Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. [link.springer.com]

These data suggest that 1) androgens from the androblastoma are responsible for virilization despite aromatizing enzyme activities within normal limits, and 2) both the delta 5 and delta 4 pathways are involved in the biosynthesis of androgens, with that [ncbi.nlm.nih.gov]

Many patients have symptoms of virilization depending on the quantity of androgen production. A small subset are hyperoestrogenic. Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain. [radiopaedia.org]

The effect of a virilization is more provided with cages of Leydiga, effect of feminization (at premature isosexual development) – Sertoli's cells. [medicine-for-you.com]

Edited by four leading surgical pathologists - Noel Weidner, MD, Richard J. Cote, MD, Saul Suster, MD and Lawrence M. [books.google.com]

The criteria of testicular differentiation, and the relation of endocrine function to morphology and age, are discussed. 1982International Society of Gynecological Pathologists Related Articles [journals.lww.com]

A pathologist examines the biopsy under a microscope. After putting together clinical findings, special studies on tissues (if needed) and with microscope findings, the pathologist arrives at a definitive diagnosis. [dovemed.com]

[…] cell tumors Sertoli cell tumor (SCT) large cell calcifying Sertoli cell tumor (LCCSCT) Sertoli-Leydig cell tumor Leydig cell tumor Links Sertoli-Leydig Cell Tumor at WebPathology References Sertoli-Leydig cell tumours of the ovary and testis: a CGH and FISH [humpath.com]

Ultrasonography examination revealed a large cystic mass with multiple echo space and thyroid nodules. [spandidos-publications.com]

[…] of voice, due to enlargement of the voice box Cessation of menses Decrease in size of breasts Redistribution of fat Broadening of the shoulders Acne of the face and chest Loss of sexual desire Increased musculature Abdominal pain may occur in some cases [dovemed.com]

Electron microscopic study of the tonsillar mass revealed crystalloid structures suggestive of the Leydig cell origin of the tumor. [ncbi.nlm.nih.gov]

Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible [humpath.com]

Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization. [link.springer.com]

Sertoli-Leydig cell tumor of the ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism [orpha.net]

Electron microscopic study of the tonsillar mass revealed crystalloid structures suggestive of the Leydig cell origin of the tumor. [ncbi.nlm.nih.gov]

The present data suggest that: 1) androblastomas have a biosynthetic capacity for androgen, estrogen, or both in which both the Δ 5 and Δ 4 pathways are involved, and 2) little correlation exists between the endocrine function and cellular composition [link.springer.com]

Exploratory laparotomy with a hysterectomy and salpingo-oophorectomy has been suggested for these patients. [glowm.com]

Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible [humpath.com]

atrophy and menstrual irregularity or amenorrhea ( Am J Surg Pathol 1985;9:543 ) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone [pathologyoutlines.com]

Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible [humpath.com]

atrophy and menstrual irregularity or amenorrhea ( Am J Surg Pathol 1985;9:543 ) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone [pathologyoutlines.com]

Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible [humpath.com]

The recommendation to include the measurement of androgen levels in the routine diagnosis of secondary amenorrhea must therefore be endorsed. [ncbi.nlm.nih.gov]

[…] ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea [orpha.net]

Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977). [books.google.es]

On physical examination, the obstetrician palpates a right adnexal mass. Ultrasonographic evaluation confirms the presence of a solid mass in the right ovary. The ovary is removed and sent to pathology. [prep4usmle.com]

mass Radiology images Images hosted on other servers: Large tumor Gross description Almost always unilateral ( Am J Surg Pathol 1985;9:543 ) Tumor size ranges widely from 1 cm to 35 cm (mean 12 - 14 cm) ( Am J Surg Pathol 1985;9:543 ) Cut surface is [pathologyoutlines.com]

Characterization of adnexal masses. AJR 1996;166:385-93 11. Foshager MC and Walsch JW. CT anatomy of the female pelvis : a second look. Radiographics 1994;14:51-66 12. Sutton CL, McKinney CD et al. [mafiadoc.com]

When seen in cases of the syndrome, the lesion is typically small, bilateral, and calcified whereas those unassociated with the syndrome form unilateral adnexal masses. Figure 19 Sex cord tumor with annular tubules. [nature.com]

Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. Cause [ edit ] The exact cause of Sertoli-Leydig Cell Tumor is not known. [en.wikipedia.org]

[…] below ) Clinical features Clinical presentation may include pelvic pain or a pelvic mass, rarely with ascites and tumor rupture Androgenic hormonal symptoms (virilization) are common and present in approximately 50% of patients; they include hirsutism, clitoromegaly [pathologyoutlines.com]

The recommendation to include the measurement of androgen levels in the routine diagnosis of secondary amenorrhea must therefore be endorsed. [ncbi.nlm.nih.gov]

Testosterone-producing ovarian tumor associated with erythrocytosis, hyperuricemia, and recurrent deep vein thrombosis. Am. J. Obstet. Gynecol. 129 : 467, 1977. PubMed Google Scholar 16. Sato T., Shinada T., Matsumoto S. [link.springer.com]

When performing blood tests on hormones at patients with androblastomy an ovary increase in level of testosterone, decrease in level of lyuteineziruyushchy and follikulstimuliruyushchy hormone comes to light. [medicine-for-you.com]

Intraoperatively, a large multicystic right ovarian mass measuring 22 15 18 cm was found (Figure 1). The mass was removed, together with the ipsilateral fallopian tube. [hormones.gr]

OVARIAN MASSES NON-NEOPLASTIC OVARIAN MASSES 1/ Follicular cysts Follicular cysts are often found incidentally in asymptomatic patients of reproductive age, and range 1-20 cm3 in size. [mafiadoc.com]