Presentation
A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. [books.google.com]
It typically presents with body aches, weakness, alongwith signs of bone tenderness and proximal myopathy. [pubmed.ncbi.nlm.nih.gov]
The amount of matrix present is normal or slightly increased. [pubs.rsna.org]
262 Breech Presentation 269 Transverse or Oblique Lie 283 Compound Presentations 289 Multiple Pregnancy 293 Dystocia due to Anomalies of the Expulsive Forces 300 Dystocia due to Abnormalities of the Maternal Soft Parts 311 [books.google.it]
Entire Body System
- Weakness
Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets. [fpnotebook.com]
There was no cranial nerve weakness and sensory examination was normal. A provisional diagnosis of limb girdle weakness of probable inflammatory or nutritional etiology was made. [annalsofian.org]
Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with waddling gait Hypocalcemia (positive Chvostek sign ) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy [wikidoc.org]
- Fatigue
Classic signs of fibromyalgia are muscle pain, bone aches, weakness, and fatigue. As you can see, these are not very different from the symptoms known to be caused by vitamin D deficiency. [paulthomasmd.com]
Most of the time, the only alleged symptom is chronic fatigue, while bone aches are not spontaneous but only revealed by pressure or shocks. It differs from renal osteodystrophy, where the latter shows hyperphosphatemia. References [wikidoc.org]
The disease is accompanied by pain in the pelvis and sacrum and other parts of the skeleton (especially when pressed), fatigue, reductions resulting muscles of the hips, difficulty in walking (duck gait). [medicalency.com]
[…] aluminium-containing phosphate-binding antacid ifosfamide drugs affecting bone mineralization aluminium etidronate fluoride Presentation Symptoms generalized bone and muscle pain fractures of long bones, ribs and vertebrae proximal muscle weakness weakness fatigue [orthobullets.com]
- Falling
To prevent stress fractures and falls, learn and use proper body mechanics. [glutenfreeworks.com]
A lack of vitamin D causes plasma calcium concentrations to fall. Low plasma calcium levels stimulate parathyroid hormone (PTH). PTH raises calcium concentration but also increases renal clearance of phosphate. [wikilectures.eu]
Vitamin D supplementation does not prevent fractures or falls, nor does it have a clinically meaningful impact on bone mineral density. [patient.info]
[…] rickets and osteomalacia are increased blood concentration of the enzyme alkaline phosphatase, believed to be important for bone formation or resorption, and decreased blood concentrations of calcium or phosphate or both; the calcium concentration may fall [britannica.com]
But it is important to realize that T scores are not the only indication of osteoporosis; if someone has a bone fracture without trauma (or after falling from standing height), then they have osteoporosis by definition, regardless of T score. [medicinenet.com]
- Short Stature
A 23-year-old female patient reported with short stature and depressed nasal bridge with oral manifestation showing partial anodontia and periodontitis. [jisponline.com]
This case affirms that chronic untreated celiac disease, can lead to irreversible complications like skeletal deformities and short stature. [panafrican-med-journal.com]
stature Irritability Uncontrolled muscle spasms all over the body (tetany) and even seizures Soft skull Chest deformities Widening of wrist raises early suspicion Deformed pelvis and Bow legs Harrison's groove(pigeon chest) Spinal deformity Beading of [infonet-biovision.org]
stature (3) Transverse diagonal measurement < 9.5 cm (a measurement of the mother’s pelvis) (4) The mother has a history of childhood calcium deficiency or rickets (5) A variety of problems with the pelvis or birth canal Cephalopelvic disproportion may [abclawcenters.com]
In patients with the genetic forms of osteomalacia and those with childhood celiac disease, residual deformities of rickets with associated short stature may be seen Pain in osteomalacia is felt in bones. [boneandspine.com]
- Asymptomatic
Patients with osteomalacia may be asymptomatic or present with bone pain/tenderness and/or muscular weakness. [radiopaedia.org]
