Very frequently present symptoms in 80-99% of the cases: Increased bone mineral density Abnormal form of the vertebral bodies Kyphosis Scoliosis Vertebral body sclerosis Occasionally present symptoms in 5-29% of the cases: Abnormal cortical bone morphology [dovemed.com]

Osteomesopyknosis presents with chronic, low-grade back pain in the thoracic and lumbar regions. Life expectancy is normal. Height and intellect are not affected. Dense diffuse osteosclerosis of axial spine, pelvis and proximal long bones. [radiopaedia.org]

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

She had presented 6 years ago, at the age of 33, with neck pain. [docksci.com]

• Fear

  The female patient from our case report had to live about 6 years with the fear of suffering from a malignant disease, without having a diagnosis. [docksci.com]

• Focal Neurological Deficit

  A 34-year-old, otherwise healthy male patient presented with diffuse lower back pain without any focal neurologic deficits. Plain radiographs of the thoracic and lumbar spine did not depict any abnormalities (Fig. 1). [docksci.com]

[…] some cases, due to treatment also. [dovemed.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

He is an active member of multiple international societies focusing on bone diseases and their treatment. [books.google.com]

OSTEOMESOPYKNOSIS, Datagenno Interactive Research Overview Therapies & Treatments Scientific Articles Laboratories Foundations Forum Members Presentation, Natural History and Genetics List of Genes Reorder Groups Close Signs / Symptoms (5) General Ovarian [datagenno.com]

Osteomesopyknosis, usually discovered incidentally on radiographic examination, is a mild form of familial osteosclerosis and must be distinguished from osteopetrosis which carries a worse prognosis. [link.springer.com]

Prognosis - Axial osteosclerosis Not supplied. Treatment - Axial osteosclerosis Not supplied. Resources - Axial osteosclerosis [checkorphan.org]

It is usually discovered incidentally on radiographic examination, is a mild form of familial osteosclerosis and must be distinguished from osteopetrosis which carries a worse prognosis. A marked increase uptake may be found on bone scintigraphy. [gamma.wustl.edu]

The prognosis is not good. There are no treatments. Margaret helped us to digest all of this information. Despite our endless calls and emails, Margaret made us feel that talking to our family was the most important thing she had to do. [invitae.com]

Etiology The genetic basis underlying the disorder is not known. Genetic counseling The disorder appears to follow an autosomal dominant pattern of inheritance. The documents contained in this web site are presented for information purposes only. [orpha.net]

Camacho Published in Endocrine practice : official journal of the… 2014 DOI: 10.4158/EP13352.CR OBJECTIVE We present a case of osteomesopyknosis, a nonmalignant sclerosing bone dysplasia of the axial skeleton, with unknown etiology and unknown prevalence [semanticscholar.org]

Case Report 1, Pauline Camacho 1 1 Osteoporosis and Metabolic Bone Disease Center, Loyola University Medical Center Objective: We present a case of osteomesopyknosis, a nonmalignant sclerosing bone dysplasia of the axial skeleton, with unknown etiology [journals.aace.com]

(Etiology) Osteomesopyknosis is inherited in an autosomal dominant manner, but the genetic cause has not yet been identified. [dovemed.com]

Summary Epidemiology The prevalence and incidence of this disorder are not known. It has been reported in fewer than 5 families, primarily in France. [orpha.net]

Epidemiological, clinical and radiological aspects of osteopoikilosis. J Bone Joint Surg Br. 1992;74:504–6. [docksci.com]

Nerlich AG, Rohrbach H, Bachmeier B, Zink AR: Malignant tumors in two ancient populations: an approach to historical tumor epidemiology. Oncol Rep 2006;16:197-202. [karger.com]

Investigations of BMP signaling in FOP may suggest research strategies to characterize altered signaling events that lead to melorheostosis pathophysiology and/or that can be used to identify cellular targets for melorheostosis treatment. [melorheostosis.com]

How can Osteomesopyknosis be Prevented? Currently, Osteomesopyknosis may not be preventable, since it is a genetic disorder. [dovemed.com]

Symptoms - Axial osteosclerosis Causes - Axial osteosclerosis Prevention - Axial osteosclerosis Not supplied. Diagnosis - Axial osteosclerosis It is usually diagnosed incidentally in young adults complaining of back pain. [checkorphan.org]

[…] hypointense lesions on T1- and T2-weighted images, variable increase of intensity on STIR sequences, very similar to osteomesopyknosis Spinal column, vertebral bodies Any bone can be involved Skeletal Radiol diagnostic radiologic features of this disease can prevent [docksci.com]