a person’s quality of life as part of the treatment decision-making for any[mdanderson.org]
  • Free lodging near treatment. A 24/7/365 live helpline. Rides to treatment. This is far from a complete list, but it makes one thing clear. When it comes to cancer, we are the only organization attacking from every angle.[cancer.org]

Prognosis

  • Its prognosis is largely dependent upon tumour-stage at the time of diagnosis.[eurjcancerprev.com]
  • Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) depends on the following: Whether the patient has HPV infection of the oropharynx.[cancer.gov]
  • “The prognosis is good, and the survival rate is high. Unfortunately the treatment will be rough on my body, and my voice.”[jambase.com]
  • The most important factors that were associated with a poor prognosis were stage IV in oropharyngeal [Hazard ratio (HR) 3.68, 95% confidence interval (CI) 0.97–13.92] and hypopharyngeal cancer (HR 3.99, CI 1.51–10.67) and age over 65 years in nasopharyngeal[springerlink.com]

Etiology

  • This article discusses the etiology and clinical presentation of HPV-positive and HPV-negative oropharyngeal cancer, noting distinctions between the 2 types. Recommendations for screening and prevention are provided.[ncbi.nlm.nih.gov]
  • Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer. 2001;93:232–5. PubMed Google Scholar 7. Braakhuis BJ, Snijders PJ, Keune WJ, et al.[doi.org]
  • View Article PubMed Google Scholar Lewin F, Norell SE, Johansson H, Gustavsson P, Wennerberg J, Biorklund A, Rutqvist LE: Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population–based case–referent[biomedcentral.com]

Epidemiology

  • Discussion This epidemiologic study provides support for the association between HPV and a subgroup of oropharyngeal cancers.[content.nejm.org]
  • The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Italian population.[ncbi.nlm.nih.gov]
  • ., Montplaisi, J. (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology.[scindeks.ceon.rs]
  • Further molecular and epidemiological studies should be done to examine the relation between carcinogens and cancers in CDKN2A mutation carriers. CDKN2A p.Arg112dup mutation carriers should be strongly advised to abstain from tobacco smoking.[doi.org]
  • Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck 2007;29(8):779-792. [ Links ] 26. Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, et al.[scielo.org.mx]
Sex distribution
Age distribution

Prevention

  • Recommendations for screening and prevention are provided.[ncbi.nlm.nih.gov]
  • These strategies should be directed at prevention and early diagnosis in order to increase patient survival and quality of life and decrease the consumption of health care resources. 1 Division of Oral Medicine, Department of Odontostomatological and[eurjcancerprev.com]
  • Strong epidemiologic data would provide additional support for a causal association between HPV and oropharyngeal cancers and might guide future cancer-prevention programs involving vaccination to prevent oral HPV infection or screening to detect it.[content.nejm.org]
  • However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”[cancer.gov]

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