Case Report A 64-year-old woman presented with abdominal pain. Her past medical history was unremarkable. Her physical examination was also unremarkable. The heart and the lung were normal. [brieflands.com]

Mild periosteal reaction along the lateral margin of the lesion is present. Overlying cortex appears thinned. Loading images... [radiopaedia.org]

Case presentation Clinical presentation A 26 year old male was admitted with impaired hearing and tinnitus on the right side and swelling of the right temporal region which was gradually progressive for the last two years. [doi.org]

To the best of our knowledge, this is the first study in the medical literature of such a presentation. [spandidos-publications.com]

• Bone Disorder

  Source: Websters Dictionary (01 Mar 1998) osteologist A doctor who specialises in the diagnosis and treatment of bone disorders. (09 Oct 1997) osteology <study> The medical study of diseases and disorders of bones. (09 Oct 1997) [kmle.co.kr]

  But in some cases, they have been linked to Paget disease of bone. This is a chronic bone disorder in which bones become enlarged and misshapen. What are the symptoms of a giant cell tumor? Below are the most common symptoms of a giant cell tumor. [urmc.rochester.edu]

  Lesions in this disorder are multiple lesions in one bone, then very quickly going to the surrounding bone metastasis to the lung or lungs. [herryyudha.blogspot.com]

• Bony Swelling

  Figure 1: Bony swelling anteromedial aspect of proximal left thigh (margins if swelling marked by*) with abduction deformity of left lower extremity Click here to view Neurological examination of lower extremity was normal without any neurodeficit. [jscisociety.com]

  On extraoral examination, there was a diffuse bony swelling of the left maxilla which was slightly tender on palpation. [hindawi.com]

Correct modern preoperative neuroimaging workup, coupled with microneurosurgical technique, allowed successful lesion removal with good outcome. [ncbi.nlm.nih.gov]

In addition, lesions may mechanically interfere with the spinal cord or nerve roots, producing neurologic deficits. [26, 27] Preferred examination The preliminary radiologic workup should consist of radiography at the site of the patient's pain. [1, 2 [emedicine.medscape.com]

There is an 18% incidence of multicentric foci indicating that a bone scan should be a part of routine workup of these tumors 2. Overall they appear in a younger age group and recur more rapidly in the hand than they do in other locations. [ispub.com]

Diagnosis[edit] When diagnosing osteoblastoma, the preliminary radiologic workup should consist of radiography of the site of the patient's pain. [en.wikipedia.org]

• Multiple Pulmonary Nodules

  (e) Chest CT scan shows multiple pulmonary nodules in both lungs (arrowheads). [doi.org]

• Hypochromatism

  The nuclei are generally hypochromatic with inconspicuous nucleoli and mitotic figures are uncommon [ 4 ]. Histological differentiation of GCT may be challenging. [doi.org]

• Multilocular Cyst

  There are certain lesions of bone which present radiographic features which may be mistaken for those of this tumour, e.g., multilocular cyst, osteitis fibrosa cystica (simple or due to hyperparathyroidism), chondroma, single lesions of polyostotic fibrous [pubs.rsna.org]

Treatment / Management The treatment of choice for patients with a giant cell tumor of bone involving the appendicular skeleton is surgery. [ncbi.nlm.nih.gov]

The recurrence rate of patients who received first treatment at our institution was 16.6%. The most common primary treatment was curettage (188 patients) usually followed by adjuvant local therapy. [doi.org]

[citation needed] Treatment[edit] General treatment regimens have not changed much in the past 30 years, in part due to the lack of randomized clinical trials.[4] Surgery is the treatment of choice if the tumor is determined to be resectable. [en.wikipedia.org]

Treatment is usually curettage or wide resection, with typically a good prognosis. Rarely GCTB can under malignant transformation. These may be primary or secondary. [pubmed.ncbi.nlm.nih.gov]

Malignant GCTB has a poor prognosis. Copyright © 2022, StatPearls Publishing LLC. [pubmed.ncbi.nlm.nih.gov]

Prognosis The overall prognosis of a giant cell tumor of bone is good, though local recurrence can vary widely. [ncbi.nlm.nih.gov]

