Symptoma

Osteoclastoma

Bone Giant Cell Tumor

Classical manifestations of the disease are present in about 15-20% of patients. [ncbi.nlm.nih.gov]

Case presentation Clinical presentation A 26 year old male was admitted with impaired hearing and tinnitus on the right side and swelling of the right temporal region which was gradually progressive for the last two years. [doi.org]

  • Camping

    […] cells (osteoclasts) and a minor population of mononuclear cells. [125I]-sCT competitive binding studies indicated a Kd of 5 x 10(-10) M and receptor number of approximately 1 million sites/osteoclast. sCT treatment resulted in a dose-dependent rise in cAMP [ncbi.nlm.nih.gov]

  • Bony Swelling

    Figure 1: Bony swelling anteromedial aspect of proximal left thigh (margins if swelling marked by*) with abduction deformity of left lower extremity Click here to view Neurological examination of lower extremity was normal without any neurodeficit. [jscisociety.com]

    On extraoral examination, there was a diffuse bony swelling of the left maxilla which was slightly tender on palpation. [hindawi.com]

  • Short Legs

    (Fig. 5) The patient was advised non weight bearing on the affected limb for 8 weeks and mobilized in a short leg walking cast thereafter. Figure 4 Intraoperative image showing the lesion. [faoj.org]

  • Flexion Contracture

    Postoperatively, she was asked to lie supine or prone (to tolerance) to prevent hip flexion contracture. She was continued on sliding scale as mentioned before till the sugar levels returned to normal. [hindawi.com]

  • Urinary Urgency

    Weakness was associated with urinary urgency with decreased sensation in the legs extending to the lower thorax. Neurological examination showed cortical functions and cranial nerve pairs to be normal. [elsevier.es]

  • Clonus

    Assessment of motor functions revealed mild lower limb spasticity, global and symmetrical muscle strength of 4/5 in lower extremities, hyperreflexia, ankle clonus, and bilateral Babinski signs. Hypoesthesia was present up to the D8 level. [elsevier.es]

  • Cranial Neuropathy

    This paper has described an unusual case of osteoclastoma of the petrous temporal bone which presented with multiple cranial neuropathies. A radical course of radiotherapy reversed the neuropathies but it is too early to comment on possible cure. [ncbi.nlm.nih.gov]

Correct modern preoperative neuroimaging workup, coupled with microneurosurgical technique, allowed successful lesion removal with good outcome. [ncbi.nlm.nih.gov]

In addition, lesions may mechanically interfere with the spinal cord or nerve roots, producing neurologic deficits. [26, 27] Preferred examination The preliminary radiologic workup should consist of radiography at the site of the patient's pain. [1, 2 [emedicine.medscape.com]

There is an 18% incidence of multicentric foci indicating that a bone scan should be a part of routine workup of these tumors 2. Overall they appear in a younger age group and recur more rapidly in the hand than they do in other locations. [ispub.com]

  • Hypochromatism

    The nuclei are generally hypochromatic with inconspicuous nucleoli and mitotic figures are uncommon [ 4 ]. Histological differentiation of GCT may be challenging. [doi.org]

  • Multilocular Cyst

    multilocular cyst, osteitis fibrosa cystica (simple or due to hyperparathyroidism), chondroma, single lesions of polyostotic fibrous dysplasia, plasmocytoma or solitary myeloma, certain sarcomata, secondary carcinoma, and tuberculosis. [pubs.rsna.org]

All patients had quantitation of pre-treatment tumour volume and post-treatment response using a radiographic grid. CT scan measurements have complimented the grid quantitation in recent years. [ncbi.nlm.nih.gov]

The recurrence rate of patients who received first treatment at our institution was 16.6%. The most common primary treatment was curettage (188 patients) usually followed by adjuvant local therapy. [doi.org]

Prognosis The overall prognosis of a giant cell tumor of bone is good, though local recurrence can vary widely. [ncbi.nlm.nih.gov]

Etiology The exact etiology of this tumor is not fully understood. But the mononuclear cells are thought to be derived from primitive mesenchymal cells. [ncbi.nlm.nih.gov]

From Epidemiology relatively uncommon 4-5% of primary bone tumors 20% of benign bone tumors higher incidence in Asia Pathology multinucleated giant cells ( osteoclasts or osteoclast -like) generally benign giant cell tumour stromal cells of osteoblastic [anvita.info]

[Article in English, Polish] Author information 1 Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok. [email protected] Abstract The author presents the epidemiology, classification, clinical features and strategies [ncbi.nlm.nih.gov]

Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology and End Results Program (1975-2004). [ 6 ] Campanacci, M., Baldini, N., Boriani, S. and Sudanese [scirp.org]

Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology and End Results Program (1975-2004). [file.scirp.org]

Pathophysiology The pathophysiology is not entirely understood but is thought to be caused by the RANK/RANKL signaling pathway overexpression by osteoblast-like mononuclear stromal cells. [ncbi.nlm.nih.gov]

Osteoclastoma rarely involves the vertebrae, and treatment, whether by surgery or radiotherapy, seldom results in eradication of the lesion or prevention of recurrence. [ncbi.nlm.nih.gov]

Elastic stockinette was wrapped over the postoperative dressing to prevent edema accumulation in the residual limb. Postoperatively, she was asked to lie supine or prone (to tolerance) to prevent hip flexion contracture. [hindawi.com]

Differential-diagnosis osteosarcoma chondroblastoma osteoid osteoma osteoblastoma bone cyst brown tumor of hyperparathyroidism Management surgery if tumor is resectable curettage is most common technique zoledronate is thought to induce osteoclast apoptosis, preventing [anvita.info]

Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint. Giant cell tumors are named for the characteristic way they look when viewed under the microscope. [orthoinfo.aaos.org]

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