Table I. n Causes of Osteomalacia Clinical featues Osteomalacia can present with following clinical features: Asymptomatic: Patients can be asymptomatic even with striking biochemical and densitometric findings of osteomalacia (eg: 29 year old women with [endocrinologyadvisor.com]
Causes of Osteomalacia Clinical featues Osteomalacia can present with following clinical features: Asymptomatic: Patients can be asymptomatic even with striking biochemical and densitometric findings of osteomalacia (eg: 29 year old women with severe [clinicaladvisor.com]
Bone mineral affection in asymptomatic adult patients with coeliac disease. Am J Gastroenterol.1994 Dec;89(12):2130-4. PubMed | Google Scholar Faten Frikha, Mouna Snoussi, Zouhir Bahloul. [panafrican-med-journal.com]
In 0.06% - 5% of cases these incidents are due to the presence of diverticula of the small intestine, which are asymptomatic and unrecognized in most patients and are only fully diagnosed in cases when complications occur. Case report. [giornalechirurgia.it]
Respiratoric
- Dyspnea
If the patient develops dyspnea and pneumoderma during or after this procedure, a chest radiogram or thoracoabdominal CT should be taken for diagnostic purposes. [giornalechirurgia.it]
Gastrointestinal
- Vomiting
Signs of toxicity include nausea, vomiting, poor appetite, constipation, weakness, and weight loss. Excess vitamin D can also damage the kidneys. Too much vitamin D also raises the level of calcium in your blood. [icdlist.com]
She was having recurrent vomiting and reduced oral intake after the surgery. Her weight had reduced by 21 kg over 2½ months after surgery. She had no co-morbidities. [annalsofian.org]
A 91 years-old man was admitted to Emergency Department reporting abdominal pain and vomit. [giornalechirurgia.it]
Today, I’ve got slightly more effective pain relief–after a pretty horrible trip out yesterday evening–and am enough less upset about the whole situation to (hopefully) avoid the angry word vomit approach to writing. [urocyon.wordpress.com]
- Nausea
Signs of toxicity include nausea, vomiting, poor appetite, constipation, weakness, and weight loss. Excess vitamin D can also damage the kidneys. Too much vitamin D also raises the level of calcium in your blood. [icdlist.com]
Nausea is another reason I got into a problem with not eating enough. Making a big deal out of nothing, my bony broke butt. [urocyon.wordpress.com]
- Intestinal Disease
disease: gluten-sensitive enteropathy / regional enteritis Hepatobiliary disease: chronic biliary obstruction / biliary cirrhosis Pancreatic disease: chronic pancreatitis Primary hypophosphatemia; vitamin D-deficiency rickets Renal disease Chronic renal [learningradiology.com]
Academic Press, San Diego, pp 831–847 Google Scholar Davies M, Mawer EB, Krawitt EL (1980) Comparative absorption of vitamin D3 and 25-hydroxyvitamin D3 in intestinal disease. [link.springer.com]
- Steatorrhea
Causes Of Rickets Abnormality In Vitamin D Metabolism Associated with hyperparathyroidism Vitamin D deficiency Dietary lack of vitamin D Famine osteomalacia Lack of sunshine exposure Malabsorption of vitamin D Pancreatitis and biliary tract disease Steatorrhea [learningradiology.com]
Classically, the disease manifests with diarrhea, sometimes steatorrhea, weight loss and complications caused by anemia [ 1, 2 ]. [panafrican-med-journal.com]
Jaw & Teeth
- Dental Caries
[…] problems such as delayed tooth eruption, dental caries, soft easily broken teeth Muscle weakness which can lead to baby being floppy Frequent fractures or breakage of bones Skeletal deformity Toddlers: Bowed legs Older children: Knock-knees Cranial, [infonet-biovision.org]
Osteomalacia and dental caries. Br Med J 1940;2:221-2. [ PUBMED ] 9. Glickman I. The experimental basis for the bone factor concept in periodontal disease. J Periodontol 1949;20:7-22. [ PUBMED ] 10. [jisponline.com]
Dental deformities include delayed formation of teeth, enamel hypoplasia, and increased incidence of cavities in the teeth (dental caries). [patient.info]
Eyes
- Prolapse
appearance of impending fetal or maternal distress - rupture of membrane for more 12hrs - pulsating cord prolapse - failure of labour progress in present of good uterine contraction - uterine inertia not response to tx and becoming worse - starting [quizlet.com]
