Case presentation Clinical presentation A 26 year old male was admitted with impaired hearing and tinnitus on the right side and swelling of the right temporal region which was gradually progressive for the last two years. [doi.org]

Increasing pain at the tumor site is the most common presenting symptom. Three types of GCT can be distinguished radiographically according to the Cappanacci or Enneking classification. [ncbi.nlm.nih.gov]

Case presentation A 20 year-old boy presented with chief complaints of insidious onset pain in the left ankle since the last two years, swelling in the left ankle since the last six months and inability to bear weight on right side since the last six [faoj.org]

• Small Hand

  GCTB less commonly affects craniofacial bones, vertebral body, sacrum, and the small hand and feet bones. Interestingly, some patients have no symptoms, often being found incidentally or as a result of a pathological fracture. [ncbi.nlm.nih.gov]

• Bone Disorder

  Source: Websters Dictionary (01 Mar 1998) osteologist A doctor who specialises in the diagnosis and treatment of bone disorders. (09 Oct 1997) osteology <study> The medical study of diseases and disorders of bones. (09 Oct 1997) [kmle.co.kr]

  But in some cases, they have been linked to Paget disease of bone. This is a chronic bone disorder in which bones become enlarged and misshapen. What are the symptoms of a giant cell tumor? Below are the most common symptoms of a giant cell tumor. [urmc.rochester.edu]

  Lesions in this disorder are multiple lesions in one bone, then very quickly going to the surrounding bone metastasis to the lung or lungs. [herryyudha.blogspot.com]

• Bony Swelling

  Figure 1: Bony swelling anteromedial aspect of proximal left thigh (margins if swelling marked by*) with abduction deformity of left lower extremity Click here to view Neurological examination of lower extremity was normal without any neurodeficit. [jscisociety.com]

  On extraoral examination, there was a diffuse bony swelling of the left maxilla which was slightly tender on palpation. [hindawi.com]

• Short Legs

  (Fig. 5) The patient was advised non weight bearing on the affected limb for 8 weeks and mobilized in a short leg walking cast thereafter. Figure 4 Intraoperative image showing the lesion. [faoj.org]

• Flexion Contracture

  Postoperatively, she was asked to lie supine or prone (to tolerance) to prevent hip flexion contracture. She was continued on sliding scale as mentioned before till the sugar levels returned to normal. [hindawi.com]

• Neck Mass

  She also complained of difficulty in breathing for the past one and a half months along with increased sweating, headache, loss of appetite and weight along with a rapid increase in the size of the neck mass. [jcytol.org]

Correct modern preoperative neuroimaging workup, coupled with microneurosurgical technique, allowed successful lesion removal with good outcome. [ncbi.nlm.nih.gov]

In addition, lesions may mechanically interfere with the spinal cord or nerve roots, producing neurologic deficits. [26, 27] Preferred examination The preliminary radiologic workup should consist of radiography at the site of the patient's pain. [1, 2 [emedicine.medscape.com]

There is an 18% incidence of multicentric foci indicating that a bone scan should be a part of routine workup of these tumors 2. Overall they appear in a younger age group and recur more rapidly in the hand than they do in other locations. [ispub.com]

Diagnosis[edit] When diagnosing osteoblastoma, the preliminary radiologic workup should consist of radiography of the site of the patient's pain. [en.wikipedia.org]

• Hypochromatism

  The nuclei are generally hypochromatic with inconspicuous nucleoli and mitotic figures are uncommon [ 4 ]. Histological differentiation of GCT may be challenging. [doi.org]

• Multilocular Cyst

  There are certain lesions of bone which present radiographic features which may be mistaken for those of this tumour, e.g., multilocular cyst, osteitis fibrosa cystica (simple or due to hyperparathyroidism), chondroma, single lesions of polyostotic fibrous [pubs.rsna.org]

The recurrence rate of patients who received first treatment at our institution was 16.6%. The most common primary treatment was curettage (188 patients) usually followed by adjuvant local therapy. [doi.org]

The role of cryosurgery as a supplement to curettage and partial excision. - Giant cell tumor of the sacrum. - Treatment of Giant-Cell Tumor of the Pelvis. - Surgical treatment of giant cell tumors of the pelvis. [wheelessonline.com]

Surgery is the mainstay of treatment and usually consists of intralesional curettage; local control rates range from 80% to 90% after this procedure. [ncbi.nlm.nih.gov]

Prognosis The overall prognosis of a giant cell tumor of bone is good, though local recurrence can vary widely. [ncbi.nlm.nih.gov]

It is hypointense to isointense on T1-weighted MRI and has variable presentation on T2-weighted MRI. [21] The etiology of osteoblastoma is unknown. [emedicine.medscape.com]

North Bengal Medical College, Darjeeling,West Bengal Sankarshan Bhaduri Asit Chandra Ray Keywords: Giant cell tumor, metacarpal, FNAC Abstract Giant cell tumor (GCT) or osteoclastoma is a common benign tumor which is locally aggressive and is of unknown etiology [pacificejournals.com]

The exact etiology of osteoblastoma is still unknown, and so are the predisposing factors. [ncbi.nlm.nih.gov]

Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment. Ortop Traumatol Rehabil. 2010 May-Jun;12(3):207-15. Review. PMID: &dopt=Abstract Thomas DM, Skubitz KM. Giant cell tumour of bone. [anvita.info]

[Article in English, Polish] Author information 1 Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok. [email protected] Abstract The author presents the epidemiology, classification, clinical features and strategies [ncbi.nlm.nih.gov]

The Journal of Bone & Joint Surgery, 69, 106-114. [ 5 ] Beebe-Dimmer, J.L., Cetin, K., Fryzek, J.P., Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology [scirp.org]

Beebe-Dimmer, J.L., Cetin, K., Fryzek, J.P., Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology and End Results Program (1975-2004). [file.scirp.org]

Pathology and Forensic Medicine (340) Internal Medicine (289) Oncology, Radiation Therapy (237) Surgery, Traumatology and Orthopaedics (162) Physiology and Pathophysiology (161) Medical Chemistry and Biochemistry (148) Paediatrics, Neonatology (109) Genetics [portal.mefanet.cz]

Pathophysiology The pathophysiology is not entirely understood but is thought to be caused by the RANK/RANKL signaling pathway overexpression by osteoblast-like mononuclear stromal cells. [ncbi.nlm.nih.gov]

Elastic stockinette was wrapped over the postoperative dressing to prevent edema accumulation in the residual limb. Postoperatively, she was asked to lie supine or prone (to tolerance) to prevent hip flexion contracture. [hindawi.com]

Differential-diagnosis osteosarcoma chondroblastoma osteoid osteoma osteoblastoma bone cyst brown tumor of hyperparathyroidism Management surgery if tumor is resectable curettage is most common technique zoledronate is thought to induce osteoclast apoptosis, preventing [anvita.info]

About XGEVA XGEVA was approved by the FDA for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors in 2010. XGEVA is not indicated for the prevention of SREs in patients with multiple myeloma. [amgen.com]

Treatment measures for Giant Cell Tumor of Soft Tissue include the following: Surgical excision with complete removal of the entire lesion is normally sufficient treatment If there is any pain, it is controlled through pain medications In order to prevent [dovemed.com]

Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint. Giant cell tumors are named for the characteristic way they look when viewed under the microscope. [orthoinfo.aaos.org]