Edit concept Question Editor Create issue ticket

Ovarian Androblastoma

Ovarian Sertoli Cell Tumor


Presentation

  • Lutein cell clusters were present in all cases and tubules were present in five. The ideas developed for interpreting the androblastoma family are reviewed historically and related to the foregoing.[ncbi.nlm.nih.gov]
  • While they can present at any age, they typically present In 30-50% of patients, the presenting symptoms are related to clinical signs of androgenic activity 6 .[radiopaedia.org]
  • The present editor organized and chaired a symposium entitled "Recent Progress in Diagnostic Pathology of Gynecological Tumors" held in Sendai, Japan on 11 April 1986 in close cooperation with Prof. T.[books.google.com]
Virilization
  • Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization.[link.springer.com]
  • These data suggest that 1) androgens from the androblastoma are responsible for virilization despite aromatizing enzyme activities within normal limits, and 2) both the delta 5 and delta 4 pathways are involved in the biosynthesis of androgens, with that[ncbi.nlm.nih.gov]
  • Many patients have symptoms of virilization depending on the quantity of androgen production. A small subset are hyperoestrogenic. Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain.[radiopaedia.org]
  • The effect of a virilization is more provided with cages of Leydiga, effect of feminization (at premature isosexual development) – Sertoli's cells.[medicine-for-you.com]
Pathologist
  • Edited by four leading surgical pathologists - Noel Weidner, MD, Richard J. Cote, MD, Saul Suster, MD and Lawrence M.[books.google.com]
  • The criteria of testicular differentiation, and the relation of endocrine function to morphology and age, are discussed. 1982International Society of Gynecological Pathologists Related Articles[journals.lww.com]
  • A pathologist examines the biopsy under a microscope. After putting together clinical findings, special studies on tissues (if needed) and with microscope findings, the pathologist arrives at a definitive diagnosis.[dovemed.com]
Italian
  • Google Scholar Copyright information Italian Society of Endocrinology (SIE) 1984 Authors and Affiliations Masao Munemura 1 S. Inoue 1 R. Himeno 3 N. Koyama 1 J. Mizumoto 1 M. Maeyama 1 T. Iwamasa 2 1.[link.springer.com]
  • Synonym(s): androblastoma Sertoli, Enrico, Italian histologist, 1842-1910. Sertoli cell tumor - a testicular tumor.[medical-dictionary.thefreedictionary.com]
  • […] maligne de l'ovaire, Tumeur maligne ovarienne German Krebs des Eierstocks, boesartige Neubildung des Eierstocks, Ka des Eierstocks, Ovarialkarzinom NNB, Ovarialkarzinom, Boesartige Neubildung des Ovars, Ovarialkrebs, Krebs des Ovars, Ovarieller Krebs Italian[fpnotebook.com]
  • Translator German - Tamil Sertoli-Leydig செல் கட்டி 75 millions of speakers Translator German - Marathi Sertoli-Leydig सेल अर्बुद 75 millions of speakers Translator German - Turkish Sertoli Leydig Hücre Tümör 70 millions of speakers Translator German - Italian[educalingo.com]
Fishing
  • […] cell tumors Sertoli cell tumor (SCT) large cell calcifying Sertoli cell tumor (LCCSCT) Sertoli-Leydig cell tumor Leydig cell tumor Links Sertoli-Leydig Cell Tumor at WebPathology References Sertoli-Leydig cell tumours of the ovary and testis: a CGH and FISH[humpath.com]
Thyroid Nodule
Deepening of Voice
  • […] of voice, due to enlargement of the voice box Cessation of menses Decrease in size of breasts Redistribution of fat Broadening of the shoulders Acne of the face and chest Loss of sexual desire Increased musculature Abdominal pain may occur in some cases[dovemed.com]
Tonsillar Mass
  • Electron microscopic study of the tonsillar mass revealed crystalloid structures suggestive of the Leydig cell origin of the tumor.[ncbi.nlm.nih.gov]
Hirsutism
  • Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible[humpath.com]
  • Clinically, all 4 patients showed evidence of increased androgen production, manifested by either hirsutism or virilization.[link.springer.com]
  • Sertoli-Leydig cell tumor of the ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism[orpha.net]
Suggestibility
  • Electron microscopic study of the tonsillar mass revealed crystalloid structures suggestive of the Leydig cell origin of the tumor.[ncbi.nlm.nih.gov]
  • The present data suggest that: 1) androblastomas have a biosynthetic capacity for androgen, estrogen, or both in which both the Δ 5 and Δ 4 pathways are involved, and 2) little correlation exists between the endocrine function and cellular composition[link.springer.com]
  • In some cases, the tumor cells are dispersed loosely in the stroma suggesting the reticular pattern of yolk sac tumor.[nature.com]
Breast Atrophy
  • Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible[humpath.com]
  • atrophy and menstrual irregularity or amenorrhea ( Am J Surg Pathol 1985;9:543 ) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone[pathologyoutlines.com]
Breast Atrophy
  • Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible[humpath.com]
  • atrophy and menstrual irregularity or amenorrhea ( Am J Surg Pathol 1985;9:543 ) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone[pathologyoutlines.com]
Amenorrhea
  • Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization ( breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible[humpath.com]
  • The recommendation to include the measurement of androgen levels in the routine diagnosis of secondary amenorrhea must therefore be endorsed.[ncbi.nlm.nih.gov]
  • […] ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea[orpha.net]
Adnexal Mass
  • Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977).[books.google.es]
  • On physical examination, the obstetrician palpates a right adnexal mass. Ultrasonographic evaluation confirms the presence of a solid mass in the right ovary. The ovary is removed and sent to pathology.[prep4usmle.com]
  • mass Radiology images Images hosted on other servers: Large tumor Gross description Almost always unilateral ( Am J Surg Pathol 1985;9:543 ) Tumor size ranges widely from 1 cm to 35 cm (mean 12 - 14 cm) ( Am J Surg Pathol 1985;9:543 ) Cut surface is[pathologyoutlines.com]
  • When seen in cases of the syndrome, the lesion is typically small, bilateral, and calcified whereas those unassociated with the syndrome form unilateral adnexal masses. Figure 19 Sex cord tumor with annular tubules.[nature.com]
Clitoromegaly
  • Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly.[knowcancer.com]
  • Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. Cause [ edit ] The exact cause of Sertoli-Leydig Cell Tumor is not known.[en.wikipedia.org]
  • […] below ) Clinical features Clinical presentation may include pelvic pain or a pelvic mass, rarely with ascites and tumor rupture Androgenic hormonal symptoms (virilization) are common and present in approximately 50% of patients; they include hirsutism, clitoromegaly[pathologyoutlines.com]
Secondary Amenorrhea
  • The recommendation to include the measurement of androgen levels in the routine diagnosis of secondary amenorrhea must therefore be endorsed.[ncbi.nlm.nih.gov]