Prognosis[edit | edit source] The five-year survival rate of the malignant form is 50%. Chemotherapy is ineffective. [wikilectures.eu]

Sections Continuing Education Activity Introduction Etiology Epidemiology Pathophysiology Histopathology History and Physical Evaluation Treatment / Management Differential Diagnosis Staging Prognosis Complications Deterrence and Patient Education Enhancing [pubmed.ncbi.nlm.nih.gov]

Etiology The exact etiology of this tumor is not fully understood. But the mononuclear cells are thought to be derived from primitive mesenchymal cells. [ncbi.nlm.nih.gov]

It is hypointense to isointense on T1-weighted MRI and has variable presentation on T2-weighted MRI. [21] The etiology of osteoblastoma is unknown. [emedicine.medscape.com]

North Bengal Medical College, Darjeeling,West Bengal Sankarshan Bhaduri Asit Chandra Ray Keywords: Giant cell tumor, metacarpal, FNAC Abstract Giant cell tumor (GCT) or osteoclastoma is a common benign tumor which is locally aggressive and is of unknown etiology [pacificejournals.com]

Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment. Ortop Traumatol Rehabil. 2010 May-Jun;12(3):207-15. Review. PMID: &dopt=Abstract Thomas DM, Skubitz KM. Giant cell tumour of bone. [anvita.info]

[Article in English, Polish] Author information 1 Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok. [email protected] Abstract The author presents the epidemiology, classification, clinical features and strategies [ncbi.nlm.nih.gov]

The Journal of Bone & Joint Surgery, 69, 106-114. [ 5 ] Beebe-Dimmer, J.L., Cetin, K., Fryzek, J.P., Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology [scirp.org]

Sections Continuing Education Activity Introduction Etiology Epidemiology Pathophysiology Histopathology History and Physical Evaluation Treatment / Management Differential Diagnosis Staging Prognosis Complications Deterrence and Patient Education Enhancing [pubmed.ncbi.nlm.nih.gov]

Beebe-Dimmer, J.L., Cetin, K., Fryzek, J.P., Schuetze, S.M. and Schwartz, K. (1975) The Epidemiology of Malignant Giant Cell Tumors of Bone: An Analysis of Data from the Surveillance, Epidemiology and End Results Program (1975-2004). [file.scirp.org]

Sections Continuing Education Activity Introduction Etiology Epidemiology Pathophysiology Histopathology History and Physical Evaluation Treatment / Management Differential Diagnosis Staging Prognosis Complications Deterrence and Patient Education Enhancing [pubmed.ncbi.nlm.nih.gov]

Pathophysiology The pathophysiology is not entirely understood but is thought to be caused by the RANK/RANKL signaling pathway overexpression by osteoblast-like mononuclear stromal cells. [ncbi.nlm.nih.gov]

Pathology and Forensic Medicine (340) Internal Medicine (289) Oncology, Radiation Therapy (237) Surgery, Traumatology and Orthopaedics (162) Physiology and Pathophysiology (161) Medical Chemistry and Biochemistry (148) Paediatrics, Neonatology (109) Genetics [portal.mefanet.cz]

Elastic stockinette was wrapped over the postoperative dressing to prevent edema accumulation in the residual limb. Postoperatively, she was asked to lie supine or prone (to tolerance) to prevent hip flexion contracture. [hindawi.com]

Differential-diagnosis osteosarcoma chondroblastoma osteoid osteoma osteoblastoma bone cyst brown tumor of hyperparathyroidism Management surgery if tumor is resectable curettage is most common technique zoledronate is thought to induce osteoclast apoptosis, preventing [anvita.info]

About XGEVA XGEVA was approved by the FDA for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors in 2010. XGEVA is not indicated for the prevention of SREs in patients with multiple myeloma. [amgen.com]

Treatment measures for Giant Cell Tumor of Soft Tissue include the following: Surgical excision with complete removal of the entire lesion is normally sufficient treatment If there is any pain, it is controlled through pain medications In order to prevent [dovemed.com]

Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint. Giant cell tumors are named for the characteristic way they look when viewed under the microscope. [orthoinfo.aaos.org]