Caesarean section if: failed trial of labour i.e. the head did not engage or complications occur during trial as foetal distress or prolapsed pulsating cord before full cervical dilatation. [gfmer.ch]
Errors & Delays Fetal Monitoring Errors Forceps & Vacuum Extractors Periventricular Leukomalacia (PVL) Placental Abruption Premature Birth Prolonged & Arrested Labor Seizures Umbilical Cord Complications Nuchal Cord Short Umbilical Cord True Knot Cord Prolapse [abclawcenters.com]
The progress of labor is mapped with partograph:i) progressive descent of the head ii) progressive dilatation of the cervix After the membrane rupture, pelvic examination is to be done:i) to exclude cord prolapse ii) to note the color of liquor iii) [slideshare.net]
However, the most frequent indications were: disproportion cephalopelvic, no dominance inertia of the uterus, placenta previa, premature come off of placentas with normal insertion, distocic appearance, preeclampsia, eclampsia, prolapse of umbilical cord [ncbi.nlm.nih.gov]
Musculoskeletal
- Fracture
Many bone fractures due to osteopenia or osteoporosis, such as a hip fracture or vertebral fracture (fracture of a bone in the spine), are very painful. [medicinenet.com]
This is still evident in the monograph concerning fractures of the femoral neck. Later it appeared that ST. [books.google.com]
[…] site M84.30XA …… initial encounter for fracture M84.30XD …… subsequent encounter for fracture with routine healing M84.30XG …… subsequent encounter for fracture with delayed healing M84.30XK …… subsequent encounter for fracture with nonunion M84.30XP [icd10data.com]
PMID: 15631376 A histomorphometric study of osteomalacia in elderly females with fracture of the proximal femur. Beringer TR. Beringer TR. Ulster Med J. 1985 Oct;54(2):148-54. Ulster Med J. 1985. PMID: 3913090 Free PMC article. [pubmed.ncbi.nlm.nih.gov]
It has been demonstrated that celiac patients are at increased risk of fracture [ 10 ]. However, in another study, no increase in fracture risk could be demonstrated for CD [ 11 ]. [panafrican-med-journal.com]
- Osteoporosis
Osteopenia vs. osteoporosis Osteopenia and osteoporosis are related conditions. The difference between osteopenia and osteoporosis is that in osteopenia the bone loss is not as severe as in osteoporosis. [medicinenet.com]
Osteopathies and chondropathies (M80-M94)|M80-M85 Disorders of bone density and structure (M80-M85)|M83 Adult osteomalacia Results for Tumor-induced osteomalacia (disorder) and additional synonyms M83.8 Other adult osteomalacia Synonyms: Congenital cranial osteoporosis [averbis.com]
New Royal Society of Chemistry, 2003 - 755 pagine Nutritional Aspects of Bone Health provides an in-depth review of the role of diet in the development and maintenance of bone health throughout the lifecycle, and prevention of osteoporosis in later life [books.google.it]
The spine is particularly affected. osteoporosis Overview of osteoporosis. [britannica.com]
Mayo Clinic Proceedings. 2010;85(8):752-758 National Osteoporosis Sociaety (NOS) 2018. [gpnotebook.co.uk]
- Low Back Pain
Gupta AD (2009) Sacroiliac joint pathologies in low back pain. [link.springer.com]
Osteomalacia Mildly affected patients may present with widespread bone pain and tenderness (especially low back pain and in the hips), proximal muscle weakness and lethargy. [patient.info]
- Hip Pain
[…] fractures of long bones, ribs and vertebrae proximal muscle weakness weakness fatigue Physical exam inspection waddling gait from hip pain and thigh weakness difficulty rising from chair and climbing stairs Imaging Radiographs findings Bone scan findings [orthobullets.com]
Neurologic
- Seizure
[…] the epiphyseal plates Causes Vitamin D deficiency Low sun exposure Nutritional Malabsorption Billroth type II gastrectomy Jejunoileal bypass Sprue Chronic renal failure Calcium deficiency Phosphate deficiency Decreased alkaline phosphatase Phenytoin – seizure [physicianassistantexamreview.com]
Some drugs used to treat seizures, including phenytoin (Dilantin, Phenytek) and phenobarbital, can cause severe vitamin D deficiency and osteomalacia. [mayoclinic.org]
And drugs to treat seizures — like phenytoin and phenobarbital — can also result in osteomalacia. There are a few symptoms of osteomalacia. The most common is bones that fracture easily. Another is muscle weakness. [healthline.com]