Workup

Erythrocytosis
  • Testosterone-producing ovarian tumor associated with erythrocytosis, hyperuricemia, and recurrent deep vein thrombosis. Am. J. Obstet. Gynecol. 129 : 467, 1977. PubMed Google Scholar 16. Sato T., Shinada T., Matsumoto S.[link.springer.com]
Testosterone Decreased
  • When performing blood tests on hormones at patients with androblastomy an ovary increase in level of testosterone, decrease in level of lyuteineziruyushchy and follikulstimuliruyushchy hormone comes to light.[medicine-for-you.com]
Ovarian Mass
  • Intraoperatively, a large multicystic right ovarian mass measuring 22 15 18 cm was found (Figure 1). The mass was removed, together with the ipsilateral fallopian tube.[hormones.gr]

Treatment

  • Androblastoma of an ovary - treatment[medicine-for-you.com]
  • There is no agreement as to how to treat an ovarian neoplasm; by surgery alone, or, by using radiation and chemotherapy as a complement to the operative treatment.[books.google.com]
  • Treatment and prognosis Most tumors are benign although 10-20% can be malignant. ovarian tumors ovarian cancer staging Promoted articles (advertising)[radiopaedia.org]
  • Treatment Treatment for ovarian cancer may consist of surgery, chemotherapy, radiation therapy, hormone therapy, or targeted therapy. Often more than one treatment is used.[medicalnewstoday.com]
  • Diagnosis –the same as erosion Treatment.[intranet.tdmu.edu.ua]

Prognosis

  • Treatment and prognosis Most tumors are benign although 10-20% can be malignant. ovarian tumors ovarian cancer staging Promoted articles (advertising)[radiopaedia.org]
  • Prognosis recurrence or metastasis: less than 5%.[humpath.com]
  • prognosis compared with those with poor health Age of the individual: Older individuals generally have poorer prognosis than younger individuals Whether the tumor is occurring for the first time, or is a recurrent tumor.[dovemed.com]
  • Outlook (Prognosis) Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. Since these tumors are typically benign and their growth is slow, outlook is generally very positive.[knowcancer.com]
  • The prognosis is generally good as the tumour tends to grow slowly and usually is benign : 25% are malignant. [ citation needed ] For malignant tumours with undifferentiated histology, prognosis is poor. [7] See also [ edit ] Androgen-dependent syndromes[en.wikipedia.org]

Etiology

  • Malignant lipid cell tumor of the ovary: clinical, biochemical and etiologic considerations. J. Clin. Endocrinol. Metab. 30 : 336, 1970. PubMed CrossRef Google Scholar 18. Haruyama Y., Inoue H., Koike H., Yamaguchi M., Miyakawa Y., Mori N.[link.springer.com]
  • Etiology and features of a structure of an androblastoma of an ovary The reasons of development of an androblastoma of an ovary are unknown.[medicine-for-you.com]
  • Wegener granulomatosis - Autoimmune etiology and clinical course. Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies.[netdoc.com]
  • The etiology and pathogenesis of the syndrome are caused by hypothalamic disorders. In recent years, the genetic background to the disease is more clearly shown.[en.medicine-guidebook.com]

Epidemiology

  • […] specifically in the germ cells of murine gonads. [8] In vitro and in vivo studies have demonstrated that ectopic expression of TSPY favors cell proliferation and growth and predisposes cells to further genetic “hits” resulting in carcinogenesis. [7] Epidemiology[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The book emphasizes the correlation between clinical and pathologic features of female genital tract disease by examining the pathophysiology of individual organ systems.[books.google.com]
  • Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly.[knowcancer.com]
  • Pathophysiology Human development and sexual differentiation is a complicated but highly organized process.[emedicine.medscape.com]

Prevention

  • Prevention arrhenoblastoma There is no way to prevent ovarian cancer in any form, as the cause of the alarm is unknown.[omedicine.info]
  • The exact cause of Arrhenoblastoma of Ovary is unknown and the condition cannot be prevented A complete surgical removal is the treatment of choice.[dovemed.com]
  • Hormone Therapy Hormone therapy (HT) may be added to the treatment plan in order to prevent estrogen from reaching the cancer cells. Cutting off the supply of estrogen slows the growth of the cancer cells.[medicalnewstoday.com]
  • Concussion Care Excela Health's Concussion Clinic has a double-sided objective of providing education to prevent concussion and using the latest techniques to treat and evaluate recovery.[excelahealth.org]
  • The novel compounds have a high activity particularly in cancer and tumor prevention and therapy on.[google.com.na]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!