There are also certain medications that can cause Osteomalacia such as ones that are used to treat seizures like Phenobarbital and phenytoin. [gudhealth.com]
[…] and HIE Birth Injury: Overview Brain Bleeds (Hemorrhages) Cerebral Palsy C-Section Errors & Delays Fetal Monitoring Errors Forceps & Vacuum Extractors Periventricular Leukomalacia (PVL) Placental Abruption Premature Birth Prolonged & Arrested Labor Seizures [abclawcenters.com]
- Irritability
Osteomalacia during enchondral bone growth Age 4-18 months Histology Zone of preparatory calcification does not form resulting in build-up of maturing cartilage cells Also occurs in shafts so that osteoid production elevates periosteum Clinical findings Irritability [learningradiology.com]
[…] appearance of impending fetal or maternal distress - rupture of membrane for more 12hrs - pulsating cord prolapse - failure of labour progress in present of good uterine contraction - uterine inertia not response to tx and becoming worse - starting uterine irritability [quizlet.com]
Children with vitamin D deficiency may be irritable and reluctant to weight-bear, and manifest impaired growth. [patient.info]
[…] teeth Muscle weakness which can lead to baby being floppy Frequent fractures or breakage of bones Skeletal deformity Toddlers: Bowed legs Older children: Knock-knees Cranial, spinal, and pelvic deformities Growth disturbance - child has short stature Irritability [infonet-biovision.org]
[…] not be pushed down and instead the partial bone overhangs the symphysis pubis displacing the finger – sever disproportion Some times the degree of disproportion is difficult to found by this method because of:• Deflexed head • Thick abdominal wall • Irritable [slideshare.net]
- Asthenia
Osteomalacia is manifested by back pain and thighs that extend the arms and sides and a state of extreme weakness and asthenia as our patient. It has been demonstrated that celiac patients are at increased risk of fracture [ 10 ]. [panafrican-med-journal.com]
An 88-year old male patient presented with severe anaemia, asthenia and melaena in the previous days. [giornalechirurgia.it]
- Sciatica
_See_ Cicatrices Sciatic nerve, lesions of, 370 Sciatica, 371 Scirrhous cancer, 210 Sclavo's serum, 123 Scoliosis, rickety, 471 in sciatica, 372 Scorbutic ulcers, 77 Scrotum, elephantiasis of, 389 Sculler's sprain, 406 Scurvy, 473 rickets, 473 Sebaceous [en.wikisource.org]
- Convulsions
May present with symptoms of hypocalcaemia requiring urgent paediatric referral (eg, convulsions, irritability, tetany, breathing difficulties with apnoea or stridor), cardiomyopathy or cardiac arrest, especially in very young infants. [patient.info]
Workup
Serum
- Phosphate Decreased
PTH raises calcium concentration but also increases renal clearance of phosphate. When phosphate decreases below a critical level, mineralization cannot proceed normally. [wikilectures.eu]
Treatment
Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]
Surgical removal of the tumour is the only definitive treatment. When the tumour cannot be located or when complete resection is not possible, medical treatment with phosphate salts or active vitamin D is necessary. [natureasia.com]
Treatment for cephalopelvic disproportion (CPD) Treatment for CPD varies based on severity and when it is diagnosed. If it is severe and diagnosed early, a planned C-section is indicated. [abclawcenters.com]
Prognosis
Good Uterine contraction Early engagement of Head Rupture after full dilatation Good effacement &dilatation Flat pelvis Vertex presentation with anterior position BAD PROGNOSIS Weak Uterine contraction Slow descent of the head Premature rupture of membrane [slideplayer.com]
The prognosis for puerperal osteomalacia serious. Death rarely occurs from the underlying disease at a picture of gradual exhaustion. Most patients die from opportunistic diseases. [medicalency.com]
Prognosis If vitamin D levels return to normal, osteomalacia should go away within a few weeks to months. [healthand.com]
Osteomalacia prognosis With adequate and appropriate treatment to the cause of the calcium and vitamin D deficiency, some people will notice improvement of symptoms within a few weeks. [drlumbago.com]
Etiology
Etiology vitamin D deficiency (most common) inadequate intake or absorption dietary deficiency of vitamin D lack of sunlight exposure gastric surgery (e.g., gastrectomy or gastric bypass) small bowel disease (e.g., Crohn disease, celiac disease) pancreatic [radiopaedia.org]
In the etiology of puerperal Acting stresses the importance of vitamin D. If the increased need for vitamin D during pregnancy and lactation women's body does not receive it in sufficient quantity, the new bone structure little or no obesesluts. [medicalency.com]
Discussion: - is a type of metabolic bone disease in which the essential problem is a lack of available calcium or phosphorus (or both) for mineralization of newly formed osteoid; - children w/ rickets & adults w/ osteomalacia present w/ similar findings; - etiology [wheelessonline.com]
Keywords: Adult, Case Report, Female, Human, Muscular Diseases, etiology,Osteomalacia, complications,Thyrotoxicosis, complications, How to cite this article: Goswami R, Shah P, Ammini A C. Thyrotoxicosis with osteomalacia and proximal myopathy. [jpgmonline.com]
Etiology of rickets in Nigerian children. J Pediatr 1996 ;128: 692 - 694 9. Thacher TD, Ighogboja SI, Fischer PR. Rickets without vitamin D deficiency in Nigerian children. Ambulatory Child Health 1997 ;3: 56 - 64 10. [nejm.org]
Epidemiology
The book is structured such that, in the first section, an overview is provided on what is meant by the terms bone health and osteoporosis and includes key areas such as epidemiology, genetics and the impact of non-nutritional exogenous factors influencing [books.google.it]
[…] defects in phosphate metabolism: high remodeling rate: excessive osteoid formation with normal/little mineralization low remodeling rate: normal osteoid production with diminished mineralization Because of the many causes of osteomalacia worldwide, the epidemiology [radiopaedia.org]
[…] metabolic bone disease where defective mineralization results in a large amount or unmineralized osteoid qualitative defect as opposed to a quanitative defect like osteoporosis rickets and osteomalacia are manifestations of the same pathologic process Epidemiology [orthobullets.com]
Epidemiology [ ✎ edit | edit source ] Osteomalcia is rare in the United States and Western Europe. [wikilectures.eu]
Presented at the 19th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic Research; Seattle; June 20–21, 2006. [ Google Scholar ] 26. Glezerman M. [ncbi.nlm.nih.gov]
Pathophysiology
After briefly presenting an overview of the demography of subfecundity, this book goes on exploring the pathophysiology and effect on fecundity of various diseases, which are classified into three groups. [books.google.it]
The recent identification of a fusion of fibronectin and fibroblast growth factor receptor 1 (FGFR1) as a molecular driver in some tumours not only sheds light on the pathophysiology of TIO but also opens the door to a better understanding of the transcription [natureasia.com]
Pathophysiology: The biological basis for disease in adults and children (7th ed.). St. Louis, MO.: Elsevier/Mosby. [wikilectures.eu]
Pathophysiology Renal osteodystrophy is a global term applied to all pathologic features of bone in patients with renal failure. [emedicine.medscape.com]
Pathophysiology of Osteomalacia The basic pathologic finding is an excess of persisting osteoid seams. There is a normal degree of osteoclastic activity going on. [boneandspine.com]
Prevention
New Royal Society of Chemistry, 2003 - 755 pagine Nutritional Aspects of Bone Health provides an in-depth review of the role of diet in the development and maintenance of bone health throughout the lifecycle, and prevention of osteoporosis in later life [books.google.it]
Prevention Just like treatment, prevention to be effective must be directed toward the underlying cause of the osteomalacia problem. [drlumbago.com]
From Is it possible to prevent osteopenia? The best way to prevent osteopenia is by living healthfully. [medicinenet.com]
Treatment and Prevention If a lack of vitamin D is causing osteomalacia, the patient will be advised to increase their vitamin D intake. [medbroadcast.com]
Prevention Osteomalacia caused by inadequate sun exposure or a diet low in vitamin D often can be prevented by getting enough vitamin D. Eat foods high in vitamin D. [mayoclinic.org]